Application of a novel design paradigm to generate general nonpeptide combinatorial scaffolds mimicking beta turns: Synthesis of ligands for somatostatin receptors

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 23, 2003, Pages 5059-5068

  Chianelli, Dona ^a   Kim, Yong Chul ^a,c   Lvovskiy, Dmitriy ^b   Webb, Thomas R ^a,b  

^a ChemBridge Research Laboratories   (United States)

^b ChemBridge Corporation   (United States)

^c Gwangju Institute of Science and Technology (GIST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

7 (BENZO[1,3]DIOXOL 5 YLOXY) 3' 4' DIHYDRO 2H QUINOLINE 1 (4 AMINOBUTAN 1 YL) 4 SPIRO 5' 1' METHYL 3' [2 (1H INDOL 3 YL)ETHYL 1 CARBOXYLIC ACID TERT BUTYL ESTER]IMIDAZOLIDINE 2',4' DIONE; 7 (BENZO[1,3]DIOXOL 5 YLOXY) 3' 4' DIHYDRO 2H QUINOLINE 1 (4 BENZYL AMINO BUTAN 1 YL) 4 SPIRO 5' 1' METHYL 3' [2 (1H INDOL 3 YL)ETHYL 1 CARBOXYLIC ACID TERT BUTYL ESTER]IMIDAZOLIDINE 2',4' DIONE; 7 (BENZO[1,3]DIOXOL 5 YLOXY) 3' 4' DIHYDRO 2H QUINOLINE 1 (BUTYL 1 YLBENZYLCARBAMIC ACID TERT BUTYL ESTER) 4 SPIRO 5' 1' METHYL 3' [2 (1H INDOL 3 YL)ETHYL 1 CARBOXYLIC ACID TERT BUTYL ESTER]IMIDAZOLIDINE 2',4' DIONE; 7 HYDROXY 3',4' DIHYDRO 2H QUINOLINE 1 (BUTYL 1 YLBENZYLCARBAMIC ACID TERT BUTYL ESTER) 4 SPIRO 5' 1' METHYL 3' [2 (1H INDOL 3 YL)ETHYL 1 CARBOXYLIC ACID TERT BUTYL ESTER]IMIDAZOLIDINE 2',4' DIONE; 7 PHENOXY 3',4' DIHYDRO 2H QUINOLINE 1 (4 AMINOBUTAN 1 YL) 4 SPIRO 5' 1' (1H INDOL 3 YLMETHYL) 3' METHYLIMIDAZOLIDINE 2',4' DIONE; 7 PHENOXY 3',4' DIHYDRO 2H QUINOLINE 1 (4 BENZYLAMINOBUTAN 1 YL) 4 SPIRO 5' 1' (1H INDOL 3 YLMETHYL) 3' METHYLIMIDAZOLIDINE 2',4' DIONE; 7 PHENOXY 3',4' DIHYDRO 2H QUINOLINE 1 (BUTYL 1 YLBENZYLCARBAMIC ACID TERT BUTYL ESTER) 4 SPIRO 5' 1' (1H INDOL 3 YLMETHYL) 3' METHYLIMIDAZOLIDINE 2',4' DIONE; 7 PHENOXY 3,4 DIHYDRO 2H QUINOLINE 1 (4 AMINO 1 YLBUTAN 1 ONE) 4 SPIRO 5' 1' (1H INDOL 3 YLMETHYL) 3' METHYLIMIDAZOLINE 2',4' DIONE; 7 PHENOXY 3,4 DIHYDRO 2H QUINOLINE 1 (4 AMINO 1 YLBUTAN 1 ONE) 4 SPIRO 5' 1' METHYL 3' (1H INDOL 3 YLMETHYL)IMIDAZOLINE 2',4' DIONE TRIFLATE; 7 PHENOXY 3,4 DIHYDRO 2H QUINOLINE 1 (4 BENZYLAMINO 1 YLBUTAN 1 ONE) 4 SPIRO 5' 1' (1H INDOL 3 YLMETHYL) 3' METHYLIMIDAZOLINE 2',4' DIONE; 7 PHENOXY 3,4 DIHYDRO 2H QUINOLINE 1 (4 OXO 1 YLBUTYLBENZYLCARBAMIC ACID TERT BUTYL ESTER) 4 SPIRO 5' 1' (1H INDOL 3 YLMETHYL) 3' METHYLIMIDAZOLINE 2',4' DIONE; 7 PHENOXY 3,4 DIHYDRO 2H QUINOLINE 1 (4 OXO 1 YLBUTYLCARBAMIC ACID TERT BUTYL ESTER) 4 SPIRO 5' 1' METHYL 3' (1H INDOL 3 YLMETHYL 1 CARBOXYLIC ACID TERT BUTYL ESTER)IMIDAZOLE 2',4' DIONE; 7 TOLYLOXY 3',4' DIHYDRO 2H QUINOLINE 1 (4 AMINOBUTAN 1 YL) 4 SPIRO 5' 1' METHYL 3' [2 (1H INDOL 3 YL)ETHYL 1 CARBOXYLIC ACID TERT BUTYL ESTER]IMIDAZOLIDINE 2',4' DIONE; 7 TOLYLOXY 3',4' DIHYDRO 2H QUINOLINE 1 (4 BENZYLAMINOBUTAN 1 YL) 4 SPIRO 5' 1' (1H INDOL 3 YLMETHYL) 3' METHYLIMIDAZOLIDINE 2',4' DIONE; 7 TOLYLOXY 3',4' DIHYDRO 2H QUINOLINE 1 (4 BENZYLAMINOBUTAN 1 YL) 4 SPIRO 5' 1' METHYL 3' [2 (1H INDOL 3 YL)ETHYL 1 CARBOXYLIC ACID TERT BUTYL ESTER]IMIDAZOLIDINE 2',4' DIONE; 7 TOLYLOXY 3',4' DIHYDRO 2H QUINOLINE 1 (4 BUTAN 1 YLBENZYLCARBAMIC ACID TERT BUTYL ESTER) 4 SPIRO 5' 1' (1H INDOL 3 YLMETHYL) 3' METHYLIMIDAZOLIDINE 2',4' DIONE; 7 TOLYLOXY 3',4' DIHYDRO 2H QUINOLINE 1 (AMINOBUTAN 1 YL) 4 SPIRO 5' 1' (1H INDOL 3 YLMETHYL) 3' METHYLIMIDAZOLIDINE 2',4' DIONE; 7 TOLYLOXY 3',4' DIHYDRO 2H QUINOLINE 1 (BUTYL 1 YLBENZYLCARBAMIC ACID TERT BUTYL ESTER) 4 SPIRO 5' 1' METHYL 3' [2 (1H INDOL 3 YL)ETHYL 1 CARBOXYLIC ACID TERT BUTYL ESTER]IMIDAZOLIDINE 2',4' DIONE; 7 TOLYLOXY 3',4' DIHYDRO 2H QUINOLINE 1' (1H INDOL 3 YLMETHYL) 3' METHYLIMIDAZOLIDINE 2',4' DIONE; HORMONE RECEPTOR STIMULATING AGENT; QUINOLINE DERIVATIVE; SOMATOSTATIN RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; COMBINATORIAL CHEMISTRY; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; PHARMACOPHORE; PROTEIN FOLDING;

EID: 0242266516     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.08.022     Document Type: Article

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