Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis

FASEB Journal

Volumn 30, Issue 6, 2016, Pages 2187-2197

  Haggie, Peter M ^a,b   Phuan, Puay Wah ^a,b   Tan, Joseph Anthony ^a,b   Zlock, Lorna ^a   Finkbeiner, Walter E ^a   Verkman, A S ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ASL; Drug discovery; High throughput screening; Inflammatory airway disease

Indexed keywords

ANILINE; INTERLEUKIN 13; PENDRIN ANION EXCHANGE INHIBITOR; PROTEIN INHIBITOR; PYRAZOLE; SULFONAMIDE; THIOPHENE; UNCLASSIFIED DRUG; BICARBONATE CHLORIDE ANTIPORTER; CARRIER PROTEIN; PENDRIN PROTEIN, RAT; PYRIDINE DERIVATIVE; SLC26A4 PROTEIN, HUMAN;

AIRWAY SURFACE LIQUID VOLUME; ALKALINIZATION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; DIGESTIVE TRACT PARAMETERS; DRUG EFFICACY; DRUG IDENTIFICATION; EPITHELIUM CELL; FLUORESCENCE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; NONHUMAN; PRIMARY CELL CULTURE; PRIORITY JOURNAL; RAT; RESPIRATORY EPITHELIUM; STRUCTURE ACTIVITY RELATION; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CHEMISTRY; CHLOROCEBUS AETHIOPS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; RESPIRATORY SYSTEM;

ANIMALS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CHLORIDE-BICARBONATE ANTIPORTERS; CYSTIC FIBROSIS; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-13; MEMBRANE TRANSPORT PROTEINS; PYRIDINES; RATS; RESPIRATORY SYSTEM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84973137939     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.201600223R     Document Type: Article

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