Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis

ACS Infectious Diseases

Volumn 1, Issue 1, 2015, Pages 59-72

  Mann, Paul A ^a   McLellan, Catherine A ^b,c   Koseoglu, Sandra ^a   Si, Qian ^a   Kuzmin, Elena ^d   Flattery, Amy ^a   Harris, Guy ^a   Sher, Xinwei ^a   Murgolo, Nicholas ^a   Wang, Hao ^a   Devito, Kristine ^a   De Pedro, Nuria ^e   Genilloud, Olga ^e   Kahn, Jennifer Nielsen ^a   Jiang, Bo ^a   Costanzo, Michael ^d   Boone, Charlie ^d   Garlisi, Charles G ^a   Lindquist, Susan ^b,c   Roemer, Terry ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

^e Centro de Desarrollo Farmaceutico y Alimentario Parque Tecnologico de Ciencias de la Salud   (Spain)

Author keywords

antifungal; Candida albicans fitness test; chemical biology; glycosylphosphatidylinositol; GPI; GWT1; MCD4; natural product; next generation sequencing; yeast cell wall

Indexed keywords

ANTIFUNGAL AGENT; CELL MEMBRANE PROTEIN; ENZYME INHIBITOR; GLUCOSAMINE; GLYCOSYLPHOSPHATIDYLINOSITOL; NATURAL PRODUCT; PHOSPHATIDYLINOSITOL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CANDIDA ALBICANS; CELL WALL; CONTROLLED STUDY; DRUG TARGETING; ENDOPLASMIC RETICULUM; FUNGUS GROWTH; INVASIVE CANDIDIASIS; LETHALITY; MOUSE; MUTANT; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVERSE GENETICS; SACCHAROMYCES CEREVISIAE;

EID: 84969165087     PISSN: None     EISSN: 23738227     Source Type: Journal    
DOI: 10.1021/id5000212     Document Type: Article

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