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Volumn 127, Issue 2, 2017, Pages 99-108

Brain biometals and Alzheimer's disease–boon or bane?

Author keywords

Alzheimer's disease; amyloid ; metal neurotoxicity; oxidative stress

Indexed keywords

ALUMINUM; COPPER; IRON; MAGNESIUM; MANGANESE; METAL; ZINC; TRACE ELEMENT;

EID: 84966615005     PISSN: 00207454     EISSN: 15635279     Source Type: Journal    
DOI: 10.3109/00207454.2016.1174118     Document Type: Review
Times cited : (52)

References (97)
  • 1
    • 77954132249 scopus 로고    scopus 로고
    • Amyloid-[beta]-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
    • Palop JJ, Mucke L. Amyloid-[beta]-induced neuronal dysfunction in Alzheimer's disease:from synapses toward neural networks. Nat Neurosci 2010;13:812–8.
    • (2010) Nat Neurosci , vol.13 , pp. 812-818
    • Palop, J.J.1    Mucke, L.2
  • 2
    • 84864471159 scopus 로고    scopus 로고
    • A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
    • Jonsson T, Atwal JK, Steinberg S, et al. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature 2012;488:96–9.
    • (2012) Nature , vol.488 , pp. 96-99
    • Jonsson, T.1    Atwal, J.K.2    Steinberg, S.3
  • 3
    • 70349558522 scopus 로고    scopus 로고
    • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
    • Harold D, Abraham R, Hollingworth P, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet 2009;41:1088–93.
    • (2009) Nat Genet , vol.41 , pp. 1088-1093
    • Harold, D.1    Abraham, R.2    Hollingworth, P.3
  • 4
    • 35948933394 scopus 로고    scopus 로고
    • Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins
    • Ray S, Britschgi M, Herbert C, et al. Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins. Nat Med 2007;13:1359–62.
    • (2007) Nat Med , vol.13 , pp. 1359-1362
    • Ray, S.1    Britschgi, M.2    Herbert, C.3
  • 5
    • 67349213205 scopus 로고    scopus 로고
    • Synaptic degeneration in Alzheimer's disease
    • Arendt T., Synaptic degeneration in Alzheimer's disease. Acta Neuropathol 2009;118:167–79.
    • (2009) Acta Neuropathol , vol.118 , pp. 167-179
    • Arendt, T.1
  • 6
    • 79959252555 scopus 로고    scopus 로고
    • Function and comorbidities of apolipoprotein e in Alzheimer's disease
    • Leduc V, Domenger D, De Beaumont L, et al. Function and comorbidities of apolipoprotein e in Alzheimer's disease. Int J Alzheimers Dis 2011;2011:974361.
    • (2011) Int J Alzheimers Dis , vol.2011 , pp. 974361
    • Leduc, V.1    Domenger, D.2    De Beaumont, L.3
  • 7
    • 84896978402 scopus 로고    scopus 로고
    • Apolipoprotein E gene polymorphism and serum lipid profile in Saudi patients with psoriasis
    • Al Harthi F, Huraib GB, Zouman A, et al. Apolipoprotein E gene polymorphism and serum lipid profile in Saudi patients with psoriasis. Dis Markers 2014;2014:239645.
    • (2014) Dis Markers , vol.2014 , pp. 239645
    • Al Harthi, F.1    Huraib, G.B.2    Zouman, A.3
  • 8
    • 84863337843 scopus 로고    scopus 로고
    • Alzheimer mechanisms and therapeutic strategies
    • Huang Y, Mucke L. Alzheimer mechanisms and therapeutic strategies. Cell 2012;148:1204–22.
    • (2012) Cell , vol.148 , pp. 1204-1222
    • Huang, Y.1    Mucke, L.2
  • 9
    • 58049202374 scopus 로고    scopus 로고
    • Oxidative stress signaling in Alzheimers disease
    • Su B, Wang X, Nunomura A, et al. Oxidative stress signaling in Alzheimers disease. Curr Alzheimer Res 2008;5:525–32.
    • (2008) Curr Alzheimer Res , vol.5 , pp. 525-532
    • Su, B.1    Wang, X.2    Nunomura, A.3
  • 10
    • 77953675879 scopus 로고    scopus 로고
    • Probing the biology of Alzheimer's disease in mice
    • Ashe KH, Zahs KR. Probing the biology of Alzheimer's disease in mice. Neuron 2010;66:631–45.
    • (2010) Neuron , vol.66 , pp. 631-645
    • Ashe, K.H.1    Zahs, K.R.2
  • 11
    • 84655164280 scopus 로고    scopus 로고
    • The role of metallobiology and amyloid‐β peptides in Alzheimer's disease
    • Roberts BR, Ryan TM, Bush AI, et al. The role of metallobiology and amyloid‐β peptides in Alzheimer's disease. J Neurochem 2012;120:149–66.
    • (2012) J Neurochem , vol.120 , pp. 149-166
    • Roberts, B.R.1    Ryan, T.M.2    Bush, A.I.3
  • 12
    • 78449282609 scopus 로고    scopus 로고
    • Metals, oxidative stress and neurodegenerative disorders
    • Jomova K, Vondrakova D, Lawson M, et al. Metals, oxidative stress and neurodegenerative disorders. Mol Cell Biochem 2010;345:91–104.
    • (2010) Mol Cell Biochem , vol.345 , pp. 91-104
    • Jomova, K.1    Vondrakova, D.2    Lawson, M.3
  • 13
    • 80455137197 scopus 로고    scopus 로고
    • Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases
    • Breydo L, Uversky VN. Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases. Metallomics 2011;3:1163–80.
    • (2011) Metallomics , vol.3 , pp. 1163-1180
    • Breydo, L.1    Uversky, V.N.2
  • 14
    • 84885588060 scopus 로고    scopus 로고
    • Accelerated tau aggregation, apoptosis and neurological dysfunction caused by chronic oral administration of aluminum in a mouse model of tauopathies
    • Oshima E, Ishihara T, Yokota O, et al. Accelerated tau aggregation, apoptosis and neurological dysfunction caused by chronic oral administration of aluminum in a mouse model of tauopathies. Brain Pathol 2013;23:633–44.
    • (2013) Brain Pathol , vol.23 , pp. 633-644
    • Oshima, E.1    Ishihara, T.2    Yokota, O.3
  • 15
    • 84890095304 scopus 로고    scopus 로고
    • Histological study of the effects of aluminium chloride exposure on the testis of Wistar rats
    • Buraimoh AA, Ojo SA, Hambolu JO, et al. Histological study of the effects of aluminium chloride exposure on the testis of Wistar rats. Am Int J Contemp Res 2012;2:114–22.
    • (2012) Am Int J Contemp Res , vol.2 , pp. 114-122
    • Buraimoh, A.A.1    Ojo, S.A.2    Hambolu, J.O.3
  • 16
    • 0014046826 scopus 로고
    • Neuropathological aspects of brain edema
    • Klatzo I. Neuropathological aspects of brain edema. J Neuropathol Exp Neurol 1967;26:1–14.
    • (1967) J Neuropathol Exp Neurol , vol.26 , pp. 1-14
    • Klatzo, I.1
  • 17
    • 0018906175 scopus 로고
    • Intranuclear aluminum content in Alzheimer's disease, dialysis encephalopathy, and experimental aluminum encephalopathy
    • Crapper D, Quittkat S, Krishnan S, et al. Intranuclear aluminum content in Alzheimer's disease, dialysis encephalopathy, and experimental aluminum encephalopathy. Acta Neuropathol 1980;50:19–24.
    • (1980) Acta Neuropathol , vol.50 , pp. 19-24
    • Crapper, D.1    Quittkat, S.2    Krishnan, S.3
  • 18
    • 33751107948 scopus 로고    scopus 로고
    • Aluminium and iron, but neither copper nor zinc, are key to the precipitation of β-sheets of Aβ 42 in senile plaque cores in Alzheimer's disease
    • Exley C., Aluminium and iron, but neither copper nor zinc, are key to the precipitation of β-sheets of Aβ 42 in senile plaque cores in Alzheimer's disease. J Alzheimers Dis 2006;10:173–7.
    • (2006) J Alzheimers Dis , vol.10 , pp. 173-177
    • Exley, C.1
  • 19
    • 3042666730 scopus 로고    scopus 로고
    • Aluminium, iron, zinc and copper influence the in vitro formation of amyloid fibrils of Abeta42 in a manner which may have consequences for metal chelation therapy in Alzheimer's disease
    • House E, Collingwood J, Khan A, et al. Aluminium, iron, zinc and copper influence the in vitro formation of amyloid fibrils of Abeta42 in a manner which may have consequences for metal chelation therapy in Alzheimer's disease. J Alzheimers Dis. 2004;6:291–301.
    • (2004) J Alzheimers Dis , vol.6 , pp. 291-301
    • House, E.1    Collingwood, J.2    Khan, A.3
  • 20
    • 33745316086 scopus 로고    scopus 로고
    • Severe cerebral congophilic angiopathy coincident with increased brain aluminium in a resident of Camelford, Cornwall, UK
    • Exley C, Esiri M. Severe cerebral congophilic angiopathy coincident with increased brain aluminium in a resident of Camelford, Cornwall, UK. J Neurol Neurosurg Psychiatry 2006;77:877–9.
    • (2006) J Neurol Neurosurg Psychiatry , vol.77 , pp. 877-879
    • Exley, C.1    Esiri, M.2
  • 21
    • 79955394531 scopus 로고    scopus 로고
    • Link between aluminum and the pathogenesis of Alzheimer's disease: the integration of the aluminum and amyloid cascade hypotheses
    • Kawahara M, Kato-Negishi M. Link between aluminum and the pathogenesis of Alzheimer's disease:the integration of the aluminum and amyloid cascade hypotheses. Int J Alzheimers Dis 2011;2011:276393.
    • (2011) Int J Alzheimers Dis , vol.2011 , pp. 276393
    • Kawahara, M.1    Kato-Negishi, M.2
  • 22
    • 81355123407 scopus 로고    scopus 로고
    • Aluminum induces neurodegeneration and its toxicity arises from increased iron accumulation and reactive oxygen species (ROS) production
    • 199
    • Wu Z, Du Y, Xue H, et al. Aluminum induces neurodegeneration and its toxicity arises from increased iron accumulation and reactive oxygen species (ROS) production. Neurobiol Aging 2012;33:199/e1–12.
    • (2012) Neurobiol Aging , vol.33 , pp. e1-e12
    • Wu, Z.1    Du, Y.2    Xue, H.3
  • 23
    • 84871803726 scopus 로고    scopus 로고
    • Possible relationship between Al/ferritin complex and Alzheimer's disease
    • De Sole P, Rossi C, Chiarpotto M, et al. Possible relationship between Al/ferritin complex and Alzheimer's disease. Clin Biochem 2013;46:89–93.
    • (2013) Clin Biochem , vol.46 , pp. 89-93
    • De Sole, P.1    Rossi, C.2    Chiarpotto, M.3
  • 24
    • 0033998274 scopus 로고    scopus 로고
    • Absorption of aluminium-26 in Alzheimer's disease, measured using accelerator mass spectrometry
    • Moore PB, Day JP, Taylor GA, et al. Absorption of aluminium-26 in Alzheimer's disease, measured using accelerator mass spectrometry. Dement Geriatr Cogn Disord 2000;11:66–9.
    • (2000) Dement Geriatr Cogn Disord , vol.11 , pp. 66-69
    • Moore, P.B.1    Day, J.P.2    Taylor, G.A.3
  • 25
    • 0742322782 scopus 로고    scopus 로고
    • Chronic exposure to aluminum in drinking water increases inflammatory parameters selectively in the brain
    • Campbell A, Becaria A, Lahiri D, et al. Chronic exposure to aluminum in drinking water increases inflammatory parameters selectively in the brain. J Neurosci Res 2004;75:565–72.
    • (2004) J Neurosci Res , vol.75 , pp. 565-572
    • Campbell, A.1    Becaria, A.2    Lahiri, D.3
  • 26
    • 54249163572 scopus 로고    scopus 로고
    • Aluminum modulates effects of β amyloid1-42 on neuronal calcium homeostasis and mitochondria functioning and is altered in a triple transgenic mouse model of Alzheimer's disease
    • Drago D, Cavaliere A, Mascetra N, et al. Aluminum modulates effects of β amyloid1-42 on neuronal calcium homeostasis and mitochondria functioning and is altered in a triple transgenic mouse model of Alzheimer's disease. Rejuvenation Res 2008;11:861–71.
    • (2008) Rejuvenation Res , vol.11 , pp. 861-871
    • Drago, D.1    Cavaliere, A.2    Mascetra, N.3
  • 27
    • 15944418620 scopus 로고    scopus 로고
    • The aluminium-amyloid cascade hypothesis and Alzheimer's disease
    • Exley C., The aluminium-amyloid cascade hypothesis and Alzheimer's disease. Subcell Biochem 2005;38:225–34.
    • (2005) Subcell Biochem , vol.38 , pp. 225-234
    • Exley, C.1
  • 28
    • 60149098848 scopus 로고    scopus 로고
    • Aluminum and silica in drinking water and the risk of Alzheimer's disease or cognitive decline: findings from 15-year follow-up of the PAQUID cohort
    • Rondeau V, Jacqmin-Gadda H, Commenges D, et al. Aluminum and silica in drinking water and the risk of Alzheimer's disease or cognitive decline:findings from 15-year follow-up of the PAQUID cohort. Am J Epidemiol 2009;169:489–96.
    • (2009) Am J Epidemiol , vol.169 , pp. 489-496
    • Rondeau, V.1    Jacqmin-Gadda, H.2    Commenges, D.3
  • 30
    • 70350220417 scopus 로고    scopus 로고
    • Zinc in the physiology and pathology of the CNS
    • Sensi SL, Paoletti P, Bush AI, et al. Zinc in the physiology and pathology of the CNS. Nat Rev Neurosci 2009;10:780–91.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 780-791
    • Sensi, S.L.1    Paoletti, P.2    Bush, A.I.3
  • 33
    • 84875196486 scopus 로고    scopus 로고
    • The SLC30 family of zinc transporters–a review of current understanding of their biological and pathophysiological roles
    • Huang L, Tepaamorndech S. The SLC30 family of zinc transporters–a review of current understanding of their biological and pathophysiological roles. Mol Aspects Med 2013;34:548–60.
    • (2013) Mol Aspects Med , vol.34 , pp. 548-560
    • Huang, L.1    Tepaamorndech, S.2
  • 34
    • 70449627047 scopus 로고    scopus 로고
    • Insight into zinc signaling from dietary zinc deficiency
    • Takeda A, Tamano H. Insight into zinc signaling from dietary zinc deficiency. Brain Res Rev 2009;62:33–44.
    • (2009) Brain Res Rev , vol.62 , pp. 33-44
    • Takeda, A.1    Tamano, H.2
  • 35
    • 84864532442 scopus 로고    scopus 로고
    • Metal ions and amyloid fiber formation in neurodegenerative diseases. Copper, zinc and iron in Alzheimer's, Parkinson's and prion diseases
    • Viles JH., Metal ions and amyloid fiber formation in neurodegenerative diseases. Copper, zinc and iron in Alzheimer's, Parkinson's and prion diseases. Coord Chem Rev 2012;256:2271–84.
    • (2012) Coord Chem Rev , vol.256 , pp. 2271-2284
    • Viles, J.H.1
  • 36
    • 80053627394 scopus 로고    scopus 로고
    • Zinc stimulates tau S214 phosphorylation by the activation of Raf/mitogen-activated protein kinase-kinase/extracellular signal-regulated kinase pathway
    • Kim I, Park EJ, Seo J, et al. Zinc stimulates tau S214 phosphorylation by the activation of Raf/mitogen-activated protein kinase-kinase/extracellular signal-regulated kinase pathway. Neuroreport 2011;22:839–44.
    • (2011) Neuroreport , vol.22 , pp. 839-844
    • Kim, I.1    Park, E.J.2    Seo, J.3
  • 37
    • 84883447761 scopus 로고    scopus 로고
    • Peripherally applied synthetic peptide isoAsp7-Aβ (1-42) triggers cerebral β-amyloidosis
    • Kozin S, Cheglakov I, Ovsepyan A, et al. Peripherally applied synthetic peptide isoAsp7-Aβ (1-42) triggers cerebral β-amyloidosis. Neurotox Res 2013;24:370–6.
    • (2013) Neurotox Res , vol.24 , pp. 370-376
    • Kozin, S.1    Cheglakov, I.2    Ovsepyan, A.3
  • 38
    • 76149093866 scopus 로고    scopus 로고
    • Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer's disease?
    • Adlard PA, Parncutt JM, Finkelstein DI, Bush AI. Cognitive loss in zinc transporter-3 knock-out mice:a phenocopy for the synaptic and memory deficits of Alzheimer's disease? J Neurosci 2010;30:1631–6.
    • (2010) J Neurosci , vol.30 , pp. 1631-1636
    • Adlard, P.A.1    Parncutt, J.M.2    Finkelstein, D.I.3    Bush, A.I.4
  • 39
    • 0033844944 scopus 로고    scopus 로고
    • Characterization of copper interactions with Alzheimer apeptides: identification of an attomolar affinity copper binding site on A1-42
    • Atwood CS, Scarpa RC, Huang X, et al. Characterization of copper interactions with Alzheimer apeptides:identification of an attomolar affinity copper binding site on A1-42. J Neurochem 2000;75:1219–33.
    • (2000) J Neurochem , vol.75 , pp. 1219-1233
    • Atwood, C.S.1    Scarpa, R.C.2    Huang, X.3
  • 40
    • 0032507975 scopus 로고    scopus 로고
    • Copper, iron and zinc in Alzheimer's disease senile plaques
    • Lovell M, Robertson J, Teesdale W, et al. Copper, iron and zinc in Alzheimer's disease senile plaques. J Neurol Sci 1998;158:47–52.
    • (1998) J Neurol Sci , vol.158 , pp. 47-52
    • Lovell, M.1    Robertson, J.2    Teesdale, W.3
  • 41
    • 38849184781 scopus 로고    scopus 로고
    • Barriers to palliative care for children: perceptions of pediatric health care providers
    • Davies B, Sehring SA, Partridge JC, et al. Barriers to palliative care for children:perceptions of pediatric health care providers. Pediatrics 2008;121:282–8.
    • (2008) Pediatrics , vol.121 , pp. 282-288
    • Davies, B.1    Sehring, S.A.2    Partridge, J.C.3
  • 42
    • 84875740221 scopus 로고    scopus 로고
    • Astrocyte functions in the copper homeostasis of the brain
    • Scheiber IF, Dringen R. Astrocyte functions in the copper homeostasis of the brain. Neurochem Int 2013;62:556–65.
    • (2013) Neurochem Int , vol.62 , pp. 556-565
    • Scheiber, I.F.1    Dringen, R.2
  • 43
    • 0042890397 scopus 로고    scopus 로고
    • Methods for studying synaptosomal copper release
    • Hopt A, Korte S, Fink H, et al. Methods for studying synaptosomal copper release. J Neurosci Methods 2003;128:159–72.
    • (2003) J Neurosci Methods , vol.128 , pp. 159-172
    • Hopt, A.1    Korte, S.2    Fink, H.3
  • 44
    • 77955092432 scopus 로고    scopus 로고
    • Zinc prevents the copper-induced damage of cultured astrocytes
    • Scheiber IF, Schmidt MM, Dringen R. Zinc prevents the copper-induced damage of cultured astrocytes. Neurochem Int 2010;57:314–22.
    • (2010) Neurochem Int , vol.57 , pp. 314-322
    • Scheiber, I.F.1    Schmidt, M.M.2    Dringen, R.3
  • 45
    • 37049007204 scopus 로고    scopus 로고
    • Copper and manganese induce yeast apoptosis via different pathways
    • Liang Q, Zhou B. Copper and manganese induce yeast apoptosis via different pathways. Mol Biol Cell 2007;18:4741–9.
    • (2007) Mol Biol Cell , vol.18 , pp. 4741-4749
    • Liang, Q.1    Zhou, B.2
  • 47
    • 84863337843 scopus 로고    scopus 로고
    • Alzheimer mechanisms and therapeutic strategies
    • Huang Y, Mucke L. Alzheimer mechanisms and therapeutic strategies. Cell 2012;148:1204–22.
    • (2012) Cell , vol.148 , pp. 1204-1222
    • Huang, Y.1    Mucke, L.2
  • 48
    • 84873355344 scopus 로고    scopus 로고
    • Copper (I)-α-synuclein interaction: structural description of two independent and competing metal binding sites
    • Camponeschi F, Valensin D, Tessari I, et al. Copper (I)-α-synuclein interaction:structural description of two independent and competing metal binding sites. Inorg Chem 2013;52:1358–67.
    • (2013) Inorg Chem , vol.52 , pp. 1358-1367
    • Camponeschi, F.1    Valensin, D.2    Tessari, I.3
  • 49
    • 84949094362 scopus 로고    scopus 로고
    • Removing carbonyl sulfide with metal-modified activated carbon
    • Qiu J, Ning P, Wang X, et al. Removing carbonyl sulfide with metal-modified activated carbon. Frontiers Environ Sci Eng 2014;10:11–8.
    • (2014) Frontiers Environ Sci Eng , vol.10 , pp. 11-18
    • Qiu, J.1    Ning, P.2    Wang, X.3
  • 50
    • 84881031036 scopus 로고    scopus 로고
    • Metal concentrations in sediments from tourist beaches of Miri City, Sarawak, Malaysia (Borneo Island)
    • Nagarajan R, Jonathan M, Roy PD, et al. Metal concentrations in sediments from tourist beaches of Miri City, Sarawak, Malaysia (Borneo Island). Mar Pollut Bull 2013;73:369–73.
    • (2013) Mar Pollut Bull , vol.73 , pp. 369-373
    • Nagarajan, R.1    Jonathan, M.2    Roy, P.D.3
  • 51
    • 79955675293 scopus 로고    scopus 로고
    • Copper in Alzheimer's disease: a meta-analysis of serum, plasma, and cerebrospinal fluid studies
    • Bucossi S, Ventriglia M, Panetta V, et al. Copper in Alzheimer's disease:a meta-analysis of serum, plasma, and cerebrospinal fluid studies. J Alzheimers Dis 2011;24:175–85.
    • (2011) J Alzheimers Dis , vol.24 , pp. 175-185
    • Bucossi, S.1    Ventriglia, M.2    Panetta, V.3
  • 52
    • 84884905903 scopus 로고    scopus 로고
    • Manganese neurotoxicity and the role of reactive oxygen species
    • Martinez-Finley EJ, Gavin CE, Aschner M, et al. Manganese neurotoxicity and the role of reactive oxygen species. Free Radic Biol Med 2013;62:65–75.
    • (2013) Free Radic Biol Med , vol.62 , pp. 65-75
    • Martinez-Finley, E.J.1    Gavin, C.E.2    Aschner, M.3
  • 53
    • 84858129031 scopus 로고    scopus 로고
    • In vivo manganese exposure modulates Erk, Akt and Darpp-32 in the striatum of developing rats, and impairs their motor function
    • Cordova FM, Aguiar Jr AS, Peres TV, et al. In vivo manganese exposure modulates Erk, Akt and Darpp-32 in the striatum of developing rats, and impairs their motor function. PLOS One 2012;7:e33057.
    • (2012) PLOS One , vol.7 , pp. e33057
    • Cordova, F.M.1    Aguiar Jr, A.S.2    Peres, T.V.3
  • 54
    • 77956229051 scopus 로고    scopus 로고
    • APLP1, Alzheimer's-like pathology and neurodegeneration in the frontal cortex of manganese-exposed non-human primates
    • Guilarte TR., APLP1, Alzheimer's-like pathology and neurodegeneration in the frontal cortex of manganese-exposed non-human primates. Neurotoxicology 2010;31:572–4.
    • (2010) Neurotoxicology , vol.31 , pp. 572-574
    • Guilarte, T.R.1
  • 55
    • 34248999831 scopus 로고    scopus 로고
    • Manganese: recent advances in understanding its transport and neurotoxicity
    • Aschner M, Guilarte TR, Schneider JS, Zheng W. Manganese:recent advances in understanding its transport and neurotoxicity. Toxicol Appl Pharmacol 2007;221:131–47.
    • (2007) Toxicol Appl Pharmacol , vol.221 , pp. 131-147
    • Aschner, M.1    Guilarte, T.R.2    Schneider, J.S.3    Zheng, W.4
  • 56
    • 34249092704 scopus 로고    scopus 로고
    • Calcium and neurodegeneration
    • Mattson MP., Calcium and neurodegeneration. Aging Cell 2007;6:337–50.
    • (2007) Aging Cell , vol.6 , pp. 337-350
    • Mattson, M.P.1
  • 57
    • 79955846348 scopus 로고    scopus 로고
    • In vivo measurement of brain GABA concentrations by magnetic resonance spectroscopy in smelters occupationally exposed to manganese
    • Dydak U, Jiang Y-M, Long L-L, et al. In vivo measurement of brain GABA concentrations by magnetic resonance spectroscopy in smelters occupationally exposed to manganese. Environ Health Perspect 2011;119:219–24.
    • (2011) Environ Health Perspect , vol.119 , pp. 219-224
    • Dydak, U.1    Jiang, Y.-M.2    Long, L.-L.3
  • 58
    • 33747178918 scopus 로고    scopus 로고
    • Speciation of manganese in cells and mitochondria: a search for the proximal cause of manganese neurotoxicity
    • Gunter TE, Gavin CE, Aschner M, Gunter KK. Speciation of manganese in cells and mitochondria:a search for the proximal cause of manganese neurotoxicity. Neurotoxicology 2006;27:765–76.
    • (2006) Neurotoxicology , vol.27 , pp. 765-776
    • Gunter, T.E.1    Gavin, C.E.2    Aschner, M.3    Gunter, K.K.4
  • 59
    • 1842556556 scopus 로고    scopus 로고
    • Oxidative basis of manganese neurotoxicity
    • Hamai D, Bondy SC. Oxidative basis of manganese neurotoxicity. Ann New York Acad Sci 2004;1012:129–41.
    • (2004) Ann New York Acad Sci , vol.1012 , pp. 129-141
    • Hamai, D.1    Bondy, S.C.2
  • 60
    • 67650487089 scopus 로고    scopus 로고
    • Manganese disrupts astrocyte glutamine transporter expression and function
    • Sidoryk‐Węgrzynowicz M, Lee E, Albrecht J, Aschner M. Manganese disrupts astrocyte glutamine transporter expression and function. J Neurochem 2009;110:822–30.
    • (2009) J Neurochem , vol.110 , pp. 822-830
    • Sidoryk‐Węgrzynowicz, M.1    Lee, E.2    Albrecht, J.3    Aschner, M.4
  • 61
    • 84921370581 scopus 로고    scopus 로고
    • Respiratory manganese particle size, time-course and neurobehavioral outcomes in workers at a manganese alloy production plant
    • Park RM, Bouchard MF, Baldwin M, et al. Respiratory manganese particle size, time-course and neurobehavioral outcomes in workers at a manganese alloy production plant. Neurotoxicology 2014;45:276–84.
    • (2014) Neurotoxicology , vol.45 , pp. 276-284
    • Park, R.M.1    Bouchard, M.F.2    Baldwin, M.3
  • 62
    • 82455199108 scopus 로고    scopus 로고
    • Motor function in adults of an Ohio community with environmental manganese exposure
    • Kim Y, Bowler RM, Abdelouahab N, et al. Motor function in adults of an Ohio community with environmental manganese exposure. Neurotoxicology 2011;32:606–14.
    • (2011) Neurotoxicology , vol.32 , pp. 606-614
    • Kim, Y.1    Bowler, R.M.2    Abdelouahab, N.3
  • 63
    • 79952260309 scopus 로고    scopus 로고
    • Mesoporous silica-coated hollow manganese oxide nanoparticles as positive T 1 contrast agents for labeling and MRI tracking of adipose-derived mesenchymal stem cells
    • Kim T, Momin E, Choi J, et al. Mesoporous silica-coated hollow manganese oxide nanoparticles as positive T 1 contrast agents for labeling and MRI tracking of adipose-derived mesenchymal stem cells. J Am Chem Soc 2011;133:2955–61.
    • (2011) J Am Chem Soc , vol.133 , pp. 2955-2961
    • Kim, T.1    Momin, E.2    Choi, J.3
  • 64
    • 1842504357 scopus 로고    scopus 로고
    • The metabolism of neuronal iron and its pathogenic role in neurological disease: review
    • Moos T, Morgan EH. The metabolism of neuronal iron and its pathogenic role in neurological disease:review. Ann New York Acad Sci 2004;1012:14–26.
    • (2004) Ann New York Acad Sci , vol.1012 , pp. 14-26
    • Moos, T.1    Morgan, E.H.2
  • 65
    • 84927125803 scopus 로고    scopus 로고
    • Ruthenium anticancer compounds with biologically‐derived ligands
    • Mu C, Walsby CJ. Ruthenium anticancer compounds with biologically‐derived ligands. In:Ligand design in medicinal inorganic chemistry. Chichester:John Wiley & Sons, Ltd; 2014. DOI:10.1002/9781118697191.ch15
    • (2014) Ligand design in medicinal inorganic chemistry
    • Mu, C.1    Walsby, C.J.2
  • 66
    • 62149099955 scopus 로고    scopus 로고
    • Clinical and genetic delineation of neurodegeneration with brain iron accumulation
    • Gregory A, Polster BJ, Hayflick SJ. Clinical and genetic delineation of neurodegeneration with brain iron accumulation. J Med Genet 2009;46:73–80.
    • (2009) J Med Genet , vol.46 , pp. 73-80
    • Gregory, A.1    Polster, B.J.2    Hayflick, S.J.3
  • 67
    • 84884824793 scopus 로고    scopus 로고
    • Magnesium in disease prevention and overall health
    • Volpe SL., Magnesium in disease prevention and overall health. Adv Nutr 2013;4:378S–83S.
    • (2013) Adv Nutr , vol.4 , pp. 378S-383S
    • Volpe, S.L.1
  • 68
    • 80054761323 scopus 로고    scopus 로고
    • Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral amygdala
    • Abumaria N, Yin B, Zhang L, et al. Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral amygdala. J Neurosci 2011;31:14871–81.
    • (2011) J Neurosci , vol.31 , pp. 14871-14881
    • Abumaria, N.1    Yin, B.2    Zhang, L.3
  • 69
    • 74549162377 scopus 로고    scopus 로고
    • Enhancement of learning and memory by elevating brain magnesium
    • Slutsky I, Abumaria N, Wu L-J, et al. Enhancement of learning and memory by elevating brain magnesium. Neuron 2010;65:165–77.
    • (2010) Neuron , vol.65 , pp. 165-177
    • Slutsky, I.1    Abumaria, N.2    Wu, L.-J.3
  • 70
    • 44549087765 scopus 로고    scopus 로고
    • Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior
    • Selkoe DJ., Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior. Behav Brain Res 2008;192:106–13.
    • (2008) Behav Brain Res , vol.192 , pp. 106-113
    • Selkoe, D.J.1
  • 71
    • 79957463048 scopus 로고    scopus 로고
    • Magnesium and anabolic hormones in older men
    • Maggio M, Ceda G, Lauretani F, et al. Magnesium and anabolic hormones in older men. Int J Androl 2011;34:e594–e600.
    • (2011) Int J Androl , vol.34 , pp. e594-e600
    • Maggio, M.1    Ceda, G.2    Lauretani, F.3
  • 72
    • 50449093260 scopus 로고    scopus 로고
    • A randomized, controlled trial of magnesium sulfate for the prevention of cerebral palsy
    • Rouse DJ, Hirtz DG, Thom E, et al. A randomized, controlled trial of magnesium sulfate for the prevention of cerebral palsy. N Engl J Med 2008;359:895–905.
    • (2008) N Engl J Med , vol.359 , pp. 895-905
    • Rouse, D.J.1    Hirtz, D.G.2    Thom, E.3
  • 73
    • 84904582549 scopus 로고    scopus 로고
    • Interactions of metals and apolipoprotein E in Alzheimer's disease
    • Xu H, Finkelstein DI, Adlard PA. Interactions of metals and apolipoprotein E in Alzheimer's disease. Front Aging Neurosci 2014;12:1–7.
    • (2014) Front Aging Neurosci , vol.12 , pp. 1-7
    • Xu, H.1    Finkelstein, D.I.2    Adlard, P.A.3
  • 74
    • 78349309559 scopus 로고    scopus 로고
    • Apolipoprotein E ablation decreases synaptic vesicular zinc in the brain
    • Lee J, Y Cho E, Kim TY, et al. Apolipoprotein E ablation decreases synaptic vesicular zinc in the brain. Biometals 2010;23:1085–95
    • (2010) Biometals , vol.23 , pp. 1085-1095
    • Lee, J.1    Y Cho, E.2    Kim, T.Y.3
  • 75
    • 33751074919 scopus 로고    scopus 로고
    • Metals and Alzheimer's disease
    • Adlard PA, Bush AI. Metals and Alzheimer's disease. J Alzheimers Dis 2006;10:145–63
    • (2006) J Alzheimers Dis , vol.10 , pp. 145-163
    • Adlard, P.A.1    Bush, A.I.2
  • 76
    • 7444268624 scopus 로고    scopus 로고
    • Essential trace metals and brain function
    • Takeda A., Essential trace metals and brain function. Yakugaku Zasshi 2004;124:577–85.
    • (2004) Yakugaku Zasshi , vol.124 , pp. 577-585
    • Takeda, A.1
  • 77
    • 0028915120 scopus 로고
    • Zinc deficiency causes oxidative damage to proteins, lipids and DNA in rat testes
    • Oteiza PI, Olin KL, Fraga CG, et al. Zinc deficiency causes oxidative damage to proteins, lipids and DNA in rat testes. J Nutr 1995;125:823–9.
    • (1995) J Nutr , vol.125 , pp. 823-829
    • Oteiza, P.I.1    Olin, K.L.2    Fraga, C.G.3
  • 78
    • 84878770600 scopus 로고    scopus 로고
    • Roles and therapeutic potential of metallothioneins in neurodegenerative diseases
    • Hozumi I., Roles and therapeutic potential of metallothioneins in neurodegenerative diseases. Curr Pharm Biotechnol 2013;14:408–13.
    • (2013) Curr Pharm Biotechnol , vol.14 , pp. 408-413
    • Hozumi, I.1
  • 80
    • 84884224309 scopus 로고    scopus 로고
    • The link between copper and Wilson's disease
    • Purchase R., The link between copper and Wilson's disease. Sci Prog 2013;96:213–23.
    • (2013) Sci Prog , vol.96 , pp. 213-223
    • Purchase, R.1
  • 81
    • 33746932518 scopus 로고    scopus 로고
    • Activation of superoxide dismutases: putting the metal to the pedal
    • Culotta VC, Yang M, O'Halloran TV. Activation of superoxide dismutases:putting the metal to the pedal. Biochim Biophys Acta 2006;1763:747–58.
    • (2006) Biochim Biophys Acta , vol.1763 , pp. 747-758
    • Culotta, V.C.1    Yang, M.2    O'Halloran, T.V.3
  • 82
    • 79961193678 scopus 로고    scopus 로고
    • Superoxide dismutases: role in redox signaling, vascular function, and diseases
    • Fukai T, Ushio-Fukai M. Superoxide dismutases:role in redox signaling, vascular function, and diseases. Antioxid Redox Signal 2011;15:1583–606.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 1583-1606
    • Fukai, T.1    Ushio-Fukai, M.2
  • 84
    • 84856044221 scopus 로고    scopus 로고
    • Neurodegeneration with brain iron accumulation - clinical syndromes and neuroimaging
    • Schipper HM., Neurodegeneration with brain iron accumulation - clinical syndromes and neuroimaging. Biochim Biophys Acta 2012;1822:350–60.
    • (2012) Biochim Biophys Acta , vol.1822 , pp. 350-360
    • Schipper, H.M.1
  • 85
    • 84920646171 scopus 로고    scopus 로고
    • A novel model for brain iron uptake: introducing the concept of regulation
    • Simpson IA, Ponnuru P, Klinger ME, et al. A novel model for brain iron uptake:introducing the concept of regulation. J Cereb Blood Flow Metab 2015;35:48–57.
    • (2015) J Cereb Blood Flow Metab , vol.35 , pp. 48-57
    • Simpson, I.A.1    Ponnuru, P.2    Klinger, M.E.3
  • 86
    • 33748569185 scopus 로고    scopus 로고
    • Distribution of the iron-regulating protein hepcidin in the murine central nervous system
    • Zechel S, Huber-Wittmer K, von Bohlen und Halbach O. Distribution of the iron-regulating protein hepcidin in the murine central nervous system. J Neurosci Res 2006;84:790–800.
    • (2006) J Neurosci Res , vol.84 , pp. 790-800
    • Zechel, S.1    Huber-Wittmer, K.2    von Bohlen und Halbach, O.3
  • 87
    • 0035153971 scopus 로고    scopus 로고
    • Iron biology in immune function, muscle metabolism and neuronal functioning
    • Beard JL., Iron biology in immune function, muscle metabolism and neuronal functioning. J Nutr 2001;131:568S–79S.
    • (2001) J Nutr , vol.131 , pp. 568S-579S
    • Beard, J.L.1
  • 88
    • 0029765553 scopus 로고    scopus 로고
    • Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides
    • Miyata M, Smith JD. Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides. Nat Genet 1996;14:55–61.
    • (1996) Nat Genet , vol.14 , pp. 55-61
    • Miyata, M.1    Smith, J.D.2
  • 89
    • 22244479388 scopus 로고    scopus 로고
    • Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis
    • Valentine JS, Doucette PA, Zittin Potter S. Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis. Annu Rev Biochem 2005;74:563–93.
    • (2005) Annu Rev Biochem , vol.74 , pp. 563-593
    • Valentine, J.S.1    Doucette, P.A.2    Zittin Potter, S.3
  • 90
    • 58049209924 scopus 로고    scopus 로고
    • Role of metal ions in the abeta oligomerization in Alzheimer's disease and in other neurological disorders
    • Drago D, Bolognin S, Zatta P. Role of metal ions in the abeta oligomerization in Alzheimer's disease and in other neurological disorders. Curr Alzheimer Res 2008;5:500–7.
    • (2008) Curr Alzheimer Res , vol.5 , pp. 500-507
    • Drago, D.1    Bolognin, S.2    Zatta, P.3
  • 91
    • 84903627065 scopus 로고    scopus 로고
    • Occupational exposure to aluminum and its amyloidogenic link with cognitive functions
    • Zawilla NH, Taha FM, Kishk NA, et al. Occupational exposure to aluminum and its amyloidogenic link with cognitive functions. J Inorg Biochem 2014;139:57–64.
    • (2014) J Inorg Biochem , vol.139 , pp. 57-64
    • Zawilla, N.H.1    Taha, F.M.2    Kishk, N.A.3
  • 92
    • 84861463152 scopus 로고    scopus 로고
    • APP/PS1 transgenic mice treated with aluminum: an update of Alzheimer's disease model
    • Zhang QL, Jia L, Jiao X, et al. APP/PS1 transgenic mice treated with aluminum:an update of Alzheimer's disease model. Int J Immunopathol Pharmacol 2012;25:49–58.
    • (2012) Int J Immunopathol Pharmacol , vol.25 , pp. 49-58
    • Zhang, Q.L.1    Jia, L.2    Jiao, X.3
  • 93
    • 77953940704 scopus 로고    scopus 로고
    • Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics
    • Duce JA, Bush AI. Biological metals and Alzheimer's disease:implications for therapeutics and diagnostics. Prog Neurobiol 2010;92:1–18.
    • (2010) Prog Neurobiol , vol.92 , pp. 1-18
    • Duce, J.A.1    Bush, A.I.2
  • 95
    • 84929353447 scopus 로고    scopus 로고
    • ApoE4 and Aβ Oligomers reduce BDNF expression via HDAC nuclear translocation
    • Sen A, Nelson TJ, Alkon DL. ApoE4 and Aβ Oligomers reduce BDNF expression via HDAC nuclear translocation. J Neurosci 2015;35:7538–51.
    • (2015) J Neurosci , vol.35 , pp. 7538-7551
    • Sen, A.1    Nelson, T.J.2    Alkon, D.L.3
  • 96
    • 84950325643 scopus 로고    scopus 로고
    • Zinc affects the proteolytic stability of apolipoprotein E in an isoform-dependent way
    • Xu H, Gupta VB, Martins IJ, et al. Zinc affects the proteolytic stability of apolipoprotein E in an isoform-dependent way. Neurobiol Dis 2015;81:38–48.
    • (2015) Neurobiol Dis , vol.81 , pp. 38-48
    • Xu, H.1    Gupta, V.B.2    Martins, I.J.3
  • 97
    • 44649174339 scopus 로고    scopus 로고
    • An observational study on the influence of the APOE-epsilon4 allele on the correlation between 'free' copper toxicosis and EEG activity in Alzheimer disease
    • Zappasodi F, Salustri C, Babiloni C, et al. An observational study on the influence of the APOE-epsilon4 allele on the correlation between 'free' copper toxicosis and EEG activity in Alzheimer disease. Brain Res 2008;1215:183–9.
    • (2008) Brain Res , vol.1215 , pp. 183-189
    • Zappasodi, F.1    Salustri, C.2    Babiloni, C.3


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