메뉴 건너뛰기




Volumn 5, Issue 2, 2005, Pages 141-145

The role of genetics in the development of asthma and atopy

Author keywords

Asthma; Atopy; Genes; Genetics

Indexed keywords

DIPEPTIDYL PEPTIDASE; DIPEPTIDYL PEPTIDASE 10; HLA DR ANTIGEN; LYMPHOTOXIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 15944397667     PISSN: 15284050     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.all.0000162306.12728.c2     Document Type: Review
Times cited : (79)

References (62)
  • 1
    • 5444231505 scopus 로고    scopus 로고
    • Evidence that negative feedback between antibody concentration and affinity regulates humoral response consolidation to a non-infectious antigen in infants
    • Jackola DR, Liebeler CL, Lin C-Y, et al. Evidence that negative feedback between antibody concentration and affinity regulates humoral response consolidation to a non-infectious antigen in infants. Mol Immunol 2005; 42:19-30. These investigators demonstrated that all individuals usually respond to allergens, but in atopy there is an increased production of high affinity IgE antibody while non-atopic individuals produce an equally high affinity IgG1 antibody.
    • (2005) Mol Immunol , vol.42 , pp. 19-30
    • Jackola, D.R.1    Liebeler, C.L.2    Lin, C.-Y.3
  • 3
    • 3142739347 scopus 로고    scopus 로고
    • A demonstration and findings of a statistical approach a through reanalysis of inflammatory bowel disease data
    • Lo S-H, Zheng T. A demonstration and findings of a statistical approach a through reanalysis of inflammatory bowel disease data. Proc Natl Acad Sci U S A 2004; 101:10386-10391. This paper uses a new statistical approach of the backward haplotype transmission association algorithm on genome-screen data for an analysis of inflammatory bowel disease data. The technique can be used for other complex phenotype studies such as asthma and atopy.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 10386-10391
    • Lo, S.-H.1    Zheng, T.2
  • 4
    • 0345257807 scopus 로고    scopus 로고
    • Multipoint linkage disequilibrium mapping for complex diseases
    • Liang K-Y, Hsu F-C, Beaty TH. Multipoint linkage disequilibrium mapping for complex diseases. Genet Epidemiol 2003; 25:285-292. These authors discuss using a multipoint linkage disequilibrium method to estimate the location of a susceptibility gene. They discuss how this method can be used to address issues such as gene-gene and gene-environment interactions, genetic heterogeneity, phenotypic refinement and parental versus maternal transmission.
    • (2003) Genet Epidemiol , vol.25 , pp. 285-292
    • Liang, K.-Y.1    Hsu, F.-C.2    Beaty, T.H.3
  • 5
    • 0036436758 scopus 로고    scopus 로고
    • Backward haplotype transmission association (BHTA) algorithm: A fast multiple-marker screening method
    • Lo S-H, Zheng T. Backward haplotype transmission association (BHTA) algorithm: a fast multiple-marker screening method. Hum Hered 2002; 53:197-215.
    • (2002) Hum Hered , vol.53 , pp. 197-215
    • Lo, S.-H.1    Zheng, T.2
  • 6
    • 0347992868 scopus 로고    scopus 로고
    • Family-based tests for associating haplotypes with general phenotype data: Application to asthma genetics
    • Horvath S, Xu X, Lake SL, et al. Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol 2004; 26:61-69.
    • (2004) Genet Epidemiol , vol.26 , pp. 61-69
    • Horvath, S.1    Xu, X.2    Lake, S.L.3
  • 7
    • 12144285594 scopus 로고    scopus 로고
    • Assessing the impact of population stratification on genetic association studies
    • Freedman ML, Reich D, Penney KL, et al. Assessing the impact of population stratification on genetic association studies. Nat Genet 2004; 36:388-393.
    • (2004) Nat Genet , vol.36 , pp. 388-393
    • Freedman, M.L.1    Reich, D.2    Penney, K.L.3
  • 8
    • 0036888556 scopus 로고    scopus 로고
    • Present status on the genetic studies of asthma
    • Hoffjan S, Ober C. Present status on the genetic studies of asthma. Curr Opin Immunol 2002; 14:709-717.
    • (2002) Curr Opin Immunol , vol.14 , pp. 709-717
    • Hoffjan, S.1    Ober, C.2
  • 9
    • 15944391243 scopus 로고    scopus 로고
    • A genome scan of asthma phenotypes in a large collection of families from Europe, Australia and US
    • Pillai SG, Mathias C, Lam R, et al. A genome scan of asthma phenotypes in a large collection of families from Europe, Australia and US [abstract]. J Allergy Clin Immunol 2004; 113:S329.
    • (2004) J Allergy Clin Immunol , vol.113
    • Pillai, S.G.1    Mathias, C.2    Lam, R.3
  • 10
    • 0037932789 scopus 로고    scopus 로고
    • Evidence for asthma susceptibility genes on chromosome 11 in an African-American population
    • Huang SK, Mathias RA, Ehrlich E, et al. Evidence for asthma susceptibility genes on chromosome 11 in an African-American population. Hum Genet 2003; 113:71-75. Using a genome screen, these authors report an asthma susceptibility gene on chromosome 11 in an African-American population.
    • (2003) Hum Genet , vol.113 , pp. 71-75
    • Huang, S.K.1    Mathias, R.A.2    Ehrlich, E.3
  • 11
    • 10744229617 scopus 로고    scopus 로고
    • A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of Asthma
    • Blumenthal MN, Langefeld CD, Beaty TH, et al. A genome-wide search for allergic response (atopy) genes in three ethnic groups: Collaborative Study on the Genetics of Asthma. Hum Genet 2004; 114:157-164. Using the Collaborative Study on the Genetics of Asthma database, the results of a genome screen for an atopy phenotype is reported which demonstrates several possible sites.
    • (2004) Hum Genet , vol.114 , pp. 157-164
    • Blumenthal, M.N.1    Langefeld, C.D.2    Beaty, T.H.3
  • 12
    • 1942429729 scopus 로고    scopus 로고
    • Genome scan for loci linked to mite sensitivity
    • Blumenthal MN, Ober C, Beaty TH, et al. Genome scan for loci linked to mite sensitivity. Genes Immun 2004; 5:226-231. Several susceptibility loci for mite sensitivity were noted in different ethnic groups using a Collaborative Study on the Genetics of Asthma genome screen database. Mite reactivity showed a relatively high lod score for the combined ethnic groups as well as in Caucasians on chromosome 11q.
    • (2004) Genes Immun , vol.5 , pp. 226-231
    • Blumenthal, M.N.1    Ober, C.2    Beaty, T.H.3
  • 13
    • 1942494043 scopus 로고    scopus 로고
    • Association studies for asthma and atopic diseases: A comprehensive review of the literature
    • Hoffjan S, Nicolae D, Ober C. Association studies for asthma and atopic diseases: a comprehensive review of the literature. Respir Res 2003; 4:14. These authors present a very thorough literature review of genetic association studies for asthma and atopic disease.
    • (2003) Respir Res , vol.4 , pp. 14
    • Hoffjan, S.1    Nicolae, D.2    Ober, C.3
  • 14
    • 0242329880 scopus 로고    scopus 로고
    • Positional cloning of a novel gene influencing asthma from chromosome 2q14
    • Allen M, Heinzmann A, Noguchi E, et al. Positional cloning of a novel gene influencing asthma from chromosome 2q14. Nat Genet 2003; 35:258-263. The identification of a new asthma gene DDP10 located on chromosome 2q14 was reported.
    • (2003) Nat Genet , vol.35 , pp. 258-263
    • Allen, M.1    Heinzmann, A.2    Noguchi, E.3
  • 15
    • 0037603549 scopus 로고    scopus 로고
    • Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma
    • Zhang Y, Leaves NI, Anderson GG, et al. Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma. Nat Genet 2003; 24:181-186. A new asthma gene located on chromosome 13q14 called PHF11 is described in this article.
    • (2003) Nat Genet , vol.24 , pp. 181-186
    • Zhang, Y.1    Leaves, N.I.2    Anderson, G.G.3
  • 16
    • 11144357144 scopus 로고    scopus 로고
    • Characterization of a common susceptibility locus for asthma-related traits
    • Laitinen T, Polvi A, Rydman P, et al. Characterization of a common susceptibility locus for asthma-related traits. Science 2004; 304:300-304. These investigators describe the identification and characterization of a new asthma gene on chromosome 7p called GPRA.
    • (2004) Science , vol.304 , pp. 300-304
    • Laitinen, T.1    Polvi, A.2    Rydman, P.3
  • 17
    • 2542483648 scopus 로고    scopus 로고
    • Association of the interleukin 1 receptor antagonist gene with asthma
    • Gohlke H, Illig T, Bahnweg M, et al. Association of the interleukin 1 receptor antagonist gene with asthma. Am J Respir Crit Care Med 2004; 169:1217-1223.
    • (2004) Am J Respir Crit Care Med , vol.169 , pp. 1217-1223
    • Gohlke, H.1    Illig, T.2    Bahnweg, M.3
  • 18
    • 0043261616 scopus 로고    scopus 로고
    • A common IL-1 complex haplotype is associated with an increased risk of atopy
    • Pessi T, Karjalainen J, Hulkkonen J, et al. A common IL-1 complex haplotype is associated with an increased risk of atopy. J Med Genet 2003; 40:e66.
    • (2003) J Med Genet , vol.40
    • Pessi, T.1    Karjalainen, J.2    Hulkkonen, J.3
  • 21
    • 0842313329 scopus 로고    scopus 로고
    • Polymorphism of the immune-braking gene CTLA-4 (+49) involved in gender discrepancy of serum total IgE levels and allergic diseases
    • Yang KD, Liu C-A, Chang J-C, et al. Polymorphism of the immune-braking gene CTLA-4 (+49) involved in gender discrepancy of serum total IgE levels and allergic diseases. Clin Exp Allergy 2004; 34:32-37.
    • (2004) Clin Exp Allergy , vol.34 , pp. 32-37
    • Yang, K.D.1    Liu, C.-A.2    Chang, J.-C.3
  • 22
    • 0042387785 scopus 로고    scopus 로고
    • Novel case-control test in a founder population identifies P-selectin as an atopy-susceptibility locus
    • Bourgain C, Hoffjan S, Nicolae R, et al. Novel case-control test in a founder population identifies P-selectin as an atopy-susceptibility locus. Am J Hum Genet 2003; 73:612-626.
    • (2003) Am J Hum Genet , vol.73 , pp. 612-626
    • Bourgain, C.1    Hoffjan, S.2    Nicolae, R.3
  • 23
    • 0042622596 scopus 로고    scopus 로고
    • Polymorphisms in the interleukin-4 and interleukin-4 receptor alpha chain genes confer susceptibility to asthma and atopy in a Caucasian population
    • Beghe B, Barton S, Rorke S, et al. Polymorphisms in the interleukin-4 and interleukin-4 receptor alpha chain genes confer susceptibility to asthma and atopy in a Caucasian population. Clin Exp Allergy 2003; 33:1111-1117.
    • (2003) Clin Exp Allergy , vol.33 , pp. 1111-1117
    • Beghe, B.1    Barton, S.2    Rorke, S.3
  • 24
    • 0242467244 scopus 로고    scopus 로고
    • A complete screening of the IL4 gene: Novel polymorphisms and their association with asthma and IgE in childhood
    • Kabesch M, Tzotcheva I, Carr D, et al. A complete screening of the IL4 gene: novel polymorphisms and their association with asthma and IgE in childhood. J Allergy Clin Immunol 2003; 112:893-898.
    • (2003) J Allergy Clin Immunol , vol.112 , pp. 893-898
    • Kabesch, M.1    Tzotcheva, I.2    Carr, D.3
  • 25
    • 2342622087 scopus 로고    scopus 로고
    • A promoter polymorphism in the CD14 gene is associated with elevated levels of soluble CD14 but not with IgE or atopic diseases
    • Kabesch M, Hasemann K, Schickinger V, et al. A promoter polymorphism in the CD14 gene is associated with elevated levels of soluble CD14 but not with IgE or atopic diseases. Allergy 2004; 59:520-525.
    • (2004) Allergy , vol.59 , pp. 520-525
    • Kabesch, M.1    Hasemann, K.2    Schickinger, V.3
  • 26
    • 3442893822 scopus 로고    scopus 로고
    • A comprehensive evaluation of IL4 variants in ethnically diverse populations: Association of total serum IgE levels and asthma in white subjects
    • Basehore MJ, Howard TD, Lange LA, et al. A comprehensive evaluation of IL4 variants in ethnically diverse populations: Association of total serum IgE levels and asthma in white subjects. J Allergy Clin Immunol 2004; 114:80-87.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 80-87
    • Basehore, M.J.1    Howard, T.D.2    Lange, L.A.3
  • 27
    • 0037329595 scopus 로고    scopus 로고
    • Learning from discrepancies: CD14 polymorphisms, atopy and the endotoxin switch
    • Vercelli D. Learning from discrepancies: CD14 polymorphisms, atopy and the endotoxin switch. Clin Exp Allergy 2003; 33:153-155. Vercelli provides a very thoughtful editorial in which she discusses the conflicting reports and theories regarding CD14, atopy, and the endotoxin switch.
    • (2003) Clin Exp Allergy , vol.33 , pp. 153-155
    • Vercelli, D.1
  • 28
    • 0141956386 scopus 로고    scopus 로고
    • Association study of the IL13 variant Arg110Gln in atopic diseases and juvenile idiopathic arthritis
    • Heinzmann A, Jerkic SP, Ganter K, et al. Association study of the IL13 variant Arg110Gln in atopic diseases and juvenile idiopathic arthritis. J Allergy Clin Immunol 2003; 112:735-739.
    • (2003) J Allergy Clin Immunol , vol.112 , pp. 735-739
    • Heinzmann, A.1    Jerkic, S.P.2    Ganter, K.3
  • 29
    • 1242298443 scopus 로고    scopus 로고
    • Reduced interferon gamma production and soluble CD14 levels in early life predict recurrent wheezing by 1 year of age
    • Guerra S, Lohman IC, Halonen M, et al. Reduced interferon gamma production and soluble CD14 levels in early life predict recurrent wheezing by 1 year of age. Am J Respir Crit Care Med 2004; 169:70-76.
    • (2004) Am J Respir Crit Care Med , vol.169 , pp. 70-76
    • Guerra, S.1    Lohman, I.C.2    Halonen, M.3
  • 30
    • 0042381598 scopus 로고    scopus 로고
    • The -159 C→T polymorphism of CD14 is associated with nonatopic asthma and food allergy
    • Woo JG, Assa'ad A, Heizer AB, et al. The -159 C→T polymorphism of CD14 is associated with nonatopic asthma and food allergy. J Allergy Clin Immunol 2003; 112:438-444.
    • (2003) J Allergy Clin Immunol , vol.112 , pp. 438-444
    • Woo, J.G.1    Assa'ad, A.2    Heizer, A.B.3
  • 31
    • 1442276281 scopus 로고    scopus 로고
    • Age-specific relationship between CD14 and atopy in a cohort assessed from age 8 to 25 years
    • O'Donnell AR, Toelle BG, Marks GB, et al. Age-specific relationship between CD14 and atopy in a cohort assessed from age 8 to 25 years. Am J Respir Crit Care Med 2004; 169:615-622.
    • (2004) Am J Respir Crit Care Med , vol.169 , pp. 615-622
    • O'Donnell, A.R.1    Toelle, B.G.2    Marks, G.B.3
  • 32
    • 0041427913 scopus 로고    scopus 로고
    • The C-159T polymorphism in the CD14 promoter is associated with serum total IgE concentration in atopic Chinese children
    • Leung TF, Tang NL, Sung YM, et al. The C-159T polymorphism in the CD14 promoter is associated with serum total IgE concentration in atopic Chinese children. Pediatr Allergy Immunol 2003; 14:255-260.
    • (2003) Pediatr Allergy Immunol , vol.14 , pp. 255-260
    • Leung, T.F.1    Tang, N.L.2    Sung, Y.M.3
  • 33
    • 0141887563 scopus 로고    scopus 로고
    • Two CD14 promoter polymorphisms and atopic phenotypes in Czech patients with IgE-mediated allergy
    • Buckova D, Holla LI, Schuller M, et al. Two CD14 promoter polymorphisms and atopic phenotypes in Czech patients with IgE-mediated allergy. Allergy 2003; 58:1023-1026.
    • (2003) Allergy , vol.58 , pp. 1023-1026
    • Buckova, D.1    Holla, L.I.2    Schuller, M.3
  • 34
    • 1642313810 scopus 로고    scopus 로고
    • SPINK5: A gene for atopic dermatitis and asthma
    • Moffatt MF. SPINK5: A gene for atopic dermatitis and asthma. Clin Exp Allergy 2004; 34:325-327. This provides a nice review of the recent information regarding SPINK5 as a gene for atopic dermatitis and asthma.
    • (2004) Clin Exp Allergy , vol.34 , pp. 325-327
    • Moffatt, M.F.1
  • 35
    • 1642390161 scopus 로고    scopus 로고
    • Association between polymorphisms in serine protease inhibitor, kazal type 5 and asthma phenotypes in a large German population sample
    • Kabesch M, Carr D, Weiland SK, von Mutius E. Association between polymorphisms in serine protease inhibitor, kazal type 5 and asthma phenotypes in a large German population sample. Clin Exp Allergy 2004; 34:340-345.
    • (2004) Clin Exp Allergy , vol.34 , pp. 340-345
    • Kabesch, M.1    Carr, D.2    Weiland, S.K.3    Von Mutius, E.4
  • 36
    • 1642307771 scopus 로고    scopus 로고
    • Association between polymorphisms in the SPINK5 gene and atopic dermatitis in the Japanese
    • Nishio Y, Noguchi E, Shibasaki M, et al. Association between polymorphisms in the SPINK5 gene and atopic dermatitis in the Japanese. Genes Immun 2003; 4:515-517.
    • (2003) Genes Immun , vol.4 , pp. 515-517
    • Nishio, Y.1    Noguchi, E.2    Shibasaki, M.3
  • 37
    • 0038579516 scopus 로고    scopus 로고
    • Association of SPINK5 gene polymorphisms with atopic dermatitis in the Japanese populations
    • Kato A, Fukai K, Oiso N, et al. Association of SPINK5 gene polymorphisms with atopic dermatitis in the Japanese populations. Br J Dermatol 2003; 148:665-669.
    • (2003) Br J Dermatol , vol.148 , pp. 665-669
    • Kato, A.1    Fukai, K.2    Oiso, N.3
  • 38
    • 0038366908 scopus 로고    scopus 로고
    • Allelic association and functional studies of promoter polymorphism in the leukotriene C4 synthase gene (LTC4S) in asthma
    • Sayers I, Barton S, Rorke S, et al. Allelic association and functional studies of promoter polymorphism in the leukotriene C4 synthase gene (LTC4S) in asthma. Thorax 2003; 58:417-424.
    • (2003) Thorax , vol.58 , pp. 417-424
    • Sayers, I.1    Barton, S.2    Rorke, S.3
  • 39
    • 1242284359 scopus 로고    scopus 로고
    • Protective role of gluthatione S-transferase P1 (GSTP1) Val105Val genotype in patients with bronchial asthma
    • Aynacioglu AS, Nacak M, Filiz A, et al. Protective role of gluthatione S-transferase P1 (GSTP1) Val105Val genotype in patients with bronchial asthma. Br J Clin Pharmacol 2004; 57:213-217.
    • (2004) Br J Clin Pharmacol , vol.57 , pp. 213-217
    • Aynacioglu, A.S.1    Nacak, M.2    Filiz, A.3
  • 40
    • 0037444397 scopus 로고    scopus 로고
    • Atopy, respiratory function and HLA-DR in Aboriginal Australians
    • Moffatt MF, Faux JA, Lester S, et al. Atopy, respiratory function and HLA-DR in Aboriginal Australians. Hum Mol Genet 2003; 12:625-630.
    • (2003) Hum Mol Genet , vol.12 , pp. 625-630
    • Moffatt, M.F.1    Faux, J.A.2    Lester, S.3
  • 41
    • 1542375251 scopus 로고    scopus 로고
    • Gene-gene synergistic effect on atopic asthma: Tumour necrosis factor-alpha-308 and lymphotoxin-alpha-Ncol in Taiwan's children
    • Wang TN, Chen WY, Wang TH, et al. Gene-gene synergistic effect on atopic asthma: tumour necrosis factor-alpha-308 and lymphotoxin-alpha-Ncol in Taiwan's children. Clin Exp Allergy 2004; 34:184-188.
    • (2004) Clin Exp Allergy , vol.34 , pp. 184-188
    • Wang, T.N.1    Chen, W.Y.2    Wang, T.H.3
  • 42
    • 0037372468 scopus 로고    scopus 로고
    • Atopic asthma and TNF-308 alleles: Linkage disequilibrium and association analyses
    • Di Somma C, Charron D, Deichmann K, et al. Atopic asthma and TNF-308 alleles: linkage disequilibrium and association analyses. Hum Immunol 2003; 64:359-365.
    • (2003) Hum Immunol , vol.64 , pp. 359-365
    • Di Somma, C.1    Charron, D.2    Deichmann, K.3
  • 43
    • 10744225692 scopus 로고    scopus 로고
    • Association of tumor necrosis factor polymorphisms with asthma and serum total IgE
    • Shin HD, Park BL, Kim LH, et al. Association of tumor necrosis factor polymorphisms with asthma and serum total IgE. Hum Mol Genet 2004; 13:397-403.
    • (2004) Hum Mol Genet , vol.13 , pp. 397-403
    • Shin, H.D.1    Park, B.L.2    Kim, L.H.3
  • 44
    • 4444284277 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 6 haplotypes and asthma in the Indian population
    • Nagarkatti R, B-Rao C, Vijayan V, et al. Signal transducer and activator of transcription 6 haplotypes and asthma in the Indian population. Am J Respir Cell Mol Biol 2004; 31:317-321.
    • (2004) Am J Respir Cell Mol Biol , vol.31 , pp. 317-321
    • Nagarkatti, R.1    B-Rao, C.2    Vijayan, V.3
  • 45
    • 11144357723 scopus 로고    scopus 로고
    • Linkage and association of childhood asthma with the chromosome 12 genes
    • Shao C, Suzuki Y, Kamada F, et al. Linkage and association of childhood asthma with the chromosome 12 genes. J Hum Genet 2004; 49:115-122.
    • (2004) J Hum Genet , vol.49 , pp. 115-122
    • Shao, C.1    Suzuki, Y.2    Kamada, F.3
  • 46
    • 0038355228 scopus 로고    scopus 로고
    • Linkage and association studies of STAT6 gene polymorphisms and allergic diseases
    • Tamura K, Suzuki M, Arakawa H, et al. Linkage and association studies of STAT6 gene polymorphisms and allergic diseases. Int Arch Allergy Immunol 2003; 131:33-38.
    • (2003) Int Arch Allergy Immunol , vol.131 , pp. 33-38
    • Tamura, K.1    Suzuki, M.2    Arakawa, H.3
  • 47
    • 0034019580 scopus 로고    scopus 로고
    • Variants of STAT6 (signal transducer and activator of transcription 6) in atopic asthma
    • Gao PS, Mao XQ, Roberts MH, et al. Variants of STAT6 (signal transducer and activator of transcription 6) in atopic asthma. J Med Genet 2000; 37:380-382.
    • (2000) J Med Genet , vol.37 , pp. 380-382
    • Gao, P.S.1    Mao, X.Q.2    Roberts, M.H.3
  • 48
    • 2342545440 scopus 로고    scopus 로고
    • Neuronal nitric oxide synthase gene polymorphism and IgE-mediated allergy in the Central European population
    • Holla LI, Schuller M, Buckova D, Vacha J. Neuronal nitric oxide synthase gene polymorphism and IgE-mediated allergy in the Central European population. Allergy 2004; 59:548-552.
    • (2004) Allergy , vol.59 , pp. 548-552
    • Holla, L.I.1    Schuller, M.2    Buckova, D.3    Vacha, J.4
  • 49
    • 1642485261 scopus 로고    scopus 로고
    • Polymorphisms of the GM-CSF genes and the development of atopic disease in at-risk children
    • He JQ, Ruan J, Chan-Yeung M, et al. Polymorphisms of the GM-CSF genes and the development of atopic disease in at-risk children. Chest 2003; 123:4383.
    • (2003) Chest , vol.123 , pp. 4383
    • He, J.Q.1    Ruan, J.2    Chan-Yeung, M.3
  • 50
    • 1542616269 scopus 로고    scopus 로고
    • Associations of the IL12B promoter polymorphism in longitudinal data from asthmatic patients 7 to 42 years of age
    • Khoo SK, Hayden CM, Roberts M, et al. Associations of the IL12B promoter polymorphism in longitudinal data from asthmatic patients 7 to 42 years of age. J Allergy Clin Immunol 2004; 113:475-481.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 475-481
    • Khoo, S.K.1    Hayden, C.M.2    Roberts, M.3
  • 51
    • 0942276431 scopus 로고    scopus 로고
    • IL10 gene polymorphisms are associated with asthma phenotypes in children
    • Lyon H, Lange C, Lake S, et al. IL10 gene polymorphisms are associated with asthma phenotypes in children. Genet Epidemiol 2004; 26:155-165.
    • (2004) Genet Epidemiol , vol.26 , pp. 155-165
    • Lyon, H.1    Lange, C.2    Lake, S.3
  • 52
    • 6044239102 scopus 로고    scopus 로고
    • Making sense of asthma genes
    • Cookson W, Moffatt M. Making sense of asthma genes. N Engl J Med 2004; 351:1794-1796. The authors present an interesting discussion of the five reported asthma genes regarding their importance and function.
    • (2004) N Engl J Med , vol.351 , pp. 1794-1796
    • Cookson, W.1    Moffatt, M.2
  • 53
    • 0037173639 scopus 로고    scopus 로고
    • Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness
    • Van Eerdewegh P, Little RD, Dupuis J, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature 2002; 418:426-430.
    • (2002) Nature , vol.418 , pp. 426-430
    • Van Eerdewegh, P.1    Little, R.D.2    Dupuis, J.3
  • 54
    • 0141887468 scopus 로고    scopus 로고
    • Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations
    • Howard TD, Postma DS, Jongepier H, et al. Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations. J Allergy Clin Immunol 2003; 112:717-722.
    • (2003) J Allergy Clin Immunol , vol.112 , pp. 717-722
    • Howard, T.D.1    Postma, D.S.2    Jongepier, H.3
  • 55
    • 0842334829 scopus 로고    scopus 로고
    • Asthma is associated with single-nucleotide polymorphisms in ADAM33
    • Werner M, Herbon N, Gohlke H, et al. Asthma is associated with single-nucleotide polymorphisms in ADAM33. Clin Exp Allergy 2004; 34:26-31.
    • (2004) Clin Exp Allergy , vol.34 , pp. 26-31
    • Werner, M.1    Herbon, N.2    Gohlke, H.3
  • 56
    • 0345256319 scopus 로고    scopus 로고
    • ADAM33 is not associated with asthma in Puerto Rican or Mexican populations
    • Lind DL, Choudhry S, Ung N, et al. ADAM33 is not associated with asthma in Puerto Rican or Mexican populations. Am J Respir Crit Care Med 2003; 168:1312-1316.
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. 1312-1316
    • Lind, D.L.1    Choudhry, S.2    Ung, N.3
  • 57
    • 3042795020 scopus 로고    scopus 로고
    • ADAM33 polymorphisms and phenotype associations in childhood asthma
    • Raby BA, Silverman EK, Kwiatkowski DJ, et al. ADAM33 polymorphisms and phenotype associations in childhood asthma. J Allergy Clin Immunol 2004; 113:1071-1078.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 1071-1078
    • Raby, B.A.1    Silverman, E.K.2    Kwiatkowski, D.J.3
  • 58
    • 10744223879 scopus 로고    scopus 로고
    • Effects of dog ownership and genotype on immune development and atopy in infancy
    • Gern JE, Reardon CL, Hoffjan S, et al. Effects of dog ownership and genotype on immune development and atopy in infancy. J Allergy Clin Immunol 2004; 113:307-314. This group of investigators revisits the effect of pet exposure and genotype on immunologic development and the incidence of atopic markers and disease in the first year of life. They present data suggesting that postnatal exposure to dogs can influence immune development in the genotype-specific fashion and thereby attenuate the development of atopy in at-risk children.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 307-314
    • Gern, J.E.1    Reardon, C.L.2    Hoffjan, S.3
  • 59
    • 0242432596 scopus 로고    scopus 로고
    • Evidence for gene-environment interactions in a linkage study of asthma and smoking exposure
    • Colilla S, Nicolae D, Pluzhnikov A, et al. Evidence for gene-environment interactions in a linkage study of asthma and smoking exposure. J Allergy Clin Immunol 2003; 111:840-846. This article provides convincing data for the existence of a gene-smoking interaction in a population of individuals selected for the phenotype of asthma.
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 840-846
    • Colilla, S.1    Nicolae, D.2    Pluzhnikov, A.3
  • 60
    • 15944367326 scopus 로고    scopus 로고
    • Allergens, viruses, and asthma exacerbations
    • Murray CS, Simpson A, Custovic A. Allergens, viruses, and asthma exacerbations. Proc Am Thorac Soc 2004; 1:99-104. Information regarding the association of viral infections with asthma exacerbations is provided in this article.
    • (2004) Proc Am Thorac Soc , vol.1 , pp. 99-104
    • Murray, C.S.1    Simpson, A.2    Custovic, A.3
  • 61
    • 1142299591 scopus 로고    scopus 로고
    • Haplotype mapping of the bronchiolitis susceptibility locus near IL8
    • Hull J, Rowlands K, Lockhart E, et al. Haplotype mapping of the bronchiolitis susceptibility locus near IL8. Hum Genet 2004; 114:272-279.
    • (2004) Hum Genet , vol.114 , pp. 272-279
    • Hull, J.1    Rowlands, K.2    Lockhart, E.3
  • 62
    • 0037364530 scopus 로고    scopus 로고
    • Beta2-adrenergic receptor polymorphisms in children with status asthmaticus
    • Binaei S, Christensen M, Murphy C, et al. Beta2-adrenergic receptor polymorphisms in children with status asthmaticus. Chest 2003; 123:375S.
    • (2003) Chest , vol.123
    • Binaei, S.1    Christensen, M.2    Murphy, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.