Varicella Zoster Virus in the Nervous System

F1000Research

Volumn 4, Issue , 2015, Pages

  Gilden, Don ^a   Nagel, Maria ^a   Cohrs, Randall ^a   Mahalingam, Ravi ^a   Baird, Nicholas ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; CHICKENPOX VACCINE; GABAPENTIN; HZ SU VACCINE; PREGABALIN; SUBUNIT VACCINE; TRICYCLIC ANTIDEPRESSANT AGENT; UNCLASSIFIED DRUG; VARICELLA ZOSTER VACCINE; VIRUS DNA; VIRUS VACCINE;

ANTIBODY SCREENING; ARTICLE; BRAIN INFECTION; CEREBELLITIS; CHICKENPOX; DIAGNOSTIC IMAGING; DIAGNOSTIC TEST; DISEASE ASSOCIATION; DISEASE DURATION; GANGLION; GIANT CELL ARTERITIS; HERPES ZOSTER; HERPES ZOSTER ENCEPHALITIS; HUMAN; IMMUNIZATION; LATENT VIRUS INFECTION; MENINGORADICULITIS; NERVE CELL; NERVOUS SYSTEM; NEUROLOGICAL COMPLICATION; NONHUMAN; POSTHERPETIC NEURALGIA; SPINAL CORD DISEASE; VARICELLA ZOSTER VIRUS; VASCULAR DISEASE; VIRUS EXPRESSION; VIRUS GENE; VIRUS LATENCY; VIRUS MENINGITIS; VIRUS REACTIVATION; VIRUS VIRULENCE;

EID: 84970968884     PISSN: 20461402     EISSN: 1759796X     Source Type: Journal    
DOI: 10.12688/f1000research.7153.1     Document Type: Article

References (68)

1. Yawn BP Itzler RF Wollan PC: Health care utilization and cost burden of herpes zoster in a community population. Mayo Clin Proc. 2009;84(9):787-94. 19720776 10.4065/84.9.787 2735428 F1000 Recommendation
2. Gilden DH Dueland AN Cohrs R: Preherpetic neuralgia. Neurology. 1991;41(8):1215-8. 1866008 10.1212/WNL.41.8.1215
3. Harnisch JP: Zoster in the elderly: clinical, immunologic and therapeutic considerations. J Am Geriatr Soc. 1984;32(11):789-93. 6094642 10.1111/j.1532-5415.1984.tb06298.x
4. Gilden DH Cohrs RJ Mahalingam R: Clinical and molecular pathogenesis of varicella virus infection. Viral Immunol. 2003;16(3):243-58. 14583142 10.1089/088282403322396073
5. Tyndall MW Nasio J Agoki E: Herpes zoster as the initial presentation of human immunodeficiency virus type 1 infection in Kenya. Clin Infect Dis. 1995;21(4):1035-7. 8645797 10.1093/clinids/21.4.1035
6. Baba K Yabuuchi H Takahashi M: Increased incidence of herpes zoster in normal children infected with varicella zoster virus during infancy: community-based follow-up study. J Pediatr. 1986;108(3):372-7. 3005536 10.1016/S0022-3476(86)80875-7
7. Head H Campbell AW Kennedy PG: The pathology of Herpes Zoster and its bearing on sensory localisation. Rev Med Virol. 1997;7(3):131-43. 10398478 10.1002/(SICI)1099-1654(199709)7:3<131::AID-RMV198>3.0.CO;2-7
8. Watson CP Deck JH Morshead C: Post-herpetic neuralgia: further post-mortem studies of cases with and without pain. Pain. 1991;44(2):105-17. 1711192 10.1016/0304-3959(91)90124-G
9. Gilden DH Cohrs RJ Mahalingam R: VZV vasculopathy and postherpetic neuralgia: progress and perspective on antiviral therapy. Neurology. 2005;64(1):21-5. 15642898 10.1212/01.WNL.0000148484.19070.4D
10. Gilden DH Beinlich BR Rubinstien EM: Varicella-zoster virus myelitis: an expanding spectrum. Neurology. 1994;44(10):1818-23. 7936229 10.1212/WNL.44.10.1818
11. de Silva SM Mark AS Gilden DH: Zoster myelitis: improvement with antiviral therapy in two cases. Neurology. 1996;47(4):929-31. 8857721 10.1212/WNL.47.4.929
12. Orme HT Smith AG Nagel MA: VZV spinal cord infarction identified by diffusion-weighted MRI (DWI). Neurology. 2007;69(4):398-400. 17646633 10.1212/01.wnl.0000266390.27177.7b
13. Nagel MA Gilden D: The relationship between herpes zoster and stroke. Curr Neurol Neurosci Rep. 2015;15(4):16. 25712420 10.1007/s11910-015-0534-4
14. Nagel MA Cohrs RJ Mahalingam R: The varicella zoster virus vasculopathies: clinical, CSF, imaging, and virologic features. Neurology. 2008;70(11):853-60. 18332343 10.1212/01.wnl.0000304747.38502.e8 2938740 F1000 Recommendation
15. Nagel MA Forghani B Mahalingam R: The value of detecting anti-VZV IgG antibody in CSF to diagnose VZV vasculopathy. Neurology. 2007;68(13):1069-73. 17287447 10.1212/01.wnl.0000258549.13334.16
16. Nagel MA Traktinskiy I Azarkh Y: Varicella zoster virus vasculopathy: analysis of virus-infected arteries. Neurology. 2011;77(4):364-70. 21753174 10.1212/WNL.0b013e3182267bfa 3140801
17. Nagel MA Traktinskiy I Stenmark KR: Varicella-zoster virus vasculopathy: immune characteristics of virus-infected arteries. Neurology. 2013;80(1):62-8. 23243076 10.1212/WNL.0b013e31827b1ab9 3589199
18. Nagel MA Choe A Rempel A: Differential regulation of matrix metalloproteinases in varicella zoster virus-infected human brain vascular adventitial fibroblasts. J Neurol Sci. 2015;358(1-2):444-6. 26443282 10.1016/j.jns.2015.09.349 4628845
19. Gilden D White T Khmeleva N: Prevalence and distribution of VZV in temporal arteries of patients with giant cell arteritis. Neurology. 2015;84(19):1948-55. 25695965 10.1212/WNL.0000000000001409 4433460
20. Nagel MA White T Khmeleva N: Analysis of Varicella-Zoster Virus in Temporal Arteries Biopsy Positive and Negative for Giant Cell Arteritis. JAMA Neurol. 2015;72(11):1281-7. 26349037 10.1001/jamaneurol.2015.2101
21. Gilden D Nagel MA Cohrs RJ: Varicella-zoster. Handb Clin Neurol. 2014;123:265-83. 25015490 10.1016/B978-0-444-53488-0.00012-2
22. Virgin HW Wherry EJ Ahmed R: Redefining chronic viral infection. Cell. 2009;138(1):30-50. 19596234 10.1016/j.cell.2009.06.036
23. Eshleman E Shahzad A Cohrs RJ: Varicella zoster virus latency. Future Virol. 2011;6(3):341-55. 21695042 10.2217/fvl.10.90 3118253
24. LaGuardia JJ Cohrs RJ Gilden DH: Prevalence of varicella-zoster virus DNA in dissociated human trigeminal ganglion neurons and nonneuronal cells. J Virol. 1999;73(10):8571-7. 10482610 112877
25. Clarke P Beer T Cohrs R: Configuration of latent varicella-zoster virus DNA. J Virol. 1995;69(12):8151-4. 7494340 189772
26. Cohrs RJ Hurley MP Gilden DH: Array analysis of viral gene transcription during lytic infection of cells in tissue culture with Varicella-Zoster virus. J Virol. 2003;77(21):11718-32. 14557657 10.1128/JVI.77.21.11718-11732.2003 229365
27. Ouwendijk WJ Choe A Nagel MA: Restricted varicella-zoster virus transcription in human trigeminal ganglia obtained soon after death. J Virol. 2012;86(18):10203-6. 22740396 10.1128/JVI.01331-12 3446590
28. Cohrs RJ Barbour M Gilden DH: Varicella-zoster virus (VZV) transcription during latency in human ganglia: detection of transcripts mapping to genes 21, 29, 62, and 63 in a cDNA library enriched for VZV RNA. J Virol. 1996;70(5):2789-96. 8627753 190136
29. Nagel MA Choe A Traktinskiy I: Varicella-zoster virus transcriptome in latently infected human ganglia. J Virol. 2011;85(5):2276-87. 21177814 10.1128/JVI.01862-10 3067783
30. Zhang G Pradhan S: Mammalian epigenetic mechanisms. IUBMB Life. 2014;66(4):240-56. 24706538 10.1002/iub.1264
31. Gary L Gilden DH Cohrs RJ: Epigenetic regulation of varicella-zoster virus open reading frames 62 and 63 in latently infected human trigeminal ganglia. J Virol. 2006;80(10):4921-6. 16641283 10.1128/JVI.80.10.4921-4926.2006 1472082 F1000 Recommendation
32. Liang Y Quenelle D Vogel JL: A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency. MBio. 2013;4(1):e00558-12. 23386436 10.1128/mBio.00558-12 3565832 F1000 Recommendation
33. Schmidbauer M Budka H Pilz P: Presence, distribution and spread of productive varicella zoster virus infection in nervous tissues. Brain. 1992;115(Pt 2):383-98. 1318768 10.1093/brain/115.2.383
34. Gowrishankar K Steain M Cunningham AL: Characterization of the host immune response in human Ganglia after herpes zoster. J Virol. 2010;84(17):8861-70. 20573825 10.1128/JVI.01020-10 2919016 F1000 Recommendation
35. Steain M Sutherland JP Rodriguez M: Analysis of T cell responses during active varicella-zoster virus reactivation in human ganglia. J Virol. 2014;88(5):2704-16. 24352459 10.1128/JVI.03445-13 3958057 F1000 Recommendation
36. Lowry PW Sabella C Koropchak CM: Investigation of the pathogenesis of varicella-zoster virus infection in guinea pigs by using polymerase chain reaction. J Infect Dis. 1993;167(1):78-83. 8380293 10.1093/infdis/167.1.78
37. Wroblewska Z Devlin M Reilly K: The production of varicella Zoster virus antiserum in laboratory animals. Brief report. Arch Virol. 1982;74(2-3):233-8. 6299237 10.1007/BF01314717
38. Sadzot-Delvaux C Merville-Louis MP Delrée P: An in vivo model of varicella-zoster virus latent infection of dorsal root ganglia. J Neurosci Res. 1990;26(1):83-9. 2359148 10.1002/jnr.490260110
39. Chen JJ Gershon AA Li Z: Varicella zoster virus (VZV) infects and establishes latency in enteric neurons. J Neurovirol. 2011;17(6):578-89. 22190254 10.1007/s13365-011-0070-1 3324263 F1000 Recommendation
40. Meyer C Engelmann F Arnold N: Abortive intrabronchial infection of rhesus macaques with varicella-zoster virus provides partial protection against simian varicella virus challenge. J Virol. 2015;89(3):1781-93. 25410871 10.1128/JVI.03124-14 4300754 F1000 Recommendation
41. Mahalingam R Messaoudi I Gilden D: Simian varicella virus pathogenesis. Curr Top Microbiol Immunol. 2010;342:309-21. 20186611 10.1007/82_2009_6 3076597
42. Haberthur K Messaoudi I: Animal models of varicella zoster virus infection. Pathogens. 2013;2(2):364-82. 25437040 10.3390/pathogens2020364 4235715
43. Kennedy PG Grinfeld E Traina-Dorge V: Neuronal localization of simian varicella virus DNA in ganglia of naturally infected African green monkeys. Virus Genes. 2004;28(3):273-6. 15266108 10.1023/B:VIRU.0000025774.19557.39
44. Messaoudi I Barron A Wellish M: Simian varicella virus infection of rhesus macaques recapitulates essential features of varicella zoster virus infection in humans. PLoS Pathog. 2009;5(11):e1000657. 19911054 10.1371/journal.ppat.1000657 2770849
45. Mahalingam R Traina-Dorge V Wellish M: Simian varicella virus reactivation in cynomolgus monkeys. Virology. 2007;368(1):50-9. 17651776 10.1016/j.virol.2007.06.025
46. Traina-Dorge V Doyle-Meyers LA Sanford R: Simian Varicella Virus Is Present in Macrophages, Dendritic Cells, and T Cells in Lymph Nodes of Rhesus Macaques after Experimental Reactivation. J Virol. 2015;89(19):9817-24. 26178993 10.1128/JVI.01324-15 4577922
47. Mahalingam R Wellish M Soike K: Simian varicella virus infects ganglia before rash in experimentally infected monkeys. Virology. 2001;279(1):339-42. 11145914 10.1006/viro.2000.0700
48. Ouwendijk WJ Mahalingam R de Swart RL: T-Cell tropism of simian varicella virus during primary infection. PLoS Pathog. 2013;9(5):e1003368. 23675304 10.1371/journal.ppat.1003368 3649965
49. Ouwendijk WJ Abendroth A Traina-Dorge V: T-cell infiltration correlates with CXCL10 expression in ganglia of cynomolgus macaques with reactivated simian varicella virus. J Virol. 2013;87(5):2979-82. 23269790 10.1128/JVI.03181-12 3571377
50. Traina-Dorge V Sanford R James S: Robust pro-inflammatory and lesser anti-inflammatory immune responses during primary simian varicella virus infection and reactivation in rhesus macaques. J Neurovirol. 2014;20(5):526-30. 25139181 10.1007/s13365-014-0274-2 4394654
51. James SF Traina-Dorge V Deharo E: T cells increase before zoster and PD-1 expression increases at the time of zoster in immunosuppressed nonhuman primates latently infected with simian varicella virus. J Neurovirol. 2014;20(3):309-13. 24549971 10.1007/s13365-014-0237-7 4040158
52. Kennedy PG Grinfeld E Bell JE: Varicella-zoster virus gene expression in latently infected and explanted human ganglia. J Virol. 2000;74(24):11893-8. 11090189 10.1128/JVI.74.24.11893-11898.2000 112472
53. Nagel MA Gilden D Shade T: Rapid and sensitive detection of 68 unique varicella zoster virus gene transcripts in five multiplex reverse transcription-polymerase chain reactions. J Virol Methods. 2009;157(1):62-8. 19109999 10.1016/j.jviromet.2008.11.019 2829835
54. Christensen J Steain M Slobedman B: Differentiated neuroblastoma cells provide a highly efficient model for studies of productive varicella-zoster virus infection of neuronal cells. J Virol. 2011;85(16):8436-42. 21632750 10.1128/JVI.00515-11 3147949 F1000 Recommendation
55. Baird NL Bowlin JL Cohrs RJ: Comparison of varicella-zoster virus RNA sequences in human neurons and fibroblasts. J Virol. 2014;88(10):5877-80. 24600007 10.1128/JVI.00476-14 4019124
56. Baird NL Bowlin JL Yu X: Varicella zoster virus DNA does not accumulate in infected human neurons. Virology. 2014;458-459:1-3. 24928033 10.1016/j.virol.2014.04.014 4108071
57. Baird NL Bowlin JL Hotz TJ: Interferon Gamma Prolongs Survival of Varicella-Zoster Virus-Infected Human Neurons In Vitro. J Virol. 2015;89(14):7425-7. 25948748 10.1128/JVI.00594-15 4473560
58. Pugazhenthi S Nair S Velmurugan K: Varicella-zoster virus infection of differentiated human neural stem cells. J Virol. 2011;85(13):6678-86. 21525352 10.1128/JVI.00445-11 3126546
59. Thomson JA Itskovitz-Eldor J Shapiro SS: Embryonic stem cell lines derived from human blastocysts. Science. 1998;282(5391):1145-7. 9804556 10.1126/science.282.5391.1145
60. Markus A Grigoryan S Sloutskin A: Varicella-zoster virus (VZV) infection of neurons derived from human embryonic stem cells: direct demonstration of axonal infection, transport of VZV, and productive neuronal infection. J Virol. 2011;85(13):6220-33. 21525353 10.1128/JVI.02396-10 3126485 F1000 Recommendation
61. Dukhovny A Sloutskin A Markus A: Varicella-zoster virus infects human embryonic stem cell-derived neurons and neurospheres but not pluripotent embryonic stem cells or early progenitors. J Virol. 2012;86(6):3211-8. 22238301 10.1128/JVI.06810-11 3302301 F1000 Recommendation
62. Markus A Lebenthal-Loinger I Yang IH: An in vitro model of latency and reactivation of varicella zoster virus in human stem cell-derived neurons. PLoS Pathog. 2015;11(6):e1004885. 26042814 10.1371/journal.ppat.1004885 4456082 F1000 Recommendation
63. Goodwin TJ McCarthy M Osterrieder N: Three-dimensional normal human neural progenitor tissue-like assemblies: a model of persistent varicella-zoster virus infection. PLoS Pathog. 2013;9(8):e1003512. 23935496 10.1371/journal.ppat.1003512 3731237 F1000 Recommendation
64. Oxman MN Levin MJ Johnson GR: A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N Engl J Med. 2005;352(22):2271-84. 15930418 10.1056/NEJMoa051016 F1000 Recommendation
65. Morrison VA Johnson GR Schmader KE: Long-term persistence of zoster vaccine efficacy. Clin Infect Dis. 2015;60(6):900-9. 25416754 10.1093/cid/ciu918 4357816 F1000 Recommendation
66. Tseng HF Smith N Harpaz R: Herpes zoster vaccine in older adults and the risk of subsequent herpes zoster disease. JAMA. 2011;305(2):160-6. 21224457 10.1001/jama.2010.1983 F1000 Recommendation
67. Langan SM Smeeth L Margolis DJ: Herpes zoster vaccine effectiveness against incident herpes zoster and post-herpetic neuralgia in an older US population: a cohort study. PLoS Med. 2013;10(4):e1001420. 23585738 10.1371/journal.pmed.1001420 3621740 F1000 Recommendation
68. Lal H Cunningham AL Godeaux O: Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults. N Engl J Med. 2015;372(22):2087-96. 25916341 10.1056/NEJMoa1501184 F1000 Recommendation