Particulate systems based on pectin/chitosan association for the delivery of manuka honey components and platelet lysate in chronic skin ulcers

International Journal of Pharmaceutics

Volumn 509, Issue 1-2, 2016, Pages 59-70

  Tenci, Marika ^a   Rossi, Silvia ^a   Bonferoni, Maria Cristina ^a   Sandri, Giuseppina ^a   Boselli, Cinzia ^a   Di Lorenzo, Arianna ^a   Daglia, Maria ^a   Icaro Cornaglia, Antonia ^a   Gioglio, Luciana ^a   Perotti, Cesare ^b   Caramella, Carla ^a   Ferrari, Franca ^a  

^a UNIVERSITY OF PAVIA   (Italy)

^b FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

Chitosan; Manuka honey; Pectin; Platelet lysate; Polymeric particles; Wound healing

Indexed keywords

CALCIUM CHLORIDE; CHITOSAN; MANUKA HONEY; METHYLGLYOXAL; PECTIN; PLANT EXTRACT; POLYPHENOL; UNCLASSIFIED DRUG; WOUND HEALING PROMOTING AGENT; GEL; PLANT MEDICINAL PRODUCT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; CELL LYSATE; CELL PROLIFERATION; CELL VIABILITY; CHEMICAL COMPOSITION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; FIBROBLAST; GELATION; HONEY; HUMAN; HUMAN CELL; HYDRATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MEMBRANE RESISTANCE; NONHUMAN; PARTICLE SIZE; POWDER; PRIORITY JOURNAL; RAT; SKIN ULCER; THROMBOCYTE; WOUND HEALING; ADMINISTRATION AND DOSAGE; ANIMAL; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; GEL; LEPTOSPERMUM; WISTAR RAT;

ANIMALS; BLOOD PLATELETS; CELL PROLIFERATION; CELLS, CULTURED; CHITOSAN; FIBROBLASTS; GELS; HONEY; HUMANS; LEPTOSPERMUM; MALE; PARTICLE SIZE; PECTINS; PLANT PREPARATIONS; RATS; RATS, WISTAR; SKIN ULCER; WOUND HEALING;

EID: 84973121988     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2016.05.035     Document Type: Article

References (30)

1. E. Anitua, M. Sanchez, G. Orive, and I. Andia The potential impact of the preparation rich in growth factors (PRGF) in different medical fields Biomaterials 28 2007 4551 4560
2. J.S. Boateng, and O. Catanzano Advanced therapeutic dressings for effective wound healing J. Pharm. Sci. 104 2015 3653 3680
3. J.S. Boateng, K.H. Matthews, N.E.S. Howard, and G.M. Eccleston Wound healing dressing and drug delivery system: a review J. Pharm. Sci. 97 2008 2892 2923
4. Caramella, C., Bonferoni, M.C., Rossi, S., Sandri, G., Ferrari, F., Perotti, G., Del Fante, C., 2011. Platelet lysate and bioadhesive compositions thereof for the treatment of mucositis. US2011/0280952.
5. G. Crovetti, G. Martinelli, M. Issi, M. Barone, M. Guizzardi, B. Campanati, M. Moroni, and A. Carabelli Platelet gel for healing cutaneous chronic wounds Transfus. Apher. Sci. 30 2004 145 151
6. M. Daglia, D. Ferrari, S. Collina, and V. Curti Influence of in vitro simulated gastroduodenal digestion on methylglyoxal concentration of manuka (Lectospermum scoparium) honey J. Agric. Food Chem. 61 2013 2140 2145
7. C. Del Fante, C. Perotti, M.C. Bonferoni, S. Rossi, G. Sandri, F. Ferrari, L. Scudeller, and C. Caramella Platelet lysate mucoadhesive formulation to treat oral mucositis in graft versus host disease patients: a new therapeutic approach AAPS PharmSciTech 12 2011 893 899
8. E. Dellera, M.C. Bonferoni, G. Sandri, S. Rossi, F. Ferrari, C. Del Fante, C. Perotti, P. Grisoli, and C. Caramella Development of chitosan oleate ionic micelles loaded with silver sulfadiazine to be associated with platelet lysate for application in wound healing Eur. J. Pharm. Biopharm. 83 2014 643 650
9. E. Mavric, S. Wittmann, G. Barth, and T. Henle Identification and quantification of methylglyoxal as the dominant antibacterial constituent of Manuka (Leptospermum scoparium) honeys from New Zealand Mol. Nutr. Food Res. 52 2008 483 489
10. L. Mazzucco, P. Borzini, and R. Gope Platelet-derived factors involved in tissue repair - from signal to function Transfus. Med. Rev. 24 2010 218 234
11. P. Molan, and T. Rhodes Honey: a biologic wound dressing Wounds 27 2015 141 151
12. M. Mori, S. Rossi, M.C. Bonferoni, F. Ferrari, G. Sandri, F. Riva, C. Del Fante, C. Perotti, and C. Caramella Calcium alginate particles for the combined delivery of platelet lysate and vancomycin hydrochloride in chronic skin ulcers Int. J. Pharm. 461 2014 505 513
13. M. Mori, S. Rossi, F. Ferrari, M.C. Bonferoni, G. Sandri, T. Chlapanidas, M.L. Torre, and C. Caramella Sponge-like dressings based on the association of chitosan and sericin for the treatment of chronic skin ulcers. I. Design of experiments assisted development J. Pharm. Sci. 105 2016 1180 1187
14. M. Mori, S. Rossi, F. Ferrari, M.C. Bonferoni, G. Sandri, F. Riva, M. Tenci, C. Del Fante, G. Nicoletti, and C. Caramella Sponge-like dressings based on the association of chitosan and sericin for the treatment of chronic skin ulcers. II. Loading of the hemoderivative platelet lysate J. Pharm. Sci. 105 2016 1188 1195
15. F. Munarin, M.C. Tanzi, and P. Petrini Advances in biomedical applications of pectin gels Int. J. Biol. Macromol. 51 2012 681 689
16. R.A.A. Muzzarelli Chitins and chitosans for the repair of wounded skin nerve, cartilage and bone Carbohydr. Polym. 76 2009 167 182
17. S. Oelschlaegel, M. Gruner, P.N. Wang, A. Boettcher, I. Koelling-Speer, and K. Speer Classification and characterization of manuka honeys based on phenolic compounds and methylglyoxal J. Agric. Food Chem. 60 29 2012 7229 7237
18. E.I. Rabea, M.E.-T. Badawy, C.V. Stevens, G. Smagghe, and W. Steurbaut Chitosan as antimicrobial agent: applications and mode of action Biomacromolecules 4 2003 1457 1465
19. E. Ranzato, M. Patrone, L. Mazzucco, and B. Burlando Platelet lysate stimulates wound repair of HaCaT keratinocytes Br. J. Dermatol. 159 2008 537 545
20. J.M. Reinke, and H. Sorg Wound repair and regeneration Eur. Surg. Res. 49 2012 35 43
21. S. Rossi, M. Marciello, G. Sandri, F. Ferrari, M.C. Bonferoni, A. Papetti, and C. Caramella Wound dressings based on chitosans and hyaluronic acid for the release of chlorhexidine diacetate in skin ulcer therapy Pharm. Dev. Technol. 12 2007 415 422
22. S. Rossi, M. Marciello, M.C. Bonferoni, F. Ferrari, G. Sandri, C. Caramella, C. Dacarro, and P. Grisoli Thermally sensitive gels based on chitosan derivatives for the treatment of oral mucositis Eur. J. Pharm. Biopharm. 74 2010 248 254
23. S. Rossi, A. Faccendini, M.C. Bonferoni, F. Ferrari, G. Sandri, C. Del Fante, C. Perotti, and C. Caramella Sponge-like dressings based on biopolymers for the delivery of platelet lysate to skin chronic wounds Int. J. Pharm. 440 2013 207 215
24. S. Rossi, F. Ferrari, G. Sandri, M.C. Bonferoni, C. Del Fante, C. Perotti, and C. Caramella Wound healing: biopolymers and hemoderivatives 1st ed. M. Mishra, Encyclopedia of Biomedical Polymers and Polymeric Biomaterials vol. 11 2015 Taylor & Francis New York 8280 8298
25. G. Sandri, M.C. Bonferoni, S. Rossi, F. Ferrari, M. Mori, C. Del Fante, C. Perotti, L. Scudeller, and C. Caramella Platelet lysate formulations based on mucoadhesive polymers for the treatment of corneal lesions J. Pharm. Pharmacol. 63 2011 189 198
26. G. Sandri, M.C. Bonferoni, F. Ferrari, S. Rossi, C. Del Fante, C. Perotti, A. Gallanti, and C. Caramella An in situ gelling buccal spray containing platelet lysate for the treatment of oral mucositis Curr. Drug Discov. Technol. 8 2011 277 285
27. G. Sandri, M.C. Bonferoni, S. Rossi, F. Ferrari, M. Mori, C. Del Fante, C. Perotti, and C. Caramella Thermosensitive eyedrops containing platelet lysate for the treatment of corneal ulcers Int. J. Pharm. 426 2012 1 6
28. G. Sandri, M.C. Bonferoni, S. Rossi, F. Ferrari, M. Mori, M. Cervio, F. Riva, I. Liakos, A. Athanassiou, F. Saporito, L. Marini, and C. Caramella Platelet lysate embedded scaffolds for skin regeneration Expert Opin. Drug Deliv. 12 2015 525 545
29. S. Werner, and R. Grose Regulation of wound healing by growth factors and cytokines Physiol. Rev. 83 2003 835 870
30. L.Y. Zheng, and J.F. Zhu Study on antimicrobial activity of chitosan with different molecular weights Carbohydr. Polym. 54 2003 527 530