Varicella-zoster virus transcriptome in latently infected human ganglia

Journal of Virology

Volumn 85, Issue 5, 2011, Pages 2276-2287

  Nagel, Maria A ^a   Choe, Alexander ^a   Traktinskiy, Igor ^a   Cordery Cotter, Robert ^a   Gilden, Don ^a   Cohrs, Randall J ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; TRANSCRIPTOME; VIRUS DNA; VIRUS RNA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; FEMALE; GENE SEQUENCE; GENETIC CODE; HERPES SIMPLEX VIRUS 1; HERPES ZOSTER; HUMAN; HUMAN CELL; HUMAN TISSUE; IN SITU HYBRIDIZATION; LATENT VIRUS INFECTION; MALE; OPEN READING FRAME; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; TRANSCRIPTOMICS; TRIGEMINUS GANGLION; VARICELLA ZOSTER VIRUS; VIRUS DETECTION; VIRUS TRANSCRIPTION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BASE SEQUENCE; FEMALE; GANGLIA; GENE EXPRESSION PROFILING; HERPES ZOSTER; HERPESVIRUS 1, HUMAN; HERPESVIRUS 3, HUMAN; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; OPEN READING FRAMES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VIRAL PROTEINS; VIRUS LATENCY; YOUNG ADULT;

HUMAN HERPESVIRUS 1; HUMAN HERPESVIRUS 3;

EID: 79551702832     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01862-10     Document Type: Article

References (37)

1. Ambagala, A. P., et al. 2009. Varicella-zoster virus immediate-early 63 protein interacts with human antisilencing function 1 protein and alters its ability to bind histones h3.1 and h3.3. J. Virol. 83:200-209.
2. Bustin, S. A., et al. 2009. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin. Chem. 55:611-622.
3. Cohen, J. I. 2010. The varicella-zoster virus genome. Curr. Top. Microbiol. Immunol. 342:1-14.
4. Cohen, J. I., T. Krogmann, L. Pesnicak, and M. A. Ali. 2007. Absence or overexpression of the varicella-zoster virus (VZV) ORF29 latency-associated protein impairs late gene expression and reduces VZV latency in a rodent model. J. Virol. 81:1586-1591.
5. Cohen, J. I., S. E. Straus, and A. M. Arvin. 2007. Varicella-zoster virus replication, pathogenesis, and management, p. 2773-2818. In D. M. Knipe and P. M. Howley (ed.), Fields virology, 5th ed., vol. 2. Lippincott Williams and Wilkins, Philadelphia, PA.
6. Cohrs, R., et al. 1992. Restricted transcription of varicella-zoster virus in latently infected human trigeminal and thoracic ganglia. J. Infect. Dis. 166(Suppl. 1):S24-S29.
7. Cohrs, R. J., et al. 1994. Varicella-zoster virus (VZV) transcription during latency in human ganglia: construction of a cDNA library from latently infected human trigeminal ganglia and detection of a VZV transcript. J. Virol. 68:7900-7908. (Pubitemid 24362677)
8. Cohrs, R. J., M. Barbour, and D. H. Gilden. 1996. Varicella-zoster virus (VZV) transcription during latency in human ganglia: detection of transcripts mapping to genes 21, 29, 62, and 63 in a cDNA library enriched for VZV RNA. J. Virol. 70:2789-2796.
9. Cohrs, R. J., et al. 2000. Analysis of individual human trigeminal ganglia for latent herpes simplex virus type 1 and varicella-zoster virus nucleic acids using real-time PCR. J. Virol. 74:11464-11471. (Pubitemid 32222293)
10. Cohrs, R. J., J. Wischer, C. Essman, and D. H. Gilden. 2002. Characterization of varicella-zoster virus gene 21 and 29 proteins in infected cells. J. Virol. 76:7228-7238.
11. Cohrs, R. J., D. H. Gilden, P. R. Kinchington, E. Grinfeld, and P. G. Kennedy. 2003. Varicella-zoster virus gene 66 transcription and translation in latently infected human ganglia. J. Virol. 77:6660-6665.
12. Cohrs, R. J., and D. H. Gilden. 2007. Prevalence and abundance of latently transcribed varicella-zoster virus genes in human ganglia. J. Virol. 81:2950-2956.
13. Croen, K. D., J. M. Ostrove, L. J. Dragovic, and S. E. Straus. 1988. Patterns of gene expression and sites of latency in human nerve ganglia are different from varicella-zoster and herpes simplex viruses. Proc. Natl. Acad. Sci. U. S. A. 85:9773-9777.
14. Fowler, W. J., et al. 1995. Identification of immunodominant regions and linear B cell epitopes of the gE envelope protein of varicella-zoster virus. Virology 214:531-540. (Pubitemid 26029514)
15. Gary, L., D. H. Gilden, and R. J. Cohrs. 2006. Epigenetic regulation of varicella-zoster virus open reading frames 62 and 63 in latently infected human trigeminal ganglia. J. Virol. 80:4921-4926.
16. Gilden, D. H., R. J. Cohrs, and R. Mahalingam. 2003. Clinical and molecular pathogenesis of varicella virus infection. Viral Immunol. 16:243-258. (Pubitemid 37229539)
17. Grose, C., and P. A. Brunel. 1978. Varicella-zoster virus: isolation and propagation in human melanoma cells at 36 and 32 degrees C. Infect. Immun. 19:199-203.
18. Grose, C., W. E. Friedrichs, and G. C. Smith. 1983. Purification and molecular anatomy of the varicella-zoster virion. Biken J. 26:1-15.
19. Habran, L., et al. 2007. The varicella-zoster virus immediate-early 63 protein affects chromatin-controlled gene transcription in a cell-type dependent manner. BMC Mol. Biol. 8:99.
20. Inchauspe, G., S. Nagpal, and J. M. Ostrove. 1989. Mapping of two varicella-zoster virus-encoded genes that activate the expression of viral early and late genes. Virology 173:700-709.
21. Kennedy, P. G., E. Grinfeld, and J. W. Gow. 1999. Latent varicella-zoster virus in human dorsal root ganglia. Virology 258:451-454.
22. Kennedy, P. G., E. Grinfeld, and J. E. Bell. 2000. Varicella-zoster virus gene expression in latently infected and explanted human ganglia. J. Virol. 74:11893-11898.
23. Kennedy, P. G., et al. 2005. Transcriptomal analysis of varicella-zoster virus infection using long oligonucleotide-based microarrays. J. Gen. Virol. 86:2673-2684.
24. Kinchington, P. R., J. K. Hougland, A. M. Arvin, W. T. Ruyechan, and J. Hay. 1992. The varicella-zoster virus immediate-early protein IE62 is a major component of virus particles. J. Virol. 66:359-366.
25. Kinchington, P. R., D. Bookey, and S. E. Turse. 1995. The transcriptional regulatory proteins encoded by varicella-zoster virus open reading frames (ORFs) 4 and 63, but not ORF 61, are associated with purified virus particles. J. Virol. 69:4274-4282.
26. Kinchington, P. R., K. Fite, and S. E. Turse. 2000. Nuclear accumulation of IE62, the varicella-zoster virus (VZV) major transcriptional regulatory protein, is inhibited by phosphorylation mediated by the VZV open reading frame 66 protein kinase. J. Virol. 74:2265-2277.
27. Kinchington, P. R., K. Fite, A. Seman, and S. E. Turse. 2001. Virion association of IE62, the varicella-zoster virus (VZV) major transcriptional regulatory protein, requires expression of the VZV open reading frame 66 protein kinase. J. Virol. 75:9106-9113.
28. Mahalingam, R., M. C. Wellish, A. N. Dueland, R. J. Cohrs, and D. H. Gilden. 1992. Localization of herpes simplex virus and varicella zoster virus DNA in human ganglia. Ann. Neurol. 31:444-448.
29. Mahalingam, R., R. Lasher, M. Wellish, R. J. Cohrs, and D. H. Gilden. 1998. Localization of varicella-zoster virus gene 21 protein in virus-infected cells in culture. J. Virol. 72:6832-6837.
30. Mahalingam, R., et al. 2010. Effect of time delay after necropsy on analysis of simian varicella-zoster virus expression in latently infected ganglia of rhesus macaques. J. Virol. 84:12454-12457.
31. Meier, J. L., and S. E. Straus. 1993. Varicella-zoster virus DNA polymerase and major DNA-binding protein genes have overlapping divergent promoters. J. Virol. 67:7573-7581.
32. Mueller, N. H., L. L. Graf, D. Orlicky, D. Gilden, and R. J. Cohrs. 2009. Phosphorylation of the nuclear form of varicella-zoster virus immediate-early protein 63 by casein kinase II at serine 186. J. Virol. 83:12094-12100.
33. Nagel, M. A., D. Gilden, T. Shade, B. Gao, and R. J. Cohrs. 2009. Rapid and sensitive detection of 68 unique varicella zoster virus gene transcripts in five multiplex reverse transcription-polymerase chain reactions. J. Virol. Methods 157:62-68.
34. Perkins, D., E. F. Pereira, M. Gober, P. J. Yarowsky, and L. Aurelian. 2002. The herpes simplex virus type 2 R1 protein kinase (ICP10 PK) blocks apoptosis in hippocampal neurons, involving activation of the MEK/MAPK survival pathway. J. Virol. 76:1435-1449. (Pubitemid 34066444)
35. Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. U. S. A. 74:5463-5467.
36. Tischer, B. K., et al. 2007. A self-excisable infectious bacterial artificial chromosome clone of varicella-zoster virus allows analysis of the essential tegument protein encoded by ORF9. J. Virol. 81:13200-13208. (Pubitemid 350156957)
37. Zhang, Z., et al. 2010. Genome-wide mutagenesis reveals that ORF7 is a novel VZV skin-tropic factor. PLoS Pathog. 6:e1000971.