Neuroprotective effects of valproic acid on blood-brain barrier disruption and apoptosis-related early brain injury in rats subjected to subarachnoid hemorrhage are modulated by heat shock protein 70/matrix metalloproteinases and heat shock protein 70/AKT pathways

Neurosurgery

Volumn 79, Issue 2, 2016, Pages 286-295

  Ying, Guang Yu ^a   Jing, Chao Hui ^b   Li, Jian Ru ^a   Wu, Cheng ^c   Yan, Feng ^a   Chen, Jing Yin ^a   Wang, Lin ^a   Dixon, Brandon J ^d   Chen, Gao ^a  

^a THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c ZHEJIANG UNIVERSITY   (China)

^d LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Blood brain barrier disruption; Brain edema; Early brain injury; Subarachnoid hemorrhage; Valproic acid

Indexed keywords

CLAUDIN 5; DEOXYURIDINE TRIPHOSPHATE DERIVATIVE; DNA NUCLEOTIDYLEXOTRANSFERASE; EVANS BLUE; FLUORESCENT DYE; GELATINASE B; HEAT SHOCK PROTEIN 70; MATRIX METALLOPROTEINASE; OCCLUDIN; PROTEIN BCL 2; PROTEIN KINASE B; QUERCETIN; VALPROIC ACID; NEUROPROTECTIVE AGENT;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; BRAIN EDEMA; BRAIN INJURY; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; EARLY BRAIN INJURY; ENDOTHELIUM CELL; ENZYME ACTIVITY; EXTRAVASATION; MALE; MORTALITY; NERVE CELL; NEUROPROTECTION; NONHUMAN; PERFORATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SUBARACHNOID HEMORRHAGE; TRANSMISSION ELECTRON MICROSCOPY; TUNEL ASSAY; WESTERN BLOTTING; ZYMOGRAPHY; ANIMAL; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT; SUBARACHNOID HEMORRHAGE, TRAUMATIC;

ANIMALS; APOPTOSIS; BLOOD-BRAIN BARRIER; DISEASE MODELS, ANIMAL; HSP70 HEAT-SHOCK PROTEINS; IN SITU NICK-END LABELING; MALE; MATRIX METALLOPROTEINASES; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; SUBARACHNOID HEMORRHAGE, TRAUMATIC; VALPROIC ACID;

EID: 84973161235     PISSN: 0148396X     EISSN: 15244040     Source Type: Journal    
DOI: 10.1227/NEU.0000000000001264     Document Type: Article

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