Enhancement of Learning and Memory by Elevating Brain Magnesium

Neuron

Volumn 65, Issue 2, 2010, Pages 165-177

  Slutsky, Inna ^b,d   Abumaria, Nashat ^a   Wu, Long Jun ^c   Huang, Chao ^a   Zhang, Ling ^a   Li, Bo ^a   Zhao, Xiang ^a   Govindarajan, Arvind ^b   Zhao, Ming Gao ^c   Zhuo, Min ^c   Tonegawa, Susumu ^b   Liu, Guosong ^a,b  

^a Tsinghua University   (China)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

^d TEL AVIV UNIVERSITY   (Israel)

Author keywords

HUMDISEASE; MOLNEURO; SIGNALING

Indexed keywords

GLUCONATE MAGNESIUM; MAGNESIUM CHLORIDE; MAGNESIUM CITRATE; MAGNESIUM DERIVATIVE; MAGNESIUM ION; MAGNESIUM THREONATE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; SYNAPTOBREVIN; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

AGED; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN FUNCTION; BRAIN SLICE; CEREBROSPINAL FLUID; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LEARNING; LONG TERM MEMORY; LONG TERM POTENTIATION; MALE; MEMORY; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SHORT TERM MEMORY; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; UPREGULATION; WESTERN BLOTTING; WORKING MEMORY;

AGE FACTORS; ANIMALS; BRAIN; BRAIN CHEMISTRY; LEARNING; MAGNESIUM; MALE; MEMORY; PRESYNAPTIC TERMINALS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 74549162377     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuron.2009.12.026     Document Type: Article

References (52)

1. Abernethy M.H., and Fowler R.T. Micellar improvement of the calmagite compleximetric measurement of magnesium in plasma. Clin. Chem. 28 (1982) 520-522
2. Bardgett M.E., Schultheis P.J., McGill D.L., Richmond R.E., and Wagge J.R. Magnesium deficiency impairs fear conditioning in mice. Brain Res. 1038 (2005) 100-106
3. Barnes C.A. Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. J. Comp. Physiol. Psychol. 93 (1979) 74-104
4. Bi G.Q., and Poo M.M. Synaptic modifications in cultured hippocampal neurons: dependence on spike timing, synaptic strength, and postsynaptic cell type. J. Neurosci. 18 (1998) 10464-10472
5. Burke S.N., and Barnes C.A. Neural plasticity in the ageing brain. Nat. Rev. Neurosci. 7 (2006) 30-40
6. Chen K.S., Masliah E., Mallory M., and Gage F.H. Synaptic loss in cognitively impaired aged rats is ameliorated by chronic human nerve growth factor infusion. Neuroscience 68 (1995) 19-27
7. Clements J.D. Variance-mean analysis: a simple and reliable approach for investigating synaptic transmission and modulation. J. Neurosci. Methods 130 (2003) 115-125
8. Corman B., and Michel J.B. Glomerular filtration, renal blood flow, and solute excretion in conscious aging rats. Am. J. Physiol. 253 (1987) R555-R560
9. Diano S., Farr S.A., Benoit S.C., McNay E.C., da Silva I., Horvath B., Gaskin F.S., Nonaka N., Jaeger L.B., Banks W.A., et al. Ghrelin controls hippocampal spine synapse density and memory performance. Nat. Neurosci. 9 (2006) 381-388
10. Dudchenko P.A. How do animals actually solve the T maze?. Behav. Neurosci. 115 (2001) 850-860
11. Ennaceur A., and Delacour J. A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data. Behav. Brain Res. 31 (1988) 47-59
12. Ford E.S., and Mokdad A.H. Dietary magnesium intake in a national sample of US adults. J. Nutr. 133 (2003) 2879-2882
13. Fukushima H., Maeda R., Suzuki R., Suzuki A., Nomoto M., Toyoda H., Wu L.J., Xu H., Zhao M.G., Ueda K., et al. Upregulation of calcium/calmodulin-dependent protein kinase IV improves memory formation and rescues memory loss with aging. J. Neurosci. 28 (2008) 9910-9919
14. Gallagher M., and Rapp P.R. The use of animal models to study the effects of aging on cognition. Annu. Rev. Psychol. 48 (1997) 339-370
15. Geinisman Y., Ganeshina O., Yoshida R., Berry R.W., Disterhoft J.F., and Gallagher M. Aging, spatial learning, and total synapse number in the rat CA1 stratum radiatum. Neurobiol. Aging 25 (2004) 407-416
16. Gómez-Pinilla F. Brain foods: the effects of nutrients on brain function. Nat. Rev. Neurosci. 9 (2008) 568-578
17. Hawasli A.H., Benavides D.R., Nguyen C., Kansy J.W., Hayashi K., Chambon P., Greengard P., Powell C.M., Cooper D.C., and Bibb J.A. Cyclin-dependent kinase 5 governs learning and synaptic plasticity via control of NMDAR degradation. Nat. Neurosci. 10 (2007) 880-886
18. Katz B. The Release of Neural Transmitter Substances (1969), Liverpool University Press, Liverpool
19. Kim Y.J., McFarlane C., Warner D.S., Baker M.T., Choi W.W., and Dexter F. The effects of plasma and brain magnesium concentrations on lidocaine-induced seizures in the rat. Anesth. Analg. 83 (1996) 1223-1228
20. Landfield P.W., and Morgan G.A. Chronically elevating plasma Mg2+ improves hippocampal frequency potentiation and reversal learning in aged and young rats. Brain Res. 322 (1984) 167-171
21. Lee Y.S., and Silva A.J. The molecular and cellular biology of enhanced cognition. Nat. Rev. Neurosci. 10 (2009) 126-140
22. Li C., Brake W.G., Romeo R.D., Dunlop J.C., Gordon M., Buzescu R., Magarinos A.M., Allen P.B., Greengard P., Luine V., and McEwen B.S. Estrogen alters hippocampal dendritic spine shape and enhances synaptic protein immunoreactivity and spatial memory in female mice. Proc. Natl. Acad. Sci. USA 101 (2004) 2185-2190
23. Lichtenwalner R.J., Forbes M.E., Bennett S.A., Lynch C.D., Sonntag W.E., and Riddle D.R. Intracerebroventricular infusion of insulin-like growth factor-I ameliorates the age-related decline in hippocampal neurogenesis. Neuroscience 107 (2001) 603-613
24. Malinow R., and Tsien R.W. Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slices. Nature 346 (1990) 177-180
25. Mamiya T., Yamada K., Miyamoto Y., König N., Watanabe Y., Noda Y., and Nabeshima T. Neuronal mechanism of nociceptin-induced modulation of learning and memory: involvement of N-methyl-D-aspartate receptors. Mol. Psychiatry 8 (2003) 752-765
26. Manabe T., Noda Y., Mamiya T., Katagiri H., Houtani T., Nishi M., Noda T., Takahashi T., Sugimoto T., Nabeshima T., and Takeshima H. Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors. Nature 394 (1998) 577-581
27. Markram H., Lübke J., Frotscher M., and Sakmann B. Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs. Science 275 (1997) 213-215
28. Martin S.J., Grimwood P.D., and Morris R.G. Synaptic plasticity and memory: an evaluation of the hypothesis. Annu. Rev. Neurosci. 23 (2000) 649-711
29. Mayer M.L., Westbrook G.L., and Guthrie P.B. Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones. Nature 309 (1984) 261-263
30. McKee J.A., Brewer R.P., Macy G.E., Phillips-Bute B., Campbell K.A., Borel C.O., Reynolds J.D., and Warner D.S. Analysis of the brain bioavailability of peripherally administered magnesium sulfate: A study in humans with acute brain injury undergoing prolonged induced hypermagnesemia. Crit. Care Med. 33 (2005) 661-666
31. Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Methods 11 (1984) 47-60
32. Morris R.G., Anderson E., Lynch G.S., and Baudry M. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature 319 (1986) 774-776
33. Murnick J.G., Dubé G., Krupa B., and Liu G. High-resolution iontophoresis for single-synapse stimulation. J. Neurosci. Methods 116 (2002) 65-75
34. Nakazawa K., McHugh T.J., Wilson M.A., and Tonegawa S. NMDA receptors, place cells and hippocampal spatial memory. Nat. Rev. Neurosci. 5 (2004) 361-372
35. Nowak L., Bregestovski P., Ascher P., Herbet A., and Prochiantz A. Magnesium gates glutamate-activated channels in mouse central neurones. Nature 307 (1984) 462-465
36. O'Kusky J.R., Ye P., and D'Ercole A.J. Insulin-like growth factor-I promotes neurogenesis and synaptogenesis in the hippocampal dentate gyrus during postnatal development. J. Neurosci. 20 (2000) 8435-8442
37. Pang P.T., and Lu B. Regulation of late-phase LTP and long-term memory in normal and aging hippocampus: role of secreted proteins tPA and BDNF. Ageing Res. Rev. 3 (2004) 407-430
38. Schiavo G., Benfenati F., Poulain B., Rossetto O., Polverino de Laureto P., DasGupta B.R., and Montecucco C. Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin. Nature 359 (1992) 832-835
39. Silva A.J., Kogan J.H., Frankland P.W., and Kida S. CREB and memory. Annu. Rev. Neurosci. 21 (1998) 127-148
40. Silver R.A. Estimation of nonuniform quantal parameters with multiple-probability fluctuation analysis: theory, application and limitations. J. Neurosci. Methods 130 (2003) 127-141
41. Slutsky I., Sadeghpour S., Li B., and Liu G. Enhancement of synaptic plasticity through chronically reduced Ca2+ flux during uncorrelated activity. Neuron 44 (2004) 835-849
42. Smith T.D., Adams M.M., Gallagher M., Morrison J.H., and Rapp P.R. Circuit-specific alterations in hippocampal synaptophysin immunoreactivity predict spatial learning impairment in aged rats. J. Neurosci. 20 (2000) 6587-6593
43. Tang Y.P., Shimizu E., Dube G.R., Rampon C., Kerchner G.A., Zhuo M., Liu G., and Tsien J.Z. Genetic enhancement of learning and memory in mice. Nature 401 (1999) 63-69
44. Turrigiano G.G. The self-tuning neuron: synaptic scaling of excitatory synapses. Cell 135 (2008) 422-435
45. Vanhoutte P., and Bading H. Opposing roles of synaptic and extrasynaptic NMDA receptors in neuronal calcium signalling and BDNF gene regulation. Curr. Opin. Neurobiol. 13 (2003) 366-371
46. Vicario-Abejón C., Owens D., McKay R., and Segal M. Role of neurotrophins in central synapse formation and stabilization. Nat. Rev. Neurosci. 3 (2002) 965-974
47. Wei F., Qiu C.S., Kim S.J., Muglia L., Maas J.W., Pineda V.V., Xu H.M., Chen Z.F., Storm D.R., Muglia L.J., and Zhuo M. Genetic elimination of behavioral sensitization in mice lacking calmodulin-stimulated adenylyl cyclases. Neuron 36 (2002) 713-726
48. Williams K. Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors. Mol. Pharmacol. 44 (1993) 851-859
49. Williams S.R., and Mitchell S.J. Direct measurement of somatic voltage clamp errors in central neurons. Nat. Neurosci. 11 (2008) 790-798
50. Wilson I.A., Gallagher M., Eichenbaum H., and Tanila H. Neurocognitive aging: prior memories hinder new hippocampal encoding. Trends Neurosci. 29 (2006) 662-670
51. Wong R.W., Setou M., Teng J., Takei Y., and Hirokawa N. Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice. Proc. Natl. Acad. Sci. USA 99 (2002) 14500-14505
52. Zucker R.S., and Regehr W.G. Short-term synaptic plasticity. Annu. Rev. Physiol. 64 (2002) 355-405