Mechanism and specificity of a symmetrical benzimidazolephenylcarboxamide helicase inhibitor

Biochemistry

Volumn 49, Issue 9, 2010, Pages 1822-1832

  Belon, Craig A ^a   High, Yoji D ^a   Lin, Tse I ^b   Pauwels, Frederik ^b   Frick, David N ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b HCV Research   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ATP HYDROLYSIS; DENGUE VIRUS; DISSOCIATION CONSTANT; DNA DUPLEXES; DNA OLIGONUCLEOTIDES; HELICASES; HEPATITIS C VIRUS; HUMAN PROTEINS; INHIBITORY CONCENTRATION; INTRINSIC PROTEIN FLUORESCENCE; MOLECULAR MODELS;

BENZENE; BINDING ENERGY; BIOMOLECULES; DISSOCIATION; DNA; FLUORESCENCE; GENES; HYDROLYSIS; NUCLEIC ACIDS; OLIGONUCLEOTIDES; RNA; VIRUSES;

PROTEINS;

1 N,4 N BIS[4 (1H BENZIMIDAZOL 2 YL)PHENYL]BENZENE 1,4 DICARBOXAMIDE; BENZIMIDAZOLEPHENYLCARBOXAMIDE HELICASE INHIBITOR; HELICASE; RNA; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; BINDING SITE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DENGUE VIRUS; DISSOCIATION CONSTANT; FLAVIVIRUS; FLUORESCENCE ANALYSIS; GENOTYPE; HEPATITIS C VIRUS; HUMAN; HYDROLYSIS; JAPANESE ENCEPHALITIS VIRUS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; TURNOVER TIME;

ANTIVIRAL AGENTS; BASE SEQUENCE; BENZIMIDAZOLES; CATALYSIS; HEPACIVIRUS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; RNA HELICASES; SUBSTRATE SPECIFICITY; VIRAL NONSTRUCTURAL PROTEINS;

DENGUE VIRUS; FLAVIVIRUS; HEPATITIS C VIRUS; JAPANESE ENCEPHALITIS VIRUS;

EID: 77749289804     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi901974a     Document Type: Article

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