Effects of elevation of brain magnesium on fear conditioning, fear extinction, and synaptic plasticity in the infralimbic prefrontal cortex and lateral amygdala

Journal of Neuroscience

Volumn 31, Issue 42, 2011, Pages 14871-14881

  Abumaria, Nashat ^a   Yin, Bin ^a   Zhang, Ling ^a   Li, Xiang Yao ^b   Chen, Tao ^b   Descalzi, Giannina ^b   Zhao, Liangfang ^a   Ahn, Matae ^a   Luo, Lin ^a   Ran, Chen ^a   Zhuo, Min ^a   Liu, Guosong ^a,c  

^a Tsinghua University   (China)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; MAGNESIUM; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; BRAIN SLICE; CELL LEVEL; CONDITIONING; CONTROLLED STUDY; FEAR; IN VITRO STUDY; INFRALIMBIC PREFRONTAL CORTEX; LATERAL AMYGDALA; MALE; NERVE CELL PLASTICITY; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REINFORCEMENT; SIGNAL TRANSDUCTION;

AMYGDALA; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; BIOPHYSICS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CONDITIONING, CLASSICAL; CREB-BINDING PROTEIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXCITATORY POSTSYNAPTIC POTENTIALS; EXTINCTION, PSYCHOLOGICAL; FEAR; LONG-TERM POTENTIATION; MAGNESIUM; MAGNESIUM COMPOUNDS; MALE; PATCH-CLAMP TECHNIQUES; PREFRONTAL CORTEX; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION; SYNAPTOPHYSIN; TIME FACTORS;

EID: 80054761323     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3782-11.2011     Document Type: Article

References (46)

1. Akirav I, Maroun M (2006) Ventromedial prefrontal cortex is obligatory for consolidation and reconsolidation of object recognition memory. Cereb Cortex 16:1759-1765.
2. Alberini CM (2005) Mechanisms of memory stabilization: are consolidation and reconsolidation similar or distinct processes? Trends Neurosci 28:51-56.
3. Bauer EP, Schafe GE, Le Doux JE (2002) NMDA receptors and L-type voltage-gated calcium channels contribute to long-term potentiation and different components of fear memory formation in the lateral amygdala. J Neurosci 22:5239-5249.
4. Blanchard RJ, Blanchard DC (1969) Crouching as an index of fear. J Comp Physiol Psychol 67:370-375.
5. Bouton ME (1993) Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. Psychol Bull 114:80-99.
6. Corcoran KA, Quirk GJ (2007) Activity in prelimbic cortex is necessary for the expression of learned, but not innate, fears. J Neurosci 27:840-844.
7. Davis M (1992) The role of the amygdala in fear and anxiety. Annu Rev Neurosci 15:353-375.
8. Fanselow MS, Poulos AM (2005) The neuroscience of mammalian associative learning. Annu Rev Psychol 56:207-234.
9. Farinelli M, Deschaux O, Hugues S, Thevenet A, Garcia R (2006) Hippocampal train stimulation modulates recall of fear extinction independently of prefrontal cortex synaptic plasticity and lesions. Learn Mem 13:329-334.
10. Foa EB, Franklin ME, Moser J (2002) Context in the clinic: how well do cognitive-behavioral therapies and medications work in combination? Biol Psychiatry 52:987-997.
11. Gilmartin MR, Helmstetter FJ (2010) Trace and contextual fear conditioning require neural activity and NMDA receptor-dependent transmission in the medial prefrontal cortex. Learn Mem 17:289-296.
12. Han CJ, O'Tuathaigh CM, van Trigt L, Quinn JJ, Fanselow MS, Mongeau R, Koch C, Anderson DJ (2003) Trace but not delay fear conditioning requires attention and the anterior cingulate cortex. Proc Natl Acad Sci U S A 100:13087-13092.
13. Hawasli AH, Benavides DR, Nguyen C, Kansy JW, Hayashi K, Chambon P, Greengard P, Powell CM, Cooper DC, Bibb JA (2007) Cyclindependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation. Nat Neurosci 10:880-886.
14. Herry C, Ciocchi S, Senn V, DemmouL,Müller C, LüthiA (2008) Switching on and off fear by distinct neuronal circuits. Nature 454:600-606.
15. Hobin JA, Ji J, Maren S (2006) Ventral hippocampal muscimol disrupts context-specific fear memory retrieval after extinction in rats. Hippocampus 16:174-182.
16. Lebrón K, Milad MR, Quirk GJ (2004) Delayed recall of fear extinction in rats with lesions of ventral medial prefrontal cortex. Learn Mem 11: 544-548.
17. Le Doux JE (2000) Emotion circuits in the brain. Annu Rev Neurosci 23:155-184.
18. Maren S (2008) Pavlovian fear conditioning as a behavioral assay for hippocampus and amygdala function: cautions and caveats. Eur J Neurosci 28:1661-1666.
19. McEchron MD, Bouwmeester H, Tseng W, Weiss C, Disterhoft JF (1998) Hippocampectomy disrupts auditory trace fear conditioning and contextual fear conditioning in the rat. Hippocampus 8:638-646.
20. Milad MR, Quirk GJ (2002) Neurons in medial prefrontal cortex signal memory for fear extinction. Nature 420:70-74.
21. Misane I, Tovote P, Meyer M, Spiess J, Ogren SO, Stiedl O (2005) Timedependent involvement of the dorsal hippocampus in trace fear conditioning in mice. Hippocampus 15:418-426.
22. Miwa H, Fukaya M, Watabe AM, Watanabe M, Manabe T (2008) Functional contributions of synaptically localized NR2B subunits of the NMDA receptor to synaptic transmission and long-term potentiation in the adult mouse CNS. J Physiol 586:2539-2550.
23. Monfils MH, Cowansage KK, Klann E, Le Doux JE (2009) Extinctionreconsolidation boundaries: key to persistent attenuation of fear memories. Science 324:951-955.
24. Morgan MA, Le Doux JE (1995) Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats. Behav Neurosci 109:681-688.
25. Myers KM, Davis M (2007) Mechanisms of fear extinction. Mol Psychiatry 12:120-150.
26. Myers KM, Ressler KJ, Davis M (2006) Different mechanisms of fear extinction dependent on length of time since fear acquisition. Learn Mem 13:216-223.
27. Pavlov I (1927) Conditioned reflexes: an investigation of the physiological activity of the cerebral cortex. London: Oxford UP.
28. Peters J, Kalivas PW, Quirk GJ (2009) Extinction circuits for fear and addiction overlap in prefrontal cortex. Learn Mem 16:279-288.
29. Peters J, Dieppa-Perea LM, Melendez LM, Quirk GJ (2010) Induction of fear extinction with hippocampal-infralimbic BDNF. Science 328: 1288-1290.
30. Phelps EA, Delgado MR, Nearing KI, Le Doux JE (2004) Extinction learning in humans: role of the amygdala and vmPFC. Neuron 43:897-905.
31. Quirk GJ, Mueller D (2008) Neural mechanisms of extinction learning and retrieval. Neuropsychopharmacology 33:56-72.
32. Rauch SL, Shin LM, Phelps EA (2006) Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research-past, present, and future. Biol Psychiatry 60:376-382.
33. Rodrigues SM, Le Doux JE, Morrison JH (2000) Differential expression of the N-methyl-D-aspartate receptor NR2B subunit in the lateral nucleus divisions of the rat amygdala. Soc Neurosci Abstract 26:465.411.
34. Sanders MJ, Wiltgen BJ, Fanselow MS (2003) The place of the hippocampus in fear conditioning. Eur J Pharmacol 463:217-223.
35. Sierra-Mercado D, Padilla-Coreano N, Quirk GJ (2011) Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear. Neuropsychopharmacology 36:529-538.
36. Sigurdsson T, Doyère V, Cain CK, LeDoux JE (2007) Long-term potentiation in the amygdala: a cellular mechanism of fear learning and memory. Neuropharmacology 52:215-227.
37. Singewald N, Sinner C, Hetzenauer A, Sartori SB, Murck H (2004) Magnesium-deficient diet alters depression-and anxiety-related behavior in mice: influence of desipramine and Hypericum perforatum extract. Neuropharmacology 47:1189-1197.
38. Slutsky I, Sadeghpour S, Li B, Liu G (2004) Enhancement of synaptic plasticity through chronically reduced Ca2+flux during uncorrelated activity. Neuron 44:835-849.
39. Slutsky I, Abumaria N, Wu L, Huang C, Zhang L, Li B, Zhao X, Govindarajan A, Zhao MG, Zhuo M, Tonegawa S, Liu G (2010) Enhancement of learning and memory by elevating brain magnesium. Neuron 65: 165-177.
40. Solomon PR, Vander Schaaf ER, Thompson RF, Weisz DJ (1986) Hippocampus and trace conditioning of the rabbit's classically conditioned nictitating membrane response. Behav Neurosci 100:729-744.
41. Sotres-Bayon F, Quirk GJ (2010) Prefrontal control of fear: more than just extinction. Curr Opin Neurobiol 20:231-235.
42. Tang YP, Shimizu E, Dube GR, Rampon C, Kerchner GA, Zhuo M, Liu G, Tsien JZ (1999) Genetic enhancement of learning and memory in mice. Nature 401:63-69.
43. Weisskopf MG, Le Doux JE (1999) Distinct populations of NMDA receptors at subcortical and cortical inputs to principal cells of the lateral amygdala. J Neurophysiol 81:930-934.
44. Westbrook RF, Iordanova M, McNally G, Richardson R, Harris JA (2002) Reinstatement of fear to an extinguished conditioned stimulus: two roles for context. J Exp Psychol Anim Behav Process 28:97-110.
45. Whittle N, Hauschild M, Lubec G, Holmes A, Singewald N (2010) Rescue of impaired fear extinction and normalization of corticoamygdala circuit dysfunction in a genetic mouse model by dietary zinc restriction. J Neurosci 30:13586-13596.
46. Zhao MG, Toyoda H, Lee YS, Wu LJ, Ko SW, Zhang XH, Jia Y, Shum F, Xu H, Li BM, Kaang BK, Zhuo M (2005) Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Neuron 47:859-872.