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Volumn 7, Issue APR, 2016, Pages

Screening of bifidobacteria and lactobacilli able to antagonize the cytotoxic effect of Clostridium difficile upon intestinal epithelial HT29 monolayer

Author keywords

Bifidobacterium; Clostridium difficile; Lactobacillus; Microscopy; Probiotics; RTCA; Toxins; XCelligence

Indexed keywords

ANALYSIS OF VARIANCE; ARTICLE; BACTERIAL VIABILITY; BIFIDOBACTERIUM BIFIDUM; BIFIDOBACTERIUM LONGUM; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; INTESTINE EPITHELIUM CELL; LACTOBACILLUS CASEI; MICROBIAL MORPHOLOGY; MICROSCOPY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PEPTOCLOSTRIDIUM DIFFICILE; TRANSCRIPTION INITIATION;

EID: 84966351198     PISSN: None     EISSN: 1664302X     Source Type: Journal    
DOI: 10.3389/fmicb.2016.00577     Document Type: Article
Times cited : (48)

References (57)
  • 1
    • 84887390865 scopus 로고    scopus 로고
    • Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial
    • Allen, S. J., Wareham, K., Wang, D., Bradley, C., Hutchings, H., Harris, W., et al. (2013). Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial. Lancet 382, 1249-1257. doi: 10.1016/S0140-6736(13)61218-0
    • (2013) Lancet , vol.382 , pp. 1249-1257
    • Allen, S.J.1    Wareham, K.2    Wang, D.3    Bradley, C.4    Hutchings, H.5    Harris, W.6
  • 2
    • 84928885373 scopus 로고    scopus 로고
    • Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R, and Lactobacillus rhamnosus CLR2 (Bio-K+): characterization, manufacture, mechanisms of action, and quality control of a specific probiotic combination for primary prevention of Clostridium difficile infection
    • Auclair, J., Frappier, M., and Millette, M. (2015). Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R, and Lactobacillus rhamnosus CLR2 (Bio-K+): characterization, manufacture, mechanisms of action, and quality control of a specific probiotic combination for primary prevention of Clostridium difficile infection. Clin. Infect. Dis. 60, S135-S143. doi: 10.1093/cid/civ179
    • (2015) Clin. Infect. Dis , vol.60 , pp. S135-S143
    • Auclair, J.1    Frappier, M.2    Millette, M.3
  • 4
    • 77951667024 scopus 로고    scopus 로고
    • Lactobacillus delbrueckii ssp. bulgaricus B-30892 can inhibit cytotoxic effects and adhesion of pathogenic Clostridium difficile to Caco-2 cells
    • Banerjee, P., Merkel, G. J., and Bhunia, A. K. (2009). Lactobacillus delbrueckii ssp. bulgaricus B-30892 can inhibit cytotoxic effects and adhesion of pathogenic Clostridium difficile to Caco-2 cells. Gut Pathog. 1:8. doi: 10.1186/1757-4749-1-8
    • (2009) Gut Pathog , vol.1 , pp. 8
    • Banerjee, P.1    Merkel, G.J.2    Bhunia, A.K.3
  • 5
    • 84922892218 scopus 로고    scopus 로고
    • Potential sources of Clostridium difficile in human infection
    • Bauer, M. P., and Kuijper, E. J. (2015). Potential sources of Clostridium difficile in human infection. Infect. Dis. Clin. North. Am. 29, 29-35. doi: 10.1016/j.idc.2014.11.010
    • (2015) Infect. Dis. Clin. North. Am , vol.29 , pp. 29-35
    • Bauer, M.P.1    Kuijper, E.J.2
  • 6
    • 84872457994 scopus 로고    scopus 로고
    • Kefir-isolated Lactococcus lactis subsp. lactis inhibits the cytotoxic effect of Clostridium difficile in vitro
    • Bolla, P. A., Carasi, P., Serradell, M. A., and De Antoni, G. L. (2013). Kefir-isolated Lactococcus lactis subsp. lactis inhibits the cytotoxic effect of Clostridium difficile in vitro. J. Dairy Res. 80, 96-102. doi: 10.1017/S0022029912000623
    • (2013) J. Dairy Res , vol.80 , pp. 96-102
    • Bolla, P.A.1    Carasi, P.2    Serradell, M.A.3    De Antoni, G.L.4
  • 7
    • 84903413896 scopus 로고    scopus 로고
    • Lactobacillus rhamnosus L34 and Lactobacillus casei L39 suppress Clostridium difficile-induced IL-8 production by colonic epithelial cells
    • Boonma, P., Spinler, J. K., Venable, S. F., Versalovic, J., and Tumwasorn, S. (2014). Lactobacillus rhamnosus L34 and Lactobacillus casei L39 suppress Clostridium difficile-induced IL-8 production by colonic epithelial cells. BMC Microbiol. 14:177. doi: 10.1186/1471-2180-14-177
    • (2014) BMC Microbiol , vol.14 , pp. 177
    • Boonma, P.1    Spinler, J.K.2    Venable, S.F.3    Versalovic, J.4    Tumwasorn, S.5
  • 8
    • 84856756985 scopus 로고    scopus 로고
    • Surface proteins from Lactobacillus kefir antagonize in vitro cytotoxic effect of Clostridium difficile toxins
    • Carasi, P., Trejo, F. M., Pérez, P. F., De Antoni, G. L., and Serradell, M. A. (2012). Surface proteins from Lactobacillus kefir antagonize in vitro cytotoxic effect of Clostridium difficile toxins. Anaerobe 18, 135-142. doi: 10.1016/j.anaerobe.2011.11.002
    • (2012) Anaerobe , vol.18 , pp. 135-142
    • Carasi, P.1    Trejo, F.M.2    Pérez, P.F.3    De Antoni, G.L.4    Serradell, M.A.5
  • 9
    • 84936972465 scopus 로고    scopus 로고
    • Defining the roles of TcdA and TcdB in localized gastrointestinal disease, systemic organ damage, and the host response during Clostridium difficile infections
    • Carter, G. P., Chakravorty, A., Nguyen, T. A. P., Mileto, S., Schreiber, F., Li, L., et al. (2015). Defining the roles of TcdA and TcdB in localized gastrointestinal disease, systemic organ damage, and the host response during Clostridium difficile infections. mBio 6:e551. doi: 10.1128/mBio.00551-15
    • (2015) mBio , vol.6
    • Carter, G.P.1    Chakravorty, A.2    Nguyen, T.A.P.3    Mileto, S.4    Schreiber, F.5    Li, L.6
  • 10
    • 84855510455 scopus 로고    scopus 로고
    • The role of toxin A and toxin B in the virulence of Clostridium difficile
    • Carter, G. P., Rood, J. I., and Lyras, D. (2012). The role of toxin A and toxin B in the virulence of Clostridium difficile. Trends Microbiol. 20, 21-29. doi: 10.1016/j.tim.2011.11.003
    • (2012) Trends Microbiol , vol.20 , pp. 21-29
    • Carter, G.P.1    Rood, J.I.2    Lyras, D.3
  • 11
    • 10544226189 scopus 로고    scopus 로고
    • Saccharomyces boulardii protease inhibits Clostridium difficile Toxin A effects in the rat ileum
    • Castagliuolo, I., Lamont, J. T., Nikulasson, S. T., and Pothoulakis, C. (1996). Saccharomyces boulardii protease inhibits Clostridium difficile Toxin A effects in the rat ileum. Infect. Immun. 64, 5225-5232
    • (1996) Infect. Immun , vol.64 , pp. 5225-5232
    • Castagliuolo, I.1    Lamont, J.T.2    Nikulasson, S.T.3    Pothoulakis, C.4
  • 12
    • 84862737741 scopus 로고    scopus 로고
    • Identification of iron-regulated genes of Bifidobacterium breve UCC2003 as a basis for controlled gene expression
    • Cronin, M., Zomer, A., Fitzgerald, G., and van Sinderen, D. (2012). Identification of iron-regulated genes of Bifidobacterium breve UCC2003 as a basis for controlled gene expression. Bioeng. Bugs. 3, 157-167. doi: 10.4161/bbug.18985
    • (2012) Bioeng. Bugs , vol.3 , pp. 157-167
    • Cronin, M.1    Zomer, A.2    Fitzgerald, G.3    van Sinderen, D.4
  • 13
    • 84929485093 scopus 로고    scopus 로고
    • Toxin synthesis by Clostridium difficile is regulated through quorum signaling
    • Darkoh, C., DuPont, H. L., Norris, S. J., and Kaplan, H. B. (2015). Toxin synthesis by Clostridium difficile is regulated through quorum signaling. mBio 6:e2569. doi: 10.1128/mBio.02569-14
    • (2015) mBio , vol.6
    • Darkoh, C.1    DuPont, H.L.2    Norris, S.J.3    Kaplan, H.B.4
  • 14
    • 84884358530 scopus 로고    scopus 로고
    • In vivo physiological and transcriptional profiling reveals host responses to Clostridium difficile Toxin A and Toxin B
    • D'Auria, K. M., Kolling, G. L., Donato, G. M., Warren, C. A., Gray, M. C., Hewlett, E. L., et al. (2013). In vivo physiological and transcriptional profiling reveals host responses to Clostridium difficile Toxin A and Toxin B. Infect. Immun. 81, 3814-3824. doi: 10.1128/IAI.00869-13
    • (2013) Infect. Immun , vol.81 , pp. 3814-3824
    • D'Auria, K.M.1    Kolling, G.L.2    Donato, G.M.3    Warren, C.A.4    Gray, M.C.5    Hewlett, E.L.6
  • 15
    • 84905385283 scopus 로고    scopus 로고
    • The CD27L and CTP1L endolysins targeting Clostridia contain a built-in trigger and release factor
    • Dunne, M., Mertens, H. D. T., Garefalaki, V., Jeffries, C. M., Thompson, A., Lemke, E. A., et al. (2014). The CD27L and CTP1L endolysins targeting Clostridia contain a built-in trigger and release factor. PLoS Pathog. 10:e1004228. doi: 10.1371/journal.ppat.1004228
    • (2014) PLoS Pathog , vol.10
    • Dunne, M.1    Mertens, H.D.T.2    Garefalaki, V.3    Jeffries, C.M.4    Thompson, A.5    Lemke, E.A.6
  • 17
    • 84928409059 scopus 로고    scopus 로고
    • A modified R-type bacteriocin specifically targeting Clostridium difficile prevents colonization of mice without affecting gut microbiota diversity
    • Gebhart, D., Lok, S., Clare, S., Tomas, M., Stares, M., Scholl, D., et al. (2015). A modified R-type bacteriocin specifically targeting Clostridium difficile prevents colonization of mice without affecting gut microbiota diversity. mBio 6:e2368. doi: 10.1128/mBio.02368-14
    • (2015) mBio , vol.6
    • Gebhart, D.1    Lok, S.2    Clare, S.3    Tomas, M.4    Stares, M.5    Scholl, D.6
  • 18
    • 84905675648 scopus 로고    scopus 로고
    • The International scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic
    • Hill, C., Guarner, F., Reid, G., Gibson, G. R., Merenstein, D. J., Pot, B., et al. (2014). The International scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat. Rev. Gastroenterol. Hepatol. 11, 506-514. doi: 10.1038/nrgastro.2014.66
    • (2014) Nat. Rev. Gastroenterol. Hepatol , vol.11 , pp. 506-514
    • Hill, C.1    Guarner, F.2    Reid, G.3    Gibson, G.R.4    Merenstein, D.J.5    Pot, B.6
  • 19
    • 29144533433 scopus 로고    scopus 로고
    • Enzymatic ability of Bifidobacterium animalis subsp. lactis to hydrolyze milk proteins: identification and characterization of Endopeptidase O
    • Janer, C., Arigoni, F., Lee, B. H., Peláez, C., and Requena, T. (2005). Enzymatic ability of Bifidobacterium animalis subsp. lactis to hydrolyze milk proteins: identification and characterization of Endopeptidase O. Appl. Environ. Microbiol. 71, 8460-8465. doi: 10.1128/AEM.71.12.8460-8465.2005
    • (2005) Appl. Environ. Microbiol , vol.71 , pp. 8460-8465
    • Janer, C.1    Arigoni, F.2    Lee, B.H.3    Peláez, C.4    Requena, T.5
  • 20
    • 84902899123 scopus 로고    scopus 로고
    • International Clostridium difficile animal strain collection and large diversity of animal associated strains
    • Janezic, S., Zidaric, V., Pardon, B., Indra, A., Kokotovic, B., Blanco, J. L., et al. (2014). International Clostridium difficile animal strain collection and large diversity of animal associated strains. BMC Microbiol. 14:173. doi: 10.1186/1471-2180-14-173
    • (2014) BMC Microbiol , vol.14 , pp. 173
    • Janezic, S.1    Zidaric, V.2    Pardon, B.3    Indra, A.4    Kokotovic, B.5    Blanco, J.L.6
  • 21
    • 84933505084 scopus 로고    scopus 로고
    • Diversity and evolution in the genome of Clostridium difficile
    • Knight, D. R., Elliott, B., Chang, B. J., Perkins, T. T., and Riley, T. V. (2015). Diversity and evolution in the genome of Clostridium difficile. Clin. Microbiol. Rev. 28, 721-741. doi: 10.1128/CMR.00127-14
    • (2015) Clin. Microbiol. Rev , vol.28 , pp. 721-741
    • Knight, D.R.1    Elliott, B.2    Chang, B.J.3    Perkins, T.T.4    Riley, T.V.5
  • 22
    • 84868549640 scopus 로고    scopus 로고
    • Lactic acid production by Streptococcus thermophilus alters Clostridium difficile infection and in vitro Toxin A production
    • Kolling, G. L., Wu, M., Warren, C. A., Durmaz, E., Klaenhammer, T. R., and Guerrant, R. L. (2012). Lactic acid production by Streptococcus thermophilus alters Clostridium difficile infection and in vitro Toxin A production. Gut Microbes 3, 523-529. doi: 10.4161/gmic.21757
    • (2012) Gut Microbes , vol.3 , pp. 523-529
    • Kolling, G.L.1    Wu, M.2    Warren, C.A.3    Durmaz, E.4    Klaenhammer, T.R.5    Guerrant, R.L.6
  • 23
    • 84908874020 scopus 로고    scopus 로고
    • A novel multi-strain probiotic and synbiotic supplement for prevention of Clostridium difficile infection in a murine model
    • Kondepudi, K. K., Ambalam, P., Karagin, P. H., Nilsson, I., Wadström, T., and Ljungh, A. (2014). A novel multi-strain probiotic and synbiotic supplement for prevention of Clostridium difficile infection in a murine model. Microbiol. Immunol. 58, 552-558. doi: 10.1111/1348-0421.12184
    • (2014) Microbiol. Immunol , vol.58 , pp. 552-558
    • Kondepudi, K.K.1    Ambalam, P.2    Karagin, P.H.3    Nilsson, I.4    Wadström, T.5    Ljungh, A.6
  • 24
    • 84868158515 scopus 로고    scopus 로고
    • Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice
    • Lawley, T. D., Clare, S., Walker, A. W., Stares, M. D., Connor, T. R., Raisen, C., et al. (2012). Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice. PLoS Pathog. 8:e1002995. doi: 10.1371/journal.ppat.1002995
    • (2012) PLoS Pathog , vol.8
    • Lawley, T.D.1    Clare, S.2    Walker, A.W.3    Stares, M.D.4    Connor, T.R.5    Raisen, C.6
  • 25
    • 84928023485 scopus 로고    scopus 로고
    • Clostridium difficile infection
    • Leffler, D. A., and Lamont, J. T. (2015). Clostridium difficile infection. N. Engl. J. Med. 372, 1539-1548. doi: 10.1056/NEJMra1403772
    • (2015) N. Engl. J. Med , vol.372 , pp. 1539-1548
    • Leffler, D.A.1    Lamont, J.T.2
  • 26
    • 84919478713 scopus 로고    scopus 로고
    • Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function
    • Leslie, J. L., Huang, S., Opp, J. S., Nagy, M. S., Kobayashi, M., Young, V. B., et al. (2015). Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function. Infect. Immun. 83, 138-145. doi: 10.1128/IAI.02561-14
    • (2015) Infect. Immun , vol.83 , pp. 138-145
    • Leslie, J.L.1    Huang, S.2    Opp, J.S.3    Nagy, M.S.4    Kobayashi, M.5    Young, V.B.6
  • 27
    • 84855765762 scopus 로고    scopus 로고
    • Exopolysaccharide-producing Bifidobacterium strains elicit different in vitro responses upon interaction with human cells
    • López, P., Monteserín, D. C., Gueimonde, M., de los Reyes-Gavilán, C. G., Margolles, A., Suárez, A., et al. (2012). Exopolysaccharide-producing Bifidobacterium strains elicit different in vitro responses upon interaction with human cells. Food Res. Int. 46, 99-107. doi: 10.1016/j.foodres.2011.11.020
    • (2012) Food Res. Int , vol.46 , pp. 99-107
    • López, P.1    Monteserín, D.C.2    Gueimonde, M.3    de los Reyes-Gavilán, C.G.4    Margolles, A.5    Suárez, A.6
  • 28
    • 77951246352 scopus 로고    scopus 로고
    • 'Revised road map to the phylum Firmicutes, '
    • 2nd Edn. eds P. De Vos, G. M. Garrity, D. Jones, N. R. Krieg, W. Ludwig, F. A. Rainey, et al. (New York, NY: Springer)
    • Ludwig, W., Schleifer, K. H., and Whitman, W. B. (2009). "Revised road map to the phylum Firmicutes, " in Bergey's Manual of Systematic Bacteriology The Firmicutes, 2nd Edn, Vol. 3, eds P. De Vos, G. M. Garrity, D. Jones, N. R. Krieg, W. Ludwig, F. A. Rainey, et al. (New York, NY: Springer), 1-13
    • (2009) Bergey's Manual of Systematic Bacteriology The Firmicutes , vol.3 , pp. 1-13
    • Ludwig, W.1    Schleifer, K.H.2    Whitman, W.B.3
  • 29
    • 84907267761 scopus 로고    scopus 로고
    • Investigation of the evolutionary development of the genus Bifidobacterium by comparative genomics
    • Lugli, G. A., Milani, C., Turroni, F., Duranti, S., Ferrario, C., Viappiani, A., et al. (2014). Investigation of the evolutionary development of the genus Bifidobacterium by comparative genomics. Appl. Environ. Microbiol. 80, 6383-6394. doi: 10.1128/AEM.02004-14
    • (2014) Appl. Environ. Microbiol , vol.80 , pp. 6383-6394
    • Lugli, G.A.1    Milani, C.2    Turroni, F.3    Duranti, S.4    Ferrario, C.5    Viappiani, A.6
  • 30
    • 84883598946 scopus 로고    scopus 로고
    • Clostridium difficile: biological therapies
    • Martin, J., Mawer, D., and Wilcox, M. H. (2013). Clostridium difficile: biological therapies. Curr. Opin. Infect. Dis. 26, 454-460. doi: 10.1097/01.qco.0000433319.82618.8f
    • (2013) Curr. Opin. Infect. Dis , vol.26 , pp. 454-460
    • Martin, J.1    Mawer, D.2    Wilcox, M.H.3
  • 31
    • 84922032670 scopus 로고    scopus 로고
    • The potential for emerging therapeutic options for Clostridium difficile infection
    • Mathur, H., Rea, M. C., Cotter, P. D., Ross, R. P., and Hill, C. (2015). The potential for emerging therapeutic options for Clostridium difficile infection. Gut Microb. 5, 696-710. doi: 10.4161/19490976.2014.983768
    • (2015) Gut Microb , vol.5 , pp. 696-710
    • Mathur, H.1    Rea, M.C.2    Cotter, P.D.3    Ross, R.P.4    Hill, C.5
  • 32
    • 84943636849 scopus 로고    scopus 로고
    • Clostridium difficile: new Insights into the evolution of the pathogenicity locus
    • Monot, M., Eckert, C., Lemire, A., Hamiot, A., Dubois, T., Tessier, C., et al. (2015). Clostridium difficile: new Insights into the evolution of the pathogenicity locus. Sci. Rep. 5:15023. doi: 10.1038/srep15023
    • (2015) Sci. Rep , vol.5 , pp. 15023
    • Monot, M.1    Eckert, C.2    Lemire, A.3    Hamiot, A.4    Dubois, T.5    Tessier, C.6
  • 34
    • 78650291202 scopus 로고    scopus 로고
    • Microbiota restoration: natural and supplemented recovery of human microbial communities
    • Reid, G., Younes, J. A., Van der Mei, H. C., Gloor, G. B., Knight, R., and Busscher, H. J. (2011). Microbiota restoration: natural and supplemented recovery of human microbial communities. Nat. Rev. Microbiol. 9, 27-38. doi: 10.1038/nrmicro2473
    • (2011) Nat. Rev. Microbiol , vol.9 , pp. 27-38
    • Reid, G.1    Younes, J.A.2    Van der Mei, H.C.3    Gloor, G.B.4    Knight, R.5    Busscher, H.J.6
  • 35
    • 78449235886 scopus 로고    scopus 로고
    • Exopolysaccharides produced by Lactobacillus and Bifidobacterium strains abrogate in vitro the cytotoxic effect of bacterial toxins on eukaryotic cells
    • Ruas-Madiedo, P., Medrano, M., Salazar, N., de los Reyes-Gavilán, C. G., Pérez, P. F., and Abraham, A. G. (2010). Exopolysaccharides produced by Lactobacillus and Bifidobacterium strains abrogate in vitro the cytotoxic effect of bacterial toxins on eukaryotic cells. J. Appl. Microbiol. 109, 2079-2086. doi: 10.1111/j.1365-2672.2010.04839.x
    • (2010) J. Appl. Microbiol , vol.109 , pp. 2079-2086
    • Ruas-Madiedo, P.1    Medrano, M.2    Salazar, N.3    de los Reyes-Gavilán, C.G.4    Pérez, P.F.5    Abraham, A.G.6
  • 36
    • 67649391053 scopus 로고    scopus 로고
    • Clostridium difficile infection: new developments in epidemiology and pathogenesis
    • Rupnik, M., Wilcox, M. H., and Gerding, D. N. (2009). Clostridium difficile infection: new developments in epidemiology and pathogenesis. Nat. Rev. Microbiol. 7, 526-536. doi: 10.1038/nrmicro2164
    • (2009) Nat. Rev. Microbiol , vol.7 , pp. 526-536
    • Rupnik, M.1    Wilcox, M.H.2    Gerding, D.N.3
  • 37
    • 84915804068 scopus 로고    scopus 로고
    • Simple faecal preparation and efficacy of frozen inoculum in faecal microbiota transplantation for recurrent Clostridium difficile infection - an observational cohort study
    • Satokari, R., Mattila, E., Kainulainen, V., and Arkkila, P. E. T. (2015). Simple faecal preparation and efficacy of frozen inoculum in faecal microbiota transplantation for recurrent Clostridium difficile infection - an observational cohort study. Aliment. Pharmacol. Ther. 41, 46-53. doi: 10.1111/apt.13009
    • (2015) Aliment. Pharmacol. Ther , vol.41 , pp. 46-53
    • Satokari, R.1    Mattila, E.2    Kainulainen, V.3    Arkkila, P.E.T.4
  • 38
    • 0037195083 scopus 로고    scopus 로고
    • The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract
    • Schell, M. A., Karmirantzou, M., Snel, B., Vilanova, D., Berger, B., Pessi, G., et al. (2002). The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract. Proc. Natl Acad. Sci. U.S.A. 99, 14422-14427. doi: 10.1073/pnas.212527599
    • (2002) Proc. Natl Acad. Sci. U.S.A , vol.99 , pp. 14422-14427
    • Schell, M.A.1    Karmirantzou, M.2    Snel, B.3    Vilanova, D.4    Berger, B.5    Pessi, G.6
  • 39
    • 84875624651 scopus 로고    scopus 로고
    • In vitro inhibition of Clostridium difficile and Clostridium perfringens by commercial probiotic strains
    • Schoster, A., Kokotovic, B., Permin, A., Pedersen, P. D., Dal Bello, F., and Guardabassi, L. (2013). In vitro inhibition of Clostridium difficile and Clostridium perfringens by commercial probiotic strains. Anaerobe 20, 36-41. doi: 10.1016/j.anaerobe.2013.02.006
    • (2013) Anaerobe , vol.20 , pp. 36-41
    • Schoster, A.1    Kokotovic, B.2    Permin, A.3    Pedersen, P.D.4    Dal Bello, F.5    Guardabassi, L.6
  • 40
    • 84924603401 scopus 로고    scopus 로고
    • Inhibition of adhesion of Clostridium difficile to human intestinal cells after treatment with serum and intestinal fluid isolated from mice immunized with nontoxigenic C. difficile membrane fraction
    • Senoh, M., Iwaki, M., Yamamoto, A., Kato, H., Fukuda, T., and Shibayama, K. (2015). Inhibition of adhesion of Clostridium difficile to human intestinal cells after treatment with serum and intestinal fluid isolated from mice immunized with nontoxigenic C. difficile membrane fraction. Microb. Pathog. 81, 1-5. doi: 10.1016/j.micpath.2015.03.001
    • (2015) Microb. Pathog , vol.81 , pp. 1-5
    • Senoh, M.1    Iwaki, M.2    Yamamoto, A.3    Kato, H.4    Fukuda, T.5    Shibayama, K.6
  • 41
    • 34548482492 scopus 로고    scopus 로고
    • Characterization of a Bifidobacterium longum BORI dipeptidase belonging to the U34 family
    • Seo, J. M., Ji, G. E., Cho, S. H., Park, M. S., and Lee, H. J. (2007). Characterization of a Bifidobacterium longum BORI dipeptidase belonging to the U34 family. Appl. Environ. Microbiol. 73, 5598-5606. doi: 10.1128/AEM.00642-07
    • (2007) Appl. Environ. Microbiol , vol.73 , pp. 5598-5606
    • Seo, J.M.1    Ji, G.E.2    Cho, S.H.3    Park, M.S.4    Lee, H.J.5
  • 42
    • 77953231134 scopus 로고    scopus 로고
    • Establishment and development of lactic acid bacteria and bifidobacteria microbiota in breast-milk and the infant gut
    • Solís, G., de los Reyes-Gavilán, C. G., Fernández, N., Margolles, A., and Gueimonde, M. (2010). Establishment and development of lactic acid bacteria and bifidobacteria microbiota in breast-milk and the infant gut. Anaerobe 16, 307-310. doi: 10.1016/j.anaerobe.2010.02.004
    • (2010) Anaerobe , vol.16 , pp. 307-310
    • Solís, G.1    de los Reyes-Gavilán, C.G.2    Fernández, N.3    Margolles, A.4    Gueimonde, M.5
  • 43
    • 84923139085 scopus 로고    scopus 로고
    • Small molecule inhibitors of Clostridium difficile toxin B-induced cellular damage
    • Tam, J., Beilhartz, G. L., Auger, A., Gupta, P., Therien, A. G., and Melnyk, R. A. (2015). Small molecule inhibitors of Clostridium difficile toxin B-induced cellular damage. Chem. Biol. 22, 175-185. doi: 10.1016/j.chembiol.2014.12.010
    • (2015) Chem. Biol , vol.22 , pp. 175-185
    • Tam, J.1    Beilhartz, G.L.2    Auger, A.3    Gupta, P.4    Therien, A.G.5    Melnyk, R.A.6
  • 44
    • 84880850101 scopus 로고    scopus 로고
    • Protective effect of bifidobacteria in an experimental model of Clostridium difficile associated colitis
    • Trejo, F. M., De Antoni, G. L., and Pérez, P. F. (2013). Protective effect of bifidobacteria in an experimental model of Clostridium difficile associated colitis. J. Dairy Res. 80, 263-269. doi: 10.1017/S0022029913000216
    • (2013) J. Dairy Res , vol.80 , pp. 263-269
    • Trejo, F.M.1    De Antoni, G.L.2    Pérez, P.F.3
  • 45
    • 77951667378 scopus 로고    scopus 로고
    • Co-culture with potentially probiotic microorganisms antagonises virulence factors of Clostridium difficile in vitro
    • Trejo, F. M., Pérez, P. F., and De Antoni, G. L. (2010). Co-culture with potentially probiotic microorganisms antagonises virulence factors of Clostridium difficile in vitro. Antonie Van Leeuwenhoek 98, 19-29. doi: 10.1007/s10482-010-9424-6
    • (2010) Antonie Van Leeuwenhoek , vol.98 , pp. 19-29
    • Trejo, F.M.1    Pérez, P.F.2    De Antoni, G.L.3
  • 46
    • 84930004587 scopus 로고    scopus 로고
    • Toxigenic Clostridium difficile PCR ribotypes in edible marine bivalve molluscs in Italy
    • Troiano, T., Harmanus, C., Sanders, I. M. J. G., Pasquale, V., Dumontet, S., Capuano, F., et al. (2015). Toxigenic Clostridium difficile PCR ribotypes in edible marine bivalve molluscs in Italy. Int. J. Food Microbiol. 208, 30-34. doi: 10.1016/j.ijfoodmicro.2015.05.002
    • (2015) Int. J. Food Microbiol , vol.208 , pp. 30-34
    • Troiano, T.1    Harmanus, C.2    Sanders, I.M.J.G.3    Pasquale, V.4    Dumontet, S.5    Capuano, F.6
  • 48
    • 84943624042 scopus 로고    scopus 로고
    • Monitoring in real time the cytotoxic effect of Clostridium difficile upon the intestinal epithelial cell line HT29
    • Valdés, L., Gueimonde, M., and Ruas-Madiedo, P. (2015). Monitoring in real time the cytotoxic effect of Clostridium difficile upon the intestinal epithelial cell line HT29. J. Microbiol. Methods 119, 66-73. doi: 10.1016/j.mimet.2015.09.022
    • (2015) J. Microbiol. Methods , vol.119 , pp. 66-73
    • Valdés, L.1    Gueimonde, M.2    Ruas-Madiedo, P.3
  • 49
    • 84923928905 scopus 로고    scopus 로고
    • Bifidobacteria strains isolated from stools of iron deficient infants can efficiently sequester iron
    • Vazquez-Gutierrez, P., Lacroix, C. H., Jaeggi, T., Zeder, C. H., Zimmerman, M. B., and Chassard, C. H. (2015). Bifidobacteria strains isolated from stools of iron deficient infants can efficiently sequester iron. BMC Microbiol. 15:3. doi: 10.1186/s12866-014-0334-z
    • (2015) BMC Microbiol , vol.15 , pp. 3
    • Vazquez-Gutierrez, P.1    Lacroix, C.H.2    Jaeggi, T.3    Zeder, C.H.4    Zimmerman, M.B.5    Chassard, C.H.6
  • 50
    • 84928715619 scopus 로고    scopus 로고
    • A randomised phase 1 study to investigate safety, pharmacokinetics and impact on gut microbiota following single and multiple oral doses in healthy male subjects of SMT19969, a novel agent for Clostridium difficile infections
    • Vickers, R., Robinson, N., Best, E., Echols, R., Tillotson, G., and Wilcox, M. (2015). A randomised phase 1 study to investigate safety, pharmacokinetics and impact on gut microbiota following single and multiple oral doses in healthy male subjects of SMT19969, a novel agent for Clostridium difficile infections. BMC Infect. Dis. 15:91. doi: 10.1186/s12879-015-0759-5
    • (2015) BMC Infect. Dis , vol.15 , pp. 91
    • Vickers, R.1    Robinson, N.2    Best, E.3    Echols, R.4    Tillotson, G.5    Wilcox, M.6
  • 51
    • 17444366186 scopus 로고    scopus 로고
    • Clostridium difficile toxins: mechanism of action and role in disease
    • Voth, D. E., and Ballard, J. D. (2005). Clostridium difficile toxins: mechanism of action and role in disease. Clin. Microbiol. Rev. 18, 247-263. doi: 10.1128/CMR.18.2.247-263.2005
    • (2005) Clin. Microbiol. Rev , vol.18 , pp. 247-263
    • Voth, D.E.1    Ballard, J.D.2
  • 52
    • 84938117616 scopus 로고    scopus 로고
    • Mechanisms of hypervirulent Clostridium difficile ribotype 027 displacement of endemic strains: an epidemiological model
    • Yakob, L., Riley, T. V., Paterson, D. L., Marquess, J., Soares-Magalhaes, R. J., Furuya-Kanamori, L., et al. (2015). Mechanisms of hypervirulent Clostridium difficile ribotype 027 displacement of endemic strains: an epidemiological model. Sci. Rep. 5:12666. doi: 10.1038/srep12666
    • (2015) Sci. Rep , vol.5 , pp. 12666
    • Yakob, L.1    Riley, T.V.2    Paterson, D.L.3    Marquess, J.4    Soares-Magalhaes, R.J.5    Furuya-Kanamori, L.6
  • 53
    • 84921364699 scopus 로고    scopus 로고
    • Mechanisms of protection against Clostridium difficile infection by the monoclonal antitoxin antibodies actoxumab and bezlotoxumab
    • Yang, Z., Ramsey, J., Hamza, T., Zhang, Y., Li, S., Yfantis, H. G., et al. (2015). Mechanisms of protection against Clostridium difficile infection by the monoclonal antitoxin antibodies actoxumab and bezlotoxumab. Infect. Immun. 83, 822-831. doi: 10.1128/IAI.02897-14
    • (2015) Infect. Immun , vol.83 , pp. 822-831
    • Yang, Z.1    Ramsey, J.2    Hamza, T.3    Zhang, Y.4    Li, S.5    Yfantis, H.G.6
  • 54
    • 84908681868 scopus 로고    scopus 로고
    • Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection
    • Youngster, I., Russell, G. H., Pindar, C., Ziv-Baran, T., Sauk, J., and Hohmann, E. L. (2014). Oral, capsulized, frozen fecal microbiota transplantation for relapsing Clostridium difficile infection. JAMA 312, 1772-1778. doi: 10.1001/jama.2014.13875
    • (2014) JAMA , vol.312 , pp. 1772-1778
    • Youngster, I.1    Russell, G.H.2    Pindar, C.3    Ziv-Baran, T.4    Sauk, J.5    Hohmann, E.L.6
  • 55
    • 84904416174 scopus 로고    scopus 로고
    • Lactobacillus acidophilus modulates the virulence of Clostridium difficile
    • Yun, B., Oh, S., and Griffiths, M. W. (2014). Lactobacillus acidophilus modulates the virulence of Clostridium difficile. J. Dairy Sci. 97, 4745-4758. doi: 10.3168/jds.2014-7921
    • (2014) J. Dairy Sci , vol.97 , pp. 4745-4758
    • Yun, B.1    Oh, S.2    Griffiths, M.W.3
  • 56
    • 84885176098 scopus 로고    scopus 로고
    • A genomic update on clostridial phylogeny: gram-negative spore formers and other misplaced clostridia
    • Yutin, N., and Galperin, M. Y. (2013). A genomic update on clostridial phylogeny: gram-negative spore formers and other misplaced clostridia. Environ. Microbiol. 15, 2631-2641. doi: 10.1111/1462-2920.12173
    • (2013) Environ. Microbiol , vol.15 , pp. 2631-2641
    • Yutin, N.1    Galperin, M.Y.2
  • 57
    • 84936933490 scopus 로고    scopus 로고
    • Capability of exopolysaccharide-producing Lactobacillus paraplantarum BGCG11 and its non-producing isogenic strain NB1, to counteract the effect of enteropathogens upon the epithelial cell line HT29-MTX
    • Zivkovic, M., Hidalgo-Cantabrana, C., Kojic, M., Gueimonde, M., Golic, N., and Ruas-Madiedo, P. (2015). Capability of exopolysaccharide-producing Lactobacillus paraplantarum BGCG11 and its non-producing isogenic strain NB1, to counteract the effect of enteropathogens upon the epithelial cell line HT29-MTX. Food Res. Int. 74, 199-207. doi: 10.1016/j.foodres.2015.05.012
    • (2015) Food Res. Int , vol.74 , pp. 199-207
    • Zivkovic, M.1    Hidalgo-Cantabrana, C.2    Kojic, M.3    Gueimonde, M.4    Golic, N.5    Ruas-Madiedo, P.6


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