Species-specific chromosome engineering greatly improves fully human polyclonal antibody production profile in cattle

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Matsushita, Hiroaki ^a,e   Sano, Akiko ^b,e   Wu, Hua ^a,e   Wang, Zhongde ^c,e   Jiao, Jin An ^a,e   Kasinathan, Poothappillai ^d,e   Sullivan, Eddie J ^a,e   Kuroiwa, Yoshimi ^b,e  

^a SAB Biotherapeutics   (United States)

^b KYOWA HAKKO KOGYO CO LTD   (Japan)

^c UTAH STATE UNIVERSITY   (United States)

^d Trans Ova Genetics   (United States)

^e Hematech Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G1; IMMUNOGLOBULIN M; PRE B CELL RECEPTOR; SURROGATE IMMUNOGLOBULIN LIGHT CHAIN; ANTIGEN; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANTIBODY PRODUCTION; ANTIBODY STRUCTURE; ARTICLE; BIGHG1 GENE; BOVINE; CH GENE; CHROMOSOME 14; CHROMOSOME 2; CHROMOSOME TRANSLOCATION; EXON; GENE; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; GENE LOCUS; HIGG1 GENE; HIGHG1 GENE; IMMUNOGLOBULIN BLOOD LEVEL; NONHUMAN; PROMOTER REGION; ANIMAL; BIOSYNTHESIS; CHEMISTRY; CHICKEN; CHROMOSOMAL MAPPING; CYTOLOGY; GENE INACTIVATION; GENE VECTOR; GENETIC ENGINEERING; GENETICS; HUMAN; HUMAN ARTIFICIAL CHROMOSOME; IMMUNIZATION; IMMUNOLOGY; LYMPHOCYTE; METABOLISM; SPECIES DIFFERENCE; TRANSGENIC ANIMAL; TUMOR CELL LINE;

ANIMALIA; BOS; BOVINAE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIBODIES, MONOCLONAL; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIGENS; CATTLE; CELL LINE, TUMOR; CHICKENS; CHROMOSOME MAPPING; CHROMOSOMES, ARTIFICIAL, HUMAN; GENE KNOCKOUT TECHNIQUES; GENETIC ENGINEERING; GENETIC VECTORS; HUMANS; IMMUNIZATION; IMMUNOGLOBULIN G; LYMPHOCYTES; PRE-B CELL RECEPTORS; SPECIES SPECIFICITY;

EID: 84939129686     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0130699     Document Type: Article

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