Varicella-zoster virus infection of differentiated human neural stem cells

Journal of Virology

Volumn 85, Issue 13, 2011, Pages 6678-6686

  Pugazhenthi, Subbiah ^a,b   Nair, Sreekala ^a   Velmurugan, Kalpana ^a,b   Liang, Qiaoling ^a   Mahalingam, Ravi ^a   Cohrs, Randall J ^a   Nagel, Maria A ^a   Gilden, Don ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2',3' CYCLIC NUCLEOTIDE 3' PHOSPHODIESTERASE; BETA TUBULIN; BRAIN DERIVED NEUROTROPHIC FACTOR; BUCLADESINE; CASPASE 3; CELL MARKER; FIBROBLAST GROWTH FACTOR 2; GFAP PROTEIN; LAMININ; MAP2A PROTEIN; NERVE GROWTH FACTOR; POLYLYSINE; RETINOIC ACID; UNCLASSIFIED DRUG; VARICELLA ZOSTER VACCINE; VIRUS DNA; VIRUS PROTEIN;

APOPTOSIS; ARTICLE; ASTROCYTE; CELL DIFFERENTIATION; CELL POPULATION; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; ENZYME ACTIVATION; FETUS; FETUS LUNG; FIBROBLAST; HERPES ZOSTER; HUMAN; HUMAN CELL; IN VITRO STUDY; NERVE CELL; NEURAL STEM CELL; NICK END LABELING; OLIGODENDROGLIA; OPEN READING FRAME; PRIORITY JOURNAL; VIRUS CELL INTERACTION; ANIMAL; CELL CULTURE; CYTOLOGY; EVALUATION; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; LUNG; METABOLISM; METHODOLOGY; MOUSE; PATHOGENICITY; PHYSIOLOGY; VARICELLA ZOSTER VIRUS; VIROLOGY;

DNA VIRUSES; HUMAN HERPESVIRUS 3;

ANIMALS; APOPTOSIS; ASTROCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; CYTOPATHOGENIC EFFECT, VIRAL; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE; HERPESVIRUS 3, HUMAN; HUMANS; LUNG; MICE; NEURAL STEM CELLS; NEURONS; VIRAL PROTEINS; VIROLOGY;

EID: 80052071698     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00445-11     Document Type: Article

References (22)

1. Azarkh, Y., D. Gilden, and R. J. Cohrs. 2010. Molecular characterization of varicella zoster virus (VZV) in latently infected human ganglia: physical state and abundance of VZV DNA, quantitation of viral transcripts and detection of VZV-specific proteins. Curr. Top. Microbiol. Immunol. 342:229-241.
2. Baiker, A., et al. 2004. Varicella-zoster virus infection of human neural cells in vivo. Proc. Natl. Acad. Sci. U. S. A. 101:10792-10797.
3. Bottai, D., et al. 2003. Neural stem cells in the adult nervous system. J. Hematother. Stem Cell Res. 12:655-670.
4. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principles of protein-dye binding. Anal. Biochem. 72:248-254.
5. Brazeau, E., et al. 2010. Varicella-zoster virus-induced apoptosis in MeWo cells is accompanied by down-regulation of Bcl-2 expression. J. Neurovirol. 16:133-140.
6. Cohrs, R. J., D. H. Gilden, and R. Mahalingam. 2004. Varicella zoster virus latency, neurological disease and experimental models: an update. Front. Biosci. 9:751-762.
7. Galli, R., A. Gritti, L. Bonfanti, and A. L. Vescovi. 2003. Neural stem cells: an overview. Circ. Res. 92:598-608.
8. Gershon, A. A., J. Chen, and M. D. Gershon. 2008. A model of lytic, latent, and reactivating varicella-zoster virus infections in isolated enteric neurons. J. Infect. Dis. 197:S61-S65.
9. Gilden, D. H., et al. 1983. Varicella-zoster virus DNA in human sensory ganglia. Nature 306:478-480.
10. Gilden, D. H., B. K. Kleinschmidt-DeMasters, J. J. LaGuardia, R. Mahalingam, and R. J. Cohrs. 2000. Neurologic complications of the reactivation of varicella-zoster virus. N. Engl. J. Med. 342:635-645.
11. Gilden, D. H., et al. 2001. Presence of VZV and HSV-1 DNA in human nodose and celiac ganglia. Virus Genes 23:145-147.
12. Gilden, D. H., R. J. Cohrs, and R. Mahalingam. 2003. Clinical and molecular pathogenesis of varicella virus infection. Viral Immunol. 16:243-258.
13. Gowrishankar, K., et al. 2007. Productive varicella-zoster virus infection of cultured intact human ganglia. J. Virol. 81:6752-6756.
14. Hood, C., A. L. Cunningham, B. Slobedman, R. A. Boadle, and A. Abendroth. 2003. Varicella-zoster virus-infected human sensory neurons are resistant to apoptosis, yet human foreskin fibroblasts are susceptible: evidence for a cell-type-specific apoptotic response. J. Virol. 77:12852-12864.
15. Hood, C., et al. 2006. Varicella-zoster virus ORF63 inhibits apoptosis of primary human neurons. J. Virol. 80:1025-1031.
16. Lindvall, O., and Z. Kokaia. 2010. Stem cells in human neurodegenerative disorders-time for clinical translation? J. Clin. Invest. 120:29-40.
17. Mahalingam, R., et al. 1990. Latent varicella-zoster viral DNA in human trigeminal and thoracic ganglia. N. Engl. J. Med. 323:627-631.
18. Mahalingam, R., et al. 1996. Expression of protein encoded by varicellazoster zoster virus open reading frame 63 in latently infected human ganglionic neurons. Proc. Natl. Acad. Sci. U. S. A. 93:2122-2124.
19. Nagel, M. A., et al. 2011. Varicella-zoster virus transcriptome in latently infected human ganglia. J. Virol. 85:2276-2278.
20. Pugazhenthi, S., et al. 2009. Simian varicella virus induces apoptosis in monkey kidney cells by the intrinsic pathway and involves downregulation of bcl-2 expression. J. Virol. 83:9273-9282.
21. Zerboni, L., C.-C. Ku, C. D. Jones, J. L. Zehnder, and A. M. Arvin. 2005. Varicella-zoster virus infection of human dorsal root ganglia in vivo. Proc. Natl. Acad. Sci. U. S. A. 102:6490-6495.
22. Zerboni, L., et al. 2007. Aberrant infection and persistence of varicella-zoster virus in human dorsal root ganglia in vivo in the absence of glycoprotein I. Proc. Natl. Acad. Sci. U. S. A. 104:14086-14091.