Differentiation of human embryonic, fetal and adult stem cells to islet cells of the pancreas

Stem Cells: From Bench to Bedside

Volumn , Issue , 2005, Pages 325-344

  Roche, Enrique ^a   Soria, Bernat ^a  

^a MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84967592339     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1142/9789812569370_0016     Document Type: Chapter

References (64)

1. DeFronzo RA, Ferrannini E, Keen H, Zimmet P. (2004) International Textbook of Diabetes Mellitus, 3rd ed. Chichester, UK: John Wiley and Sons.
2. Shapiro AMJ, Lakey JRT, Ryan EA, et al. (2000) Islet transplantation in seven patients with type 1 diabetes mellitus using a corticoid-free immunosuppressive regime. N Eng J Med 343: 230-238.
3. Smith AG. (1991) Culture and differentiation of embryonic stem cells. J Tissue Culture Methods 13: 89-94.
4. Soria B, Skoudy A, Martín F. (2001) From stem cells to beta cells: New strategies in cell therapy of diabetes mellitus. Diabetologia 44: 407-415.
5. Shiroi A, Yoshikawa M, Yokota H, et al. (2002) Identification of insulin- producing cells derived from embryonic stem cells by zinc-chelating dithi- zone. Stem Cells 20: 284-292.
6. Kahan BW, Jacobson LM, Hullett DA, et al. (2003) Pancreatic precursors and differentiated islet cell types from murine embryonic stem cells. An in vitro model to study islet differentiation. Diabetes 52: 2016-2024.
7. Soria B, Roche E, Berná G, et al. (2000) Insulin-secreting cells derived from embryonic item cells normalize glicemia in streptozotocin-induced diabetic mice. Diabetes 49: 157-162.
8. Klug MG, Soonpa MH, Koh GY, Field LJ. (1996) Genetically selected cardiomyocytes from differentiating embryonic stem cells form stable intracardiac grafts. J Clin Invest 98: 216-224.
9. Roche E, Burcin MM, Esser S, et al. (2003) The use of gating technology in bioengineering insulin-secreting cells from embryonic stem cells. Cytotechnology 41: 145-151.
10. Otonkoski T, Beattie GM, Mally MI, et al. (1993) Nicotinamide is a potent inducer of endocrine differentiation in cultured human fetal pancreatic cells. J Clin Invest 92: 1459-1466.
11. León-Quinto T, Jones J, Skoudy A, et al. (2004) In vitro directed differentiation of mouse embryonic stem cells into insulin-producing cells. Diabetologia 47: 1442-1451.
12. Chakrabarti SK, Mirmira RG. (2003) Transcription factors direct the development and function of pancreatic β cells. Trends Endocrinol Metab 14: 78-84.
13. Zulewski H, Abraham EJ, Gerlach MJ, et al. (2001) Multipotential nestin- positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine and hepatic phenotypes. Diabetes 50: 521-533.
14. Treutelaar MK, Skidmore JM, Dias-Leme CL, et al. (2003) Nestin-lineage cells contribute to the microvasculature but not endocrine cells of the islet. Diabetes 52: 2503-2512.
15. Lumelsky N, Blondel O, Laeng P, et al. (2001) Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 292: 1389-1394.
16. Hori Y, Rulifson IC, Tsai BC, et al. (2002) Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc Natl Acad Sci USA 99: 16105-16110.
17. Blyszczuk P, Czyz J, Kania G, et al. (2003) Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin- producing cells. Proc Natl Acad Sci USA 100: 998-1003.
18. Miyazaki S, Yamato E, Miyazaki J. (2004) Regulated expression of Pdx-1 promotes in vitro differentiation of insulin-producing cells from embryonic stem cells. Diabetes 53: 1030-1037.
19. Moritoh Y, Yamato E, Yasui Y, et al. (2003) Analysis of insulin-producing cells during in vitro differentiation from feeder-free embryonic stem cells. Diabetes 52: 1163-1168.
20. Assady S, Maor G, Amit M, et al. (2001) Insulin production by human embryonic stem cells. Diabetes 50: 1691-1697.
21. Segev H, Fishman B, Ziskind A, et al. (2004) Differentiation of human embryonic stem cells into insulin-producing clusters. Stem Cells 22: 265-274.
22. Polak M, Bouchareb-Banaei L, Scharfmann R, Czernichow P. (2000) Early pattern of differentiation in the human pancreas. Diabetes 49: 225-232.
23. Rajagopal J, Anderson WJ, Kume S, et al. (2003) Insulin staining of ES cell progeny from insulin uptake. Science 299: 363.
24. Dumm-Meynell AA, Rawson NE, Levin BE. (1998) Distribution and phenotype of neurons containing the ATP-sensitive K+ channel in rat brain. Brain Res 814: 41-54.
25. Lang J. (1999) Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion. Eur J Biochem 259: 3-17.
26. Gerber SH, Südhof TC. (2002) Molecular determinants of regulated exocytosis. Diabetes 51 (Suppl. 1): S3-S11.
27. Rorsman P, Renström E. (2003) Insulin granule dynamics in pancreatic beta cells. Diabetologia 46: 1029-1045.
28. Yang XJ, Kow LM, Funabashi T, Mobbs CHV. (1999) Hypothalamic glucose sensor. Similarities to and differences from pancreatic β-cell mechanisms. Diabetes 48: 1767-1772.
29. Schuit FC, Huypens P, Heimberg H, Pipeleers DG. (2001) Glucose sensing in pancreatic beta-cells: A model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus. Diabetes 50: 1-11.
30. Sommer L, Ma Q, Anderson DJ. (1996) Neurogenins, a novel family of atonal- related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS. Mol Cell Neurosci 8: 221-241.
31. Chu K, Nemoz-Gaillard E, Tsai MJ. (2001) BETA2 and pancreatic islet development. Recent Prog Horm Res 56: 23-46.
32. Lemke G. (1993) Transcriptional regulation of the development of neurons and glia. Curr Opin Neurobiol 3: 703-708.
33. Pérez-Villamil B, Schwartz PT, Vallejo M. (1999) The pancreatic home- odomain transcription factor IDX1/IPF1 is expressed in neuronal cells during brain development. Endocrinology 140: 3857-3860.
34. Pattyn A, Vallstedt A, Días JM, et al. (2003) Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain. Development 130: 4149-4159.
35. Alpert S, Hanahan D, Teitelman G. (1988) Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neurons. Cell 53: 295-308.
36. Melloul D, Marshak S, Cerasi E. (2002) Regulation of insulin gene transcription. Diabetologia 45: 309-326.
37. Pérez-Villamil B, de la Rosa EJ, Morales AV, de Pablo F. (1994) Developmentally regulated expression of the preproinsulin gene in the chicken embryo during grastrulation and neurulation. Endocrinology 135: 2342-2350.
38. Hernández-Sánchez C, Mansilla A, de la Rosa EJ, et al. (2003) Upstream AUGs in embryonic proinsulin mRNA control its low translation level. EMBO J 22: 5582-5592.
39. Vicario-Abejón C, Yusta-Boyo MJ, Fernández-Moreno C, de Pablo F. (2003) Locally born olfactory bulb stem cells proliferate in response to insulin-related factors and require endogenous insulin-like growth factor-I for differentiation into neurons and glia. J Neurosci 23: 895-906.
40. Hernández-Sánchez C, Rubio E, Serna J, de la Rosa EJ, de Pablo F. (2002) Unprocessed proinsulin promotes cell survival during neurulation in the chick embryo. Diabetes 51: 770-777.
41. de la Rosa EJ, de Pablo F. (2000) Cell death in early neural development: Beyond the neurotrophic theory. Trends Neurosci 23: 454-458.
42. Nielsen JH. (1985) Growth and function of the pancreatic β-cell in vitro: Effects of glucose, hormones and serum factors on mouse, rat and human pancreatic islets in organ culture. Acta Endocrinol 108: 1-40.
43. Beattie GM, Rubin JS, Mally MI, et al. (1996) Regulation of proliferation and differentiation of human fetal pancreatic islet cells by extracellular matrix, hepatocyte growth factor and cell-cell contact. Diabetes 45: 1223-1228.
44. Beattie GM, Montgomery AM, Lopez AD, et al. (2002) A novel approach to increase human islet cell mass while preserving β-cell function. Diabetes 51: 3435-3439.
45. Demeterco C, Beattie GM, Dib SA, et al. (2000) A role for activin A and betacellulin in human fetal pancreatic cell differentiation and growth. J Clin Endocrinol Metab 85: 3892-3897.
46. Huang H, Tang X. (2003) Phenotypic determination and characterization of nestin-positive precursors derived from human fetal pancreas. Lab Invest 83: 539-547.
47. Humphrey RK, Bucay N, Beattie GM, et al. (2003) Characterization and isolation of promoter-defined nestin-positive cells from the human fetal pancreas. Diabetes 52: 2519-2525.
48. Gao R, Ustinov J, Pulkkinen M-A, et al. (2003) Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture. Diabetes 52: 2007-2015.
49. Bonner-Weir S, Taneja M, Weir GC, et al. (2000) In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci USA 97: 7999-8004.
50. Dor Y, Brown J, Martínez OI, Melton DA. (2004) Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429: 41-46.
51. Jiang Y, Jahagirdar BN, Reinhardt RL, et al. (2002) Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 418: 41-49.
52. Ianus A, Holz GG, Theise ND, Hussain MA. (2003) In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest 111: 843-850.
53. Choi JB, Uchino H, Azuma K, et al. (2003) Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells. Diabetologia 46: 1366-1374.
54. Lechner A, Yang Y-G, Blacken RA, et al. (2004) No evidence for significant transdifferentiation of bone marrow into pancreatic β-cells in vivo. Diabetes 53: 616-623.
55. Hess D, Li L, Martin M, et al. (2003) Bone marrow-derived stem cells initiate pancreatic regeneration. Nat Biotech 21: 763-770.
56. Kim SK, Hebrok, M. (2001) Intercellular signals regulating pancreas development and function. Genes Dev 15: 11-127.
57. Ruhnke M, et al. (2005) Gastroenterology (in press).
58. Ruhnke M, et al. (2005) Transplantation (in press).
59. Zhao Y, Glesne D, Huberman E. (2003) A human peripheral blood monocyte- derived subset acts as pluripotent stem cell. Proc Natl Acad Sci USA 100: 2426-2431.
60. Ferber S, Halkin A, Cohen H, et al. (2000) Pancreatic and duodenal home- obox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med 6: 568-572.
61. Kojima H, Fujimiya M, Matsumura K, et al. (2003) NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med 9:596-603.
62. Zalzman M, Gupta S, Giri RK, et al. (2003) Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells. Proc Natl Acad Sci USA 100: 7253-7258.
63. Colman A. (2004) Making new beta cells from stem cells. Semin Cell Dev Biol 15: 337-345.
64. Roche E, Soria B. (2004) Generation of new islets from stem cells. Cell Biochem Biophys 40 (Suppl): 113-123.