Methicillin resistance in Staphylococcus isolates: The "mec alphabet" with specific consideration of mecC, a mec homolog associated with zoonotic S. aureus lineages

International Journal of Medical Microbiology

Volumn 304, Issue 7, 2014, Pages 794-804

  Becker, Karsten ^a   Ballhausen, Britta ^a   Köck, Robin ^a   Kriegeskorte, André ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Companion animal; Diagnostics; Livestock; MecC; Methicillin resistant Staphylococcus aureus; Wildlife animal; Zoonosis

Indexed keywords

BACTERIUM ISOLATION; DNA POLYMORPHISM; FOOD INDUSTRY; GEOGRAPHIC DISTRIBUTION; HUMAN; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL DIVERSITY; NONHUMAN; SHORT SURVEY; VETERINARY MEDICINE; ZOONOSIS; ANIMAL; BOVINE; DISEASE CARRIER; DRUG EFFECTS; EUROPE; GENETIC VARIABILITY; GENETICS; GENOTYPE; ISOLATION AND PURIFICATION; MICROBIOLOGY; MOLECULAR EPIDEMIOLOGY; PENICILLIN RESISTANCE; RODENT; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; TRANSMISSION; VETERINARY; ZOONOSES;

BACTERIAL PROTEIN;

ANIMALS; BACTERIAL PROTEINS; CATTLE; DISEASE RESERVOIRS; EUROPE; GENETIC VARIATION; GENOTYPE; HUMANS; METHICILLIN RESISTANCE; MOLECULAR EPIDEMIOLOGY; RODENTIA; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; ZOONOSES;

EID: 84927693497     PISSN: 14384221     EISSN: 16180607     Source Type: Journal    
DOI: 10.1016/j.ijmm.2014.06.007     Document Type: Short Survey

References (91)

1. Baba T., Kuwahara-Arai K., Uchiyama I., Takeuchi F., Ito T., Hiramatsu K. Complete genome sequence of Macrococcus caseolyticus strain JCSCS5402, reflecting the ancestral genome of the human-pathogenic staphylococci. J. Bacteriol. 2009, 191:1180-1190.
2. Ballhausen B., Kriegeskorte A., Kuhn D., Schleimer N., Peters G., Becker K. The mecA homolog mecC confers resistance against betalactams in Staphylococcus aureus irrespective of the genetic strain background. 3rd ASM-ESCMID Conference on MRSA in Animals 2013, 4.
3. Baos E., Candel F.J., Merino P., Pena I., Picazo J.J. Characterization and monitoring of linezolid-resistant clinical isolates of Staphylococcus epidermidis in an intensive care unit 4 years after an outbreak of infection by cfr-mediated linezolid-resistant Staphylococcus aureus. Diagn. Microbiol. Infect. Dis. 2013, 76:325-329.
4. Barbier F., Lebeaux D., Hernandez D., Delannoy A.S., Caro V., Francois P., Schrenzel J., Ruppe E., Gaillard K., Wolff M., Brisse S., Andremont A., Ruimy R. High prevalence of the arginine catabolic mobile element in carriage isolates of methicillin-resistant Staphylococcus epidermidis. J. Antimicrob. Chemother. 2011, 66:29-36.
5. Barraud O., Laurent F., François B., Bes M., Vignon P., Ploy M.C. Severe human bone infection due to methicillin-resistant Staphylococcus aureus carrying the novel mecC variant. J. Antimicrob. Chemother. 2013, 68:2949-2950.
6. Basset P., Prod'hom G., Senn L., Greub G., Blanc D.S. Very low prevalence of meticillin-resistant Staphylococcus aureus carrying the mecC gene in western Switzerland. J. Hosp. Infect. 2013, 83:257-259.
7. Becker K., Larsen A.R., Skov R.L., Paterson G.K., Holmes M.A., Sabat A.J., Friedrich A.W., Köck R., Peters G., Kriegeskorte A. Evaluation of a modular multiplex-PCR methicillin-resistant Staphylococcus aureus (MRSA) detection assay adapted for mecC detection. J. Clin. Microbiol. 2013, 51:1917-1919.
8. Becker K., von Eiff C. Fehlendes Leerzeichen hinter: Staphylococcus, Micrococcus, and other catalase-positive cocci. Manual of Clinical Microbiology 2011, ASM Press, Washington, DC. J. Versalovic, K.C. Carroll, G. Funke, J.H. Jorgensen, M.L. Landry, D.W. Warnock (Eds.).
9. Boundy S., Safo M.K., Wang L., Musayev F.N., O'Farrell H.C., Rife J.P., Archer G.L. Characterization of the Staphylococcus aureus rRNA methyltransferase encoded by orfX, the gene containing the staphylococcal chromosome cassette mec (SCCmec) insertion site. J. Biol. Chem. 2013, 288:132-140.
10. Brakstad O.G., Aasbakk K., Maeland J.A. Detection of Staphylococcus aureus by polymerase chain reaction amplification of the nuc gene. J. Clin. Microbiol. 1992, 30:1654-1660.
11. Cherifi S., Byl B., Deplano A., Nonhoff C., Denis O., Hallin M. Comparative epidemiology of Staphylococcus epidermidis isolates from patients with catheter-related bacteremia and from healthy volunteers. J. Clin. Microbiol. 2013, 51:1541-1547.
12. Couto I., de Lencastre H., Severina E., Kloos W., Webster J.A., Hubner R.J., Sanches I.S., Tomasz A. Ubiquitous presence of a mecA homologue in natural isolates of Staphylococcus sciuri. Microb. Drug Resist. 1996, 2:377-391.
13. Cuny C., Layer F., Strommenger B., Witte W. Rare occurrence of methicillin-resistant Staphylococcus aureus CC130 with a novel mecA homologue in humans in Germany. PLoS ONE 2011, 6:e24360.
14. Donnio P.Y., Oliveira D.C., Faria N.A., Wilhelm N., Le Coustumier A., de Lencastre H. Partial excision of the chromosomal cassette containing the methicillin resistance determinant results in methicillin-susceptible Staphylococcus aureus. J. Clin. Microbiol. 2005, 43:4191-4193.
15. Eriksson J., Espinosa-Gongora C., Stamphoj I., Larsen A.R., Guardabassi L. Carriage frequency, diversity and methicillin resistance of Staphylococcus aureus in Danish small ruminants. Vet. Microbiol. 2013, 163:110-115.
16. Espinosa-Gongora C., Harrison E.M., Moodley A., Guardabassi L., Holmes M.A. Methicillin-resistant Staphylococcus aureus carrying mecC in captive mara. 3rd ASM-ESCMID Conference on MRSA in Animals 2013, (abstract).
17. Feßler A.T., Calvo N., Gutiérrez N., Muñoz Bellido J.L., Fajardo M., Garduño E., Monecke S., Ehricht R., Kadlec K., Schwarz S. Cfr-mediated linezolid resistance in methicillin-resistant Staphylococcus aureus and Staphylococcus haemolyticus associated with clinical infections in humans: two case reports. J. Antimicrob. Chemother. 2014, 69:268-270.
18. Ganesan A., Crawford K., Mende K., Murray C.K., Lloyd B., Ellis M., Tribble D.R., Weintrob A.C. Evaluation for a novel methicillin resistance (mecC) homologue in methicillin-resistant Staphylococcus aureus isolates obtained from injured military personnel. J. Clin. Microbiol. 2013, 51:3073-3075.
19. García-Álvarez M., Holden M.T., Lindsay H., Webb C.R., Brown D.F., Curran M.D., Walpole E., Brooks K., Pickard D.J., Teale C., Parkhill J., Bentley S.D., Edwards G.F., Girvan E.K., Kearns A.M., Pichon B., Hill R.L., Larsen A.R., Skov R.L., Peacock S.J., Maskell D.J., Holmes M.A. Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study. Lancet Infect. Dis. 2011, 11:595-603.
20. García-Garrote F., Cercenado E., Marín M., Bal M., Trincado P., Corredoira J., Ballesteros C., Pita J., Alonso P., Vindel A. Methicillin-resistant Staphylococcus aureus carrying the mecC gene: emergence in Spain and report of a fatal case of bacteraemia. J. Antimicrob. Chemother. 2014, 69:45-50.
21. Gindonis V., Taponen S., Myllyniemi A.L., Pyörälä S., Nykäsenoja S., Salmenlinna S., Lindholm L., Rantala M. Occurrence and characterization of methicillin-resistant staphylococci from bovine mastitis milk samples in Finland. Acta Vet. Scand. 2013, 55:61.
22. Goering R.V., McDougal L.K., Fosheim G.E., Bonnstetter K.K., Wolter D.J., Tenover F.C. Epidemiologic distribution of the arginine catabolic mobile element among selected methicillin-resistant and methicillin-susceptible Staphylococcus aureus isolates. J. Clin. Microbiol. 2007, 45:1981-1984.
23. Harrison E.M., Paterson G.K., Holden M.T., Ba X., Rolo J., Morgan F.J., Pichon B., Kearns A., Zadoks R.N., Peacock S.J., Parkhill J., Holmes M.A. A novel hybrid SCCmec-mecC region in Staphylococcus sciuri. J. Antimicrob. Chemother. 2014, 69:911-918.
24. Harrison E.M., Paterson G.K., Holden M.T., Morgan F.J., Larsen A.R., Petersen A., Leroy S., De Vliegher S., Perreten V., Fox L.K., Lam T.J., Sampimon O.C., Zadoks R.N., Peacock S.J., Parkhill J., Holmes M.A. A Staphylococcus xylosus isolate with a new mecC allotype. Antimicrob. Agents Chemother. 2013, 57:1524-1528.
25. Hartman B.J., Tomasz A. Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus. J. Bacteriol. 1984, 158:513-516.
26. Hiramatsu K., Asada K., Suzuki E., Okonogi K., Yokota T. Molecular cloning and nucleotide sequence determination of the regulator region of mecA gene in methicillin-resistant Staphylococcus aureus (MRSA). FEBS Lett. 1992, 298:133-136.
27. Hiramatsu K., Katayama Y., Yuzawa H., Ito T. Molecular genetics of methicillin-resistant Staphylococcus aureus. Int. J. Med. Microbiol. 2002, 292:67-74.
28. Huletsky A., Giroux R., Rossbach V., Gagnon M., Vaillancourt M., Bernier M., Gagnon F., Truchon K., Bastien M., Picard F.J., van Belkum A., Ouellette M., Roy P.H., Bergeron M.G. New real-time PCR assay for rapid detection of methicillin-resistant Staphylococcus aureus directly from specimens containing a mixture of staphylococci. J. Clin. Microbiol. 2004, 42:1875-1884.
29. Hussain M., von Eiff C., Sinha B., Joost I., Herrmann M., Peters G., Becker K. eap Gene as novel target for specific identification of Staphylococcus aureus. J. Clin. Microbiol. 2008, 46:470-476.
30. International Working Group on the Classification of Staphylococcal Cassette Chromosome Elements (IWG-SCC) Classification of staphylococcal cassette chromosome mec (SCCmec): guidelines for reporting novel SCCmec elements. Antimicrob. Agents Chemother. 2009, 53:4961-4967.
31. Ito T., Hiramatsu K., Tomasz A., de Lencastre H., Perreten V., Holden M.T., Coleman D.C., Goering R., Giffard P.M., Skov R.L., Zhang K., Westh H., O'Brien F., Tenover F.C., Oliveira D.C., Boyle-Vavra S., Laurent F., Kearns A.M., Kreiswirth B., Ko K.S., Grundmann H., Sollid J.E., John J.F., Daum R., Soderquist B., Buist G. Guidelines for reporting novel mecA gene homologues. Antimicrob. Agents Chemother. 2012, 56:4997-4999.
32. Ito T., Katayama Y., Asada K., Mori N., Tsutsumimoto K., Tiensasitorn C., Hiramatsu K. Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 2001, 45:1323-1336.
33. Iwao Y., Takano T., Higuchi W., Yamamoto T. A new staphylococcal cassette chromosome mec IV encoding a novel cell-wall-anchored surface protein in a major ST8 community-acquired methicillin-resistant Staphylococcus aureus clone in Japan. J. Infect. Chemother. 2012, 18:96-104.
34. Jørgensen H.J., Mørk T., Caugant D.A., Kearns A., Rørvik L.M. Genetic variation among Staphylococcus aureus strains from Norwegian bulk milk. Appl. Environ. Microbiol. 2005, 71:8352-8361.
35. Katayama Y., Ito T., Hiramatsu K. A new class of genetic element, staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus. Antimicrob. Agents Chemother. 2000, 44:1549-1555.
36. Katayama Y., Takeuchi F., Ito T., Ma X.X., Ui-Mizutani Y., Kobayashi I., Hiramatsu K. Identification in methicillin-susceptible Staphylococcus hominis of an active primordial mobile genetic element for the staphylococcal cassette chromosome mec of methicillin-resistant Staphylococcus aureus. J. Bacteriol. 2003, 185:2711-2722.
37. Kim C., Milheirico C., Gardete S., Holmes M.A., Holden M.T., de Lencastre H., Tomasz A. Properties of a novel PBP2A protein homolog from Staphylococcus aureus strain LGA251 and its contribution to the β-lactam-resistant phenotype. J. Biol. Chem. 2012, 287:36854-36863.
38. Kinnevey P.M., Shore A.C., Brennan G.I., Sullivan D.J., Ehricht R., Monecke S., Coleman D.C. Extensive genetic diversity identified among sporadic methicillin-resistant Staphylococcus aureus isolates recovered in Irish hospitals between 2000 and 2012. Antimicrob. Agents Chemother. 2014, 58:1907-1917.
39. Kloos W.E., Ballard D.N., George C.G., Webster J.A., Hubner R.J., Ludwig W., Schleifer K.H., Fiedler F., Schubert K. Delimiting the genus Staphylococcus through description of Macrococcus caseolyticus gen. nov., comb. nov. and Macrococcus equipercicus sp. nov., and Macrococcus bovicus sp. no. and Macrococcus carouselicus sp. nov. Int. J. Syst. Bacteriol. 1998, 48(Pt 3):859-877.
40. Kriegeskorte A., Ballhausen B., Idelevich E.A., Köck R., Friedrich A.W., Karch H., Peters G., Becker K. Human MRSA isolates with novel genetic homolog, Germany. Emerg. Infect. Dis. 2012, 18:1016-1018.
41. Lamers R.P., Muthukrishnan G., Castoe T.A., Tafur S., Cole A.M., Parkinson C.L. Phylogenetic relationships among Staphylococcus species and refinement of cluster groups based on multilocus data. BMC Evol. Biol. 2012, 12:171.
42. Laurent F., Chardon H., Haenni M., Bes M., Reverdy M.E., Madec J.Y., Lagier E., Vandenesch F., Tristan A. MRSA harboring mecA variant gene mecC, France. Emerg. Infect. Dis. 2012, 18:1465-1467.
43. Loncaric I., Kübber-Heiss A., Posautz A., Stalder G.L., Hoffmann D., Rosengarten R., Walzer C. Characterization of methicillin-resistant Staphylococcus spp. carrying the mecC gene, isolated from wildlife. J. Antimicrob. Chemother. 2013, 68:2222-2225.
44. Long K.S., Poehlsgaard J., Kehrenberg C., Schwarz S., Vester B. The Cfr rRNA methyltransferase confers resistance to phenicols, lincosamides, oxazolidinones, pleuromutilins, and streptogramin A antibiotics. Antimicrob. Agents Chemother. 2006, 50:2500-2505.
45. Luong T.T., Ouyang S., Bush K., Lee C.Y. Type 1 capsule genes of Staphylococcus aureus are carried in a staphylococcal cassette chromosome genetic element. J. Bacteriol. 2002, 184:3623-3629.
46. Matsuhashi M., Song M.D., Ishino F., Wachi M., Doi M., Inoue M., Ubukata K., Yamashita N., Konno M. Molecular cloning of the gene of a penicillin-binding protein supposed to cause high resistance to beta-lactam antibiotics in Staphylococcus aureus. J. Bacteriol. 1986, 167:975-980.
47. Medhus A., Slettemeås J.S., Marstein L., Larssen K.W., Sunde M. Methicillin-resistant Staphylococcus aureus with the novel mecC gene variant isolated from a cat suffering from chronic conjunctivitis. J. Antimicrob. Chemother. 2012, 68:968-969.
48. Medhus A., Slettemeås J.S., Marstein L., Larssen K.W., Sunde M. Methicillin-resistant Staphylococcus aureus with the novel mecC gene variant isolated from a cat suffering from chronic conjunctivitis. J. Antimicrob. Chemother. 2013, 68:968-969.
49. Meemken D., Blaha T., Hotzel H., Strommenger B., Klein G., Ehricht R., Monecke S., Kehrenberg C. Genotypic and phenotypic characterization of Staphylococcus aureus isolates from wild boars. Appl. Environ. Microbiol. 2013, 79:1739-1742.
50. Miragaia M., Couto I., de Lencastre H. Genetic diversity among methicillin-resistant Staphylococcus epidermidis (MRSE). Microb. Drug Resist. 2005, 11:83-93.
51. Miragaia M., de Lencastre H., Perdreau-Remington F., Chambers H.F., Higashi J., Sullam P.M., Lin J., Wong K.I., King K.A., Otto M., Sensabaugh G.F., Diep B.A. Genetic diversity of arginine catabolic mobile element in Staphylococcus epidermidis. PLoS ONE 2009, 4:e7722.
52. Monecke S., Bandt D., Coleman D.C., Gavier-Widen D., Hotzel H., Lazaris A., Mattsson R., Peters M., Rangstrup-Christensen L., Schlotter K., Shore A.C., Ehricht R. Host range and distribution of mecC positive CC130 MRSA. 3rd ASM-ESCMID Conference on MRSA in Animals 2013, (abstract).
53. Monecke S., Engelmann I., Archambault M., Coleman D.C., Coombs G.W., Cortez de Jäckel S., Pelletier-Jacques G., Schwarz S., Shore A.C., Slickers P., Ehricht R. Distribution of SCCmec-associated phenol-soluble modulin in staphylococci. Mol. Cell Probes 2012, 26:99-103.
54. Monecke S., Gavier-Widen D., Mattsson R., Rangstrup-Christensen L., Lazaris A., Coleman D.C., Shore A.C., Ehricht R. Detection of mecC-positive Staphylococcus aureus (CC130-MRSA-XI) in diseased European hedgehogs (Erinaceus europaeus) in Sweden. PLoS ONE 2013, 8:e66166.
55. Monecke S., Müller E., Schwarz S., Hotzel H., Ehricht R. Rapid microarray-based identification of different mecA alleles in staphylococci. Antimicrob. Agents Chemother. 2012, 56:5547-5554.
56. Mongkolrattanothai K., Boyle S., Murphy T.V., Daum R.S. Novel non-mecA-containing staphylococcal chromosomal cassette composite island containing pbp4 and tagF genes in a commensal staphylococcal species: a possible reservoir for antibiotic resistance islands in Staphylococcus aureus. Antimicrob. Agents Chemother. 2004, 48:1823-1836.
57. Paterson G.K., Harrison E.M., Holmes M.A. The emergence of mecC methicillin-resistant Staphylococcus aureus. Trends Microbiol. 2014, 22:42-47.
58. LGA251, is present in methicillin-resistant Staphylococcus aureus isolates from a diverse range of host species. J. Antimicrob. Chemother. 2012, 67:2809-2813.
59. Paterson G.K., Morgan F.J., Harrison E.M., Cartwright E.J., Török M.E., Zadoks R.N., Parkhill J., Peacock S.J., Holmes M.A. Prevalence and characterization of human mecC methicillin-resistant Staphylococcus aureus isolates in England. J. Antimicrob. Chemother. 2014, (in press).
60. Paterson G.K., Morgan F.J., Harrison E.M., Peacock S.J., Parkhill J., Zadoks R.N., Holmes M.A. Prevalence and properties of mecC methicillin-resistant Staphylococcus aureus (MRSA) in bovine bulk tank milk in Great Britain. J. Antimicrob. Chemother. 2014, 69:598-602.
61. Petersen A., Stegger M., Heltberg O., Christensen J., Zeuthen A., Knudsen L.K., Urth T., Sorum M., Schouls L., Larsen J., Skov R., Larsen A.R. Epidemiology of methicillin-resistant Staphylococcus aureus carrying the novel mecC gene in Denmark corroborates a zoonotic reservoir with transmission to humans. Clin. Microbiol. Infect. 2013, 19:E16-E22.
62. LGA251. J. Antimicrob. Chemother. 2012, 67:2338-2341.
63. Queck S.Y., Khan B.A., Wang R., Bach T.H., Kretschmer D., Chen L., Kreiswirth B.N., Peschel A., DeLeo F.R., Otto M. Mobile genetic element-encoded cytolysin connects virulence to methicillin resistance in MRSA. PLoS Pathog. 2009, 5:e1000533.
64. Romero-Gómez M.P., Mora-Rillo M., Lázaro-Perona F., Gómez-Gil M.R., Mingorance J. Bacteraemia due to meticillin-resistant Staphylococcus aureus carrying the mecC gene in a patient with urothelial carcinoma. J. Med. Microbiol. 2013, 62:1914-1916.
65. Rubin J.E., Chirino-Trejo M. Inducibly cefoxitin-resistant Macrococcus-like organism falsely identified as methicillin-resistant Staphylococcus aureus on CHROMagar with oxacillin. J. Clin. Microbiol. 2010, 48:3037-3038.
66. Ruppé E., Barbier F., Mesli Y., Maiga A., Cojocaru R., Benkhalfat M., Benchouk S., Hassaine H., Maiga I., Diallo A., Koumaré A.K., Ouattara K., Soumaré S., Dufourcq J.B., Nareth C., Sarthou J.L., Andremont A., Ruimy R. Diversity of staphylococcal cassette chromosome mec structures in methicillin-resistant Staphylococcus epidermidis and Staphylococcus haemolyticus strains among outpatients from four countries. Antimicrob. Agents Chemother. 2009, 53:442-449.
67. Sabat A.J., Koksal M., Akkerboom V., Monecke S., Kriegeskorte A., Hendrix R., Ehricht R., Köck R., Becker K., Friedrich A.W. Detection of new methicillin-resistant Staphylococcus aureus strains that carry a novel genetic homologue and important virulence determinants. J. Clin. Microbiol. 2012, 50:3374-3377.
68. Schaumburg F., Köck R., Mellmann A., Richter L., Hasenberg F., Kriegeskorte A., Friedrich A.W., Gatermann S., Peters G., von Eiff C., Becker K. Population dynamics among methicillin resistant Staphylococcus aureus in Germany during a 6-year period. J. Clin. Microbiol. 2012, 50:3186-3192.
69. Schnellmann C., Gerber V., Rossano A., Jaquier V., Panchaud Y., Doherr M.G., Thomann A., Straub R., Perreten V. Presence of new mecA and mph(C) variants conferring antibiotic resistance in Staphylococcus spp. isolated from the skin of horses before and after clinic admission. J. Clin. Microbiol. 2006, 44:4444-4454.
70. Schwarz S., Werckenthin C., Kehrenberg C. Identification of a plasmid-borne chloramphenicol-florfenicol resistance gene in Staphylococcus sciuri. Antimicrob. Agents Chemother. 2000, 44:2530-2533.
71. Shore A.C., Coleman D.C. Staphylococcal cassette chromosome mec: recent advances and new insights. Int. J. Med. Microbiol. 2013, 303:350-359.
72. Shore A.C., Deasy E.C., Slickers P., Brennan G., O'Connell B., Monecke S., Ehricht R., Coleman D.C. Detection of staphylococcal cassette chromosome mec type XI encoding highly divergent mecA, mecI, mecR1, blaZ and ccr genes in human clinical clonal complex 130 methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 2011, 55:3765-3773.
73. Shore A.C., Rossney A.S., Brennan O.M., Kinnevey P.M., Humphreys H., Sullivan D.J., Goering R.V., Ehricht R., Monecke S., Coleman D.C. Characterization of a novel arginine catabolic mobile element (ACME) and staphylococcal chromosomal cassette mec composite island with significant homology to Staphylococcus epidermidis ACME type II in methicillin-resistant Staphylococcus aureus genotype ST22-MRSA-IV. Antimicrob. Agents Chemother. 2011, 55:1896-1905.
74. Shore A.C., Rossney A.S., O'Connell B., Herra C.M., Sullivan D.J., Humphreys H., Coleman D.C. Detection of staphylococcal cassette chromosome mec-associated DNA segments in multiresistant methicillin-susceptible Staphylococcus aureus (MSSA) and identification of Staphylococcus epidermidis ccrAB4 in both methicillin-resistant S. aureus and MSSA. Antimicrob. Agents Chemother. 2008, 52:4407-4419.
75. Simpson V.R., Davison N.J., Kearns A.M., Pichon B., Hudson L.O., Koylass M., Blackett T., Butler H., Rasigade J.P., Whatmore A.M. Association of a lukM-positive clone of Staphylococcus aureus with fatal exudative dermatitis in red squirrels (Sciurus vulgaris). Vet. Microbiol. 2013, 162:987-991.
76. Skov R., Larsen A.R., Kearns A., Holmes M., Teale C., Edwards G., Hill R. Phenotypic detection of mecC-MRSA: cefoxitin is more reliable than oxacillin. J. Antimicrob. Chemother. 2014, 69:133-135.
77. Sung J.M., Lloyd D.H., Lindsay J.A. Staphylococcus aureus host specificity: comparative genomics of human versus animal isolates by multi-strain microarray. Microbiology 2008, 154:1949-1959.
78. Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y., Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C., Hiramatsu K. Whole-genome sequencing of Staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species. J. Bacteriol. 2005, 187:7292-7308.
79. Tamura K., Stecher G., Peterson D., Filipski A., Kumar S. MEGA6: molecular evolutionary genetics analysis version 6.0. Mol. Biol. Evol. 2013, 30:2725-2729.
80. Tesch W., Ryffel C., Strässle A., Kayser F.H., Berger-Bächi B. Evidence of a novel staphylococcal mec-encoded element (mecR) controlling expression of penicillin-binding protein 2'. Antimicrob. Agents Chemother. 1990, 34:1703-1706.
81. Tsubakishita S., Kuwahara-Arai K., Baba T., Hiramatsu K. Staphylococcal cassette chromosome mec-like element in Macrococcus caseolyticus. Antimicrob. Agents Chemother. 2010, 54:1469-1475.
82. Tsubakishita S., Kuwahara-Arai K., Sasaki T., Hiramatsu K. Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. Antimicrob. Agents Chemother. 2010, 54:4352-4359.
83. Ubukata K., Nonoguchi R., Matsuhashi M., Konno M. Expression and inducibility in Staphylococcus aureus of the mecA gene, which encodes a methicillin-resistant S. aureus-specific penicillin-binding protein. J. Bacteriol. 1989, 171:2882-2885.
84. Ubukata K., Nonoguchi R., Song M.D., Matsuhashi M., Konno M. Homology of mecA gene in methicillin-resistant Staphylococcus haemolyticus and Staphylococcus simulans to that of Staphylococcus aureus. Antimicrob. Agents Chemother. 1990, 34:170-172.
85. Unnerstad H.E., Bengtsson B., Horn af Rantzien M., Börjesson S. Methicillin-resistant Staphylococcus aureus containing mecC in Swedish dairy cows. Acta Vet. Scand. 2013, 55:6.
86. van de Giessen A.W., van Santen-Verheuvel M.G., Hengeveld P.D., Bosch T., Broens E.M., Reusken C.B. Occurrence of methicillin-resistant Staphylococcus aureus in rats living on pig farms. Prev. Vet. Med. 2009, 91:270-273.
87. Vandendriessche S., Vanderhaeghen W., Soares F.V., Hallin M., Catry B., Hermans K., Butaye P., Haesebrouck F., Struelens M.J., Denis O. Prevalence, risk factors and genetic diversity of methicillin-resistant Staphylococcus aureus carried by humans and animals across livestock production sectors. J. Antimicrob. Chemother. 2013, 68:1510-1516.
88. Walther B., Wieler L.H., Vincze S., Antão E.M., Brandenburg A., Stamm I., Kopp P.A., Kohn B., Semmler T., Lübke-Becker A. MRSA variant in companion animals. Emerg. Infect. Dis. 2012, 18:2017-2020.
89. Wu S., de Lencastre H., Tomasz A. Genetic organization of the mecA region in methicillin-susceptible and methicillin-resistant strains of Staphylococcus sciuri. J. Bacteriol. 1998, 180:236-242.
90. Wu S., Piscitelli C., de Lencastre H., Tomasz A. Tracking the evolutionary origin of the methicillin resistance gene: cloning and sequencing of a homologue of mecA from a methicillin susceptible strain of Staphylococcus sciuri. Microb. Drug Resist. 1996, 2:435-441.
91. Zong Z., Peng C., Lü X. Diversity of SCCmec elements in methicillin-resistant coagulase-negative staphylococci clinical isolates. PLoS ONE 2011, 6:e20191.