ProSAAS-derived peptides are colocalized with neuropeptide Y and function as neuropeptides in the regulation of food intake

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Wardman, Jonathan H ^a   Berezniuk, Iryna ^a   Di, Shi ^b   Tasker, Jeffrey G ^b,c   Fricker, Lloyd D ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Tulane University   (United States)

^c TULANE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GREEN FLUORESCENT PROTEIN; MESSENGER RNA; NEUROPEPTIDE Y; PEPTIDE; PROSERLYALANYLALANYLSERINE; UNCLASSIFIED DRUG; GUANINE NUCLEOTIDE BINDING PROTEIN; NERVE PROTEIN; PCSK1N PROTEIN, MOUSE;

ARCUATE NUCLEUS; ARTICLE; BRAIN REGION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FOOD INTAKE; HYPOTHALAMUS; IMMUNOREACTIVITY; MEDIOBASAL HYPOTHALAMUS; MOUSE; NERVE CELL; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; UPREGULATION; ANIMAL; C57BL MOUSE; CHEMISTRY; EATING; FEEDING BEHAVIOR; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; METABOLISM; METHODOLOGY; PATCH CLAMP; TRANSGENIC MOUSE;

ANIMALS; ARCUATE NUCLEUS; EATING; FEEDING BEHAVIOR; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; GTP-BINDING PROTEINS; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; INFUSIONS, INTRAVENTRICULAR; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; NERVE TISSUE PROTEINS; NEUROPEPTIDE Y; PATCH-CLAMP TECHNIQUES; PEPTIDES; RNA, MESSENGER;

EID: 82555184791     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028152     Document Type: Article

References (50)

1. Eipper BA, Mains RE, Herbert E, (1986) Peptides in the nervous system. Trends Neuroscience pp. 463-468.
2. Hökfelt T, Broberger C, Xu Z-QD, Sergeyev V, Ubink R, et al. (2000) Neuropeptides - an overview. Neuropharmacology 39: 1337-1356.
3. Zhou A, Webb G, Zhu X, Steiner DF, (1999) Proteolytic Processing in the Secretory Pathway. Journal of Biological Chemistry 274: 20745-20748.
4. Lindberg I, Hutton JC, (1991) Peptide processing proteinases with selectivity for paired basic residues. In: Fricker LD, editors. Peptide Biosynthesis and Processing Boca Raton, FL CRC.
5. Seidah NG, Chretien M, (1998) Proprotein convertase I. In: Barrett AJ, Rawlings ND, Woessner JF, editors. Handbook of Proteolytic Enzymes San Diego, CA Academic.
6. Seidah NG, Chretien M, (1998) Prohormone Convertase 2. In: Barrett AJ, Rawlings ND, Woessner JF, editors. Handbook of Proteolytic Enzymes San Diego, CA Academic.
7. Mains RE, Dickerson IM, May V, Stoffers DA, Perkins SN, et al. (1990) Cellular and molecular aspects of peptide hormone biosynthesis. Frontiers in Endocrinology pp. 52-89.
8. Fricker LD, (1998) Carboxypeptidase E/H. In: Barrett AJ, Rawlings ND, Woessner JF, editors. Handbook of Proteolytic Enzymes London Academic pp. 1341-1344.
9. Naggert JK, Fricker LD, Varlamov O, Nishina PM, Rouille Y, et al. (1995) Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Nat Genet 10: 135-142.
10. Fricker LD, Leiter EH, (1999) Peptides, enzymes and obesity: new insights from a 'dead' enzyme. Trends Biochem Sci 24: 390-393.
11. Fricker LD, McKinzie AA, Sun J, Curran E, Qian Y, et al. (2000) Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing. J Neurosci 20: 639-648.
12. Hsi KL, Seidah NG, De Serres G, Chrétien M, (1982) Isolation and NH2-terminal sequence of a novel porcine anterior pituitary polypeptide: Homology to proinsulin, secretin and Rous sarcoma virus transforming protein TVFV60. FEBS Letters 147: 261-266.
13. Sayah M, Fortenberry Y, Cameron A, Lindberg I, (2001) Tissue distribution and processing of proSAAS by proprotein convertases. Journal of Neurochemistry 76: 1833-1841.
14. Feng Y, Reznik SE, Fricker LD, (2002) ProSAAS and prohormone convertase 1 are broadly expressed during mouse development. Brain Res Gene Expr Patterns 1: 135-140.
15. Martens GJ, Braks JA, Eib DW, Zhou Y, Lindberg I, (1994) The neuroendocrine polypeptide 7B2 is an endogenous inhibitor of prohormone convertase PC2. Proceedings of the National Academy of Sciences of the United States of America 91: 5784-5787.
16. Martin Van Horssen A, Wilhelmina HVdH, Bailyes EM, Hutton JC, Martens GJM, et al. (1995) Identification of the Region within the Neuroendocrine Polypeptide 7B2 Responsible for the Inhibition of Prohormone Convertase PC2. Journal of Biological Chemistry 270: 14292-14296.
17. Qian Y, Devi LA, Mzhavia N, Munzer S, Seidah NG, et al. (2000) The C-terminal region of proSAAS is a potent inhibitor of prohormone convertase 1. J Biol Chem 275: 23596-23601.
18. Wei S, Feng Y, Che FY, Pan H, Mzhavia N, et al. (2004) Obesity and diabetes in transgenic mice expressing proSAAS. J Endocrinol 180: 357-368.
19. Morgan DJ, Wei S, Gomes I, Czyzyk T, Mzhavia N, et al. (2010) The propeptide precursor proSAAS is involved in fetal neuropeptide processing and body weight regulation. J Neurochem.
20. Zhang X, Che FY, Berezniuk I, Sonmez K, Toll L, et al. (2008) Peptidomics of Cpe(fat/fat) mouse brain regions: implications for neuropeptide processing. J Neurochem 107: 1596-1613.
21. Che FY, Yuan Q, Kalinina E, Fricker LD, (2005) Peptidomics of Cpe fat/fat mouse hypothalamus: effect of food deprivation and exercise on peptide levels. J Biol Chem 280: 4451-4461.
22. Paez X, Myers RD, (1991) Insatiable feeding evoked in rats by recurrent perfusion of neuropeptide Y in the hypothalamus. Peptides 12: 609-616.
23. Paez X, Nyce JW, Myers RD, (1991) Differential feeding responses evoked in the rat by NPY and NPY1-27 injected intracerebroventricularly. Pharmacology Biochemistry and Behavior 38: 379-384.
24. Stanley BG, Leibowitz SF, (1985) Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of feeding behavior. Proceedings of the National Academy of Sciences 82: 3940-3943.
25. Légrádi G, Lechan RM, (1998) The Arcuate Nucleus Is the Major Source for Neuropeptide Y-Innervation of Thyrotropin-Releasing Hormone Neurons in the Hypothalamic Paraventricular Nucleus. Endocrinology 139: 3262-3270.
26. Mzhavia N, Qian Y, Feng Y, Che FY, Devi LA, et al. (2002) Processing of proSAAS in neuroendocrine cell lines. Biochem J 361: 67-76.
27. van den Pol AN, Yao Y, Fu L-Y, Foo K, Huang H, et al. (2009) Neuromedin B and Gastrin-Releasing Peptide Excite Arcuate Nucleus Neuropeptide Y Neurons in a Novel Transgenic Mouse Expressing Strong Renilla Green Fluorescent Protein in NPY Neurons. J Neurosci 29: 4622-4639.
28. Luque RM, Park S, Kineman RD, (2007) Severity of the Catabolic Condition Differentially Modulates Hypothalamic Expression of Growth Hormone-Releasing Hormone in the Fasted Mouse: Potential Role of Neuropeptide Y and Corticotropin-Releasing Hormone. Endocrinology 148: 300-309.
29. Luther JA, Tasker JG, (2000) Voltage-gated currents distinguish parvocellular from magnocellular neurones in the rat hypothalamic paraventricular nucleus. The Journal of Physiology 523: 193-209.
30. Tasker JG, Dudek FE, (1991) Electrophysiological properties of neurones in the region of the paraventricular nucleus in slices of rat hypothalamus. The Journal of Physiology 434: 271-293.
31. Arora S, Anubhuti, (2006) Role of neuropeptides in appetite regulation and obesity- A review. Neuropeptides 40: 375-401.
32. Dickerson IM, Dixon JE, Mains RE, (1990) Biosynthesis and posttranslational processing of site-directed endoproteolytic cleavage mutants of pro-neuropeptide Y in mouse pituitary cells. Journal of Biological Chemistry 265: 2462-2469.
33. Wardman JH, Zhang X, Gagnon S, Castro LM, Zhu X, et al. (2010) Analysis of peptides in prohormone convertase 1/3 null mouse brain using quantitative peptidomics. Journal of Neurochemistry 114: 215-225.
34. Atkins N Jr, Mitchell JW, Romanova EV, Morgan DJ, Cominski TP, et al. (2010) Circadian Integration of Glutamatergic Signals by Little SAAS in Novel Suprachiasmatic Circuits. PLoS ONE 5: e12612.
35. Mizuno TM, Makimura H, Silverstein J, Roberts JL, Lopingco T, et al. (1999) Fasting Regulates Hypothalamic Neuropeptide Y, Agouti-Related Peptide, and Proopiomelanocortin in Diabetic Mice Independent of Changes in Leptin or Insulin. Endocrinology 140: 4551-4557.
36. Che FY, Fricker LD, (2002) Quantitation of neuropeptides in Cpe(fat)/Cpe(fat) mice using differential isotopic tags and mass spectrometry. Anal Chem 74: 3190-3198.
37. Schwartz MW, Sipols AJ, Grubin CE, Baskin DG, (1993) Differential effect of fasting on hypothalamic expression of genes encoding neuropeptide Y, galanin, and glutamic acid decarboxylase. Brain Research Bulletin 31: 361-367.
38. Davies L, Marks JL, (1994) Role of hypothalamic neuropeptide Y gene expression in body weight regulation. Am J Physiol Regul Integr Comp Physiol 266: R1687-1691.
39. Mercer JG, Lawrence CB, Atkinson T, (1996) Hypothalamic NPY and CRF gene expression in the food-deprived Syrian hamster. Physiology & Behavior 60: 121-127.
40. Zhang X, Pan H, Peng B, Steiner DF, Pintar JE, et al. (2010) Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neuropeptide biosynthesis. J Neurochem 112: 1168-1179.
41. Fricker LD, Berezniuk I, (2011) Endogenous Opioids. In: Pasternak GW, editors. The Opiate Receptors. 2 ed New York Humana Press pp. 93-120.
42. Yokosuka M, Kalra PS, Kalra SP, (1999) Inhibition of Neuropeptide Y (NPY)-Induced Feeding and c-Fos Response in Magnocellular Paraventricular Nucleus by a NPY Receptor Antagonist: A Site of NPY Action. Endocrinology 140: 4494-4500.
43. Feng Y, Reznik SE, Fricker LD, (2001) Distribution of SAAS-derived peptides in rat neuroendocrine tissues. Neuroscience 105: 469-478.
44. Mzhavia N, Berman Y, Che FY, Fricker LD, Devi LA, (2001) ProSAAS processing in mouse brain and pituitary. J Biol Chem 276: 6207-6213.
45. Paxinos G, Franklin KBJ, (2001) The Mouse Brain in Stereotaxic Coordinates San Diego, CA Academic Press.
46. Che FY, Zhang X, Berezniuk I, Callaway M, Lim J, et al. (2007) Optimization of neuropeptide extraction from the mouse hypothalamus. J Proteome Res 6: 4667-4676.
47. Morano C, Zhang X, Fricker LD, (2008) Multiple isotopic labels for quantitative mass spectrometry. Anal Chem 80: 9298-9309.
48. Berti DA, Morano C, Russo LC, Castro LM, Cunha FM, et al. (2009) Analysis of intracellular substrates and products of thimet oligopeptidase in human embryonic kidney 293 cells. J Biol Chem 284: 14105-14116.
49. Wardman JH, Fricker LD, (2010) Quantitative peptidomics of mice lacking peptide-processing enzymes: In Press.
50. Lein ES, Hawrylycz MJ, Ao N, Ayres M, Bensinger A, et al. (2007) Genome-wide atlas of gene expression in the adult mouse brain. Nature 445: 168-176.