Thymus-Derived Regulatory T Cells Are Positively Selected on Natural Self-Antigen through Cognate Interactions of High Functional Avidity

Immunity

Volumn 44, Issue 5, 2016, Pages 1114-1126

  Kieback, Elisa ^a,b   Hilgenberg, Ellen ^c   Stervbo, Ulrik ^c   Lampropoulou, Vicky ^c   Shen, Ping ^c   Bunse, Mario ^b   Jaimes, Yarua ^c   Boudinot, Pierre ^d   Radbruch, Andreas ^c   Klemm, Uwe ^e   Kühl, Anja A ^f   Liblau, Roland ^g   Hoevelmeyer, Nadine ^h   Anderton, Stephen M ⁱ   Uckert, Wolfgang ^a,b   Fillatreau, Simon ^c,j,k,l  

^a HUMBOLDT UNIVERSITY   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

^d INRA Institut National de la Recherche Agronomique   (France)

^e MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^f CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^g University of Toulouse III   (France)

^h JOHANNES GUTENBERG UNIVERSITY   (Germany)

ⁱ UNIVERSITY OF EDINBURGH   (United Kingdom)

^j INSTITUT NECKER ENFANTS MALADES   (France)

^k UNIVERSITÉ PARIS DESCARTES   (France)

^l HÔPITAL NECKER ENFANTS MALADES   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CD40 LIGAND; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 17; T LYMPHOCYTE RECEPTOR; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN (35-55); PEPTIDE FRAGMENT;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNITY; BINDING AFFINITY; CELL MATURATION; CONTROLLED STUDY; IMMUNOPATHOLOGY; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SPLEEN; TRANSGENIC MOUSE; ANIMAL; ANTIGEN MEDIATED CLONAL SELECTION; C57BL MOUSE; CELL CULTURE; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; GENETICS; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; MULTIPLE SCLEROSIS; PHYSIOLOGY; T LYMPHOCYTE SUBPOPULATION; THYMUS;

ANIMALS; AUTOANTIGENS; CELLS, CULTURED; CLONAL SELECTION, ANTIGEN-MEDIATED; CTLA-4 ANTIGEN; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIPLE SCLEROSIS; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL; T-CELL ANTIGEN RECEPTOR SPECIFICITY; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; THYMUS GLAND;

EID: 84967194581     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2016.04.018     Document Type: Article

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