-
1
-
-
84876804736
-
The global distribution and burden of dengue
-
Bhatt, S., Gething, P. W., Brady, O. J., Messina, J. P., Farlow, A. W., Moyes, C. L., Drake, J. M., Brownstein, J. S., Hoen, A. G., Sankoh, O., Myers, M. F., George, D. B., Jaenisch, T., Wint, G. R., Simmons, C. P., Scott, T. W., Farrar, J. J., and Hay, S. I. (2013) The global distribution and burden of dengue Nature 496, 504-507 10.1038/nature12060
-
(2013)
Nature
, vol.496
, pp. 504-507
-
-
Bhatt, S.1
Gething, P.W.2
Brady, O.J.3
Messina, J.P.4
Farlow, A.W.5
Moyes, C.L.6
Drake, J.M.7
Brownstein, J.S.8
Hoen, A.G.9
Sankoh, O.10
Myers, M.F.11
George, D.B.12
Jaenisch, T.13
Wint, G.R.14
Simmons, C.P.15
Scott, T.W.16
Farrar, J.J.17
Hay, S.I.18
-
2
-
-
84885567750
-
Ten years of dengue drug discovery: Progress and prospects
-
Lim, S. P., Wang, Q. Y., Noble, C. G., Chen, Y. L., Dong, H., Zou, B., Yokokawa, F., Nilar, S., Smith, P., Beer, D., Lescar, J., and Shi, P. Y. (2013) Ten years of dengue drug discovery: progress and prospects Antiviral Res. 100, 500-519 10.1016/j.antiviral.2013.09.013
-
(2013)
Antiviral Res.
, vol.100
, pp. 500-519
-
-
Lim, S.P.1
Wang, Q.Y.2
Noble, C.G.3
Chen, Y.L.4
Dong, H.5
Zou, B.6
Yokokawa, F.7
Nilar, S.8
Smith, P.9
Beer, D.10
Lescar, J.11
Shi, P.Y.12
-
3
-
-
84906971635
-
Characterization of the mode of action of a potent dengue virus capsid inhibitor
-
Scaturro, P., Trist, I. M., Paul, D., Kumar, A., Acosta, E. G., Byrd, C. M., Jordan, R., Brancale, A., and Bartenschlager, R. (2014) Characterization of the mode of action of a potent dengue virus capsid inhibitor J. Virol. 88, 11540-11555 10.1128/JVI.01745-14
-
(2014)
J. Virol.
, vol.88
, pp. 11540-11555
-
-
Scaturro, P.1
Trist, I.M.2
Paul, D.3
Kumar, A.4
Acosta, E.G.5
Byrd, C.M.6
Jordan, R.7
Brancale, A.8
Bartenschlager, R.9
-
4
-
-
77951984630
-
Inhibition of dengue virus polymerase by blocking of the RNA tunnel
-
Niyomrattanakit, P., Chen, Y. L., Dong, H., Yin, Z., Qing, M., Glickman, J. F., Lin, K., Mueller, D., Voshol, H., Lim, J. Y., Nilar, S., Keller, T. H., and Shi, P. Y. (2010) Inhibition of dengue virus polymerase by blocking of the RNA tunnel J. Virol. 84, 5678-5686 10.1128/JVI.02451-09
-
(2010)
J. Virol.
, vol.84
, pp. 5678-5686
-
-
Niyomrattanakit, P.1
Chen, Y.L.2
Dong, H.3
Yin, Z.4
Qing, M.5
Glickman, J.F.6
Lin, K.7
Mueller, D.8
Voshol, H.9
Lim, J.Y.10
Nilar, S.11
Keller, T.H.12
Shi, P.Y.13
-
5
-
-
78751620005
-
Anthracene-based inhibitors of dengue virus NS2B-NS3 protease
-
Tomlinson, S. M. and Watowich, S. J. (2011) Anthracene-based inhibitors of dengue virus NS2B-NS3 protease Antiviral Res. 89, 127-135 10.1016/j.antiviral.2010.12.006
-
(2011)
Antiviral Res.
, vol.89
, pp. 127-135
-
-
Tomlinson, S.M.1
Watowich, S.J.2
-
6
-
-
84864193750
-
Discovery of novel small molecule inhibitors of dengue viral NS2B-NS3 protease using virtual screening and scaffold hopping
-
Deng, J., Li, N., Liu, H., Zuo, Z., Liew, O. W., Xu, W., Chen, G., Tong, X., Tang, W., Zhu, J., Zuo, J., Jiang, H., Yang, C. G., Li, J., and Zhu, W. (2012) Discovery of novel small molecule inhibitors of dengue viral NS2B-NS3 protease using virtual screening and scaffold hopping J. Med. Chem. 55, 6278-6293 10.1021/jm300146f
-
(2012)
J. Med. Chem.
, vol.55
, pp. 6278-6293
-
-
Deng, J.1
Li, N.2
Liu, H.3
Zuo, Z.4
Liew, O.W.5
Xu, W.6
Chen, G.7
Tong, X.8
Tang, W.9
Zhu, J.10
Zuo, J.11
Jiang, H.12
Yang, C.G.13
Li, J.14
Zhu, W.15
-
7
-
-
80055106240
-
Inhibition of dengue virus by targeting viral NS4B protein
-
Xie, X., Wang, Q. Y., Xu, H. Y., Qing, M., Kramer, L., Yuan, Z., and Shi, P. Y. (2011) Inhibition of dengue virus by targeting viral NS4B protein J. Virol. 85, 11183-11195 10.1128/JVI.05468-11
-
(2011)
J. Virol.
, vol.85
, pp. 11183-11195
-
-
Xie, X.1
Wang, Q.Y.2
Xu, H.Y.3
Qing, M.4
Kramer, L.5
Yuan, Z.6
Shi, P.Y.7
-
8
-
-
84865072912
-
Identification of a novel antiviral inhibitor of the flavivirus guanylyltransferase enzyme
-
Stahla-Beek, H. J., April, D. G., Saeedi, B. J., Hannah, A. M., Keenan, S. M., and Geiss, B. J. (2012) Identification of a novel antiviral inhibitor of the flavivirus guanylyltransferase enzyme J. Virol. 86, 8730-8739 10.1128/JVI.00384-12
-
(2012)
J. Virol.
, vol.86
, pp. 8730-8739
-
-
Stahla-Beek, H.J.1
April, D.G.2
Saeedi, B.J.3
Hannah, A.M.4
Keenan, S.M.5
Geiss, B.J.6
-
9
-
-
84901627635
-
Current race in the development of DAAs (direct-acting antivirals) against HCV
-
De Clercq, E. (2014) Current race in the development of DAAs (direct-acting antivirals) against HCV Biochem. Pharmacol. 10.1016/j.bcp.2014.04.005
-
(2014)
Biochem. Pharmacol.
-
-
De Clercq, E.1
-
10
-
-
33846456636
-
The hepatitis C virus NS3 protein: A model RNA helicase and potential drug target
-
Frick, D. N. (2007) The hepatitis C virus NS3 protein: a model RNA helicase and potential drug target Curr. Issues Mol. Biol. 9, 1-20
-
(2007)
Curr. Issues Mol. Biol.
, vol.9
, pp. 1-20
-
-
Frick, D.N.1
-
11
-
-
84866952771
-
Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays
-
Mukherjee, S., Hanson, A. M., Shadrick, W. R., Ndjomou, J., Sweeney, N. L., Hernandez, J. J., Bartczak, D., Li, K., Frankowski, K. J., Heck, J. A., Arnold, L. A., Schoenen, F. J., and Frick, D. N. (2012) Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays Nucleic Acids Res. 40, 8607-8621 10.1093/nar/gks623
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. 8607-8621
-
-
Mukherjee, S.1
Hanson, A.M.2
Shadrick, W.R.3
Ndjomou, J.4
Sweeney, N.L.5
Hernandez, J.J.6
Bartczak, D.7
Li, K.8
Frankowski, K.J.9
Heck, J.A.10
Arnold, L.A.11
Schoenen, F.J.12
Frick, D.N.13
-
12
-
-
84867418390
-
Fluorescent primuline derivatives inhibit hepatitis C virus NS3-catalyzed RNA unwinding, peptide hydrolysis and viral replicase formation
-
Ndjomou, J., Kolli, R., Mukherjee, S., Shadrick, W. R., Hanson, A. M., Sweeney, N. L., Bartczak, D., Li, K., Frankowski, K. J., Schoenen, F. J., and Frick, D. N. (2012) Fluorescent primuline derivatives inhibit hepatitis C virus NS3-catalyzed RNA unwinding, peptide hydrolysis and viral replicase formation Antiviral Res. 96, 245-255 10.1016/j.antiviral.2012.08.006
-
(2012)
Antiviral Res.
, vol.96
, pp. 245-255
-
-
Ndjomou, J.1
Kolli, R.2
Mukherjee, S.3
Shadrick, W.R.4
Hanson, A.M.5
Sweeney, N.L.6
Bartczak, D.7
Li, K.8
Frankowski, K.J.9
Schoenen, F.J.10
Frick, D.N.11
-
13
-
-
84908215132
-
Ebselen inhibits hepatitis C virus NS3 helicase binding to nucleic acid and prevents viral replication
-
Mukherjee, S., Weiner, W. S., Schroeder, C. E., Simpson, D. S., Hanson, A. M., Sweeney, N. L., Marvin, R. K., Ndjomou, J., Kolli, R., Isailovic, D., Schoenen, F. J., and Frick, D. N. (2014) Ebselen inhibits hepatitis C virus NS3 helicase binding to nucleic acid and prevents viral replication ACS Chem. Biol. 9, 2393-2403 10.1021/cb500512z
-
(2014)
ACS Chem. Biol.
, vol.9
, pp. 2393-2403
-
-
Mukherjee, S.1
Weiner, W.S.2
Schroeder, C.E.3
Simpson, D.S.4
Hanson, A.M.5
Sweeney, N.L.6
Marvin, R.K.7
Ndjomou, J.8
Kolli, R.9
Isailovic, D.10
Schoenen, F.J.11
Frick, D.N.12
-
14
-
-
84867683811
-
Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function
-
Saalau-Bethell, S. M., Woodhead, A. J., Chessari, G., Carr, M. G., Coyle, J., Graham, B., Hiscock, S. D., Murray, C. W., Pathuri, P., Rich, S. J., Richardson, C. J., Williams, P. A., and Jhoti, H. (2012) Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function Nat. Chem. Biol. 8, 920-925 10.1038/nchembio.1081
-
(2012)
Nat. Chem. Biol.
, vol.8
, pp. 920-925
-
-
Saalau-Bethell, S.M.1
Woodhead, A.J.2
Chessari, G.3
Carr, M.G.4
Coyle, J.5
Graham, B.6
Hiscock, S.D.7
Murray, C.W.8
Pathuri, P.9
Rich, S.J.10
Richardson, C.J.11
Williams, P.A.12
Jhoti, H.13
-
15
-
-
57149091105
-
Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein
-
Luo, D., Xu, T., Watson, R. P., Scherer-Becker, D., Sampath, A., Jahnke, W., Yeong, S. S., Wang, C. H., Lim, S. P., Strongin, A., Vasudevan, S. G., and Lescar, J. (2008) Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein EMBO J. 27, 3209-3219 10.1038/emboj.2008.232
-
(2008)
EMBO J.
, vol.27
, pp. 3209-3219
-
-
Luo, D.1
Xu, T.2
Watson, R.P.3
Scherer-Becker, D.4
Sampath, A.5
Jahnke, W.6
Yeong, S.S.7
Wang, C.H.8
Lim, S.P.9
Strongin, A.10
Vasudevan, S.G.11
Lescar, J.12
-
16
-
-
76249111702
-
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism
-
Gu, M. and Rice, C. M. (2010) Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism Proc. Natl. Acad. Sci. U.S.A. 107, 521-528 10.1073/pnas.0913380107
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 521-528
-
-
Gu, M.1
Rice, C.M.2
-
17
-
-
0027176287
-
NS3 is a serine protease required for processing of hepatitis C virus polyprotein
-
Tomei, L., Failla, C., Santolini, E., De Francesco, R., and La Monica, N. (1993) NS3 is a serine protease required for processing of hepatitis C virus polyprotein J. Virol. 67, 4017-4026
-
(1993)
J. Virol.
, vol.67
, pp. 4017-4026
-
-
Tomei, L.1
Failla, C.2
Santolini, E.3
De Francesco, R.4
La Monica, N.5
-
18
-
-
0033571623
-
Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase
-
Yao, N., Reichert, P., Taremi, S. S., Prosise, W. W., and Weber, P. C. (1999) Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase Structure 7, 1353-1363 10.1016/S0969-2126(00)80025-8
-
(1999)
Structure
, vol.7
, pp. 1353-1363
-
-
Yao, N.1
Reichert, P.2
Taremi, S.S.3
Prosise, W.W.4
Weber, P.C.5
-
19
-
-
37349023165
-
Crystal structure of the NS3 protease-helicase from dengue virus
-
Luo, D., Xu, T., Hunke, C., Gruber, G., Vasudevan, S. G., and Lescar, J. (2008) Crystal structure of the NS3 protease-helicase from dengue virus J. Virol. 82, 173-183 10.1128/JVI.01788-07
-
(2008)
J. Virol.
, vol.82
, pp. 173-183
-
-
Luo, D.1
Xu, T.2
Hunke, C.3
Gruber, G.4
Vasudevan, S.G.5
Lescar, J.6
-
20
-
-
72849147739
-
Crystal structure of a novel conformational state of the flavivirus NS3 protein: Implications for polyprotein processing and viral replication
-
Assenberg, R., Mastrangelo, E., Walter, T. S., Verma, A., Milani, M., Owens, R. J., Stuart, D. I., Grimes, J. M., and Mancini, E. J. (2009) Crystal structure of a novel conformational state of the flavivirus NS3 protein: implications for polyprotein processing and viral replication J. Virol. 83, 12895-12906 10.1128/JVI.00942-09
-
(2009)
J. Virol.
, vol.83
, pp. 12895-12906
-
-
Assenberg, R.1
Mastrangelo, E.2
Walter, T.S.3
Verma, A.4
Milani, M.5
Owens, R.J.6
Stuart, D.I.7
Grimes, J.M.8
Mancini, E.J.9
-
21
-
-
33745025763
-
Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus
-
Erbel, P., Schiering, N., D'Arcy, A., Renatus, M., Kroemer, M., Lim, S. P., Yin, Z., Keller, T. H., Vasudevan, S. G., and Hommel, U. (2006) Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus Nat. Struct Mol. Biol. 13, 372-373 10.1038/nsmb1073
-
(2006)
Nat. Struct Mol. Biol.
, vol.13
, pp. 372-373
-
-
Erbel, P.1
Schiering, N.2
D'Arcy, A.3
Renatus, M.4
Kroemer, M.5
Lim, S.P.6
Yin, Z.7
Keller, T.H.8
Vasudevan, S.G.9
Hommel, U.10
-
22
-
-
34247625945
-
Structural evidence for regulation and specificity of flaviviral proteases and evolution of the Flaviviridae fold
-
Aleshin, A. E., Shiryaev, S. A., Strongin, A. Y., and Liddington, R. C. (2007) Structural evidence for regulation and specificity of flaviviral proteases and evolution of the Flaviviridae fold Protein Sci. 16, 795-806 10.1110/ps.072753207
-
(2007)
Protein Sci.
, vol.16
, pp. 795-806
-
-
Aleshin, A.E.1
Shiryaev, S.A.2
Strongin, A.Y.3
Liddington, R.C.4
-
23
-
-
84892910710
-
The interdomain interface in bifunctional enzyme protein 3/4A (NS3/4A) regulates protease and helicase activities
-
Aydin, C., Mukherjee, S., Hanson, A. M., Frick, D. N., and Schiffer, C. A. (2013) The interdomain interface in bifunctional enzyme protein 3/4A (NS3/4A) regulates protease and helicase activities Protein Sci. 22, 1786-1798 10.1002/pro.2378
-
(2013)
Protein Sci.
, vol.22
, pp. 1786-1798
-
-
Aydin, C.1
Mukherjee, S.2
Hanson, A.M.3
Frick, D.N.4
Schiffer, C.A.5
-
24
-
-
77953306294
-
Flexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implications
-
Luo, D., Wei, N., Doan, D. N., Paradkar, P. N., Chong, Y., Davidson, A. D., Kotaka, M., Lescar, J., and Vasudevan, S. G. (2010) Flexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implications J. Biol. Chem. 285, 18817-18827 10.1074/jbc.M109.090936
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 18817-18827
-
-
Luo, D.1
Wei, N.2
Doan, D.N.3
Paradkar, P.N.4
Chong, Y.5
Davidson, A.D.6
Kotaka, M.7
Lescar, J.8
Vasudevan, S.G.9
-
26
-
-
23244450531
-
Structure of the flavivirus helicase: Implications for catalytic activity, protein interactions, and proteolytic processing
-
Wu, J., Bera, A. K., Kuhn, R. J., and Smith, J. L. (2005) Structure of the flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing J. Virol. 79, 10268-10277 10.1128/JVI.79.16.10268-10277.2005
-
(2005)
J. Virol.
, vol.79
, pp. 10268-10277
-
-
Wu, J.1
Bera, A.K.2
Kuhn, R.J.3
Smith, J.L.4
-
27
-
-
0041876131
-
NTPase/helicase of Flaviviridae: Inhibitors and inhibition of the enzyme
-
Borowski, P., Niebuhr, A., Schmitz, H., Hosmane, R. S., Bretner, M., Siwecka, M. A., and Kulikowski, T. (2002) NTPase/helicase of Flaviviridae: inhibitors and inhibition of the enzyme Acta Biochim. Polym. 49, 597-614 10.1002/actp.1988.010391017
-
(2002)
Acta Biochim. Polym.
, vol.49
, pp. 597-614
-
-
Borowski, P.1
Niebuhr, A.2
Schmitz, H.3
Hosmane, R.S.4
Bretner, M.5
Siwecka, M.A.6
Kulikowski, T.7
-
28
-
-
84864523421
-
Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: New prospects for an old drug
-
Mastrangelo, E., Pezzullo, M., De Burghgraeve, T., Kaptein, S., Pastorino, B., Dallmeier, K., de Lamballerie, X., Neyts, J., Hanson, A. M., Frick, D. N., Bolognesi, M., and Milani, M. (2012) Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug J. Antimicrob. Chemother. 67, 1884-1894 10.1093/jac/dks147
-
(2012)
J. Antimicrob. Chemother.
, vol.67
, pp. 1884-1894
-
-
Mastrangelo, E.1
Pezzullo, M.2
De Burghgraeve, T.3
Kaptein, S.4
Pastorino, B.5
Dallmeier, K.6
De Lamballerie, X.7
Neyts, J.8
Hanson, A.M.9
Frick, D.N.10
Bolognesi, M.11
Milani, M.12
-
29
-
-
84875173228
-
Novel benzoxazole inhibitor of dengue virus replication that targets the NS3 helicase
-
Byrd, C. M., Grosenbach, D. W., Berhanu, A., Dai, D., Jones, K. F., Cardwell, K. B., Schneider, C., Yang, G., Tyavanagimatt, S., Harver, C., Wineinger, K. A., Page, J., Stavale, E., Stone, M. A., Fuller, K. P., Lovejoy, C., Leeds, J. M., Hruby, D. E., and Jordan, R. (2013) Novel benzoxazole inhibitor of dengue virus replication that targets the NS3 helicase Antimicrob. Agents Chemother. 57, 1902-1912 10.1128/AAC.02251-12
-
(2013)
Antimicrob. Agents Chemother.
, vol.57
, pp. 1902-1912
-
-
Byrd, C.M.1
Grosenbach, D.W.2
Berhanu, A.3
Dai, D.4
Jones, K.F.5
Cardwell, K.B.6
Schneider, C.7
Yang, G.8
Tyavanagimatt, S.9
Harver, C.10
Wineinger, K.A.11
Page, J.12
Stavale, E.13
Stone, M.A.14
Fuller, K.P.15
Lovejoy, C.16
Leeds, J.M.17
Hruby, D.E.18
Jordan, R.19
-
30
-
-
84918509852
-
Suramin inhibits helicase activity of NS3 protein of dengue virus in a fluorescence-based high throughput assay format
-
Basavannacharya, C. and Vasudevan, S. G. (2014) Suramin inhibits helicase activity of NS3 protein of dengue virus in a fluorescence-based high throughput assay format Biochem. Biophys. Res. Commun. 10.1016/j.bbrc.2014.09.113
-
(2014)
Biochem. Biophys. Res. Commun.
-
-
Basavannacharya, C.1
Vasudevan, S.G.2
-
31
-
-
85082163669
-
-
available from
-
Li, K., Frankowski, K. J., Hanson, A. M., Ndjomou, J., Shanahan, M. A., Mukherjee, S., Kolli, R., Shadrick, W. R., Sweeney, N. L., Belon, C. A., Neuenswander, B., Ferguson, J., Aube, J., Schoenen, F. J., Blagg, B. S. J., and Frick, D. N. (2011) Hepatitis C virus NS3 helicase inhibitor discovery Probe Reports from the NIH Molecular Libraries Program, available from http://www.ncbi.nlm.nih.gov/books/NBK143540/.
-
(2011)
Hepatitis C virus NS3 Helicase Inhibitor Discovery Probe Reports from the NIH Molecular Libraries Program
-
-
Li, K.1
Frankowski, K.J.2
Hanson, A.M.3
Ndjomou, J.4
Shanahan, M.A.5
Mukherjee, S.6
Kolli, R.7
Shadrick, W.R.8
Sweeney, N.L.9
Belon, C.A.10
Neuenswander, B.11
Ferguson, J.12
Aube, J.13
Schoenen, F.J.14
Blagg, B.S.J.15
Frick, D.N.16
-
32
-
-
23244464646
-
Structure of the dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4 Å
-
Xu, T., Sampath, A., Chao, A., Wen, D., Nanao, M., Chene, P., Vasudevan, S. G., and Lescar, J. (2005) Structure of the dengue virus helicase/nucleoside triphosphatase catalytic domain at a resolution of 2.4 Å J. Virol. 79, 10278-10288 10.1128/JVI.79.16.10278-10288.2005
-
(2005)
J. Virol.
, vol.79
, pp. 10278-10288
-
-
Xu, T.1
Sampath, A.2
Chao, A.3
Wen, D.4
Nanao, M.5
Chene, P.6
Vasudevan, S.G.7
Lescar, J.8
-
33
-
-
0033003760
-
A simple statistical parameter for use in evaluation and validation of high throughput screening assays
-
Zhang, J. H., Chung, T. D., and Oldenburg, K. R. (1999) A simple statistical parameter for use in evaluation and validation of high throughput screening assays J. Biomol. Screen. 4, 67-73 10.1177/108705719900400206
-
(1999)
J. Biomol. Screen.
, vol.4
, pp. 67-73
-
-
Zhang, J.H.1
Chung, T.D.2
Oldenburg, K.R.3
-
34
-
-
84884253048
-
Aurintricarboxylic acid modulates the affinity of hepatitis C virus NS3 helicase for both nucleic acid and ATP
-
Shadrick, W. R., Mukherjee, S., Hanson, A. M., Sweeney, N. L., and Frick, D. N. (2013) Aurintricarboxylic acid modulates the affinity of hepatitis C virus NS3 helicase for both nucleic acid and ATP Biochemistry 52, 6151-6159 10.1021/bi4006495
-
(2013)
Biochemistry
, vol.52
, pp. 6151-6159
-
-
Shadrick, W.R.1
Mukherjee, S.2
Hanson, A.M.3
Sweeney, N.L.4
Frick, D.N.5
-
35
-
-
84880077036
-
Primuline derivatives that mimic RNA to stimulate hepatitis C virus NS3 helicase-catalyzed ATP hydrolysis
-
Sweeney, N. L., Shadrick, W. R., Mukherjee, S., Li, K., Frankowski, K. J., Schoenen, F. J., and Frick, D. N. (2013) Primuline derivatives that mimic RNA to stimulate hepatitis C virus NS3 helicase-catalyzed ATP hydrolysis J. Biol. Chem. 288, 19949-19957 10.1074/jbc.M113.463166
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 19949-19957
-
-
Sweeney, N.L.1
Shadrick, W.R.2
Mukherjee, S.3
Li, K.4
Frankowski, K.J.5
Schoenen, F.J.6
Frick, D.N.7
-
36
-
-
84859790281
-
Optimization of potent hepatitis C virus NS3 helicase inhibitors isolated from the yellow dyes thioflavine S and primuline
-
Li, K., Frankowski, K. J., Belon, C. A., Neuenswander, B., Ndjomou, J., Hanson, A. M., Shanahan, M. A., Schoenen, F. J., Blagg, B. S., Aube, J., and Frick, D. N. (2012) Optimization of potent hepatitis C virus NS3 helicase inhibitors isolated from the yellow dyes thioflavine S and primuline J. Med. Chem. 55, 3319-3330 10.1021/jm300021v
-
(2012)
J. Med. Chem.
, vol.55
, pp. 3319-3330
-
-
Li, K.1
Frankowski, K.J.2
Belon, C.A.3
Neuenswander, B.4
Ndjomou, J.5
Hanson, A.M.6
Shanahan, M.A.7
Schoenen, F.J.8
Blagg, B.S.9
Aube, J.10
Frick, D.N.11
-
37
-
-
84862994750
-
Identification and analysis of inhibitors targeting the hepatitis C virus NS3 helicase
-
Hanson, A. M., Hernandez, J. J., Shadrick, W. R., and Frick, D. N. (2012) Identification and analysis of inhibitors targeting the hepatitis C virus NS3 helicase Methods Enzymol. 511, 463-483 10.1016/B978-0-12-396546-2.00021-8
-
(2012)
Methods Enzymol.
, vol.511
, pp. 463-483
-
-
Hanson, A.M.1
Hernandez, J.J.2
Shadrick, W.R.3
Frick, D.N.4
-
38
-
-
3242884682
-
Enhanced nucleic acid binding to ATP-bound hepatitis C virus NS3 helicase at low pH activates RNA unwinding
-
Lam, A. M., Rypma, R. S., and Frick, D. N. (2004) Enhanced nucleic acid binding to ATP-bound hepatitis C virus NS3 helicase at low pH activates RNA unwinding Nucleic Acids Res. 32, 4060-4070 10.1093/nar/gkh74310.1093/nar/gkh743
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. 4060-4070
-
-
Lam, A.M.1
Rypma, R.S.2
Frick, D.N.3
-
39
-
-
84990940961
-
PH-dependent conformational changes in the HCV NS3 protein modulate its ATPase and helicase activities
-
Ventura, G. T., Costa, E. C., Capaccia, A. M., and Mohana-Borges, R. (2014) pH-dependent conformational changes in the HCV NS3 protein modulate its ATPase and helicase activities PLoS One 9 e115941 10.1371/journal.pone.0115941
-
(2014)
PLoS One
, vol.9
, pp. e115941
-
-
Ventura, G.T.1
Costa, E.C.2
Capaccia, A.M.3
Mohana-Borges, R.4
-
40
-
-
54949108677
-
PubChem: Integrated platform of small molecules and biological activities
-
Bolton, E. E., Wang, Y., Thiessen, P. A., and Bryant, S. H. (2008) PubChem: integrated platform of small molecules and biological activities Annu. Rep. Comput. Chem. 4, 217-241 10.1016/S1574-1400(08)00012-1
-
(2008)
Annu. Rep. Comput. Chem.
, vol.4
, pp. 217-241
-
-
Bolton, E.E.1
Wang, Y.2
Thiessen, P.A.3
Bryant, S.H.4
-
41
-
-
21644477919
-
Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo
-
Whitby, K., Pierson, T. C., Geiss, B., Lane, K., Engle, M., Zhou, Y., Doms, R. W., and Diamond, M. S. (2005) Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo J. Virol. 79, 8698-8706 10.1128/JVI.79.14.8698-8706.2005
-
(2005)
J. Virol.
, vol.79
, pp. 8698-8706
-
-
Whitby, K.1
Pierson, T.C.2
Geiss, B.3
Lane, K.4
Engle, M.5
Zhou, Y.6
Doms, R.W.7
Diamond, M.S.8
-
42
-
-
2942717110
-
Helicase primase: Targeting the Achilles heel of herpes simplex viruses
-
Kleymann, G. (2004) Helicase primase: targeting the Achilles heel of herpes simplex viruses Antivir Chem. Chemother. 15, 135-140
-
(2004)
Antivir Chem. Chemother.
, vol.15
, pp. 135-140
-
-
Kleymann, G.1
-
43
-
-
84873648615
-
The helicase-primase complex as a target for effective herpesvirus antivirals
-
Field, H. J. and Mickleburgh, I. (2013) The helicase-primase complex as a target for effective herpesvirus antivirals Adv. Exp. Med. Biol. 767, 145-159 10.1007/978-1-4614-5037-5-7
-
(2013)
Adv. Exp. Med. Biol.
, vol.767
, pp. 145-159
-
-
Field, H.J.1
Mickleburgh, I.2
-
44
-
-
0036107516
-
Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease
-
Crute, J. J., Grygon, C. A., Hargrave, K. D., Simoneau, B., Faucher, A. M., Bolger, G., Kibler, P., Liuzzi, M., and Cordingley, M. G. (2002) Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease Nat. Med. 8, 386-391 10.1038/nm0402-386
-
(2002)
Nat. Med.
, vol.8
, pp. 386-391
-
-
Crute, J.J.1
Grygon, C.A.2
Hargrave, K.D.3
Simoneau, B.4
Faucher, A.M.5
Bolger, G.6
Kibler, P.7
Liuzzi, M.8
Cordingley, M.G.9
-
45
-
-
0036111626
-
New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease
-
Kleymann, G., Fischer, R., Betz, U. A., Hendrix, M., Bender, W., Schneider, U., Handke, G., Eckenberg, P., Hewlett, G., Pevzner, V., Baumeister, J., Weber, O., Henninger, K., Keldenich, J., Jensen, A., Kolb, J., Bach, U., Popp, A., Maben, J., Frappa, I., Haebich, D., Lockhoff, O., and Rubsamen-Waigmann, H. (2002) New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease Nat. Med. 8, 392-398 10.1038/nm0402-392
-
(2002)
Nat. Med.
, vol.8
, pp. 392-398
-
-
Kleymann, G.1
Fischer, R.2
Betz, U.A.3
Hendrix, M.4
Bender, W.5
Schneider, U.6
Handke, G.7
Eckenberg, P.8
Hewlett, G.9
Pevzner, V.10
Baumeister, J.11
Weber, O.12
Henninger, K.13
Keldenich, J.14
Jensen, A.15
Kolb, J.16
Bach, U.17
Popp, A.18
Maben, J.19
Frappa, I.20
Haebich, D.21
Lockhoff, O.22
Rubsamen-Waigmann, H.23
more..
-
46
-
-
33947286682
-
Superior efficacy of helicase-primase inhibitor BAY 57-1293 for herpes infection and latency in the Guinea pig model of human genital herpes disease
-
Baumeister, J., Fischer, R., Eckenberg, P., Henninger, K., Ruebsamen-Waigmann, H., and Kleymann, G. (2007) Superior efficacy of helicase-primase inhibitor BAY 57-1293 for herpes infection and latency in the guinea pig model of human genital herpes disease Antivir Chem. Chemother. 18, 35-48
-
(2007)
Antivir Chem. Chemother.
, vol.18
, pp. 35-48
-
-
Baumeister, J.1
Fischer, R.2
Eckenberg, P.3
Henninger, K.4
Ruebsamen-Waigmann, H.5
Kleymann, G.6
-
47
-
-
38549166190
-
Efficacy of a helicase-primase inhibitor in animal models of ocular herpes simplex virus type 1 infection
-
Kaufman, H. E., Varnell, E. D., Gebhardt, B. M., Thompson, H. W., Atwal, E., Rubsamen-Waigmann, H., and Kleymann, G. (2008) Efficacy of a helicase-primase inhibitor in animal models of ocular herpes simplex virus type 1 infection J. Ocul. Pharmacol. Ther 24, 34-42 10.1089/jop.2007.0084
-
(2008)
J. Ocul. Pharmacol. Ther
, vol.24
, pp. 34-42
-
-
Kaufman, H.E.1
Varnell, E.D.2
Gebhardt, B.M.3
Thompson, H.W.4
Atwal, E.5
Rubsamen-Waigmann, H.6
Kleymann, G.7
-
48
-
-
84892608050
-
Helicase-primase inhibitor pritelivir for HSV-2 infection
-
Wald, A., Corey, L., Timmler, B., Magaret, A., Warren, T., Tyring, S., Johnston, C., Kriesel, J., Fife, K., Galitz, L., Stoelben, S., Huang, M. L., Selke, S., Stobernack, H. P., Ruebsamen-Schaeff, H., and Birkmann, A. (2014) Helicase-primase inhibitor pritelivir for HSV-2 infection N. Engl. J. Med. 370, 201-210 10.1056/NEJMoa1301150
-
(2014)
N. Engl. J. Med.
, vol.370
, pp. 201-210
-
-
Wald, A.1
Corey, L.2
Timmler, B.3
Magaret, A.4
Warren, T.5
Tyring, S.6
Johnston, C.7
Kriesel, J.8
Fife, K.9
Galitz, L.10
Stoelben, S.11
Huang, M.L.12
Selke, S.13
Stobernack, H.P.14
Ruebsamen-Schaeff, H.15
Birkmann, A.16
-
49
-
-
84858162396
-
ASP2151 for the treatment of genital herpes: A randomized, double-blind, placebo- and valacyclovir-controlled, dose-finding study
-
Tyring, S., Wald, A., Zadeikis, N., Dhadda, S., Takenouchi, K., and Rorig, R. (2012) ASP2151 for the treatment of genital herpes: a randomized, double-blind, placebo- and valacyclovir-controlled, dose-finding study J. Infect. Dis. 205, 1100-1110 10.1093/infdis/jis019
-
(2012)
J. Infect. Dis.
, vol.205
, pp. 1100-1110
-
-
Tyring, S.1
Wald, A.2
Zadeikis, N.3
Dhadda, S.4
Takenouchi, K.5
Rorig, R.6
-
50
-
-
84862550432
-
Susceptibility of herpes simplex virus isolated from genital herpes lesions to ASP2151, a novel helicase-primase inhibitor
-
Katsumata, K., Weinberg, A., Chono, K., Takakura, S., Kontani, T., and Suzuki, H. (2012) Susceptibility of herpes simplex virus isolated from genital herpes lesions to ASP2151, a novel helicase-primase inhibitor Antimicrob. Agents Chemother. 56, 3587-3591 10.1128/AAC.00133-12
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 3587-3591
-
-
Katsumata, K.1
Weinberg, A.2
Chono, K.3
Takakura, S.4
Kontani, T.5
Suzuki, H.6
-
51
-
-
84880836962
-
Discovering new medicines targeting helicases: Challenges and recent progress
-
Shadrick, W. R., Ndjomou, J., Kolli, R., Mukherjee, S., Hanson, A. M., and Frick, D. N. (2013) Discovering new medicines targeting helicases: challenges and recent progress J. Biomol. Screen. 18, 761-781 10.1177/1087057113482586
-
(2013)
J. Biomol. Screen.
, vol.18
, pp. 761-781
-
-
Shadrick, W.R.1
Ndjomou, J.2
Kolli, R.3
Mukherjee, S.4
Hanson, A.M.5
Frick, D.N.6
-
52
-
-
0037047352
-
The determination of phosphorus and the discovery of phosphocreatine and ATP: The work of Fiske and SubbaRow
-
Simoni, R. D., Hill, R. L., and Vaughan, M. (2002) The determination of phosphorus and the discovery of phosphocreatine and ATP: the work of Fiske and SubbaRow J. Biol. Chem. 277, 21e
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 21e
-
-
Simoni, R.D.1
Hill, R.L.2
Vaughan, M.3
-
53
-
-
0018600707
-
An improved assay for nanomole amounts of inorganic phosphate
-
Lanzetta, P. A., Alvarez, L. J., Reinach, P. S., and Candia, O. A. (1979) An improved assay for nanomole amounts of inorganic phosphate Anal. Biochem. 100, 95-97 10.1016/0003-2697(79)90115-5
-
(1979)
Anal. Biochem.
, vol.100
, pp. 95-97
-
-
Lanzetta, P.A.1
Alvarez, L.J.2
Reinach, P.S.3
Candia, O.A.4
-
54
-
-
33845771358
-
Role of divalent metal cations in ATP hydrolysis catalyzed by the hepatitis C virus NS3 helicase: Magnesium provides a bridge for ATP to fuel unwinding
-
Frick, D. N., Banik, S., and Rypma, R. S. (2007) Role of divalent metal cations in ATP hydrolysis catalyzed by the hepatitis C virus NS3 helicase: magnesium provides a bridge for ATP to fuel unwinding J. Mol. Biol. 365, 1017-1032 10.1016/j.jmb.2006.10.023
-
(2007)
J. Mol. Biol.
, vol.365
, pp. 1017-1032
-
-
Frick, D.N.1
Banik, S.2
Rypma, R.S.3
-
55
-
-
84856294427
-
High-throughput screening identifies a bisphenol inhibitor of SV40 large T antigen ATPase activity
-
Seguin, S. P., Evans, C. W., Nebane-Akah, M., McKellip, S., Ananthan, S., Tower, N. A., Sosa, M., Rasmussen, L., White, E. L., Maki, B. E., Matharu, D. S., Golden, J. E., Aube, J., Brodsky, J. L., and Noah, J. W. (2012) High-throughput screening identifies a bisphenol inhibitor of SV40 large T antigen ATPase activity J. Biomol. Screen. 17, 194-203 10.1177/1087057111421630
-
(2012)
J. Biomol. Screen.
, vol.17
, pp. 194-203
-
-
Seguin, S.P.1
Evans, C.W.2
Nebane-Akah, M.3
McKellip, S.4
Ananthan, S.5
Tower, N.A.6
Sosa, M.7
Rasmussen, L.8
White, E.L.9
Maki, B.E.10
Matharu, D.S.11
Golden, J.E.12
Aube, J.13
Brodsky, J.L.14
Noah, J.W.15
-
56
-
-
84860153620
-
Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus
-
Wagstaff, K. M., Sivakumaran, H., Heaton, S. M., Harrich, D., and Jans, D. A. (2012) Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus Biochem. J. 443, 851-856 10.1042/BJ20120150
-
(2012)
Biochem. J.
, vol.443
, pp. 851-856
-
-
Wagstaff, K.M.1
Sivakumaran, H.2
Heaton, S.M.3
Harrich, D.4
Jans, D.A.5
-
57
-
-
77749289804
-
Mechanism and specificity of a symmetrical benzimidazolephenylcarboxamide helicase inhibitor
-
Belon, C. A., High, Y. D., Lin, T. I., Pauwels, F., and Frick, D. N. (2010) Mechanism and specificity of a symmetrical benzimidazolephenylcarboxamide helicase inhibitor Biochemistry 49, 1822-1832 10.1021/bi901974a
-
(2010)
Biochemistry
, vol.49
, pp. 1822-1832
-
-
Belon, C.A.1
High, Y.D.2
Lin, T.I.3
Pauwels, F.4
Frick, D.N.5
|