메뉴 건너뛰기




Volumn 25, Issue , 2016, Pages 38-49

Activation of AMPK/Nrf2 signalling by Manuka honey protects human dermal fibroblasts against oxidative damage by improving antioxidant response and mitochondrial function promoting wound healing

Author keywords

AMPK; Manuka honey; Nrf2; ROS; Wound healing

Indexed keywords


EID: 84969849829     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2016.05.008     Document Type: Article
Times cited : (149)

References (45)
  • 1
    • 0021318441 scopus 로고
    • Catalase in vitro
    • Aebi H. Catalase in vitro. Methods in Enzymology 1984, 105:121-126.
    • (1984) Methods in Enzymology , vol.105 , pp. 121-126
    • Aebi, H.1
  • 3
    • 0030586361 scopus 로고    scopus 로고
    • The ferric reducing ability of plasma (FRAP) as a measure of antioxidant power: The FRAP assay
    • Benzie I.F., Strain J. The ferric reducing ability of plasma (FRAP) as a measure of antioxidant power: The FRAP assay. Analytical Biochemistry 1996, 239:70-76.
    • (1996) Analytical Biochemistry , vol.239 , pp. 70-76
    • Benzie, I.F.1    Strain, J.2
  • 4
    • 84856680561 scopus 로고    scopus 로고
    • Use of Medihoney as a non-surgical therapy for chronic pressure ulcers in patients with spinal cord injury
    • Biglari B., vd Linden P.H., Simon A., Aytac S., Gerner H.J., Moghaddam A. Use of Medihoney as a non-surgical therapy for chronic pressure ulcers in patients with spinal cord injury. Spinal Cord 2012, 50:165-169.
    • (2012) Spinal Cord , vol.50 , pp. 165-169
    • Biglari, B.1    vd Linden, P.H.2    Simon, A.3    Aytac, S.4    Gerner, H.J.5    Moghaddam, A.6
  • 5
    • 84955586232 scopus 로고    scopus 로고
    • Effect of Manuka honey gel on the transforming growth factor β1 and β3 concentrations, bacterial counts and histomorphology of contaminated full-thickness skin wounds in equine distal limbs
    • Bischofberger A.S., Dart C.M., Horadagoda N., Perkins N.R., Jeffcott L.B., Little C.B., Dart A.J. Effect of Manuka honey gel on the transforming growth factor β1 and β3 concentrations, bacterial counts and histomorphology of contaminated full-thickness skin wounds in equine distal limbs. Australian Veterinary Journal 2016, 94:27-34.
    • (2016) Australian Veterinary Journal , vol.94 , pp. 27-34
    • Bischofberger, A.S.1    Dart, C.M.2    Horadagoda, N.3    Perkins, N.R.4    Jeffcott, L.B.5    Little, C.B.6    Dart, A.J.7
  • 8
    • 0017184389 scopus 로고
    • Rapid and sensitive method for quantification of microgram quantities of protein utilizing the principle dye binding
    • Bradford M.M. Rapid and sensitive method for quantification of microgram quantities of protein utilizing the principle dye binding. Analytical Biochemistry 1976, 72:248-254.
    • (1976) Analytical Biochemistry , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 9
    • 79953180902 scopus 로고    scopus 로고
    • Assessing mitochondrial dysfunction in cells
    • Brandd M.D., Nicholls D.G. Assessing mitochondrial dysfunction in cells. Biochemical Journal 2011, 435:297-312.
    • (2011) Biochemical Journal , vol.435 , pp. 297-312
    • Brandd, M.D.1    Nicholls, D.G.2
  • 10
    • 84952636599 scopus 로고    scopus 로고
    • Nrf2-ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases
    • Buendia I., Michalska P., Navarro E., Gameiro I., Egea J., León R. Nrf2-ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases. Pharmacology & Therapeutics 2016, 157:84-104.
    • (2016) Pharmacology & Therapeutics , vol.157 , pp. 84-104
    • Buendia, I.1    Michalska, P.2    Navarro, E.3    Gameiro, I.4    Egea, J.5    León, R.6
  • 11
    • 84879044608 scopus 로고    scopus 로고
    • Analysis of the flavonoid component of bioactive New Zealand manuka (Leptospermum scoparium) honey and the isolation, characterisation and synthesis of an unusual pyrrole
    • Chan C.W., Deadman B.J., Manley-Harris M., Wilkins A.L., Alber D.G., Harry E. Analysis of the flavonoid component of bioactive New Zealand manuka (Leptospermum scoparium) honey and the isolation, characterisation and synthesis of an unusual pyrrole. Food Chemistry 2013, 141:1772-1781.
    • (2013) Food Chemistry , vol.141 , pp. 1772-1781
    • Chan, C.W.1    Deadman, B.J.2    Manley-Harris, M.3    Wilkins, A.L.4    Alber, D.G.5    Harry, E.6
  • 12
    • 67650882500 scopus 로고    scopus 로고
    • AMPKalpha1 regulates the antioxidant status of vascular endothelial cells
    • Colombo S.L., Moncada S. AMPKalpha1 regulates the antioxidant status of vascular endothelial cells. Biochemical Journal 2009, 421:163-169.
    • (2009) Biochemical Journal , vol.421 , pp. 163-169
    • Colombo, S.L.1    Moncada, S.2
  • 13
    • 0036430016 scopus 로고    scopus 로고
    • The sensitivity to honey of Gram positive cocci of clinical significance isolated from wounds
    • Copper R.A., Molan P.C., Harding K.G. The sensitivity to honey of Gram positive cocci of clinical significance isolated from wounds. Journal of Applied Microbiology 2002, 93:857-863.
    • (2002) Journal of Applied Microbiology , vol.93 , pp. 857-863
    • Copper, R.A.1    Molan, P.C.2    Harding, K.G.3
  • 14
    • 84875953344 scopus 로고    scopus 로고
    • Dietary (poly)phenolics in human health: Structures, bioavailability, and evidence of protective effects against chronic diseases
    • Del Rio D., Rodriguez-Mateos A., Spencer J.P., Tognolini M., Borges G., Crozier A. Dietary (poly)phenolics in human health: Structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxidant Redox Signal 2013, 18:1818-1892.
    • (2013) Antioxidant Redox Signal , vol.18 , pp. 1818-1892
    • Del Rio, D.1    Rodriguez-Mateos, A.2    Spencer, J.P.3    Tognolini, M.4    Borges, G.5    Crozier, A.6
  • 15
    • 84879410655 scopus 로고    scopus 로고
    • Steroidal glycosides from the bulbs of Easter lily (Lilium longiflorum Thunb.) promote dermal fibroblast migration in vitro
    • Esposito D., Munafo J.P., Lucibello T., Baldeon M., Komarnytsky S., Gianfagna T.J. Steroidal glycosides from the bulbs of Easter lily (Lilium longiflorum Thunb.) promote dermal fibroblast migration in vitro. Journal of Ethnopharmacology 2013, 148:433-440.
    • (2013) Journal of Ethnopharmacology , vol.148 , pp. 433-440
    • Esposito, D.1    Munafo, J.P.2    Lucibello, T.3    Baldeon, M.4    Komarnytsky, S.5    Gianfagna, T.J.6
  • 18
    • 28244477914 scopus 로고    scopus 로고
    • Case series of use of Manuka honey in leg ulceration
    • Gethin G., Cowman S. Case series of use of Manuka honey in leg ulceration. International Wound Journal 2005, 2:10-15.
    • (2005) International Wound Journal , vol.2 , pp. 10-15
    • Gethin, G.1    Cowman, S.2
  • 22
    • 15544389238 scopus 로고    scopus 로고
    • Identification of phenolic compound in manuka honey as specific superoxide anion radical scavenger using electron spin resonance (ESR) and liquid chromatography with coulometric array detection
    • Inoue K., Murayama S., Seshimo F., Takeba K., Yoshimura Y., Nakazawa H. Identification of phenolic compound in manuka honey as specific superoxide anion radical scavenger using electron spin resonance (ESR) and liquid chromatography with coulometric array detection. Journal of the Science of Food and Agriculture 2005, 85:872-878.
    • (2005) Journal of the Science of Food and Agriculture , vol.85 , pp. 872-878
    • Inoue, K.1    Murayama, S.2    Seshimo, F.3    Takeba, K.4    Yoshimura, Y.5    Nakazawa, H.6
  • 23
    • 0026632930 scopus 로고
    • Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein
    • Jiang Z.Y., Hunt J.V., Wolff S.P. Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein. Analytical Biochemistry 1992, 202:384-389.
    • (1992) Analytical Biochemistry , vol.202 , pp. 384-389
    • Jiang, Z.Y.1    Hunt, J.V.2    Wolff, S.P.3
  • 30
    • 84930753309 scopus 로고    scopus 로고
    • (2R,3S)-Pinobanksin-3-cinnamate improves cognition and reduces oxidative stress in rats with vascular dementia
    • Liu H., Zhao M., Yang S., Gong D.R., Chen D.Z., Du D.Y. (2R,3S)-Pinobanksin-3-cinnamate improves cognition and reduces oxidative stress in rats with vascular dementia. Journal of Natural Medicines 2015, 69:358-365.
    • (2015) Journal of Natural Medicines , vol.69 , pp. 358-365
    • Liu, H.1    Zhao, M.2    Yang, S.3    Gong, D.R.4    Chen, D.Z.5    Du, D.Y.6
  • 31
    • 77955871829 scopus 로고    scopus 로고
    • PGC-1 alpha regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overload
    • Lu Z., Xu X., Hu X., Fassett J., Zhu G., Tao Y., Li J., Huang Y., Zhang P., Zhao B., Chen Y. PGC-1 alpha regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overload. Antioxidant and Redox Signal 2010, 13:1011-1022.
    • (2010) Antioxidant and Redox Signal , vol.13 , pp. 1011-1022
    • Lu, Z.1    Xu, X.2    Hu, X.3    Fassett, J.4    Zhu, G.5    Tao, Y.6    Li, J.7    Huang, Y.8    Zhang, P.9    Zhao, B.10    Chen, Y.11
  • 32
    • 84862332247 scopus 로고    scopus 로고
    • Mono-(2-ethylhexyl)-phthalate (MEHP) affects ERK-dependent GDNF signalling in mouse stem-progenitor spermatogonia
    • Lucas B.E., Fields C., Joshi N., Hofmann M.C. Mono-(2-ethylhexyl)-phthalate (MEHP) affects ERK-dependent GDNF signalling in mouse stem-progenitor spermatogonia. Toxicology 2012, 299:10-19.
    • (2012) Toxicology , vol.299 , pp. 10-19
    • Lucas, B.E.1    Fields, C.2    Joshi, N.3    Hofmann, M.C.4
  • 33
    • 84961730160 scopus 로고    scopus 로고
    • Antistaphylococcal activity and metabolite profiling of manuka honey (Leptospermum scoparium L.) after in vitro simulated digestion
    • Mannina L., Sobolev A.P., Coppo E., Di Lorenzo A., Nabavi S.M., Marchese A., Daglia M. Antistaphylococcal activity and metabolite profiling of manuka honey (Leptospermum scoparium L.) after in vitro simulated digestion. Food & Function 2016, 7:1664-1670.
    • (2016) Food & Function , vol.7 , pp. 1664-1670
    • Mannina, L.1    Sobolev, A.P.2    Coppo, E.3    Di Lorenzo, A.4    Nabavi, S.M.5    Marchese, A.6    Daglia, M.7
  • 34
    • 0030934532 scopus 로고    scopus 로고
    • Wound healing-aiming for perfect skin regeneration
    • Martin P. Wound healing-aiming for perfect skin regeneration. Science 1997, 276:75-81.
    • (1997) Science , vol.276 , pp. 75-81
    • Martin, P.1
  • 35
    • 84872473676 scopus 로고    scopus 로고
    • The evidence and the rationale for the use of honey as a wound dressing
    • Molan P.C. The evidence and the rationale for the use of honey as a wound dressing. Wound Practice and Research 2011, 19:204-220.
    • (2011) Wound Practice and Research , vol.19 , pp. 204-220
    • Molan, P.C.1
  • 36
    • 84931064613 scopus 로고    scopus 로고
    • Honey: A biologic wound dressing
    • Molan P., Rhodes T. Honey: A biologic wound dressing. Wounds 2015, 27:141-151.
    • (2015) Wounds , vol.27 , pp. 141-151
    • Molan, P.1    Rhodes, T.2
  • 37
    • 0018384650 scopus 로고
    • Assay for lipid peroxide in animal tissue by thiobarbituric acid reaction
    • Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxide in animal tissue by thiobarbituric acid reaction. Analytical Biochemistry 1979, 95:331-358.
    • (1979) Analytical Biochemistry , vol.95 , pp. 331-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 39
    • 80054875266 scopus 로고    scopus 로고
    • Modulation of Nrf2/ARE pathway by food polyphenols: A nutritional neuroprotective strategy for cognitive and neurodegenerative disorders
    • Scapagnini G., Vasto S., Abraham N.G., Caruso C., Zella D., Fabio G. Modulation of Nrf2/ARE pathway by food polyphenols: A nutritional neuroprotective strategy for cognitive and neurodegenerative disorders. Molecular Neurobiology 2011, 44:192-201.
    • (2011) Molecular Neurobiology , vol.44 , pp. 192-201
    • Scapagnini, G.1    Vasto, S.2    Abraham, N.G.3    Caruso, C.4    Zella, D.5    Fabio, G.6
  • 41
    • 84875736170 scopus 로고    scopus 로고
    • Methyl syringate, a low-molecular-weight phenolic ester, as an activator of the chemosensory ion channel TRPA1
    • Son H.J., Kim M.J., Park J.H., Ishii S., Misaka T., Rhyu M.R. Methyl syringate, a low-molecular-weight phenolic ester, as an activator of the chemosensory ion channel TRPA1. Archives of Pharmacal Research 2012, 35:2211-2218.
    • (2012) Archives of Pharmacal Research , vol.35 , pp. 2211-2218
    • Son, H.J.1    Kim, M.J.2    Park, J.H.3    Ishii, S.4    Misaka, T.5    Rhyu, M.R.6
  • 44
    • 84949817409 scopus 로고    scopus 로고
    • Pinocembrin attenuates MPP(+)-induced neurotoxicity by the induction of heme oxygenase-1 through ERK1/2 pathway
    • Wang H., Wang Y., Zhao L., Cui Q., Wang Y., Du G. Pinocembrin attenuates MPP(+)-induced neurotoxicity by the induction of heme oxygenase-1 through ERK1/2 pathway. Neuroscience Letters 2016, 612:104-109.
    • (2016) Neuroscience Letters , vol.612 , pp. 104-109
    • Wang, H.1    Wang, Y.2    Zhao, L.3    Cui, Q.4    Wang, Y.5    Du, G.6
  • 45
    • 84935922636 scopus 로고    scopus 로고
    • Pinocembrin inhibits lipopolysaccharide-induced inflammatory mediators production in BV2 microglial cells through suppression of PI3K/Akt/NF-κB pathway
    • Zhou L.T., Wang K.J., Li L., Li H., Geng M. Pinocembrin inhibits lipopolysaccharide-induced inflammatory mediators production in BV2 microglial cells through suppression of PI3K/Akt/NF-κB pathway. European Journal of Pharmacology 2015, 761:211-216.
    • (2015) European Journal of Pharmacology , vol.761 , pp. 211-216
    • Zhou, L.T.1    Wang, K.J.2    Li, L.3    Li, H.4    Geng, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.