Triggering of Parkin mitochondrial translocation in mitophagy: Implications for liver diseases

Frontiers in Pharmacology

Volumn 7, Issue APR, 2016, Pages

  Eid, Nabil ^a   Ito, Yuko ^a   Otsuki, Yoshinori ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

8 OHdG; Ethanol; Lipophagy; Liver; Mitophagy; Parkin; Spheroids

Indexed keywords

PARKIN; PROTEIN SERINE THREONINE KINASE; PTEN INDUCED KINASE 1; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG;

ALCOHOLIC FATTY LIVER; ARTICLE; AUTOPHAGY; DNA DAMAGE; DNA REPAIR; GENE EXPRESSION; GENE OVEREXPRESSION; GENE TRANSLOCATION; LIVER CELL; MITOCHONDRIAL TRANSLOCATION; MITOPHAGY; NONALCOHOLIC FATTY LIVER; NONHUMAN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; UPREGULATION;

EID: 84967194475     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2016.00100     Document Type: Article

References (37)

1. Amadoro, G., Corsetti, V., Florenzano, F., Atlante, A., Bobba, A., Nicolin, V., et al. (2014). Morphological and bioenergetic demands underlying the mitophagy in post-mitotic neurons: the pink-parkin pathway. Front. Aging Neurosci. 6:18. doi: 10.3389/fnagi.2014.00018
2. Cook, K. L., Soto-Pantoja, D. R., Abu-Asab, M., Clarke, P. A., Roberts, D. D., and Clarke, R. (2014). Mitochondria directly donate their membrane to form autophagosomes during a novel mechanism of parkin-associated mitophagy. Cell Biosci. 4, 16. doi: 10.1186/2045-3701-4-16
3. Das, S., Mitrovsky, G., Vasanthi, H. R., and Das, D. K. (2014). Antiaging properties of a grape-derived antioxidant are regulated by mitochondrial balance of fusion and fission leading to mitophagy triggered by a signaling network of Sirt1-Sirt3-Foxo3-PINK1-PARKIN. Oxid. Med. Cell. Longev. 2014, 345105. doi: 10.1155/2014/345105
4. Ding, W. X., Li, M., Chen, X., Ni, H. M., Lin, C. W., Gao, W., et al. (2010). Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice. Gastroenterology 139, 1740-1752. doi: 10.1053/j.gastro.2010.07.041
5. Eid, N., Ito, Y., Akio Horibe, A., and Otsuki, Y. (2016). Ethanol-induced mitophagy in liver is associated with activation of the PINK1-Parkin pathway triggered by oxidative DNA damage. Histol. Histopathol. doi: 10.14670/HH-11-747 [Epub ahead of print]
6. Eid, N., Ito, Y., Maemura, K., and Otsuki, Y. (2013a). Elevated autophagic sequestration of mitochondria and lipid droplets in steatotic hepatocytes of chronic ethanol treated rats: an immunohistochemical and electron microscopic study. J. Mol. Histol. 44, 311-326. doi: 10.1007/s10735-013-9483-x
7. Eid, N., Ito, Y., and Otsuki, Y. (2013b). The autophagic response to alcohol toxicity: the missing layer. J. Hepatol. 59, 398. doi: 10.1016/j.jhep.2013.03.038
8. Eid, N., Ito, Y., and Otsuki, Y. (2015). Mitophagy in steatotic hepatocytes of ethanol-treated wild-type and Parkin knockout mice. Am. J. Physiol. Gastrointest. Liver Physiol. 309, 513-514. doi: 10.1152/ajpgi.00254.2015
9. Eskelinen, E. L., Reggiori, F., Baba, M., Kovács, A. L., and Seglen, P. O. (2011). Seeing is believing: the impact of electron microscopy on autophagy research. Autophagy 7, 935-956. doi: 10.4161/auto.7.9.15760
10. Gao, D., Wei, C., Chen, L., Huang, J., Yang, S., and Diehl, A. M. (2004). Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease. Am. J. Physiol. Gastrointest. Liver Physiol. 287, 1070-1077. doi: 10.1152/ajpgi.00228.2004
11. Gmitterová, K., Heinemann, U., Gawinecka, J., Varges, D., Ciesielczyk, B., Valkovic, P., et al. (2009). 8-OHdG in cerebrospinal fluid as a marker of oxidative stress in various neurodegenerative diseases. Neurodegener. Dis. 6, 263-269. doi: 10.1159/000237221
12. Grenier, K., McLelland, G. L., and Fon, E. A. (2013). Parkin- and PINK1-dependent mitophagy in neurons: will the real pathway please stand up? Front. Neurol. 4:100. doi: 10.3389/fneur.2013.00100
13. Guo, L., Yang, J. Y., and Wu, C. F. (2008). Oxidative DNA damage induced by ethanol in mouse peripheral leucocytes. Basic Clin. Pharmacol. Toxicol. 103, 222-227. doi: 10.1111/j.1742-7843.2008.00258.x
14. Hoek, J. B., Cahill, A., and Pastorino, J. G. (2002). Alcohol and mitochondria: a dysfunctional relationship. Gastroenterology 122, 2049-2063. doi: 10.1053/gast.2002.33613
15. Hoshino, A., Mita, Y., Okawa, Y., Ariyoshi, M., Iwai-Kanai, E., Ueyama, T., et al. (2013). Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart. Nat Commun. 4, 2308. doi: 10.1038/ncomms3308
16. Kao, S. Y. (2009). DNA damage induces nuclear translocation of parkin. J. Biomed. Sci. 16, 67. doi: 10.1186/1423-0127-16-67
17. Khalil, B., El Fissi, N., Aouane, A., Cabirol-Pol, M. J., Rival, T., and Liévens, J. C. (2015). PINK1-induced mitophagy promotes neuroprotection in Huntington's disease. Cell Death Dis. 6:e1617. doi: 10.1038/cddis.2014.581
18. Kim, S. J., Syed, G. H., and Siddiqui, A. (2013). Hepatitis C virus induces the mitochondrial translocation of Parkin and subsequent mitophagy. PLoS Pathog. 9:e1003285. doi: 10.1371/journal.ppat.1003285
19. Lemasters, J. J. (2014). Variants of mitochondrial autophagy: types 1 and 2 mitophagy and micromitophagy (type 3). Redox Biol. 2, 749-754. doi: 10.1016/j.redox.2014.06.004
20. Lenzi, P., Marongiu, R., Falleni, A., Gelmetti, V., Busceti, C. L., Michiorri, S., et al. (2012). Subcellular analysis of genetic modulation of PINK1 on mitochondrial alterations, autophagy and cell death. Arch. Ital. Biol. 150, 194-217. doi: 10.4449/aib.v150i2/3.1417
21. Lin, C. W., Zhang, H., Li, M., Xiong, X., Chen, X., Chen, X., et al. (2013). Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice. J. Hepatol. 58, 993-999. doi: 10.1016/j.jhep.2013.01.011
22. McLelland, G. L., Soubannier, V., Chen, C. X., McBride, H. M., and Fon, E. A. (2014). Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control. EMBO J. 33, 282-295. doi: 10.1002/embj.201385902
23. Ni, H. M., Du, K., You, M., and Ding, W. X. (2013). Critical role of FoxO3a in alcohol-induced autophagy and hepatotoxicity. Am. J. Pathol. 183, 1815-1825. doi: 10.1016/j.ajpath.2013.08.011
24. Nogales, F., Rua, R. M., Ojeda, M. L., Murillo, M. L., and Carreras, O. (2014). Oral or intraperitoneal binge drinking and oxidative balance in adolescent rats. Chem. Res. Toxicol. 27, 1926-1933. doi: 10.1021/tx5002628
25. Osna, N. A., Thomes, P. G., and Jr, T. M. (2011). Involvement of autophagy in alcoholic liver injury and hepatitis C pathogenesis. World J. Gastroenterol. 17, 2507-2514. doi: 10.3748/wjg.v17.i20.2507
26. Rothfuss, O., Fischer, H., Hasegawa, T., Maisel, M., Leitner, P., Miesel, F., et al. (2009). Parkin protects mitochondrial genome integrity and supports mitochondrial DNA repair. Hum. Mol. Genet. 18, 3832-3850. doi: 10.1093/hmg/ddp327
27. Saita, S., Shirane, M., and Nakayama, K. I. (2013). Selective escape of proteins from the mitochondria during mitophagy. Nat. Commun. 4, 1410. doi: 10.1038/ncomms2400
28. Schneider, J. L., and Cuervo, A. M. (2014). Liver autophagy: much more than just taking out the trash. Nat. Rev. Gastroenterol. Hepatol. 11, 187-200. doi: 10.1038/nrgastro.2013.211
29. Siddiqui, A., Hanson, I., and Andersen, J. K. (2012). Mao-B elevation decreases parkin's ability to efficiently clear damaged mitochondria: protective effects of rapamycin. Free Radic. Res. 46, 1011-1018. doi: 10.3109/10715762.2012.662277
30. Song, Y. M., Lee, W. K., Lee, Y. H., Kang, E. S., Cha, B. S., and Lee, B. W. (2016). Metformin restores parkin-mediated mitophagy, suppressed by cytosolic p53. Int. J. Mol. Sci. 17:E122. doi: 10.3390/ijms17010122
31. Williams, J. A., Ni, H. M., Ding, Y., and Ding, W. X. (2015). Parkin regulates mitophagy and mitochondrial function to protect against alcohol-induced liver injury and steatosis in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 309, 324-340. doi: 10.1152/ajpgi.00108.2015
32. Yin, X. M., and Ding, W. X. (2013). The reciprocal roles of PARK2 and mitofusins in mitophagy and mitochondrial spheroid formation. Autophagy 9, 1687-1692. doi: 10.4161/auto.24871
33. Yoshii, S. R., Kishi, C., Ishihara, N., and Mizushima, N. (2011). Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane. J. Biol. Chem. 286, 19630-19640. doi: 10.1074/jbc.M110.209338
34. Youle, R. J., and Narendra, D. P. (2011). Mechanisms of mitophagy. Nat. Rev. Mol. Cell Biol. 12, 9-14. doi: 10.1038/nrm3028
35. Yu, X., Xu, Y., Zhang, S., Sun, J., Liu, P., Xiao, L., et al. (2016). Quercetin attenuates chronic ethanol-induced hepatic mitochondrial damage through enhanced mitophagy. Nutrients 8:E27. doi: 10.3390/nu8010027
36. Zhang, J. (2015). Teaching the basics of autophagy and mitophagy to redox biologists-mechanisms and experimental approaches. Redox Biol. 4, 242-259. doi: 10.1016/j.redox.2015.01.003
37. Zhong, Z., Ramshesh, V. K., Rehman, H., Liu, Q., Theruvath, T. P., Krishnasamy, Y., et al. (2014). Acute ethanol causes hepatic mitochondrial depolarization in mice: role of ethanol metabolism. PLoS ONE 9:e91308. doi: 10.1371/journal.pone.0091308