A Reductionist approach to chemogenomics in the design of drug molecules and focused libraries

Chemogenomics: Knowledge-Based Approaches to Drug Discovery

Volumn , Issue , 2006, Pages 85-108

  Crossley, Roger ^a   Slater, Martin ^b  

^a BioFocus ^*

^b BioFocus DPI   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84967642606     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1142/9781860948114_0004     Document Type: Chapter

References (24)

1. Crossley R, Opalko A. (1996) The structure-activity relationships of potassium channel Blockers, in: JM Evans, et al. (eds), Potassium Channels and their Modulators, Taylor and Francis.
2. Bryan J, Vila-Carriles WH, Zhao G, et al. (2004) Diabetes S104.
3. Sanchez-Chapula JA, Ferrer T, Navarro-Polanco RA, Sanguinetti MC. (2003) Mol. Pharmacol. 1051.
4. Gallivan JP, Dougherty D. (1999) Proc. Natl. Acad. Sci. USA 9459.
5. Zhong W, Gallivan JP, Zhang Y, et al. (1998) Proc. Natl. Acad. Sci. USA 12088.
6. Mecozzi S, West Jr AP, Dougherty DA. (1996) Proc. Natl. Acad. Sci. USA 10566.
7. Cheeseright T, Mackey M, Vinter A. (2004) Drug Discov. Today: BIOSILICO 57.
8. Crossley R, Rose VS, Stevens AP. (2003) PCT Int. Appl. WO 03/004147.
9. Chambers JJ, Nichols DE. (2002) J. Comp.-Aided Mol. Design 511.
10. Gouldson PR, Kidley NJ, Bywater RP, et al. (2004) Proteins: Struct. Funct. Bioinform. 67.
11. Elling CE, Thirstrup K, Holst B, Schwartz TW. (1999) Proc. Natl. Acad. Sci. USA 12322.
12. Horwell DC, Birchmore B, Boden PR, et al. (1990) Eur. J. Med. Chem. 53.
13. Lavrador K, Murphy B, Saunders J, et al. (2004) J. Med. Chem. 6864.
14. Chianelli D, Kim YC, Lvovskiy D, Webb TR. (2003) Bioorg. Med. Chem. 5059.
15. Mason JS, Morize I, Menard PR, et al. (1999) J. Med. Chem. 3251.
16. Jacoby E, Fauchère JL, Raimbaud E, et al. (1999) Quant. Struct.-Act. Relat. 561.
17. Jacoby E. (2001) Quant. Struct.-Act. Relat. 115.
18. Milligan G, Kellett E, Dacquet C, et al. (2001) Neuropharmacol. 334.
19. Nordling E, Homan E. (2004) J. Chem. Inf. Comput. Sci. 2207.
20. Doyle DA, Morais CJ, Pfuetzner RA, et al. (1998) Science 280:69-77.
21. Jiang Y, Lee A, Chen J, et al. (2002) Nature 417:515.
22. Jiang Y, Lee A, Chen J, et al. (2003) Nature 423:33.
23. Kuo A, Gulbis JM, Antcliff JF, et al. (2003) Science 300:1922.
24. Haverkamp W, Eckardt L, Matz J, Frederiksen K. (2002) Internat. J. Psychiatry Clin. Pract. S11.