GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 40, 2013, Pages 16211-16216

  Gomes, Ivone ^a   Aryal, Dipendra K ^b   Wardman, Jonathan H ^a,c   Gupta, Achla ^a   Gagnidze, Khatuna ^a,f   Rodriguiz, Ramona M ^b   Kumar, Sanjai ^d   Wetsel, William C ^b   Pintar, John E ^e   Fricker, Lloyd D ^c   Devi, Lakshmi A ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d CITY UNIVERSITY OF NEW YORK   (United States)

^e RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^f ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Deorphanization; Neuroendocrine peptide; NPY AgRP; Orexigenic; ProSAAS

Indexed keywords

AMINO ACID; AMINO ACID DERIVATIVE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 171; MESSENGER RNA; NEUROPEPTIDE; PEPTIDE; PEPTIDE ANTIBODY; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVATION; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVITY; FEEDING BEHAVIOR; FOOD INTAKE; GENE OVEREXPRESSION; HYPOTHALAMUS; LIGAND BINDING; MALE; MOUSE; NEURO2A CELL; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM;

DEORPHANIZATION; NEUROENDOCRINE PEPTIDE; NPY/AGRP; OREXIGENIC; PROSAAS;

ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; BODY WEIGHT; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; FEEDING BEHAVIOR; IMMUNOHISTOCHEMISTRY; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; NEUROPEPTIDES; PHOSPHORYLATION; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84885050464     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1312938110     Document Type: Article

References (41)

1. Luquet S, Perez FA, Hnasko TS, Palmiter RD (2005) NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 310(5748):683-685.
2. Krashes MJ, et al. (2011) Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. J Clin Invest 121(4):1424-1428.
3. Qian S, et al. (2002) Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice. Mol Cell Biol 22(14): 5027-5035.
4. Flier JS (2006) AgRP in energy balance: Will the real AgRP please stand up? Cell Metab 3(2):83-85.
5. Fricker LD, et al. (2000) Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing. J Neurosci 20(2):639-648.
6. Fricker LD (2012) Neuropeptides and Other Bioactive Peptides: From Discovery to Function (Morgan & Claypool Life Sciences, Princeton, NJ) pp 1-109.
7. Mzhavia N, Berman Y, Che FY, Fricker LD, Devi LA (2001) ProSAAS processing in mouse brain and pituitary. J Biol Chem 276(9):6207-6213.
8. Wardman JH, Berezniuk I, Di S, Tasker JG, Fricker LD (2011) ProSAAS-derived peptides are colocalized with neuropeptide Y and function as neuropeptides in the regulation of food intake. PLoS ONE 6(12):e28152.
9. Hatcher NG, et al. (2008) Mass spectrometry-based discovery of circadian peptides. Proc Natl Acad Sci USA 105(34):12527-12532.
10. Wei S, et al. (2004) Obesity and diabetes in transgenic mice expressing proSAAS. J Endocrinol 180(3):357-368.
11. Morgan DJ, et al. (2010) The propeptide precursor proSAAS is involved in fetal neuropeptide processing and body weight regulation. J Neurochem 113(5):1275-1284.
12. He JC, et al. (2005) The G α(o/i)-coupled cannabinoid receptor-mediated neurite outgrowth involves Rap regulation of Src and Stat3. J Biol Chem 280(39):33426-33434.
13. Rios C, Gomes I, Devi LA (2006) mu opioid and CB1 cannabinoid receptor interactions: Reciprocal inhibition of receptor signaling and neuritogenesis. Br J Pharmacol 148(4): 387-395.
14. Fricker AD, Rios C, Devi LA, Gomes I (2005) Serotonin receptor activation leads to neurite outgrowth and neuronal survival. Brain Res Mol Brain Res 138(2):228-235.
15. Jordan JD, et al. (2005) Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII. J Biol Chem 280(12):11413-11421.
16. Regard JB, Sato IT, Coughlin SR (2008) Anatomical profiling of G protein-coupled receptor expression. Cell 135(3):561-571.
17. Bromberg KD, Ma'ayan A, Neves SR, Iyengar R (2008) Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth. Science 320(5878): 903-909.
18. Lein ES, et al. (2007) Genome-wide atlas of gene expression in the adult mouse brain. Nature 445(7124):168-176.
19. Wittenberger T, Schaller HC, Hellebrand S (2001) An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. J Mol Biol 307(3):799-813.
20. Gonzalez NS, Communi D, Hannedouche S, Boeynaems JM (2004) The fate of P2Yrelated orphan receptors: GPR80/99 and GPR91 are receptors of dicarboxylic acids. Purinergic Signal 1(1):17-20.
21. Rossi L, Lemoli RM, Goodell MA (2013) Gpr171, a putative P2Y-like receptor, negatively regulates myeloid differentiation in murine hematopoietic progenitors. Exp Hematol 41(1):102-112.
22. Sugiyama T, Ohgami S, Nakayama D (2010) Novel lysophosphatidylserine receptor. Int Patent App No. PCT/JP2009/066348.
23. Heintz N (2004) Gene expression nervous system atlas (GENSAT). Nat Neurosci 7(5):483.
24. Clarke S, Zimmer A, Zimmer AM, Hill RG, Kitchen I (2003) Region selective up-regulation of micro-, δ-and κ-opioid receptors but not opioid receptor-like 1 receptors in the brains of enkephalin and dynorphin knockout mice. Neuroscience 122(2):479-489.
25. Livesey G, Elia M (1988) Estimation of energy expenditure, net carbohydrate utilization, and net fat oxidation and synthesis by indirect calorimetry: Evaluation of errors with special reference to the detailed composition of fuels. Am J Clin Nutr 47(4): 608-628.
26. McGuinness OP, Ayala JE, Laughlin MR, Wasserman DH (2009) NIH experiment in centralized mouse phenotyping: The Vanderbilt experience and recommendations for evaluating glucose homeostasis in the mouse. Am J Physiol Endocrinol Metab 297(4):E849-E855.
27. Arora S, Anubhuti (2006) Role of neuropeptides in appetite regulation and obesity- a review. Neuropeptides 40(6):375-401.
28. Hillebrand JJG, de Wied D, Adan RAH (2002) Neuropeptides, food intake and body weight regulation: A hypothalamic focus. Peptides 23(12):2283-2306.
29. Dietrich MO, et al. (2012) AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors. Nat Neurosci 15(8):1108-1110.
30. Maury E, Ramsey KM, Bass J (2010) Circadian rhythms and metabolic syndrome: From experimental genetics to human disease. Circ Res 106(3):447-462.
31. Gomes I, Ijzerman AP, Ye K, Maillet EL, Devi LA (2011) G protein-coupled receptor heteromerization: A role in allosteric modulation of ligand binding. Mol Pharmacol 79(6):1044-1052.
32. Rozenfeld R, et al. (2011) AT1R-CBR heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II. EMBO J 30(12):2350-2363.
33. Gupta A, et al. (2010) Increased abundance of opioid receptor heteromers after chronic morphine administration. Sci Signal 3(131):ra54.
34. Heimann AS, et al. (2007) Hemopressin is an inverse agonist of CB1 cannabinoid receptors. Proc Natl Acad Sci USA 104(51):20588-20593.
35. Gupta A, et al. (2007) Conformation state-sensitive antibodies to G-protein-coupled receptors. J Biol Chem 282(8):5116-5124.
36. Trapaidze N, Gomes I, Cvejic S, Bansinath M, Devi LA (2000) Opioid receptor endocytosis and activation of MAP kinase pathway. Brain Res Mol Brain Res 76(2):220-228.
37. Gomes I, Filipovska J, Devi LA (2003) Opioid receptor oligomerization. Detection and functional characterization of interacting receptors. Methods Mol Med 84:157-183.
38. Gomes I, et al. (2009) Novel endogenous peptide agonists of cannabinoid receptors. FASEB J 23(9):3020-3029.
39. Pfaffl MW, Horgan GW, Dempfle L (2002) Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in realtime PCR. Nucleic Acids Res 30(9):e36.
40. Cawley NX, et al. (2004) The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits. Endocrinology 145(12):5807-5819.
41. Thupari JN, Landree LE, Ronnett GV, Kuhajda FP (2002) C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci USA 99(14):9498-9502.