Antibiotic resistance profiles of coagulase-negative staphylococci in livestock environments

Veterinary Microbiology

Volumn 200, Issue , 2017, Pages 79-87

  Schoenfelder, Sonja M K ^a   Dong, Ying ^a   Feßler, Andrea T ^b   Schwarz, Stefan ^b   Schoen, Christoph ^c   Köck, Robin ^d   Ziebuhr, Wilma ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^c UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^d UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Antimicrobial resistance; CoNS; Livestock environment; S. sciuri

Indexed keywords

APRAMYCIN; CHLORAMPHENICOL; CIPROFLOXACIN; CLINDAMYCIN; COTRIMOXAZOLE; DAPTOMYCIN; DNA 16S; ERYTHROMYCIN; FLORFENICOL; FUSIDIC ACID; GENTAMICIN; LINEZOLID; MOXIFLOXACIN; OXACILLIN; PENICILLIN DERIVATIVE; PENICILLIN G; RIFAMPICIN; SPECTINOMYCIN; TEICOPLANIN; TETRACYCLINE; TETRACYCLINE DERIVATIVE; TIGECYCLINE; VANCOMYCIN; ANTIINFECTIVE AGENT;

AGRICULTURAL LAND; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; COAGULASE NEGATIVE STAPHYLOCOCCUS; CONTROLLED STUDY; DUST; ECOLOGICAL NICHE; GENE POOL; GERMANY; LIVESTOCK; MANURE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; NONHUMAN; PENICILLIN RESISTANCE; PIG FARMING; STAPHYLOCOCCUS SCIURI; ANIMAL; DRUG EFFECTS; GENETICS; ISOLATION AND PURIFICATION; MICROBIOLOGY; PIG; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS; VETERINARY;

ANIMALS; ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, BACTERIAL; GERMANY; LIVESTOCK; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS; SWINE;

EID: 84966702657     PISSN: 03781135     EISSN: 18732542     Source Type: Journal    
DOI: 10.1016/j.vetmic.2016.04.019     Document Type: Article

References (50)

1. Antignac, A., Tomasz, A., Reconstruction of the phenotypes of methicillin-resistant Staphylococcus aureus by replacement of the staphylococcal cassette chromosome mec with a plasmid-borne copy of Staphylococcus sciuri pbpD gene. Antimicrob. Agents Chemother. 53 (2009), 435–441.
2. Argudín, M.A., Tenhagen, B.A., Fetsch, A., Sachsenroder, J., Käsbohrer, A., Schroeter, A., Hammerl, J.A., Hertwig, S., Helmuth, R., Braunig, J., Mendoza, M.C., Appel, B., Rodicio, M.R., Guerra, B., Virulence and resistance determinants of German Staphylococcus aureus ST398 isolates from nonhuman sources. Appl. Environ. Microbiol. 77 (2011), 3052–3060.
3. Bayer, A.S., Schneider, T., Sahl, H.G., Mechanisms of daptomycin resistance in Staphylococcus aureus: role of the cell membrane and cell wall. Ann. N. Y. Acad. Sci. 1277 (2013), 139–158.
4. Becker, K., Ballhausen, B., Kock, R., Kriegeskorte, A., Methicillin resistance in Staphylococcus isolates: the mec alphabet with specific consideration of mecC, a mec homolog associated with zoonotic S. aureus lineages. Int. J. Med. Microbiol. 304 (2014), 794–804.
5. Bertsche, U., Yang, S.J., Kuehner, D., Wanner, S., Mishra, N.N., Roth, T., Nega, M., Schneider, A., Mayer, C., Grau, T., Bayer, A.S., Weidenmaier, C., Increased cell wall teichoic acid production and D-alanylation are common phenotypes among daptomycin-resistant methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates. PLoS One, 8, 2013, e67398.
6. Chambers, H.F., DeLeo, F.R., Waves of resistance: Staphylococcus aureus in the antibiotic era. Nat. Rev. Microbiol. 7 (2009), 629–641.
7. Chopra, I., Roberts, M., Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance. Microbiol Mol. Biol. Rev. 65 (2001), 232–260 (second page, table of contents).
8. Couto, I., Wu, S.W., Tomasz, A., de Lencastre, H., Development of methicillin resistance in clinical isolates of Staphylococcus sciuri by transcriptional activation of the mecA homologue native to the species. J. Bacteriol. 185 (2003), 645–653.
9. Dai, L., Wu, C.M., Wang, M.G., Wang, Y., Wang, Y., Huang, S.Y., Xia, L.N., Li, B.B., Shen, J.Z., First report of the multidrug resistance gene cfr and the phenicol resistance gene fexA in a Bacillus strain from swine feces. Antimicrob. Agents Chemother. 54 (2010), 3953–3955.
10. Feßler, A.T., Kadlec, K., Schwarz, S., Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates. Antimicrob. Agents Chemother. 55 (2011), 373–375.
11. Feßler, A.T., Calvo, N., Gutierrez, N., Munoz Bellido, J.L., Fajardo, M., Garduno, E., Monecke, S., Ehricht, R., Kadlec, K., Schwarz, S., Cfr-mediated linezolid resistance in methicillin-resistant Staphylococcus aureus and Staphylococcus haemolyticus associated with clinical infections in humans: two case reports. J. Antimicrob. Chemother. 69 (2014), 268–270.
12. Garcia-Cobos, S., Kock, R., Mellmann, A., Frenzel, J., Friedrich, A.W., Rossen, J.W., Molecular typing of Enterobacteriaceae from pig holdings in north-Western Germany reveals extended- spectrum and AmpC beta-Lactamases producing but no carbapenem resistant ones. PLoS One, 10, 2015, e0134533.
13. Harrison, E.M., Paterson, G.K., Holden, M.T., Ba, X., Rolo, J., Morgan, F.J., Pichon, B., Kearns, A., Zadoks, R.N., Peacock, S.J., Parkhill, J., Holmes, M.A., A novel hybrid SCCmec-mecC region in Staphylococcus sciuri. J. Antimicrob. Chemother. 69 (2014), 911–918.
14. Hauschild, T., Stepanovic, S., Dakic, I., Djukic, S., Ranin, L., Jezek, P., Schwarz, S., Tetracycline resistance and distribution of tet genes in members of the Staphylococcus sciuri group isolated from humans, animals and different environmental sources. Intern. J. Antimicrob. Agents 29 (2007), 356–358.
15. Hauschild, T., Feßler, A.T., Billerbeck, C., Wendlandt, S., Kaspar, H., Mankertz, J., Schwarz, S., Kadlec, K., Target gene mutations among methicillin-resistant Staphylococcus aureus and methicillin-susceptible S. aureus with elevated MICs of enrofloxacin obtained from diseased food-producing animals or food of animal origin. J. Antimicrob. Chemother. 67 (2012), 1791–1793.
16. Hayden, M.K., Rezai, K., Hayes, R.A., Lolans, K., Quinn, J.P., Weinstein, R.A., Development of Daptomycin resistance in vivo in methicillin-resistant Staphylococcus aureus. J. Clin. Microbiol. 43 (2005), 5285–5287.
17. He, T., Wang, Y., Schwarz, S., Zhao, Q., Shen, J., Wu, C., Genetic environment of the multi-resistance gene cfr in methicillin-resistant coagulase-negative staphylococci from chickens, ducks, and pigs in China. Int. J. Med. Microbiol. 304 (2014), 257–261.
18. Jamrozy, D.M., Coldham, N.G., Butaye, P., Fielder, M.D., Identification of a novel plasmid-associated spectinomycin adenyltransferase gene spd in methicillin-resistant Staphylococcus aureus ST398 isolated from animal and human sources. J. Antimicrob. Chemother. 69 (2014), 1193–1196.
19. Köck, R., Ballhausen, B., Bischoff, M., Cuny, C., Eckmanns, T., Fetsch, A., Harmsen, D., Goerge, T., Oberheitmann, B., Schwarz, S., Selhorst, T., Tenhagen, B.A., Walther, B., Witte, W., Ziebuhr, W., Becker, K., The burden of zoonotic MRSA colonization and infection in Germany. MRSA als Erreger von Zoonosen in Deutschland. Berliner und Münchener Tierärztliche Wochenschrift 9 (2014), 384–398.
20. Kadlec, K., van Duijkeren, E., Wagenaar, J.A., Schwarz, S., Molecular basis of rifampicin resistance in methicillin-resistant Staphylococcus pseudintermedius isolates from dogs. J. Antimicrob. Chemother. 66 (2011), 1236–1242.
21. Kadlec, K., Feßler, A.T., Couto, N., Pomba, C.F., Schwarz, S., Unusual small plasmids carrying the novel resistance genes dfrK or apmA isolated from methicillin-resistant or –susceptible staphylococci. J. Antimicrob. Chemother. 67 (2012), 2342–2345.
22. Kadlec, K., Feßler, A.T., Hauschild, T., Schwarz, S., Novel and uncommon antimicrobial resistance genes in livestock-associated methicillin-resistant Staphylococcus aureus. Clin. Microbiol. Infect. 18 (2012), 745–755.
23. Kehrenberg, C., Schwarz, S., fexA, a novel Staphylococcus lentus gene encoding resistance to florfenicol and chloramphenicol. Antimicrob. Agents Chemother. 48 (2004), 615–618.
24. Kehrenberg, C., Schwarz, S., Florfenicol-chloramphenicol exporter gene fexA is part of the novel transposon Tn558. Antimicrob. Agents Chemother. 49 (2005), 813–815.
25. Kehrenberg, C., Schwarz, S., Distribution of florfenicol resistance genes fexA and cfr among chloramphenicol-resistant Staphylococcus isolates. Antimicrob. Agents Chemother. 50 (2006), 1156–1163.
26. Kehrenberg, C., Ojo, K.K., Schwarz, S., Nucleotide sequence and organization of the multiresistance plasmid pSCFS1 from Staphylococcus sciuri. J. Antimicrob. Chemother. 54 (2004), 936–939.
27. Kehrenberg, C., Schwarz, S., Jacobsen, L., Hansen, L.H., Vester, B., A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503. Mol. Microbiol. 57 (2005), 1064–1073.
28. Kehrenberg, C., Aarestrup, F.M., Schwarz, S., IS21-558 insertion sequences are involved in the mobility of the multiresistance gene cfr. Antimicrob. Agents Chemother. 51 (2007), 483–487.
29. Kehrenberg, C., Cuny, C., Strommenger, B., Schwarz, S., Witte, W., Methicillin-resistant and −susceptible Staphylococcus aureus strains of clonal lineages ST398 and ST9 from swine carry the multidrug resistance gene cfr. Antimicrob. Agents Chemother. 53 (2009), 779–781.
30. Kresken, M., Hafner, D., Schmitz, F.J., Wichelhaus, T.A., 2010. The authors for the study group, Antibiotic resistance situation among clinically relevant pathogens in Germany and Central Europe. Multicenter study report of the working group ‘Susceptibility testing & resistance' of the Paul-Ehrlich-Society for Chemotherapy for the year 2007. In Antiinfective Intelligence, Rheinbach. http://www.p-e-g.org/resistenz/database/index.php.
31. Leclercq, R., Canton, R., Brown, D.F., Giske, C.G., Heisig, P., MacGowan, A.P., Mouton, J.W., Nordmann, P., Rodloff, A.C., Rossolini, G.M., Soussy, C.J., Steinbakk, M., Winstanley, T.G., Kahlmeter, G., EUCAST expert rules in antimicrobial susceptibility testing. Clin. Microbiol. Infect. 19 (2013), 141–160.
32. Li, J., Shao, B., Shen, J., Wang, S., Wu, Y., Occurrence of chloramphenicol-resistance genes as environmental pollutants from swine feedlots. Environ. Sci. Technol. 47 (2013), 2892–2897.
33. Li, D., Wu, C., Wang, Y., Fan, R., Schwarz, S., Zhang, S., Identification of multiresistance gene cfr in methicillin-resistant Staphylococcus aureus from pigs: plasmid location and integration into a staphylococcal cassette chromosome mec complex. Antimicrob. Agents Chemother. 59 (2015), 3641–3644.
34. Mendes, R.E., Deshpande, L.M., Castanheira, M., DiPersio, J., Saubolle, M.A., Jones, R.N., First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States. Antimicrob. Agents Chemother. 52 (2008), 2244–2246.
35. Michalopoulos, A.S., Livaditis, I.G., Gougoutas, V., The revival of fosfomycin. Int. J. Infect. Dis. 15 (2011), e732–739.
36. Milheirico, C., Oliveira, D.C., de Lencastre, H., Update to the multiplex PCR strategy for assignment of mec element types in Staphylococcus aureus. Antimicrob. Agents Chemother. 51 (2007), 3374–3377.
37. Murphy, E., Nucleotide sequence of a spectinomycin adenyltransferase AAD(9) determinant from Staphylococcus aureus and its relationship to AAD(3) (9). Mol. Gen. Genet. 200 (1985), 33–39.
38. Nemeghaire, S., Argudín, M.A., Feßler, A.T., Hauschild, T., Schwarz, S., Butaye, P., The ecological importance of the Staphylococcus sciuri species group as a reservoir for resistance and virulence genes. Vet. Microbiol. 171 (2014), 342–356.
39. Nemeghaire, S., Vanderhaeghen, W., Argudín, M.A., Haesebrouck, F., Butaye, P., Characterization of methicillin-resistant Staphylococcus sciuri isolates from industrially raised pigs, cattle and broiler chickens. J. Antimicrob. Chemother. 69 (2014), 2928–2934.
40. O'Neill, A.J., McLaws, F., Kahlmeter, G., Henriksen, A.S., Chopra, I., Genetic basis of resistance to fusidic acid in staphylococci. Antimicrob. Agents Chemother. 51 (2007), 1737–1740.
41. Peterson, L.R., A review of tigecycline–the first glycylcycline. Intern J Antimicrob 32:Suppl. 4 (2008), S215–222.
42. Schnellmann, C., Gerber, V., Rossano, A., Jaquier, V., Panchaud, Y., Doherr, M.G., Thomann, A., Straub, R., Perreten, V., Presence of new mecA and mph(C) variants conferring antibiotic resistance in Staphylococcus spp. isolated from the skin of horses before and after clinic admission. J. Clin. Microbiol. 44 (2006), 4444–4454.
43. Shen, J., Wang, Y., Schwarz, S., Presence and dissemination of the multiresistance gene cfr in Gram-positive and Gram-negative bacteria. J. Antimicrob. Chemother. 68 (2013), 1697–1706.
44. Skiest, D.J., Treatment failure resulting from resistance of Staphylococcus aureus to daptomycin. J. Clin. Microbiol. 44 (2006), 655–656.
45. Thompson, M.K., Keithly, M.E., Goodman, M.C., Hammer, N.D., Cook, P.D., Jagessar, K.L., Harp, J., Skaar, E.P., Armstrong, R.N., Structure and function of the genomically encoded fosfomycin resistance enzyme, FosB, from Staphylococcus aureus. Biochemistry 53 (2014), 755–765.
46. Wang, Y., Li, D., Song, L., Liu, Y., He, T., Liu, H., Wu, C., Schwarz, S., Shen, J., First report of the multiresistance gene cfr in Streptococcus suis. Antimicrob. Agents Chemother. 57 (2013), 4061–4063.
47. Wendlandt, S., Li, B., Lozano, C., Ma, Z., Torres, C., Schwarz, S., Identification of the novel spectinomycin resistance gene spw in methicillin-resistant and methicillin-susceptible Staphylococcus aureus of human and animal origin. J. Antimicrob. Chemother. 68 (2013), 1679–1680.
48. Wendlandt, S., Kadlec, K., Schwarz, S., Four novel plasmids from Staphylococcus hyicus and CoNS that carry a variant of the spectinomycin resistance gene spd. J. Antimicrob. Chemother. 70 (2015), 948–949.
49. Wendlandt, S., Shen, J., Kadlec, K., Wang, Y., Li, B., Zhang, W.J., Feßler, A.T., Wu, C., Schwarz, S., Multidrug resistance genes in staphylococci from animals that confer resistance to critically and highly important antimicrobial agents in human medicine. Trends Microbiol. 23 (2015), 44–54.
50. Witte, W., Cuny, C., Emergence and spread of cfr-mediated multiresistance in staphylococci: an interdisciplinary challenge. Future Microbiol. 6 (2011), 925–931.