Long noncoding RNA MALAT1 as a potential therapeutic target in osteosarcoma

Journal of Orthopaedic Research

Volumn 34, Issue 6, 2016, Pages 932-941

  Cai, Xianyi ^a   Liu, Yunlu ^a   Yang, Wen ^a   Xia, Yun ^a   Yang, Cao ^a   Yang, Shuhua ^a   Liu, Xianzhe ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

long noncoding RNA; MALAT1; osteosarcoma

Indexed keywords

LONG UNTRANSLATED RNA; METASTASIS ASSOCIATED LUNG ADENOCARCINOMA TRANSCRIPT 1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ACTIN; MALAT1 LONG NON-CODING RNA, HUMAN; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER TISSUE; CARCINOGENESIS; CELL CYCLE ARREST; CELL CYCLE S PHASE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO PROPAGATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OSTEOSARCOMA; OSTEOSARCOMA CELL LINE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; STRESS FIBER; TUMOR XENOGRAFT; U2OS CELL LINE; UPREGULATION; WESTERN BLOTTING; WOUND HEALING; ANIMAL; BONE NEOPLASMS; CELL CYCLE CHECKPOINT; CELL MOTION; METABOLISM; MOLECULARLY TARGETED THERAPY; NUDE MOUSE; TUMOR CELL LINE;

ACTINS; ANIMALS; APOPTOSIS; BONE NEOPLASMS; CARCINOGENESIS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL MOVEMENT; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICE, NUDE; MOLECULAR TARGETED THERAPY; OSTEOSARCOMA; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; RNA, LONG NONCODING;

EID: 84970973883     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.23105     Document Type: Article

References (50)

1. Himelstein BP,. 1998. Osteosarcoma and other bone cancers. Curr Opin Oncol 10: 326-333.
2. Schwartz CL, Gorlick R, Teot L, et al., 2007. Multiple drug resistance in osteogenic sarcoma: int0133 from the Children's Oncology Group. J Clin Oncol 25: 2057-2062.
3. Kempf-Bielack B, Bielack SS, Jurgens H, et al., 2005. Osteosarcoma relapse after combined modality therapy: an analysis of unselected patients in the Cooperative Osteosarcoma Study Group (COSS). J Clin Oncol 23: 559-568.
4. Wang KC, Chang HY,. 2011. Molecular mechanisms of long noncoding RNAs. Mol Cell 43: 904-914.
5. Moran VA, Perera RJ, Khalil AM,. 2012. Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs. Nucleic Acids Res 40: 6391-6400.
6. Kim K, Jutooru I, Chadalapaka G, et al., 2013. HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene 32: 1616-1625.
7. Li H, Yu B, Li J, et al., 2014. Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancer. Oncotarget 5: 2318-2329.
8. Mourtada-Maarabouni M, Pickard MR, Hedge VL, et al., 2009. GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer. Oncogene 28: 195-208.
9. Hou P, Zhao Y, Li Z, et al., 2014. LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis. Cell Death Dis 5: e1287.
10. Fan Y, Shen B, Tan M, et al., 2014. Long non-coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling. FEBS J 281: 1750-1758.
11. Ji P, Diederichs S, Wang W, et al., 2003. MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early stage non-small cell lung cancer. Oncogene 22: 8031-8041.
12. Gutschner T, Hammerle M, Diederichs S,. 2013. MALAT1-a paradigm for long noncoding RNA function in cancer. J Mol Med (Berl) 91: 791-801.
13. Ren S, Liu Y, Xu W, et al., 2013. Long noncoding RNA MALAT-1 is a new potential therapeutic target for castration resistant prostate cancer. J Urol 190: 2278-2287.
14. Cai XY, Xiong LM, Yang SH, et al., 2014. Comparison of toxicity effects of ropivacaine, bupivacaine, and lidocaine on rabbit intervertebral disc cells in vitro. Spine J 14: 483-490.
15. Cai XY, Xia Y, Yang SH, et al., 2015. Ropivacaine- and bupivacaine-induced death of rabbit annulus fibrosus cells in vitro: involvement of the mitochondrial apoptotic pathway. Osteoarthritis Cartilage 23: 1763-1775.
16. Xia Y, Cai XY, Fan JQ, et al., 2015. Rho kinase inhibitor fasudil suppresses the vasculogenic mimicry of B16 mouse melanoma cells both in vitro and in vivo. Mol Cancer Ther 14: 1582-1590.
17. Kirschmann DA, Seftor EA, Hardy KM, et al., 2012. Molecular pathways: vasculogenic mimicry in tumor cells: diagnostic and therapeutic implications. Clin Cancer Res 18: 2726-2732.
18. Ren K, Yao N, Wang G, et al., 2014. Vasculogenic mimicry: a new prognostic sign of human osteosarcoma. Hum Pathol 45: 2120-2129.
19. Yamazaki D, Kurisu S, Takenawa T,. 2005. Regulation of cancer cell motility through actin reorganization. Cancer Sci 96: 379-386.
20. Consortium EP, Birney E, Stamatoyannopoulos JA, et al., 2007. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 447: 799-816.
21. Guttman M, Amit I, Garber M, et al., 2009. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature 458: 223-227.
22. Prensner JR, Chinnaiyan AM,. 2011. The emergence of lncRNAs in cancer biology. Cancer Discov 1: 391-407.
23. Chakrabarti R, Srivatsan ES, Wood TF, et al., 1998. Deletion mapping of endocrine tumors localizes a second tumor suppressor gene on chromosome band 11q13. Genes Chromosomes Cancer 22: 130-137.
24. Bernard D, Prasanth KV, Tripathi V, et al., 2010. A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression. EMBO J 29: 3082-3093.
25. Tripathi V, Ellis JD, Shen Z, et al., 2010. The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. Mol Cell 39: 925-938.
26. Lin R, Roychowdhury-Saha M, Black C, et al., 2011. Control of RNA processing by a large non-coding RNA over-expressed in carcinomas. FEBS Lett 585: 671-676.
27. Yang L, Lin C, Liu W, et al., 2011. NcRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell 147: 773-788.
28. Wang J, Su L, Chen X, et al., 2014. MALAT1 promotes cell proliferation in gastric cancer by recruiting SF2/ASF. Biomed Pharmacother 68: 557-564.
29. Ji Q, Zhang L, Liu X, et al., 2014. Long non-coding RNA MALAT1 promotes tumour growth and metastasis in colorectal cancer through binding to SFPQ and releasing oncogene PTBP2 from SFPQ/PTBP2 complex. Br J Cancer 111: 736-748.
30. Tripathi V, Shen Z, Chakraborty A, et al., 2013. Long noncoding RNA MALAT1 controls cell cycle progression by regulating the expression of oncogenic transcription factor B-MYB. PLoS Genet 9: e1003368.
31. Yang F, Yi F, Han X, et al., 2013. MALAT-1 interacts with hnRNP C in cell cycle regulation. FEBS Lett 587: 3175-3181.
32. Han Y, Liu Y, Nie L, et al., 2013. Inducing cell proliferation inhibition, apoptosis, and motility reduction by silencing long noncoding ribonucleic acid metastasis-associated lung adenocarcinoma transcript 1 in urothelial carcinoma of the bladder. Urology 81: 209 e201-209 e207.
33. Zhang A, Xu M, Mo YY,. 2014. Role of the lncRNA-p53 regulatory network in cancer. J Mol Cell Biol 6: 181-191.
34. Louwen F, Yuan J,. 2013. Battle of the eternal rivals: restoring functional p53 and inhibiting Polo-like kinase 1 as cancer therapy. Oncotarget 4: 958-971.
35. Wu Y, Liu H, Shi X, et al., 2015. The long non-coding RNA HNF1A-AS1 regulates proliferation and metastasis in lung adenocarcinoma. Oncotarget 6: 9160-9172.
36. Maes H, Van Eygen S, Krysko DV, et al., 2014. BNIP3 supports melanoma cell migration and vasculogenic mimicry by orchestrating the actin cytoskeleton. Cell Death Dis 5: e1127.
37. Jaffe N,. 2009. Osteosarcoma: review of the past, impact on the future. The American experience. Cancer Treat Res 152: 239-262.
38. Wang L, Lin L, Chen X, et al., 2015. Metastasis-associated in colon cancer-1 promotes vasculogenic mimicry in gastric cancer by upregulating TWIST1/2. Oncotarget 6: 11492-11506.
39. Gutschner T, Hammerle M, Eissmann M, et al., 2013. The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Res 73: 1180-1189.
40. Schmidt LH, Spieker T, Koschmieder S, et al., 2011. The long noncoding MALAT-1 RNA indicates a poor prognosis in non-small cell lung cancer and induces migration and tumor growth. J Thorac Oncol 6: 1984-1992.
41. Ying L, Chen Q, Wang Y, et al., 2012. Upregulated MALAT-1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition. Mol Biosyst 8: 2289-2294.
42. Wu XS, Wang XA, Wu WG, et al., 2014. MALAT1 promotes the proliferation and metastasis of gallbladder cancer cells by activating the ERK/MAPK pathway. Cancer Biol Ther 15: 806-814.
43. Yang MH, Hu ZY, Xu C, et al., 2015. MALAT1 promotes colorectal cancer cell proliferation/migration/invasion via PRKA kinase anchor protein 9. Biochim Biophys Acta 1852: 166-174.
44. Liu JY, Yao J, Li XM, et al., 2014. Pathogenic role of lncRNA-MALAT1 in endothelial cell dysfunction in diabetes mellitus. Cell Death Dis 5: e1506.
45. Michalik KM, You X, Manavski Y, et al., 2014. Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth. Circ Res 114: 1389-1397.
46. O'Connor K, Chen M,. 2013. Dynamic functions of RhoA in tumor cell migration and invasion. Small GTPases 4: 141-147.
47. Julian L, Olson MF,. 2014. Rho-associated coiled-coil containing kinases (ROCK): structure, regulation, and functions. Small GTPases 5: e29846.
48. Liu X, Choy E, Hornicek FJ, et al., 2011. ROCK1 as a potential therapeutic target in osteosarcoma. J Orthop Res 29: 1259-1266.
49. Wang W, Zhou X, Wei M,. 2015. MicroRNA-144 suppresses osteosarcoma growth and metastasis by targeting ROCK1 and ROCK2. Oncotarget 6: 10297-10308.
50. Zucchini C, Manara MC, Pinca RS, et al., 2014. CD99 suppresses osteosarcoma cell migration through inhibition of ROCK2 activity. Oncogene 33: 1912-1921.