The long non-coding RNA HNF1A-AS1 regulates proliferation and metastasis in lung adenocarcinoma

Oncotarget

Volumn 6, Issue 11, 2015, Pages 9160-9172

  Wu, Ying ^a   Liu, Hongbing ^a   Shi, Xuefei ^a   Yao, Yanwen ^a   Yang, Wen ^a   Song, Yong ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

HNF1A AS1; IncRNAs; Lung adenocarcinoma; Metastasis; Proliferation

Indexed keywords

BETA CATENIN; COMPLEMENTARY RNA; COMPLEMENTARY RNA 1; CYCLIN D1; DNA METHYLTRANSFERASE 1; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; LONG UNTRANSLATED RNA; NERVE CELL ADHESION MOLECULE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; UVOMORULIN; CADHERIN; CCND1 PROTEIN, MOUSE; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; HNF1A PROTEIN, HUMAN; PROTEIN BINDING; TUMOR MARKER;

AGED; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CANCER STAGING; CANCER SURVIVAL; CELL CYCLE S PHASE; CELL DIFFERENTIATION; CELL INVASION; CELL PROLIFERATION; CELL VIABILITY; COLONY FORMATION; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; EPIGENETICS; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; LUNG ADENOCARCINOMA; LUNG CANCER; LUNG CANCER CELL LINE; LUNG CARCINOGENESIS; LYMPH NODE METASTASIS; MALE; MOUSE; NONHUMAN; OVERALL SURVIVAL; PROGNOSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SIGNAL TRANSDUCTION; TUMOR VOLUME; UPREGULATION; ADENOCARCINOMA; ANIMAL; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; CELL MOTION; CELL TRANSFORMATION; DISEASE COURSE; GENE EXPRESSION REGULATION; GENETICS; LUNG TUMOR; METABOLISM; MORTALITY; NON SMALL CELL LUNG CANCER; NUDE MOUSE; PHYSIOLOGY; RNA INTERFERENCE; TUMOR CELL LINE; TUMOR INVASION; XENOGRAFT;

ADENOCARCINOMA; AGED; ANIMALS; APOPTOSIS; BETA CATENIN; BIOMARKERS, TUMOR; CADHERINS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN D1; DISEASE PROGRESSION; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; HUMANS; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM INVASIVENESS; NEOPLASM STAGING; NEOPLASM TRANSPLANTATION; PROTEIN BINDING; RNA INTERFERENCE; RNA, LONG NONCODING; RNA, SMALL INTERFERING; TRANSPLANTATION, HETEROLOGOUS; UP-REGULATION;

EID: 84928732236     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3247     Document Type: Article

References (50)

1. Ettinger DS, Akerley W, Bepler G, Blum MG, Chang A, Cheney RT, et al. Non-small cell lung cancer. J Natl Compr Cancer Netw. 2010; 8:740-801.
2. Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics. Cancer J Clin. 2014; 64:9-29.
3. Yang J, Weinberg RA. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell. 2008; 14:818-829.
4. Floor S, van Staveren WC, Larsimont D, Dumont JE, Maenhaut C. Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating-cancer stem cells: dis{reversed not sign}tinct, overlapping or same populations. Oncogene. 2011; 30:4609-4621.
5. Perl AK, Wilgenbus P, Dahl U, Semb H, Christofori G. A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature. 1998; 392:190-193.
6. Lee JM, Dedhar S, Kalluri R, Thompson EW. The epi{reversed not sign}thelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol. 2006; 172:973-981.
7. Sun M, Liu XH, Wang KM, Nie FQ, Kong R, Yang JS, et al. Downregulation of BRAF activated non-coding RNA is associated with poor prognosis for non-small cell lung cancer and promotes metastasis by affecting epithelial-mesenchymal transition. Mol Cancer. 2014; 13:68.
8. Gutschner T, Hammerle M, Eissmann M, Hsu J, Kim Y, Hung G, et al. The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Res. 2013; 73:1180-1189.
9. Elgar G, Vavouri T. Tuning in to the signals: noncod{reversed not sign}ing sequence conservation in vertebrate genomes. Trends Genet. 2008; 24:344-352.
10. Wang KC, Chang HY. Molecular mechanisms of long non{reversed not sign}coding RNAs. Mol Cell. 2011; 43:904-914.
11. Wapinski O, Chang HY. Long noncoding RNAs and human disease. Trends Cell Biol. 2011; 21:354-361.
12. Cesana M, Cacchiarelli D, Legnini I, Santini T, Sthandier O, Chinappi M, et al. A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA. Cell. 2011; 147:358-369.
13. Amaral PP, Dinger ME, Mattick JS. Non-coding RNAs in homeostasis, disease and stress responses: an evolutionary perspective. Brief Funct Genomics. 2013; 12:254-278.
14. Ulitsky I, Bartel DP. lincRNAs: genomics, evolution, and mechanisms. Cell. 2013; 154:26-46.
15. Okamoto T, Nakamura T, Ikeda J, Maruyama R, Shoji F, Miyake T, et al. Serum carcinoembryonic antigen as a pre{reversed not sign}dictive marker for sensitivity to gefitinib in advanced non-small cell lung cancer. Eur J Cancer. 2005; 41:1286-1290.
16. Zhang H, Zeitz MJ, Wang H, Niu B, Ge S, Li W, et al. Long noncoding RNA-mediated intrachromosomal interac{reversed not sign}tions promote imprinting at the Kcnq1 locus. J Cell Biol. 2014; 204:61-75.
17. Thai P, Statt S, Chen CH, Liang E, Campbell C, Wu R. Characterization of a novel long noncoding RNA, SCAL1, induced by cigarette smoke and elevated in lung cancer cell lines. Am J Respir Cell Mol Biol. 2013; 49:204-211.
18. Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, et al. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet. 2011; 43:1131-1138.
19. Yang X, Song JH, Cheng Y, Wu W, Bhagat T, Yu Y, et al. Long non-coding RNA HNF1A-AS1 regulates proliferation and migration in oesophageal adenocarcinoma cells. Gut. 2014; 63:881-890.
20. Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet. 2002; 3:415-428.
21. Figueroa ME, Lugthart S, Li Y, Erpelinck-Verschueren C, Deng X, Christos PJ, et al. DNA methylation signatures identify biologically distinct subtypes in acute myeloid leu{reversed not sign}kemia. Cancer Cell. 2010; 17:13-27.
22. Chen T, Li E. Establishment and maintenance of DNA methylation patterns in mammals. Curr Top Microbiol Immunol. 2006; 301:179-201.
23. Lin RK, Hsu HS, Chang JW, Chen CY, Chen JT, Wang YC. Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer. Lung Cancer (Amsterdam, Netherlands). 2007; 55:205-213.
24. Tang M, Xu W, Wang Q, Xiao W, Xu R. Potential of DNMT and its epigenetic regulation for lung cancer ther{reversed not sign}apy. Curr Gen. 2009; 10:336-352.
25. Klymkowsky MW, Savagner P. Epithelial-mesenchymal transition: a cancer researcher's conceptual friend and foe. Am J Pathol. 2009; 174:1588-1593.
26. Vleminckx K, Vakaet L Jr., Mareel M, Fiers W, van Roy F. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell. 1991; 66:107-119.
27. Fan H, Zhao Z, Quan Y, Xu J, Zhang J, Xie W. DNA methyltransferase 1 knockdown induces silenced CDH1 gene reexpression by demethylation of methylated CpG in hepatocellular carcinoma cell line SMMC-7721. Eur J Gastroenterol Hepatol. 2007; 19:952-961.
28. Espada J, Peinado H, Lopez-Serra L, Setien F, Lopez-Serra P, Portela A, et al. Regulation of SNAIL1 and E-cadherin function by DNMT1 in a DNA methyl{reversed not sign}ation-independent context. Nucleic Acid Res. 2011; 39:9194-9205.
29. Qiu X, Qiao F, Su X, Zhao Z, Fan H. Epigenetic activation of E-cadherin is a candidate therapeutic target in human hepatocellular carcinoma. Exp Ther Med. 2010; 1:519-523.
30. Gutschner T, Hammerle M, Diederichs S. MALAT1-a paradigm for long noncoding RNA function in cancer. J Mol Med. 2013; 91:791-801.
31. Zhang J, Zhang P, Wang L, Piao HL, Ma L. Long non-coding RNA HOTAIR in carcinogenesis and metastasis. Acta Biochim Biophys Sinica. 2014; 46:1-5.
32. Ratschiller D, Heighway J, Gugger M, Kappeler A, Pirnia F, Schmid RA, et al. Cyclin D1 overexpression in bronchial epithelia of patients with lung cancer is associated with smoking and predicts survival. J Clin Oncol. 2003; 21:2085-2093.
33. Yu Q, Geng Y, Sicinski P. Specific protection against breast cancers by cyclin D1 ablation. Nature. 2001; 411:1017-1021.
34. Fu M, Wang C, Li Z, Sakamaki T, Pestell RG. Minireview: Cyclin D1: normal and abnormal functions. Endocrinology. 2004; 145:5439-5447.
35. Cabili MN, Trapnell C, Goff L, Koziol M, Tazon-Vega B, Regev A, et al. Integrative annotation of human large inter{reversed not sign}genic noncoding RNAs reveals global properties and spe{reversed not sign}cific subclasses. Genes Dev. 2011; 25:1915-1927.
36. Djebali S, Davis CA, Merkel A, Dobin A, Lassmann T, Mortazavi A, et al. Landscape of transcription in human cells. Nature. 2012; 489:101-108.
37. Derrien T, Johnson R, Bussotti G, Tanzer A, Djebali S, Tilgner H, et al. The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolu{reversed not sign}tion, and expression. Gen Res. 2012; 22:1775-1789.
38. Hu G, Tang Q, Sharma S, Yu F, Escobar TM, Muljo SA, et al. Expression and regulation of intergenic long noncod{reversed not sign}ing RNAs during T cell development and differentiation. Nature Immunol. 2013; 14:1190-1198.
39. Katsuno Y, Lamouille S, Derynck R. TGF-beta signaling and epithelial-mesenchymal transition in cancer progres{reversed not sign}sion. Curr Opin Oncol. 2013; 25:76-84.
40. Tsai JH, Yang J. Epithelial-mesenchymal plasticity in carci{reversed not sign}noma metastasis. Gene Dev. 2013; 27:2192-2206.
41. Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell. 2009; 139:871-890.
42. Christiansen JJ, Rajasekaran AK. Reassessing epithe{reversed not sign}lial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res. 2006; 66:8319-8326.
43. Kang Y, Massague J. Epithelial-mesenchymal transi{reversed not sign}tions: twist in development and metastasis. Cell. 2004; 118:277-279.
44. Wang KC, Yang YW, Liu B, Sanyal A, Corces-Zimmerman R, Chen Y, et al. A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Nature. 2011; 472:120-124.
45. Kaneko S, Li G, Son J, Xu CF, Margueron R, Neubert TA, et al. Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA. Gene Dev. 2010; 24:2615-2620.
46. Rhee I, Bachman KE, Park BH, Jair KW, Yen RW, Schuebel KE, et al. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature. 2002; 416:552-556.
47. Robertson KD, Ait-Si-Ali S, Yokochi T, Wade PA, Jones PL, Wolffe AP. DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat Genet. 2000; 25:338-342.
48. Di Ruscio A, Ebralidze AK, Benoukraf T, Amabile G, Goff LA, TerragniJ, et al. DNMT1-interacting RNAs block gene-specific DNA methylation. Nature. 2013; 503:371-376.
49. Cline MS, Craft B, Swatloski T, Goldman M, Ma S, Haussler D, et al. Exploring TCGA Pan-Cancer data at the UCSC Cancer Genomics Browser. Sci Rep. 2013; 3:2652.
50. Kilkenny C, Browne W, Cuthill IC, Emerson M, Altman DG. Animal research: reporting in vivo experi{reversed not sign}ments-the ARRIVE guidelines. J Cereb Blood Flow Metab. 2011; 31:991-993.