-
1
-
-
33745188660
-
Screening in a spirit haunted world
-
Shoichet, B. K. (2006) Screening in a spirit haunted world Drug Discovery Today 11, 607-615 10.1016/j.drudis.2006.05.014
-
(2006)
Drug Discovery Today
, vol.11
, pp. 607-615
-
-
Shoichet, B.K.1
-
2
-
-
0042071139
-
Formation of colloidal dispersions of organic materials in aqueous media by solvent shifting
-
Brick, M. C., Palmer, H. J., and Whitesides, T. H. (2003) Formation of colloidal dispersions of organic materials in aqueous media by solvent shifting Langmuir 19, 6367-6380 10.1021/la034173o
-
(2003)
Langmuir
, vol.19
, pp. 6367-6380
-
-
Brick, M.C.1
Palmer, H.J.2
Whitesides, T.H.3
-
3
-
-
0037061628
-
A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening
-
McGovern, S. L., Caselli, E., Grigorieff, N., and Shoichet, B. K. (2002) A common mechanism underlying promiscuous inhibitors from virtual and high-throughput screening J. Med. Chem. 45, 1712-1722 10.1021/jm010533y
-
(2002)
J. Med. Chem.
, vol.45
, pp. 1712-1722
-
-
McGovern, S.L.1
Caselli, E.2
Grigorieff, N.3
Shoichet, B.K.4
-
4
-
-
0141792701
-
A specific mechanism of nonspecific inhibition
-
McGovern, S. L., Helfand, B. T., Feng, B., and Shoichet, B. K. (2003) A specific mechanism of nonspecific inhibition J. Med. Chem. 46, 4265-4272 10.1021/jm030266r
-
(2003)
J. Med. Chem.
, vol.46
, pp. 4265-4272
-
-
McGovern, S.L.1
Helfand, B.T.2
Feng, B.3
Shoichet, B.K.4
-
5
-
-
77952545106
-
Apparent activity in high-throughput screening: Origins of compound-dependent assay interference
-
Thorne, N., Auld, D. S., and Inglese, J. (2010) Apparent activity in high-throughput screening: origins of compound-dependent assay interference Curr. Opin. Chem. Biol. 14, 315-324 10.1016/j.cbpa.2010.03.020
-
(2010)
Curr. Opin. Chem. Biol.
, vol.14
, pp. 315-324
-
-
Thorne, N.1
Auld, D.S.2
Inglese, J.3
-
6
-
-
79953137976
-
Non-stoichiometric inhibition in biochemical high-throughput screening
-
Coan, K. E., Ottl, J., and Klumpp, M. (2011) Non-stoichiometric inhibition in biochemical high-throughput screening Expert Opin. Drug Discovery 6, 405-417 10.1517/17460441.2011.561309
-
(2011)
Expert Opin. Drug Discovery
, vol.6
, pp. 405-417
-
-
Coan, K.E.1
Ottl, J.2
Klumpp, M.3
-
7
-
-
84906764097
-
The essential roles of chemistry in high-throughput screening triage
-
Dahlin, J. L. and Walters, M. A. (2014) The essential roles of chemistry in high-throughput screening triage Future Med. Chem. 6, 1265-1290 10.4155/fmc.14.60
-
(2014)
Future Med. Chem.
, vol.6
, pp. 1265-1290
-
-
Dahlin, J.L.1
Walters, M.A.2
-
8
-
-
34249000046
-
A high-throughput screen for aggregation-based inhibition in a large compound library
-
Feng, B. Y., Simeonov, A., Jadhav, A., Babaoglu, K., Inglese, J., Shoichet, B. K., and Austin, C. P. (2007) A high-throughput screen for aggregation-based inhibition in a large compound library J. Med. Chem. 50, 2385-2390 10.1021/jm061317y
-
(2007)
J. Med. Chem.
, vol.50
, pp. 2385-2390
-
-
Feng, B.Y.1
Simeonov, A.2
Jadhav, A.3
Babaoglu, K.4
Inglese, J.5
Shoichet, B.K.6
Austin, C.P.7
-
9
-
-
77952733763
-
Colloid formation by drugs in simulated intestinal fluid
-
Doak, A. K., Wille, H., Prusiner, S. B., and Shoichet, B. K. (2010) Colloid formation by drugs in simulated intestinal fluid J. Med. Chem. 53, 4259-4265 10.1021/jm100254w
-
(2010)
J. Med. Chem.
, vol.53
, pp. 4259-4265
-
-
Doak, A.K.1
Wille, H.2
Prusiner, S.B.3
Shoichet, B.K.4
-
10
-
-
84865256887
-
Colloidal aggregation affects the efficacy of anticancer drugs in cell culture
-
Owen, S. C., Doak, A. K., Wassam, P., Shoichet, M. S., and Shoichet, B. K. (2012) Colloidal aggregation affects the efficacy of anticancer drugs in cell culture ACS Chem. Biol. 7, 1429-1435 10.1021/cb300189b
-
(2012)
ACS Chem. Biol.
, vol.7
, pp. 1429-1435
-
-
Owen, S.C.1
Doak, A.K.2
Wassam, P.3
Shoichet, M.S.4
Shoichet, B.K.5
-
11
-
-
0141923641
-
Identification and prediction of promiscuous aggregating inhibitors among known drugs
-
Seidler, J., McGovern, S. L., Doman, T. N., and Shoichet, B. K. (2003) Identification and prediction of promiscuous aggregating inhibitors among known drugs J. Med. Chem. 46, 4477-4486 10.1021/jm030191r
-
(2003)
J. Med. Chem.
, vol.46
, pp. 4477-4486
-
-
Seidler, J.1
McGovern, S.L.2
Doman, T.N.3
Shoichet, B.K.4
-
12
-
-
84941595522
-
An Aggregation Advisor for Ligand Discovery
-
Irwin, J. J., Duan, D., Torosyan, H., Doak, A. K., Ziebart, K. T., Sterling, T., Tumanian, G., and Shoichet, B. K. (2015) An Aggregation Advisor for Ligand Discovery J. Med. Chem. 58, 7076 10.1021/acs.jmedchem.5b01105
-
(2015)
J. Med. Chem.
, vol.58
, pp. 7076
-
-
Irwin, J.J.1
Duan, D.2
Torosyan, H.3
Doak, A.K.4
Ziebart, K.T.5
Sterling, T.6
Tumanian, G.7
Shoichet, B.K.8
-
13
-
-
84875776484
-
Liquid-Liquid Phase Separation in Highly Supersaturated Aqueous Solutions of Poorly Water-Soluble Drugs: Implications for Solubility Enhancing Formulations
-
Ilevbare, G. A. and Taylor, L. S. (2013) Liquid-Liquid Phase Separation in Highly Supersaturated Aqueous Solutions of Poorly Water-Soluble Drugs: Implications for Solubility Enhancing Formulations Cryst. Growth Des. 13, 1497-1509 10.1021/cg301679h
-
(2013)
Cryst. Growth Des.
, vol.13
, pp. 1497-1509
-
-
Ilevbare, G.A.1
Taylor, L.S.2
-
14
-
-
84961289883
-
Assessment of the amorphous "solubility" of a group of diverse drugs using new experimental and theoretical approaches
-
Almeida e Sousa, L., Reutzel-Edens, S. M., Stephenson, G. A., and Taylor, L. S. (2015) Assessment of the amorphous "solubility" of a group of diverse drugs using new experimental and theoretical approaches Mol. Pharmaceutics 12, 484-495 10.1021/mp500571m
-
(2015)
Mol. Pharmaceutics
, vol.12
, pp. 484-495
-
-
Almeida E Sousa, L.1
Reutzel-Edens, S.M.2
Stephenson, G.A.3
Taylor, L.S.4
-
15
-
-
84875733971
-
Colloidal aggregation causes inhibition of G protein-coupled receptors
-
Sassano, M. F., Doak, A. K., Roth, B. L., and Shoichet, B. K. (2013) Colloidal aggregation causes inhibition of G protein-coupled receptors J. Med. Chem. 56, 2406-2414 10.1021/jm301749y
-
(2013)
J. Med. Chem.
, vol.56
, pp. 2406-2414
-
-
Sassano, M.F.1
Doak, A.K.2
Roth, B.L.3
Shoichet, B.K.4
-
16
-
-
84878634115
-
Impact of polymers on crystal growth rate of structurally diverse compounds from aqueous solution
-
Ilevbare, G. A., Liu, H., Edgar, K. J., and Taylor, L. S. (2013) Impact of polymers on crystal growth rate of structurally diverse compounds from aqueous solution Mol. Pharmaceutics 10, 2381-2393 10.1021/mp400029v
-
(2013)
Mol. Pharmaceutics
, vol.10
, pp. 2381-2393
-
-
Ilevbare, G.A.1
Liu, H.2
Edgar, K.J.3
Taylor, L.S.4
-
17
-
-
84873362258
-
Maintaining Supersaturation in Aqueous Drug Solutions: Impact of Different Polymers on Induction Times
-
Ilevbare, G. A., Liu, H. Y., Edgar, K. J., and Taylor, L. S. (2013) Maintaining Supersaturation in Aqueous Drug Solutions: Impact of Different Polymers on Induction Times Cryst. Growth Des. 13, 740-751 10.1021/cg301447d
-
(2013)
Cryst. Growth Des.
, vol.13
, pp. 740-751
-
-
Ilevbare, G.A.1
Liu, H.Y.2
Edgar, K.J.3
Taylor, L.S.4
-
18
-
-
84906898072
-
Impact of polymers on the precipitation behavior of highly supersaturated aqueous danazol solutions
-
Jackson, M. J., Toth, S. J., Kestur, U. S., Huang, J., Qian, F., Hussain, M. A., Simpson, G. J., and Taylor, L. S. (2014) Impact of polymers on the precipitation behavior of highly supersaturated aqueous danazol solutions Mol. Pharmaceutics 11, 3027-3038 10.1021/mp500201s
-
(2014)
Mol. Pharmaceutics
, vol.11
, pp. 3027-3038
-
-
Jackson, M.J.1
Toth, S.J.2
Kestur, U.S.3
Huang, J.4
Qian, F.5
Hussain, M.A.6
Simpson, G.J.7
Taylor, L.S.8
-
19
-
-
84901285054
-
Refining stability and dissolution rate of amorphous drug formulations
-
Grohganz, H., Priemel, P. A., Lobmann, K., Nielsen, L. H., Laitinen, R., Mullertz, A., Van den Mooter, G., and Rades, T. (2014) Refining stability and dissolution rate of amorphous drug formulations Expert Opin. Drug Delivery 11, 977-989 10.1517/17425247.2014.911728
-
(2014)
Expert Opin. Drug Delivery
, vol.11
, pp. 977-989
-
-
Grohganz, H.1
Priemel, P.A.2
Lobmann, K.3
Nielsen, L.H.4
Laitinen, R.5
Mullertz, A.6
Van Den Mooter, G.7
Rades, T.8
-
20
-
-
79957747768
-
Controlling drug nanoparticle formation by rapid precipitation
-
D'Addio, S. M. and Prud'homme, R. K. (2011) Controlling drug nanoparticle formation by rapid precipitation Adv. Drug Delivery Rev. 63, 417-426 10.1016/j.addr.2011.04.005
-
(2011)
Adv. Drug Delivery Rev.
, vol.63
, pp. 417-426
-
-
D'Addio, S.M.1
Prud'homme, R.K.2
-
21
-
-
84901400939
-
Nanoprecipitation and the "ouzo effect": Application to drug delivery devices
-
Lepeltier, E., Bourgaux, C., and Couvreur, P. (2014) Nanoprecipitation and the "Ouzo effect": Application to drug delivery devices Adv. Drug Delivery Rev. 71, 86-97 10.1016/j.addr.2013.12.009
-
(2014)
Adv. Drug Delivery Rev.
, vol.71
, pp. 86-97
-
-
Lepeltier, E.1
Bourgaux, C.2
Couvreur, P.3
-
22
-
-
84901798602
-
Targeting of injectable drug nanocrystals
-
Fuhrmann, K., Gauthier, M. A., and Leroux, J. C. (2014) Targeting of injectable drug nanocrystals Mol. Pharmaceutics 11, 1762-1771 10.1021/mp5001247
-
(2014)
Mol. Pharmaceutics
, vol.11
, pp. 1762-1771
-
-
Fuhrmann, K.1
Gauthier, M.A.2
Leroux, J.C.3
-
23
-
-
39349094523
-
Small-molecule aggregates inhibit amyloid polymerization
-
Feng, B. Y., Toyama, B. H., Wille, H., Colby, D. W., Collins, S. R., May, B. C., Prusiner, S. B., Weissman, J., and Shoichet, B. K. (2008) Small-molecule aggregates inhibit amyloid polymerization Nat. Chem. Biol. 4, 197-199 10.1038/nchembio.65
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 197-199
-
-
Feng, B.Y.1
Toyama, B.H.2
Wille, H.3
Colby, D.W.4
Collins, S.R.5
May, B.C.6
Prusiner, S.B.7
Weissman, J.8
Shoichet, B.K.9
-
24
-
-
0000959912
-
Why Do Congo Red, Evans Blue, and Trypan Blue Differ in Their Complexation Properties?
-
Skowronek, M., Roterman, I., Konieczny, L., Stopa, B., Rybarska, J., and Piekarska, B. (2000) Why Do Congo Red, Evans Blue, and Trypan Blue Differ in Their Complexation Properties? J. Comput. Chem. 21, 656-667 10.1002/(SICI)1096-987X(200006)21:8<656::AID-JCC5>3.0.CO;2-J
-
(2000)
J. Comput. Chem.
, vol.21
, pp. 656-667
-
-
Skowronek, M.1
Roterman, I.2
Konieczny, L.3
Stopa, B.4
Rybarska, J.5
Piekarska, B.6
-
25
-
-
33645665186
-
Synergy and antagonism of promiscuous inhibition in multiple-compound mixtures
-
Feng, B. Y. and Shoichet, B. K. (2006) Synergy and antagonism of promiscuous inhibition in multiple-compound mixtures J. Med. Chem. 49, 2151-2154 10.1021/jm060029z
-
(2006)
J. Med. Chem.
, vol.49
, pp. 2151-2154
-
-
Feng, B.Y.1
Shoichet, B.K.2
-
26
-
-
23844500772
-
High-throughput assays for promiscuous inhibitors
-
Feng, B. Y., Shelat, A., Doman, T. N., Guy, R. K., and Shoichet, B. K. (2005) High-throughput assays for promiscuous inhibitors Nat. Chem. Biol. 1, 146-148 10.1038/nchembio718
-
(2005)
Nat. Chem. Biol.
, vol.1
, pp. 146-148
-
-
Feng, B.Y.1
Shelat, A.2
Doman, T.N.3
Guy, R.K.4
Shoichet, B.K.5
-
27
-
-
33751321865
-
A detergent-based assay for the detection of promiscuous inhibitors
-
Feng, B. Y. and Shoichet, B. K. (2006) A detergent-based assay for the detection of promiscuous inhibitors Nat. Protoc. 1, 550-553 10.1038/nprot.2006.77
-
(2006)
Nat. Protoc.
, vol.1
, pp. 550-553
-
-
Feng, B.Y.1
Shoichet, B.K.2
-
28
-
-
64549152003
-
Promiscuous aggregate-based inhibitors promote enzyme unfolding
-
Coan, K. E., Maltby, D. A., Burlingame, A. L., and Shoichet, B. K. (2009) Promiscuous aggregate-based inhibitors promote enzyme unfolding J. Med. Chem. 52, 2067-2075 10.1021/jm801605r
-
(2009)
J. Med. Chem.
, vol.52
, pp. 2067-2075
-
-
Coan, K.E.1
Maltby, D.A.2
Burlingame, A.L.3
Shoichet, B.K.4
-
29
-
-
84896953307
-
Colloidal drug formulations can explain "bell-shaped" concentration-response curves
-
Owen, S. C., Doak, A. K., Ganesh, A. N., Nedyalkova, L., McLaughlin, C. K., Shoichet, B. K., and Shoichet, M. S. (2014) Colloidal drug formulations can explain "bell-shaped" concentration-response curves ACS Chem. Biol. 9, 777-784 10.1021/cb4007584
-
(2014)
ACS Chem. Biol.
, vol.9
, pp. 777-784
-
-
Owen, S.C.1
Doak, A.K.2
Ganesh, A.N.3
Nedyalkova, L.4
McLaughlin, C.K.5
Shoichet, B.K.6
Shoichet, M.S.7
-
30
-
-
0032487847
-
Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase
-
Weston, G. S., Blazquez, J., Baquero, F., and Shoichet, B. K. (1998) Structure-based enhancement of boronic acid-based inhibitors of AmpC beta-lactamase J. Med. Chem. 41, 4577-4586 10.1021/jm980343w
-
(1998)
J. Med. Chem.
, vol.41
, pp. 4577-4586
-
-
Weston, G.S.1
Blazquez, J.2
Baquero, F.3
Shoichet, B.K.4
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