Metformin restores parkin-mediated mitophagy, suppressed by cytosolic p53

International Journal of Molecular Sciences

Volumn 17, Issue 1, 2016, Pages

  Song, Young Mi ^a   Lee, Woo Kyung ^a   Lee, Yong Ho ^a   Kang, Eun Seok ^a   Cha, Bong Soo ^a   Lee, Byung Wan ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

Metformin; Mitochondrial spheroid; Mitophagy; P53; Parkin

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; GLUCOSE; METFORMIN; PALMITIC ACID; PARKIN; PIFITHRIN ALPHA; PROTEIN P53; THAPSIGARGIN; X BOX BINDING PROTEIN 1; ANTIDIABETIC AGENT; BENZOTHIAZOLE DERIVATIVE; PIFITHRIN; SIRT1 PROTEIN, MOUSE; SIRTUIN 1; TOLUENE; UBIQUITIN PROTEIN LIGASE;

ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MITOPHAGY; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; CALORIC RESTRICTION; CELL SURVIVAL; DIET; DRUG EFFECTS; FATTY LIVER; GENE EXPRESSION REGULATION; GENETICS; HEP-G2 CELL LINE; METABOLISM; MITOCHONDRION; MOUSE MUTANT; PATHOLOGY; SIGNAL TRANSDUCTION; ULTRASTRUCTURE;

ANIMALS; BENZOTHIAZOLES; CALORIC RESTRICTION; CELL SURVIVAL; DIET; ENDOPLASMIC RETICULUM STRESS; FATTY LIVER; GENE EXPRESSION REGULATION; GLUCOSE; HEP G2 CELLS; HUMANS; HYPOGLYCEMIC AGENTS; METFORMIN; MICE; MICE, OBESE; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; PALMITIC ACID; SIGNAL TRANSDUCTION; SIRTUIN 1; TOLUENE; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES;

EID: 84954320623     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms17010122     Document Type: Article

References (27)

1. Song, Y.M.; Lee, Y.H.; Kim, J.W.; Ham, D.S.; Kang, E.S.; Cha, B.S.; Lee, H.C.; Lee, B.W. Metformin alleviates hepatosteatosis by restoring sirt1-mediated autophagy induction via an amp-activated protein kinase-independent pathway. Autophagy 2015, 11, 46-59. [CrossRef] [PubMed]
2. Franz, A.; Kevei, E.; Hoppe, T. Double-edged alliance: Mitochondrial surveillance by the ups and autophagy. Curr. Opin. Cell Biol. 2015, 37, 18-27. [CrossRef] [PubMed]
3. Zhu, J.; Wang, K.Z.; Chu, C.T. After the banquet: Mitochondrial biogenesis, mitophagy, and cell survival. Autophagy 2013, 9, 1663-1676. [CrossRef] [PubMed]
4. Tanida, I. Autophagosome formation and molecular mechanism of autophagy. Antioxid. Redox Signal. 2011, 14, 2201-2214. [CrossRef] [PubMed]
5. Ren, J.; Pulakat, L.; Whaley-Connell, A.; Sowers, J.R. Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease. J. Mol. Med. 2010, 88, 993-1001. [CrossRef] [PubMed]
6. Suzuki, S.; Tanaka, T.; Poyurovsky, M.V.; Nagano, H.; Mayama, T.; Ohkubo, S.; Lokshin, M.; Hosokawa, H.; Nakayama, T.; Suzuki, Y.; et al. Phosphate-activated glutaminase (gls2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species. Proc. Natl. Acad. Sci. USA 2010, 107, 7461-7466. [CrossRef] [PubMed]
7. Vousden, K.H.; Ryan, K.M. P53 and metabolism. Nat. Rev. Cancer 2009, 9, 691-700. [CrossRef] [PubMed]
8. Hoshino, A.; Mita, Y.; Okawa, Y.; Ariyoshi, M.; Iwai-Kanai, E.; Ueyama, T.; Ikeda, K.; Ogata, T.; Matoba, S. Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart. Nat. Commun. 2013, 4, 2308. [CrossRef] [PubMed]
9. Hoshino, A.; Ariyoshi, M.; Okawa, Y.; Kaimoto, S.; Uchihashi, M.; Fukai, K.; Iwai-Kanai, E.; Ikeda, K.; Ueyama, T.; Ogata, T.; et al. Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes. Proc. Natl. Acad. Sci. USA 2014, 111, 3116-3121. [CrossRef] [PubMed]
10. Ross, J.M.; Olson, L.; Coppotelli, G. Mitochondrial and ubiquitin proteasome system dysfunction in ageing and disease: Two sides of the same coin? Int. J. Mol. Sci. 2015, 16, 19458-19476. [CrossRef] [PubMed]
11. Chae, M.K.; Park, S.G.; Song, S.O.; Kang, E.S.; Cha, B.S.; Lee, H.C.; Lee, B.W. Pentoxifylline attenuates methionine- and choline-deficient-diet-induced steatohepatitis by suppressing TNF-α expression and endoplasmic reticulum stress. Exp. Diabetes Res. 2012, 2012. [CrossRef] [PubMed]
12. Song, Y.M.; Song, S.O.; You, Y.H.; Yoon, K.H.; Kang, E.S.; Cha, B.S.; Lee, H.C.; Kim, J.W.; Lee, B.W. Glycated albumin causes pancreatic β-cells dysfunction through autophagy dysfunction. Endocrinology 2013, 154, 2626-2639. [CrossRef] [PubMed]
13. Pyo, J.O.; Yoo, S.M.; Jung, Y.K. The interplay between autophagy and aging. Diabetes Metab. J. 2013, 37, 333-339. [CrossRef] [PubMed]
14. Caton, P.W.; Nayuni, N.K.; Kieswich, J.; Khan, N.Q.; Yaqoob, M.M.; Corder, R. Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5. J. Endocrinol. 2010, 205, 97-106. [CrossRef] [PubMed]
15. Song, Y.M.; Song, S.O.; Jung, Y.K.; Kang, E.S.; Cha, B.S.; Lee, H.C.; Lee, B.W. Dimethyl sulfoxide reduces hepatocellular lipid accumulation through autophagy induction. Autophagy 2012, 8, 1085-1097. [CrossRef] [PubMed]
16. Wang, Y. Molecular links between caloric restriction and Sir2/SIRT1 activation. Diabetes Metab. J. 2014, 38, 321-329. [CrossRef] [PubMed]
17. Delaunay-Moisan, A.; Appenzeller-Herzog, C. The antioxidant machinery of the endoplasmic reticulum: Protection and signaling. Free Radic. Biol. Med. 2015, 83, 341-351. [CrossRef] [PubMed]
18. Simon-Szabo, L.; Kokas, M.; Mandl, J.; Keri, G.; Csala, M. Metformin attenuates palmitate-induced endoplasmic reticulum stress, serine phosphorylation of IRS-1 and apoptosis in rat insulinoma cells. PLoS ONE 2014, 9, e97868. [CrossRef] [PubMed]
19. Jung, T.W.; Lee, M.W.; Lee, Y.J.; Kim, S.M. Metformin prevents endoplasmic reticulum stress-induced apoptosis through AMPK-PI3K-c-Jun NH2 pathway. Biochem. Biophys. Res. Commun. 2012, 417, 147-152. [CrossRef]
20. Ding, W.X.; Guo, F.; Ni, H.M.; Bockus, A.; Manley, S.; Stolz, D.B.; Eskelinen, E.L.; Jaeschke, H.; Yin, X.M. Parkin and mitofusins reciprocally regulate mitophagy and mitochondrial spheroid formation. J. Biol. Chem. 2012, 287, 42379-42388. [CrossRef] [PubMed]
21. Yoo, H.J.; Choi, K.M. Hepatokines as a link between obesity and cardiovascular diseases. Diabetes Metab. J. 2015, 39, 10-15. [CrossRef] [PubMed]
22. Sanyal, A.J.; Campbell-Sargent, C.; Mirshahi, F.; Rizzo, W.B.; Contos, M.J.; Sterling, R.K.; Luketic, V.A.; Shiffman, M.L.; Clore, J.N. Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001, 120, 1183-1192. [CrossRef] [PubMed]
23. Zhou, M.; Xu, A.; Tam, P.K.; Lam, K.S.; Chan, L.; Hoo, R.L.; Liu, J.; Chow, K.H.; Wang, Y. Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury. Hepatology 2008, 48, 1087-1096. [CrossRef] [PubMed]
24. Ibdah, J.A.; Perlegas, P.; Zhao, Y.; Angdisen, J.; Borgerink, H.; Shadoan, M.K.; Wagner, J.D.; Matern, D.; Rinaldo, P.; Cline, J.M. Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance. Gastroenterology 2005, 128, 1381-1390. [CrossRef] [PubMed]
25. Rector, R.S.; Thyfault, J.P.; Uptergrove, G.M.; Morris, E.M.; Naples, S.P.; Borengasser, S.J.; Mikus, C.R.; Laye, M.J.; Laughlin, M.H.; Booth, F.W.; et al. Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model. J. Hepatol. 2010, 52, 727-736. [CrossRef] [PubMed]
26. Nelson, L.E.; Valentine, R.J.; Cacicedo, J.M.; Gauthier, M.S.; Ido, Y.; Ruderman, N.B. A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells. Am. J. Physiol. Cell Physiol. 2012, 303, C4-C13. [CrossRef] [PubMed]
27. Adrain, C.; Creagh, E.M.; Martin, S.J. Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2. Embo J. 2001, 20, 6627-6636. [CrossRef] [PubMed]