Iron-chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human blood-derived neutrophils

Bioscience Reports

Volumn 36, Issue 3, 2016, Pages

  Völlger, Lena ^a   Akong Moore, Kathryn ^b   Cox, Linda ^c,d   Goldmann, Oliver ^e   Wang, Yanming ^f   Schäfer, Simon T ^c,d   Naim, Hassan Y ^a   Nizet, Victor ^b,g   Von Köckritz Blickwede, Maren ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY HOSPITAL ESSEN   (Germany)

^d UNIVERSITY OF DUISBURG ESSEN   (Germany)

^e HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^f PENNSYLVANIA STATE UNIVERSITY   (United States)

^g UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Extracellular traps; Innate immunity; Neutrophils

Indexed keywords

DEFEROXAMINE; DNA; HISTONE; PROTEIN ARGININE DEIMINASE; PROTEIN ARGININE DEIMINASE 4; PROTEINASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG; IRON CHELATING AGENT; PEPTIDE HYDROLASE; PEPTIDYLARGININE DEIMINASE TYPE IV;

ARTICLE; CELL STIMULATION; CONTROLLED STUDY; DNA HISTONE INTERACTION; DRUG MECHANISM; ENZYME ACTIVITY; EXTRACELLULAR TRAP; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; INNATE IMMUNITY; IRON CHELATION; NEUTROPHIL; OXIDATIVE STRESS; PHENOTYPE; SIGNAL TRANSDUCTION; WESTERN BLOTTING; CELL CULTURE; DRUG EFFECTS; IMMUNOLOGY; MICROBIOLOGY;

CELLS, CULTURED; DEFEROXAMINE; EXTRACELLULAR TRAPS; HUMANS; IMMUNITY, INNATE; IRON CHELATING AGENTS; NEUTROPHILS; PEPTIDE HYDROLASES; PROTEIN-ARGININE DEIMINASES; REACTIVE OXYGEN SPECIES;

EID: 84971291341     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1042/BSR20160031     Document Type: Article

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