Identification of a novel antiviral inhibitor of the flavivirus guanylyltransferase enzyme

Journal of Virology

Volumn 86, Issue 16, 2012, Pages 8730-8739

  Stahla Beek, Hillary J ^a   April, Daniel G ^b   Saeedi, Bejan J ^b   Hannah, Amanda M ^a   Keenan, Susan M ^a   Geiss, Brian J ^b  

^a UNIVERSITY OF NORTHERN COLORADO   (United States)

^b Veterinary Dentistry and Oral Surgery   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 THIOXOTHIAZOLIDIN 4 ONE DERIVATIVE; [3 [5 (4 TERT BUTYLBENZYLIDENE) 4 OXO 2 THIOXO 1,3 THIAZOLIDIN 3 YL]PROPANOIC ACID]; ANTIINFECTIVE AGENT; ANTIVIRUS AGENT; BG 115; BG 137; BG 170; BG 309; BG 310; BG 312; BG 313; BG 314; BG 315; BG 317; BG 318; BG 319; BG 320; BG 321; BG 322; BG 323; BG 324; BG 325; BG 327; BG 328; BG 329; BG 330; BG 331; BG 332; BG 5; GUANYLYLTRANSFERASE; NONSTRUCTURAL PROTEIN 5; UNCLASSIFIED DRUG; VIRUS ENZYME;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG IDENTIFICATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG TARGETING; ENZYME INHIBITION; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; REPLICON; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; VIRUS CELL INTERACTION; VIRUS INHIBITION; VIRUS REPLICATION; WEST NILE FLAVIVIRUS; YELLOW FEVER FLAVIVIRUS;

ANTIVIRAL AGENTS; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; FLAVIVIRUS; GUANOSINE TRIPHOSPHATE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICROBIAL SENSITIVITY TESTS; NUCLEOTIDYLTRANSFERASES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84865072912     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00384-12     Document Type: Article

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