Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo

Chemical Communications

Volumn 52, Issue 40, 2016, Pages 6727-6730

  Lee, Sook Y ^a,b   Brem, Jürgen ^b   Pettinati, Ilaria ^b   Claridge, Timothy D W ^b   Gileadi, Opher ^b   Schofield, Christopher J ^b   McHugh, Peter J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAM; CEFOTAXIME; CEFTAZIDIME; CEFTRIAXONE; CEPHALOSPORIN C; CEPHALOSPORIN DERIVATIVE; EXONUCLEASE; METALLO BETA LACTAMASE; NUCLEASE; SNM1A PROTEIN; SNM1B PROTEIN; UNCLASSIFIED DRUG; BETA LACTAMASE; DCLRE1A PROTEIN, HUMAN; DCLRE1B PROTEIN, HUMAN; DNA LIGASE; ENZYME INHIBITOR; EXODEOXYRIBONUCLEASE; NUCLEAR PROTEIN;

ARTICLE; CONTROLLED STUDY; DNA REPAIR; ENZYME ACTIVITY; HYDROLYSIS; PROTON NUCLEAR MAGNETIC RESONANCE; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG EFFECTS; HUMAN; METABOLISM; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

BETA-LACTAMASES; CEPHALOSPORINS; DNA REPAIR; DNA REPAIR ENZYMES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EXODEOXYRIBONUCLEASES; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NUCLEAR PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84970967343     PISSN: 13597345     EISSN: 1364548X     Source Type: Journal    
DOI: 10.1039/c6cc00529b     Document Type: Article

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