Co-ingesting milk fat with micellar casein does not affect postprandial protein handling in healthy older men

Clinical Nutrition

Volumn 36, Issue 2, 2017, Pages 429-437

  Gorissen, Stefan H M ^a,b   Burd, Nicholas A ^a,b   Kramer, Irene Fleur ^a,b   van Kranenburg, Janneau ^a,b   Gijsen, Annemie P ^a   Rooyackers, Olav ^c   van Loon, Luc J C ^a,b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b TOP INSTITUTE FOOD AND NUTRITION   (Netherlands)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Casein; Fat; Leucine; Muscle protein synthesis; Sarcopenia

Indexed keywords

CARBON 13; CASEIN; FATTY ACID; GLUCOSE; INSULIN; LEUCINE; MICELLAR CASEIN; MILK FAT; MUSCLE PROTEIN; PHENYLALANINE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; GLYCOLIPID; GLYCOPROTEIN; MILK FAT GLOBULE;

ADULT; AGED; AMINO ACID BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; FAT INTAKE; FATTY ACID BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INSULIN BLOOD LEVEL; ISOTOPE LABELING; KINETICS; MALE; MUSCLE FIBRIL; NORMAL HUMAN; POSTPRANDIAL STATE; PROTEIN BINDING; PROTEIN INTAKE; PROTEIN SYNTHESIS; RANDOMIZED CONTROLLED TRIAL; TRIACYLGLYCEROL BLOOD LEVEL; ADMINISTRATION AND DOSAGE; ANIMAL; BIOSYNTHESIS; BLOOD; BODY MASS; CHEMISTRY; DIET; EXERCISE; METABOLISM; MICELLE; MIDDLE AGED; MILK; PHARMACOKINETICS; SKELETAL MUSCLE;

AGED; ANIMALS; BLOOD GLUCOSE; BODY MASS INDEX; CASEINS; DIET; DIETARY PROTEINS; EXERCISE; GLYCOLIPIDS; GLYCOPROTEINS; HUMANS; LEUCINE; MALE; MICELLES; MIDDLE AGED; MILK; MUSCLE PROTEINS; MUSCLE, SKELETAL; PHENYLALANINE; POSTPRANDIAL PERIOD; PROTEIN BIOSYNTHESIS;

EID: 84969927135     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2015.12.011     Document Type: Article

References (32)

1. [1] Cuthbertson, D., Smith, K., Babraj, J., Leese, G., Waddell, T., Atherton, P., et al. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. Faseb J 19 (2005), 422–424.
2. [2] Katsanos, C.S., Kobayashi, H., Sheffield-Moore, M., Aarsland, A., Wolfe, R.R., Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. Am J Clin Nutr 82 (2005), 1065–1073.
3. [3] Burd, N.A., Gorissen, S.H., van Loon, L.J., Anabolic resistance of muscle protein synthesis with aging. Exerc sport Sci Rev 41 (2013), 169–173.
4. [4] Gorissen, S.H., Burd, N.A., Hamer, H.M., Gijsen, A.P., Groen, B.B., van Loon, L.J., Carbohydrate co-ingestion delays dietary protein digestion and absorption but does not modulate postprandial muscle protein accretion. J Clin Endocrinol Metab, 2014, jc20133970.
5. [5] Boirie, Y., Gachon, P., Beaufrere, B., Splanchnic and whole-body leucine kinetics in young and elderly men. Am J Clin Nutr 65 (1997), 489–495.
6. [6] Timmerman, K.L., Lee, J.L., Fujita, S., Dhanani, S., Dreyer, H.C., Fry, C.S., et al. Pharmacological vasodilation improves insulin-stimulated muscle protein anabolism but not glucose utilization in older adults. Diabetes 59 (2010), 2764–2771.
7. [7] Dickinson, J.M., Drummond, M.J., Coben, J.R., Volpi, E., Rasmussen, B.B., Aging differentially affects human skeletal muscle amino acid transporter expression when essential amino acids are ingested after exercise. Clin Nutr 32 (2013), 273–280.
8. [8] Elliot, T.A., Cree, M.G., Sanford, A.P., Wolfe, R.R., Tipton, K.D., Milk ingestion stimulates net muscle protein synthesis following resistance exercise. Med Sci Sports Exerc 38 (2006), 667–674.
9. [9] Calbet, J.A., MacLean, D.A., Role of caloric content on gastric emptying in humans. J Physiol 498:Pt 2 (1997), 553–559.
10. [10] Fouillet, H., Gaudichon, C., Mariotti, F., Bos, C., Huneau, J.F., Tome, D., Energy nutrients modulate the splanchnic sequestration of dietary nitrogen in humans: a compartmental analysis. Am J Physiol Endocrinol Metab 281 (2001), E248–E260.
11. [11] Svanberg, E., Moller-Loswick, A.C., Matthews, D.E., Korner, U., Andersson, M., Lundholm, K., The role of glucose, long-chain triglycerides and amino acids for promotion of amino acid balance across peripheral tissues in man. Clin Physiol Oxf Engl 19 (1999), 311–320.
12. [12] Boirie, Y., Dangin, M., Gachon, P., Vasson, M.P., Maubois, J.L., Beaufrere, B., Slow and fast dietary proteins differently modulate postprandial protein accretion. Proc Natl Acad Sci U. S. A 94 (1997), 14930–14935.
13. [13] Pennings, B., Boirie, Y., Senden, J.M., Gijsen, A.P., Kuipers, H., van Loon, L.J., Whey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men. Am J Clin Nutr 93 (2011), 997–1005.
14. [14] Burd, N.A., Cermak, N.M., Kouw, I.W., Gorissen, S.H., Gijsen, A.P., van Loon, L.J., The use of doubly labeled milk protein to measure postprandial muscle protein synthesis rates in vivo in humans. J Appl Physiol Bethesda Md 1985 117 (2014), 1363–1370.
15. [15] Alberti, K.G., Zimmet, P.Z., Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15 (1998), 539–553.
16. [16] Abumrad, N.N., Rabin, D., Diamond, M.P., Lacy, W.W., Use of a heated superficial hand vein as an alternative site for the measurement of amino acid concentrations and for the study of glucose and alanine kinetics in man. Metabolism 30 (1981), 936–940.
17. [17] Bergstrom, J., Percutaneous needle biopsy of skeletal muscle in physiological and clinical research. Scand J Clin Lab Invest 35 (1975), 609–616.
18. [18] Burd, N.A., Hamer, H.M., Pennings, B., Pellikaan, W.F., Senden, J.M., Gijsen, A.P., et al. Substantial differences between organ and muscle specific tracer incorporation rates in a lactating dairy cow. PLoS One, 8, 2013, e68109.
19. [19] Pennings, B., Pellikaan, W.F., Senden, J.M., van Vuuren, A.M., Sikkema, J., van Loon, L.J., The production of intrinsically labeled milk and meat protein is feasible and provides functional tools for human nutrition research. J Dairy Sci 94 (2011), 4366–4373.
20. [20] van Loon, L.J., Boirie, Y., Gijsen, A.P., Fauquant, J., de Roos, A.L., Kies, A.K., et al. The production of intrinsically labeled milk protein provides a functional tool for human nutrition research. J Dairy Sci 92 (2009), 4812–4822.
21. [21] Boirie, Y., Gachon, P., Corny, S., Fauquant, J., Maubois, J.L., Beaufrere, B., Acute postprandial changes in leucine metabolism as assessed with an intrinsically labeled milk protein. Am J Physiol 271 (1996), E1083–E1091.
22. [22] Dangin, M., Guillet, C., Garcia-Rodenas, C., Gachon, P., Bouteloup-Demange, C., Reiffers-Magnani, K., et al. The rate of protein digestion affects protein gain differently during aging in humans. J Physiol 549 (2003), 635–644.
23. [23] Glynn, E.L., Fry, C.S., Timmerman, K.L., Drummond, M.J., Volpi, E., Rasmussen, B.B., Addition of carbohydrate or alanine to an essential amino acid mixture does not enhance human skeletal muscle protein anabolism. J Nutr 143:3 (2013), 307–314.
24. [24] Katsanos, C.S., Aarsland, A., Cree, M.G., Wolfe, R.R., Muscle protein synthesis and balance responsiveness to essential amino acids ingestion in the presence of elevated plasma free fatty acid concentrations. J Clin Endocrinol Metab 94 (2009), 2984–2990.
25. [25] Pennings, B., Groen, B., de Lange, A., Gijsen, A.P., Zorenc, A.H., Senden, J.M., et al. Amino acid absorption and subsequent muscle protein accretion following graded intakes of whey protein in elderly men. Am J Physiol Endocrinol Metab 302 (2012), E992–E999.
26. [26] Houghton, L.A., Mangnall, Y.F., Read, N.W., Effect of incorporating fat into a liquid test meal on the relation between intragastric distribution and gastric emptying in human volunteers. Gut 31 (1990), 1226–1229.
27. [27] Edelbroek, M., Horowitz, M., Maddox, A., Bellen, J., Gastric emptying and intragastric distribution of oil in the presence of a liquid or a solid meal. J Nucl Med 33 (1992), 1283–1290.
28. [28] Gentilcore, D., Chaikomin, R., Jones, K.L., Russo, A., Feinle-Bisset, C., Wishart, J.M., et al. Effects of fat on gastric emptying of and the glycemic, insulin, and incretin responses to a carbohydrate meal in type 2 diabetes. J Clin Endocrinol Metab 91 (2006), 2062–2067.
29. [29] Janssen, I., Heymsfield, S.B., Ross, R., Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatrics Soc 50 (2002), 889–896.
30. [30] Kimyagarov, S., Klid, R., Fleissig, Y., Kopel, B., Arad, M., Adunsky, A., Skeletal muscle mass abnormalities are associated with survival rates of institutionalized elderly nursing home residents. J Nutr health & aging 16 (2012), 432–436.
31. [31] Landi, F., Liperoti, R., Fusco, D., Mastropaolo, S., Quattrociocchi, D., Proia, A., et al. Sarcopenia and mortality among older nursing home residents. J Am Med Dir Assoc 13 (2012), 121–126.
32. [32] Houston, D.K., Nicklas, B.J., Ding, J., Harris, T.B., Tylavsky, F.A., Newman, A.B., et al. Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the health, aging, and body composition (Health ABC) Study. Am J Clin Nutr 87 (2008), 150–155.