The Relationship Between Herpes Zoster and Stroke

Current Neurology and Neuroscience Reports

Volumn 15, Issue 4, 2015, Pages

  Nagel, Maria A ^a   Gilden, Don ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Herpes zoster; Stroke; Varicella zoster virus vasculopathy; Vascular remodeling

Indexed keywords

IMMUNOGLOBULIN G ANTIBODY; UNCLASSIFIED DRUG; VARICELLA ZOSTER VIRUS ANTIGEN; VIRUS ANTIGEN;

ANTIBODY BLOOD LEVEL; ARTERY INTIMA PROLIFERATION; B LYMPHOCYTE; BLOOD VESSEL OCCLUSION; BRAIN ANGIOGRAPHY; BRAIN ARTERY; BRAIN ARTERY ANEURYSM; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; BRAIN MAGNETIC RESONANCE IMAGING; CEREBROSPINAL FLUID LEVEL; CEREBROVASCULAR ACCIDENT; CHICKENPOX; DISEASE ASSOCIATION; HERPES ZOSTER; HUMAN; IMMUNOCOMPROMISED PATIENT; IMMUNOHISTOCHEMISTRY; INCIDENCE; INFLAMMATION; NUCLEAR MAGNETIC RESONANCE IMAGING; ONSET AGE; REVIEW; RISK FACTOR; T LYMPHOCYTE; VARICELLA ZOSTER VIRUS; VASCULAR REMODELING; VIRUS LATENCY; VIRUS REACTIVATION; ANIMAL; PATHOGENICITY; STROKE; VIROLOGY;

ANIMALS; HERPES ZOSTER; HERPESVIRUS 3, HUMAN; HUMANS; STROKE;

EID: 84923845813     PISSN: 15284042     EISSN: 15346293     Source Type: Journal    
DOI: 10.1007/s11910-015-0534-4     Document Type: Review

References (21)

1. Baudouin E, Lantué joul P. Les troublecas moteurs dans le zona. Gazette des Hopitaux. 1919.
2. Gordon IR, Tucker JF. Lesions of the central nervous sytem in herpes zoster. J Neurol Neurosurg Psychiatry. 1945;8:40–66.
3. Hughes WN. Herpes zoster of the right trigeminal nerve with left hemiplegia. Neurology. 1951;1:167–9.
4. Cope S, Jones AT. Hemiplegia complicating ophthalmic zoster. Lancet. 1954;267:898–9.
5. Nagel MA, Cohrs RJ, Mahalingam R, et al. The varicella zoster virus vasculopathies: clinical, CSF, imaging, and virologic features. Neurology. 2008;70:853–60.
6. Nagel MA, Forghani B, Mahalingam R, et al. The value of detecting anti-VZV IgG antibody in CSF to diagnose VZV vasculopathy. Neurology. 2007;68:1069–73.
7. Cravioto H, Feigin I. Noninfectious granulomatous angiitis with a predilection for the nervous system. Neurology. 1959;9:599–609.
8. Rosenblum WI, Hadfield MG. Granulomatous angiitis of the nervous system in cases of herpes zoster and lymphosarcoma. Neurology. 1972;22:348–54.
9. Gilbert GJ. Herpes zoster ophthalmicus and delayed contralateral hemiparesis. Relationship of the syndrome to central nervous system granulomatous angiitis. JAMA. 1974;229:302–4.
10. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 5–1995. A 73-year-old man with focal brain lesions and peripheral-nerve disease. N Engl J Med. 1995;332:452–9.
11. Gilden DH, Kleinschmidt-DeMasters BK, Wellish M, et al. Varicella zoster virus, a cause of waxing and waning vasculitis: the New England Journal of Medicine case 5–1995 revisited. Neurology. 1996;47:1441–6. This article was the first to demonstrate VZV DNA, antigen and herpesvirus particles, as well as Cowdry A inclusions and giant cells, in the cerebral arteries of a patient who died of VZV vasculopathy.
12. Nagel MA, Traktinskiy I, Azarkh Y, et al. Varicella zoster virus vasculopathy: analysis of virus-infected arteries. Neurology. 2011;77:364–70. Nagel et al. examined cerebral and temporal arteries from 3 patients with VZV vasculopathy and characterized changes in the intima, media and internal elastic lamina associated with infection.
13. Nagel MA, Traktinskiy I, Stenmark KR, et al. Varicella-zoster virus vasculopathy: immune characteristics of virus-infected arteries. Neurology. 2013;80:62–8.
14. Dal Canto AJ, Swanson PE, O’Guin AK, et al. IFN-gamma action in the media of the great elastic arteries, a novel immunoprivileged site. J Clin Invest. 2001;107:15–22.
15. Frid MG, Brunetti JA, Burke DL, et al. Hypoxia-induced pulmonary vascular remodeling requires recruitment of circulating mesenchymal precursors of a monocyte/macrophage lineage. Am J Pathol. 2006;168:659–69.
16. Stenmark KR, Yeager ME, El Kasmi KC, et al. The adventitia: essential regulator of vascular wall structure and function. Annu Rev Physiol. 2013;75:23–47.
17. Kang JH, Ho JD, Chen YH, et al. Increased risk of stroke after a herpes zoster attack: a population-based follow-up study. Stroke. 2009;40:3443–8.
18. Lin HC, Chien CW, Ho JD. Herpes zoster ophthalmicus and the risk of stroke: a population-based follow-up study. Neurology. 2010;74:792–7.
19. Sreenivasan N, Basit S, Wohlfahrt J, et al. The short- and long-term risk of stroke after herpes zoster—a nationwide population-based cohort study. PLoS One. 2013;8:e69156.
20. Breuer J, Pacou M, Gauthier A, Brown MM. Herpes zoster as a risk factor for stroke and TIA: a retrospective cohort study in the UK. Neurology. 2014;82:206–12.
21. Langan SM, Minassian C, Smeeth L, Thomas SL. Risk of stroke following herpes zoster: a self-controlled case-series study. Clin Infect Dis. 2014;58:1497–503. Langan et al. studied 6584 individuals with zoster and stroke using a self-controlled case series method and showed that there was an increased stroke rate within 6 months following zoster and that antiviral therapy may reduce this risk.