Analysis of changes in expression of IL-4/IL-13/STAT6 pathway and correlation with the selected clinical parameters in patients with atopic asthma

International Journal of Immunopathology and Pharmacology

Volumn 29, Issue 2, 2016, Pages 195-204

  Antczak, Adam ^a   Domańska Senderowska, Daria ^a   Górski, Paweł ^a   Pastuszak Lewandoska, Dorota ^a   Nielepkowicz Goździńska, Agnieszka ^a   Szewczyk, Karolina ^a   Kurmanowska, Zofia ^a   Kiszałkiewicz, Justyna ^a   Brzeziańska Lasota, Ewa ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

atopic asthma; Il 13; IL 4; STAT6

Indexed keywords

IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 4; STAT6 PROTEIN; IL4 PROTEIN, HUMAN; INTERLEUKIN-13, HUMAN; STAT6 PROTEIN, HUMAN;

ADULT; ALLERGIC ASTHMA; ARTICLE; CLINICAL CLASSIFICATION; CLINICAL FEATURE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; GENE EXPRESSION; HUMAN; IMMUNOEXPRESSION; IMMUNOGLOBULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PEAK EXPIRATORY FLOW; PERIPHERAL LYMPHOCYTE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; ASTHMA; CASE CONTROL STUDY; IMMUNOLOGY; MIDDLE AGED; SIGNAL TRANSDUCTION; TH1 CELL; TH2 CELL;

ASTHMA; CASE-CONTROL STUDIES; FEMALE; GENE EXPRESSION; HUMANS; INTERLEUKIN-13; INTERLEUKIN-4; MALE; MIDDLE AGED; SIGNAL TRANSDUCTION; STAT6 TRANSCRIPTION FACTOR; TH1 CELLS; TH2 CELLS;

EID: 84966711048     PISSN: 03946320     EISSN: 20587384     Source Type: Journal    
DOI: 10.1177/0394632015623794     Document Type: Article

References (49)

1. Los H, Koppelman GH, Postma DS, (1999) The importance of genetic influences in asthma. European Respiratory Journal 14: 1210-1227.
2. Custovic A, Marinho S, Simpson A, (2012) Gene-environment interactions in the development of asthma and atopy. Expert Review of Respiratory Medicine 6: 301-308.
3. Ober C, Cox NJ, Abney M, et al. (1998) Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma. Human Molecular Genetics 7: 1393-1398.
4. Blumenthal MN, (2005) The role of genetics in the development of asthma and atopy. Current Opinion in Allergy and Clinical Immunology 5: 141-145.
5. Blumenthal MN, Langefeld CD, Beaty TH, et al. (2004) A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of Asthma. Human Genetics 114: 157-164.
6. Heinzmann A, Mao XQ, Akaiwa M, et al. (2000) Genetic variants of IL-13 signalling and human asthma and atopy. Human Molecular Genetics 9: 549-559.
7. Shirakawa T, Deichmann KA, Izuhara K, et al. (2000) Atopy and asthma: Genetic variants of IL-4 and IL-13 signalling. Immunology Today 21: 60-64.
8. Hoffjan S, Ober C, (2002) Present status on the genetic studies of asthma. Current Opinion in Immunology 14: 709-717.
9. Venkayya R, Lam M, Willkom M, et al. (2002) The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells. American Journal of Respiratory Cell and Molecular Biology 26: 202-208.
10. Elias JA, Lee CG, Zheng T, et al. (2003) New insights into the pathogenesis of asthma. Journal of Clinical Investigation 111: 291-297.
11. Kuperman DA, Huang X, Koth LL, et al. (2002) Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nature Medicine 8: 885-889.
12. Christodoulopoulos P, Cameron L, Nakamura Y, et al. (2001) TH2 cytokine-associated transcription factors in atopic and nonatopic asthma: Evidence for differential signal transducer and activator of transcription 6 expression. Journal of Allergy and Clinical Immunology 107: 586-591.
13. Mullings RE, Wilson SJ, Puddicombe SM, et al. (2001) Signal transducer and activator of transcription 6 (STAT-6) expression and function in asthmatic bronchial epithelium. Journal of Allergy and Clinical Immunology 108: 832-838.
14. Mukherjee M, Sehmi R, Nair P, (2014) Anti-IL5 therapy for asthma and beyond. World Allergy Organization Journal 7: 32.
15. Maeda S, Yanagihara Y, (2001) Inflammatory cytokines (IL-4, IL-5 and IL-13). Nihon Rinsho 59: 1894-1899.
16. Garcia G, Taillé C, Laveneziana P, et al. (2013) Anti-interleukin-5 therapy in severe asthma. European Respiratory Review 22: 251-257.
17. Adjers K, Pessi T, Karjalainen J, et al. (2004) Epistatic effect of IL1A and IL4RA genes on the risk of atopy. Journal of Allergy and Clinical Immunology 113: 445-447.
18. Dolecek C, Steinberger P, Susani M, et al. (1995) Effects of IL-4 and IL-13 on total and allergen specific IgE production by cultured PBMC from allergic patients determined with recombinant pollen allergens. Clinical and Experimental Allergy 25: 879-889.
19. Humbert M, Corrigan CJ, Kimmitt P, et al. (1997) Relationship between IL-4 and IL-5 mRNA expression and disease severity in atopic asthma. American Journal of Respiratory and Critical Care Medicine 156: 7048.
20. Wynn TA, (2003) IL-13 effector functions. Annual Review of Immunology 21: 425-456.
21. Chatila TA, (2004) Interleukine-4 receptor signaling pathways in asthma pathogenesis. Trends in Molecular Medicine 10: 493-499.
22. Kaplan MH, Schindler U, Smiley ST, et al. (1996) Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells. Immunity 4: 313-319.
23. Shimoda K, van Deursen J, Sangster MY, et al. (1996) Lack of IL-4 induced Th2 response and IgE class switching in mice with disrupted stat6 gene. Nature 380: 630-633.
24. Elias JA, Lee CG, Zheng T, et al. (2003) New insights into the pathogenesis of asthma. Journal of Clinical Investigation 111: 291-297.
25. Grunig G, (1998) Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282: 2261-2263.
26. Van Der Pouw Krann TC, Van Der Zee JS, Boeije LC, et al. (1998) The role of IL-13 in IgE synthesis by allergic asthma patients. Clinical and Experimental Immunology 111: 129-135.
27. Tavakkol Afshari J, Hosseini FR, Farahabadi HS, et al. (2007) Association of the expression of IL-4 and IL-13 genes, IL-4 and IgE serum levels with allergic asthma. Iranian Journal of Allergy Asthma Immunology 6: 67-72.
28. Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma (GINA). 2014. Available at: http://www.ginasthma.org/.
29. Miller MR, Hankinson J, Brusasco V, et al. (2005) ATS/ERS Task Force: Standardisation of lung function testing; standardisation of spirometry. European Respiratory Journal 26: 319-338.
30. Heinzmann A, Daser A, (2002) Mouse models for the genetic dissection of atopy. International Archives of Allergy and Immunology 127: 170-180.
31. International Severe Asthma Forum, 11-13 2012, Gothenburg, Sweden.
32. Rabe KF, Hurd S, Anzueto A, et al. (2007) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 15: 532-555.
33. Łukaszczyk Bush A, Zar HJ, (2011) WHO universal definition of severe asthma. Current Opinion in Allergy and Clinical Immunology 11: 115-121.
34. Truyen E, Coteur L, Dilissen E, et al. (2006) Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthma patients. Thorax 61: 202-208.
35. Siddiqui S, Cruse G, McKenna S, et al. (2009) IL-13 expression by blood T cells and not eosinophils is increased in asthma compared to non-asthmatic eosinophilic bronchitis. BMC Pulmonary Medicine 9: 34.
36. Wills-Karp M, Luyimbazi J, Xu X, et al. (1998) Interleukin-13: central mediator of allergic asthma. Science 282: 2258-2261.
37. Metwally SS, Mosaad YM, Abdel-Samee ER, et al. (2004) IL-13 gene expression in patients with atopic dermatitis: Relation to IgE level and to disease severity. Egyptian Journal of Immunology 11: 171-177.
38. Fallon PG, Emson CL, Smith P, et al. (2001) IL-13 overexpression predisposes to anaphylaxis following antigen sensitization. Journal of Immunology 166: 2712-2716.
39. Kabesch M, Schedel M, Carr D, et al. (2006) IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma. Journal of Allergy and Clinical Immunology 117: 269-274.
40. Van der Pouw Kraan TC, Van der Zee JS, Boeije LC, et al. (1998) The role of IL-13 in IgE synthesis by allergic asthma patients. Clinical and Experimental Immunology 111: 129-135.
41. Park HW, Lee JE, Kim SH, et al. (2009) Genetic variation of IL13 as a risk factor of reduced lung function in children and adolescents: A cross-sectional population-based study in Korea. Respiratory Medicine 103: 284-288.
42. Lee JS, Rosengart MR, Kondragunta V, et al. (2007) Inverse association of plasma IL-13 and inflammatory chemokines with lung function impairment in stable COPD: A cross-sectional cohort study. Respiratory Research 8: 64.
43. Oh CK, Geba GP, Molfino N, (2010) Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma. European Respiratory Review 19: 46-54.
44. Shirakawa I, Deichmann KA, Izuhara I, et al. (2000) Atopy and asthma: Genetic variants of IL-4 and IL-13 signalling. Immunology Today 21: 60-64.
45. Pykäläinen M, Kinos R, Valkonen S, et al. (2005) Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes. Journal of Allergy and Clinical Immunology 115: 80-87.
46. Bernstein IL, Li JT, Bernstein DI, et al. (2008) Allergy diagnostic testing: An updated practice parameter. Annals of Allergy Asthma & Immunology 100: 1-148.
47. Godava M, Vrtel R, Vodicka R, (2013) STAT6-polymorphisms, haplotypes and epistasis in relation to atopy and asthma. Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 157: 172-180.
48. Lau M, Tsantikos E, Maxwell MJ, et al. (2012) Loss of STAT6 promotes autoimmune disease and atopy on a susceptible genetic background. Journal of Autoimmunity 39: 388-397.
49. Leung TF, Chan IH, Wong GW, et al. (2007) Association between candidate genes and lung function growth in Chinese asthmatic children. Clinical and Experimental Allergy 37: 1480-1486.