Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake

Science Signaling

Volumn 9, Issue 430, 2016, Pages

  Wardman, Jonathan H ^a,c   Gomes, Ivone ^a   Bobeck, Erin N ^a   Stockert, Jennifer A ^a   Kapoor, Abhijeet ^a   Bisignano, Paola ^a   Gupta, Achla ^a   Mezei, Mihaly ^a   Kumar, Sanjai ^b   Filizola, Marta ^a   Devi, Lakshmi A ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

^c Rigshospitalet   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; APPETITE STIMULANT; BIGLEN PROTEIN; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR 171; MESSENGER RNA; MS 0015203; MS 0016574; NEUROPEPTIDE RECEPTOR; OREXIN RECEPTOR; PEPTIDES AND PROTEINS; PROTEIN C FOS; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; ANILIDE; CALCIUM; G PROTEIN COUPLED RECEPTOR; GPR171 PROTEIN, MOUSE; LIGAND; MS0015203; NERVE PROTEIN; PCSK1N PROTEIN, MOUSE; PEPTIDE; PHTHALIC ACID DERIVATIVE; PROTEIN BINDING;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CHO CELL LINE; CHRONIC DRUG ADMINISTRATION; COMPUTER MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG EFFECT; DRUG IDENTIFICATION; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; EC50; FEEDING; FOOD INTAKE; GENE SILENCING; HYDROGEN BOND; HYPOTHALAMUS; IC50; IMMUNOHISTOCHEMISTRY; LIGAND BINDING; LIPID DIET; MALE; MOLECULAR LIBRARY; MOUSE; NERVE CELL; NEUROBLASTOMA CELL; NEUROBLASTOMA CELL LINE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; WEIGHT CONTROL; WEIGHT GAIN; AGONISTS; ANIMAL; APPETITE; BODY WEIGHT; C57BL MOUSE; CRICETULUS; DRUG EFFECTS; EATING; FEEDING BEHAVIOR; GENE EXPRESSION REGULATION; HAMSTER; METABOLISM; TUMOR CELL LINE;

ANILIDES; ANIMALS; APPETITE; BODY WEIGHT; CALCIUM; CELL LINE, TUMOR; CHO CELLS; CRICETINAE; CRICETULUS; EATING; FEEDING BEHAVIOR; GENE EXPRESSION REGULATION; LIGANDS; MALE; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; PEPTIDES; PHTHALIC ACIDS; PROTEIN BINDING; RATS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84973131381     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.aac8035     Document Type: Article

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