Aging differentially affects human skeletal muscle amino acid transporter expression when essential amino acids are ingested after exercise

Clinical Nutrition

Volumn 32, Issue 2, 2013, Pages 273-280

  Dickinson, Jared M ^a   Drummond, Micah J ^a   Coben, Jennifer R ^a   Volpi, Elena ^a   Rasmussen, Blake B ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

MTORC1 signaling; Muscle protein synthesis; Nutrition; Resistance exercise; Sarcopenia

Indexed keywords

AMINO ACID TRANSPORTER; ESSENTIAL AMINO ACID; L-TYPE AMINO ACID TRANSPORTER 1; MESSENGER RNA; SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER; UNCLASSIFIED DRUG;

ADULT; AGED; AGING; ARTICLE; EXERCISE; FOOD INTAKE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; MALE; MUSCLE BIOPSY; MUSCLE STRENGTH; NORMAL HUMAN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RESISTANCE TRAINING; REST; SKELETAL MUSCLE;

ADULT; AGED; AGING; AMINO ACID TRANSPORT SYSTEMS; AMINO ACIDS, ESSENTIAL; BLOOD GLUCOSE; EXERCISE; HUMANS; LEUCINE; MALE; MUSCLE PROTEINS; MUSCLE, SKELETAL; PROTEIN BIOSYNTHESIS; REST; RNA, MESSENGER;

EID: 84875262589     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2012.07.009     Document Type: Article

References (34)

1. Kosek D.J., Kim J.S., Petrella J.K., Cross J.M., Bamman M.M. Efficacy of 3 days/wk resistance training on myofiber hypertrophy and myogenic mechanisms in young vs. older adults. J Appl Physiol 2006, 101:531-544.
2. Fiatarone M.A., Marks E.C., Ryan N.D., Meredith C.N., Lipsitz L.A., Evans W.J. High-intensity strength training in nonagenarians. Effects on skeletal muscle. JAMA 1990, 263:3029-3034.
3. Burd N.A., Tang J.E., Moore D.R., Phillips S.M. Exercise training and protein metabolism: influences of contraction, protein intake, and sex-based differences. J Appl Physiol 2009, 106:1692-1701.
4. Drummond M.J., Dreyer H.C., Fry C.S., Glynn E.L., Rasmussen B.B. Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling. J Appl Physiol 2009, 106:1374-1384.
5. Wolfe R.R. Protein supplements and exercise. Am J Clin Nutr 2000, 72:551S-557S.
6. Fry C.S., Drummond M.J., Glynn E.L., Dickinson J.M., Gundermann D.M., Timmerman K.L., et al. Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis. Skelet Muscle 2011, 1:11.
7. Drummond M.J., Dreyer H.C., Pennings B., Fry C.S., Dhanani S., Dillon E.L., et al. Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging. J Appl Physiol 2008, 104:1452-1461.
8. Yanagida O., Kanai Y., Chairoungdua A., Kim D.K., Segawa H., Nii T., et al. Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines. Biochim Biophys Acta 2001, 1514:291-302.
9. Drummond M.J., Glynn E.L., Fry C.S., Timmerman K.L., Volpi E., Rasmussen B.B. An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle. Am J Physiol Endocrinol Metab 2010, 298:E1011-E1018.
10. Evans K., Nasim Z., Brown J., Butler H., Kauser S., Varoqui H., et al. Acidosis-sensing glutamine pump SNAT2 determines amino acid levels and mammalian target of rapamycin signalling to protein synthesis in L6 muscle cells. J Am Soc Nephrol 2007, 18:1426-1436.
11. Baird F.E., Bett K.J., MacLean C., Tee A.R., Hundal H.S., Taylor P.M. Tertiary active transport of amino acids reconstituted by coexpression of system A and L transporters in Xenopus oocytes. Am J Physiol Endocrinol Metab 2009, 297:E822-E829.
12. Christie G.R., Hajduch E., Hundal H.S., Proud C.G., Taylor P.M. Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner. J Biol Chem 2002, 277:9952-9957.
13. Hyde R., Hajduch E., Powell D.J., Taylor P.M., Hundal H.S. Ceramide down-regulates system A amino acid transport and protein synthesis in rat skeletal muscle cells. FASEB J 2005, 19:461-463.
14. Hyatt S.L., Aulak K.S., Malandro M., Kilberg M.S., Hatzoglou M. Adaptive regulation of the cationic amino acid transporter-1 (Cat-1) in Fao cells. J Biol Chem 1997, 272:19951-19957.
15. Lopez A.B., Wang C., Huang C.C., Yaman I., Li Y., Chakravarty K., et al. A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation. Biochem J 2007, 402:163-173.
16. Goberdhan D.C., Meredith D., Boyd C.A., Wilson C. PAT-related amino acid transporters regulate growth via a novel mechanism that does not require bulk transport of amino acids. Development 2005, 132:2365-2375.
17. Heublein S., Kazi S., Ogmundsdottir M.H., Attwood E.V., Kala S., Boyd C.A., et al. Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation. Oncogene 2010, 29:4068-4079.
18. Drummond M.J., Fry C.S., Glynn E.L., Timmerman K.L., Dickinson J.M., Walker D.K., et al. Skeletal muscle amino acid transporter expression is increased in young and older adults following resistance exercise. J Appl Physiol 2011, 111:135-142.
19. Bergstrom J. Muscle electrolytes in man. Scand J Med Sci Sports 1962, 68:1-110.
20. Drummond M.J., Miyazaki M., Dreyer H.C., Pennings B., Dhanani S., Volpi E., et al. Expression of growth-related genes in young and older human skeletal muscle following an acute stimulation of protein synthesis. J Appl Physiol 2009, 106:1403-1411.
21. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 2001, 25:402-408.
22. Dreyer H.C., Fujita S., Cadenas J.G., Chinkes D.L., Volpi E., Rasmussen B.B. Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle. J Physiol 2006, 576:613-624.
23. Wolfe R.R., Chinkes D.L. Isotopic tracers in metabolic research: principles and practice of kinetic analysis 2005, John Wiley & Sons, Inc., Hoboken. 2nd ed.
24. Nicklin P., Bergman P., Zhang B., Triantafellow E., Wang H., Nyfeler B., et al. Bidirectional transport of amino acids regulates mTOR and autophagy. Cell 2009, 136:521-534.
25. Hyde R., Cwiklinski E.L., MacAulay K., Taylor P.M., Hundal H.S. Distinct sensor pathways in the hierarchical control of SNAT2, a putative amino acid transceptor, by amino acid availability. J Biol Chem 2007, 282:19788-19798.
26. Pinilla J., Aledo J.C., Cwiklinski E., Hyde R., Taylor P.M., Hundal H.S. SNAT2 transceptor signalling via mTOR: a role in cell growth and proliferation?. Front Biosci (Elite Ed) 2011, 3:1289-1299.
27. Durham W.J., Casperson S.L., Dillon E.L., Keske M.A., Paddon-Jones D., Sanford A.P., et al. Age-related anabolic resistance after endurance-type exercise in healthy humans. FASEB J 2010, 24:4117-4127.
28. Hyde R., Taylor P.M., Hundal H.S. Amino acid transporters: roles in amino acid sensing and signalling in animal cells. Biochem J 2003, 373:1-18.
29. Verrey F., Closs E.I., Wagner C.A., Palacin M., Endou H., Kanai Y. CATs and HATs: the SLC7 family of amino acid transporters. Pflugers Arch 2004, 447:532-542.
30. Anthony J.C., Anthony T.G., Kimball S.R., Vary T.C., Jefferson L.S. Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation. J Nutr 2000, 130:139-145.
31. Anthony J.C., Yoshizawa F., Anthony T.G., Vary T.C., Jefferson L.S., Kimball S.R. Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. J Nutr 2000, 130:2413-2419.
32. Liu X.M., Reyna S.V., Ensenat D., Peyton K.J., Wang H., Schafer A.I., et al. Platelet-derived growth factor stimulates LAT1 gene expression in vascular smooth muscle: role in cell growth. FASEB J 2004, 18:768-770.
33. Kim C.H., Park K.J., Park J.R., Kanai Y., Endou H., Park J.C., et al. The RNA interference of amino acid transporter LAT1 inhibits the growth of KB human oral cancer cells. Anticancer Res 2006, 26:2943-2948.
34. Drummond M.J., Dickinson J.M., Fry C.S., Walker D.K., Gundermann D.M., Reidy P.T., et al. Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults. Am J Physiol Endocrinol Metab 2012, 302:E1113-E1122.