Virtual High-Throughput Screening to Identify Novel Activin Antagonists

Journal of Medicinal Chemistry

Volumn 58, Issue 14, 2015, Pages 5637-5648

  Zhu, Jie ^a,b   Mishra, Rama K ^b   Schiltz, Gary E ^b   Makanji, Yogeshwar ^a   Scheidt, Karl A ^a,b   Mazar, Andrew P ^a,b   Woodruff, Teresa K ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN A; ACTIVIN ANTAGONIST; ACTIVIN RECEPTOR 1; FOLLITROPIN; MYOSTATIN; NUCC 474; NUCC 475; NUCC 478; NUCC 479; NUCC 527; NUCC 530; NUCC 553; NUCC 555; NUCC 558; NUCC 559; NUCC 560; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; ACTIVIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; COMPETITIVE BINDING ASSAY; COMPUTER MODEL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DATA BASE; DOSE RESPONSE; DRUG BINDING SITE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; EX VIVO STUDY; FEMALE; FOLLITROPIN BLOOD LEVEL; GRANULOSA CELL; HEPG2 CELL LINE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC50; LIGAND BINDING; MOUSE; NONHUMAN; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; COMPUTER INTERFACE; CYTOLOGY; DRUG EFFECTS; DRUG SCREENING; METABOLISM; MOLECULAR DOCKING; OVARY; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

ACTIVINS; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; FEMALE; FOLLICLE STIMULATING HORMONE; HEP G2 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICE; MOLECULAR DOCKING SIMULATION; OVARY; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; USER-COMPUTER INTERFACE;

EID: 84937688319     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00753     Document Type: Article

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