WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis

Annals of the Rheumatic Diseases

Volumn 76, Issue 1, 2017, Pages 218-226

  Nalesso, Giovanna ^a   Thomas, Bethan Lynne ^a   Sherwood, Joanna Claire ^a,b   Yu, Jing ^c   Addimanda, Olga ^d,e   Eldridge, Suzanne Elizabeth ^a   Thorup, Anne Sophie ^a   Dale, Leslie ^f   Schett, Georg ^g   Zwerina, Jochen ^g   Eltawil, Noha ^a,h   Pitzalis, Costantino ^a   Dell'Accio, Francesco ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c UNIVERSITY OF VIRGINIA   (United States)

^d RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^e UNIVERSITY OF BOLOGNA   (Italy)

^f UNIVERSITY COLLEGE LONDON   (United Kingdom)

^g UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^h UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; LUBRICIN; UNCLASSIFIED DRUG; WNT PROTEIN; WNT16 PROTEIN; WNT3A PROTEIN; WNT8 PROTEIN; MESSENGER RNA; PRG4 PROTEIN, MOUSE; PROTEOGLYCAN; WNT16 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ARTICULAR CARTILAGE; CHONDROCYTE; CONTROLLED STUDY; DISEASE SEVERITY; EMBRYO; KNEE MENISCUS; MALE; MOUSE; NONHUMAN; OSTEOARTHRITIS; UPREGULATION; WNT SIGNALING PATHWAY; XENOPUS; ANIMAL; BIOSYNTHESIS; DEFICIENCY; EXPERIMENTAL ARTHRITIS; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY; WNT SIGNALING;

ANIMALS; APOPTOSIS; ARTHRITIS, EXPERIMENTAL; CARTILAGE, ARTICULAR; MALE; MICE, KNOCKOUT; OSTEOARTHRITIS; PROTEOGLYCANS; RNA, MESSENGER; UP-REGULATION; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84966267262     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2015-208577     Document Type: Article

References (38)

1. Dieppe P, Lim K, Lohmander S. Who should have knee joint replacement surgery for osteoarthritis? Int J Rheum Dis 2011; 14: 175-80.
2. Hartmann C, Tabin CJ. Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton. Cell 2001; 104: 341-51.
3. Guo X, Day TF, Jiang X, et al. Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formation. Genes Dev 2004; 18: 2404-17.
4. Yuasa T, Kondo N, Yasuhara R, et al. Transient activation of Wnt/{beta}-catenin signaling induces abnormal growth plate closure and articular cartilage thickening in postnatal mice. Am J Pathol 2009; 175: 1993-2003.
5. Yasuhara R, Ohta Y, Yuasa T, et al. Roles of β-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells. Lab Invest 2011; 91: 1739-52.
6. Koyama E, Shibukawa Y, Nagayama M, et al. A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis 3. DevBiol 2008; 316: 62-73.
7. Zhu M, Chen M, Zuscik M, et al. Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction. Arthritis Rheum 2008; 58: 2053-64.
8. Zhu M, Tang D, Wu Q, et al. Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice. J Bone Miner Res 2009; 24: 12-21.
9. Luyten FP, Tylzanowski P, Lories RJ. Wnt signaling and osteoarthritis. Bone 2009; 44: 522-7.
10. Corr M. Wnt-beta-catenin signaling in the pathogenesis of osteoarthritis. Nat Clin Pract Rheumatol 2008; 4: 550-6.
11. Sen M, Chamorro M, Reifert J, et al. Blockade of Wnt-5A/frizzled 5 signaling inhibits rheumatoid synoviocyte activation. Arthritis Rheum 2001; 44: 772-81.
12. Clevers H, Nusse R. Wnt/β-catenin signaling and disease. Cell 2012; 149: 1192-205.
13. van Amerongen R. Alternative Wnt pathways and receptors. Cold Spring Harb Perspect Biol 2012; 4. pii: a007914.
14. Lories RJU, Peeters J, Bakker A, et al. Articular cartilage and biomechanical properties of the long bones in Frzb-knockout mice. Arthritis Rheum 2007; 56: 4095-103.
15. Loughlin J, Dowling B, Chapman K, et al. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. ProcNatlAcadSci USA 2004; 101: 9757-62.
16. Diarra D, Stolina M, Polzer K, et al. Dickkopf-1 is a master regulator of joint remodeling. NatMed 2007; 13: 156-63.
17. Krönke G, Uderhardt S, Kim KA, et al. R-spondin 1 protects against inflammatory bone damage during murine arthritis by modulating the Wnt pathway. Arthritis Rheum 2010; 62: 2303-12.
18. Dell'accio F, De Bari C, Eltawil NM, et al. Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis. Arthritis Rheum 2008; 58: 1410-21.
19. Waller KA, Zhang LX, Elsaid KA, et al. Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis. Proc Natl Acad Sci USA 2013; 110: 5852-7.
20. Glasson SS, Askew R, Sheppard B, et al. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature 2005; 434: 644-8.
21. Sherwood J, Bertrand J, Nalesso G, et al. A homeostatic function of CXCR2 signalling in articular cartilage. Ann Rheum Dis 2015; 74: 2207-15.
22. Glasson SS, Chambers MG, van Den Berg WB, et al. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis Cartilage 2010; 18(Suppl 3):S17-23.
23. Nalesso G, Sherwood J, Bertrand J, et al. WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways. J Cell Biol 2011; 193: 551-64.
24. Eldridge S, Nalesso G, Ismail H, et al. Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo. Ann Rheum Dis 2016; 75: 1228-35.
25. Movérare-Skrtic S, Henning P, Liu X, et al. Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures. Nat Med 2014; 20: 1279-88.
26. Dell'accio F, Vincent TL. Joint surface defects: clinical course and cellular response in spontaneous and experimental lesions. EurCell Mater 2010; 20: 210-7.
27. Aigner T, Cook JL, Gerwin N, et al. Histopathology atlas of animal model systems - overview of guiding principles. OsteoarthritisCartilage 2010; 18(Suppl 3):S2-6.
28. Decker RS, Koyama E, Pacifici M. Genesis and morphogenesis of limb synovial joints and articular cartilage. Matrix Biol 2014; 39: 5-11.
29. Hyde G, Dover S, Aszodi A, et al. Lineage tracing using matrilin-1 gene expression reveals that articular chondrocytes exist as the joint interzone forms. DevBiol 2007; 304: 825-33.
30. Sokol S, Christian JL, Moon RT, et al. Injected Wnt RNA induces a complete body axis in Xenopus embryos. Cell 1991; 67: 741-52.
31. Lories RJ, Luyten FP. The bone-cartilage unit in osteoarthritis. Nat Rev Rheumatol 2011; 7: 43-9.
32. Seol D, McCabe DJ, Choe H, et al. Chondrogenic progenitor cells respond to cartilage injury. Arthritis Rheum 2012; 64: 3626-37.
33. Qi W, Yang C, Dai Z, et al. High Levels of Pigment Epithelium-derived Factor in Diabetes Impair Wound Healing through Suppression of Wnt Signaling. Diabetes 2015; 64: 1407-19.
34. Zhang B, Wang M, Gong A, et al. HucMSC-exosome mediated-Wnt4 signaling is required for cutaneous wound healing. Stem Cells 2015; 33: 2158-68.
35. Cheon SS, Cheah AYL, Turley S, et al. beta-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds. Proc Natl Acad Sci USA 2002; 99: 6973-8.
36. Cheon SS, Wei Q, Gurung A, et al. Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing. FASEB J 2006; 20: 692-701.
37. Bielefeld KA, Amini-Nik S, Alman BA. Cutaneous wound healing: recruiting developmental pathways for regeneration. Cell Mol Life Sci 2013; 70: 2059-81.
38. Tamamura Y, Otani T, Kanatani N, et al. Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification. J Biol Chem 2005; 280: 19185-95.