A homeostatic function of CXCR2 signalling in articular cartilage

Annals of the Rheumatic Diseases

Volumn 74, Issue 12, 2015, Pages 2207-2215

  Sherwood, Joanna ^a,b   Bertrand, Jessica ^b   Nalesso, Giovanna ^a   Poulet, Blandine ^c   Pitsillides, Andrew ^d   Brandolini, Laura ^e   Karystinou, Alexandra ^f   De Bari, Cosimo ^f   Luyten, Frank P ^g   Pitzalis, Costantino ^a   Pap, Thomas ^b   Dell'Accio, Francesco ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d ROYAL VETERINARY COLLEGE   (United Kingdom)

^e Chemistry Section   (Italy)

^f UNIVERSITY OF ABERDEEN   (United Kingdom)

^g SKELETAL BIOLOGY AND ENGINEERING RESEARCH CENTER   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; GRANULOCYTE CHEMOTACTIC PROTEIN 2; PROTEIN KINASE B; TRANSCRIPTION FACTOR SOX9;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; DISEASE SEVERITY; LIGAND BINDING; MALE; MOUSE; NONHUMAN; OSTEOARTHRITIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CHONDROCYTE; DISEASE MODEL; HOMEOSTASIS; HUMAN; METABOLISM; PATHOLOGY; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; DISEASE MODELS, ANIMAL; HOMEOSTASIS; HUMANS; MALE; MICE; MICE, INBRED BALB C; OSTEOARTHRITIS; RECEPTORS, INTERLEUKIN-8B; SIGNAL TRANSDUCTION;

EID: 84954400440     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2014-205546     Document Type: Article

References (48)

1. Goldring MB, Otero M. Inflammation in osteoarthritis. Curr Opin Rheumatol 2011;23:471-8.
2. Han Y, Lefebvre V. L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer. Mol Cell Biol 2008;28:4999-5013.
3. Lefebvre V, Huang W, Harley VR, et al. SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene. Mol Cell Biol 1997;17:2336-46.
4. Bi W, Deng JM, Zhang Z, et al. Sox9 is required for cartilage formation. Nat Genet 1999;22:85-9.
5. Sampson ER, Hilton MJ, Tian Y, et al. Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis. SciTranslMed 2011;3:101ra93.
6. Johnson K, Zhu S, Tremblay MS, et al. A stem cell-based approach to cartilage repair. Science 2012;336:717-21.
7. Coelho FM, Pinho V, Amaral FA, et al. The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature. Arthritis Rheum 2008;58:2329-37.
8. Borzì RM, Mazzetti I, Cattini L, et al. Human chondrocytes express functional chemokine receptors and release matrix-degrading enzymes in response to C-X-C and C-C chemokines. Arthritis Rheum 2000;43:1734-41.
9. Murphy PM, Baggiolini M, Charo IF, et al. International union of pharmacology. XXII. Nomenclature for chemokine receptors. Pharmacol Rev 2000;52:145-76. http://www.ncbi.nlm.nih.gov/pubmed/10699158 (accessed 11 Sep 2013).
10. Fan X, Patera AC, Pong-Kennedy A, et al. Murine CXCR1 is a functional receptor for GCP-2/CXCL6 and interleukin-8/CXCL8. JBiolChem 2007;282:11658-66.
11. Devalaraja RM, Nanney LB, Du J, et al. Delayed wound healing in CXCR2 knockout mice. J Invest Dermatol 2000;115:234-44.
12. Cacalano G, Lee J, Kikly K, et al. Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog. Science 1994;265:682-4. http://www.ncbi.nlm. nih.gov/pubmed/8036519 (accessed 11 Sep 2013).
13. Lee J, Cacalano G, Camerato T, et al. Chemokine binding and activities mediated by the mouse IL-8 receptor. J Immunol 1995;155:2158-64.
14. Thelen M. Dancing to the tune of chemokines. Nat Immunol 2001;2:129-34.
15. Bacon K, Baggiolini M, Broxmeyer H, et al. Chemokine/chemokine receptor nomenclature. J Interferon Cytokine Res 2002;22:1067-8.
16. Merz D, Liu R, Johnson K, et al. IL-8/CXCL8 and growth-related oncogene alpha/CXCL1 induce chondrocyte hypertrophic differentiation. J Immunol 2003;171: 4406-15.
17. Glasson SS, Blanchet TJ, Morris EA. The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129/SvEv mouse. Osteoarthr Cartil 2007;15:1061-9.
18. Eltawil NM, De Bari C, Achan P, et al. A novel in vivo murine model of cartilage regeneration. Age and strain-dependent outcome after joint surface injury. Osteoarthr Cartil 2009;17:695-704.
19. Nalesso G, Sherwood J, Bertrand J, et al. WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways. J Cell Biol 2011;193:551-64.
20. De Bari C, Dell'Accio F, Luyten FP. Human periosteum-derived cells maintain phenotypic stability and chondrogenic potential throughout expansion regardless of donor age. Arthritis Rheum 2001;44:85-95.
21. Muramatsu S, Wakabayashi M, Ohno T, et al. Functional gene screening system identified TRPV4 as a regulator of chondrogenic differentiation. J Biol Chem 2007;282:32158-67.
22. Dell'Accio F, De Bari C, Eltawil NM, et al. Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis. Arthritis Rheum 2008;58:1410-21.
23. Takeuchi F. Akt, a pleckstrin homology domain containing kinase, is activated primarily by phosphorylation. J Biol Chem 1996;271:21920-6.
24. Ikeda T, Kamekura S, Mabuchi A, et al. The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage. Arthritis Rheum 2004;50:3561-73.
25. Middleton J, Neil S, Wintle J, et al. Transcytosis and surface presentation of IL-8 by venular endothelial cells. Cell 1997;91:385-95.
26. Parish CR. The role of heparan sulphate in inflammation. Nat Rev Immunol 2006;6:633-43.
27. Webb LM, Ehrengruber MU, Clark-Lewis I, et al. Binding to heparan sulfate or heparin enhances neutrophil responses to interleukin 8. Proc Natl Acad Sci USA 1993;90:7158-62.
28. Dell'Accio F, De Bari C, Luyten FP. Molecular markers predictive of the capacity of expanded human articular chondrocytes to form stable cartilage in vivo. Arthritis Rheum 2001;44:1608-19.
29. Dell'Accio F, Bari CD, Luyten FP, et al. Microenvironment and phenotypic stability specify tissue formation by human articular cartilage-derived cells in vivo. Exp Cell Res 2003;287:16-27.
30. Benya PD, Shaffer JD. Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell 1982;30:215-24.
31. Lane HC, Anand AR, Ganju RK. Cbl and Akt regulate CXCL8-induced and CXCR1-and CXCR2-mediated chemotaxis. Int Immunol 2006;18:1315-25.
32. Lindemann O, Umlauf D, Frank S, et al. TRPC6 regulates CXCR2-mediated chemotaxis of murine neutrophils. J Immunol 2013;190:5496-505.
33. Yin W, Park JI, Loeser RF. Oxidative stress inhibits insulin-like growth factor-I induction of chondrocyte proteoglycan synthesis through differential regulation of phosphatidylinositol 3-Kinase-Akt and MEK-ERK MAPK signaling pathways. J BiolChem 2009;284:31972-81.
34. Henry SP, Liang S, Akdemir KC, et al. The postnatal role of Sox9 in cartilage. J bone Miner Res Off J Am Soc Bone Miner Res 2012;27:2511-25.
35. Dy P, Wang W, Bhattaram P, et al. Sox9 Directs Hypertrophic Maturation and Blocks Osteoblast Differentiation of Growth Plate Chondrocytes. Dev Cell 2012;22:597-609.
36. Ikegami D, Akiyama H, Suzuki A, et al. Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development 2011;138: 1507-19.
37. Thomas CM, Fuller CJ, Whittles CE, et al. Chondrocyte death by apoptosis is associated with cartilage matrix degradation. Osteoarthr Cartil 2007;15:27-34.
38. Aigner T, Fundel K, Saas J, et al. Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis. Arthritis Rheum 2006;54:3533-44.
39. Jacobs JP, Ortiz-Lopez A, Campbell JJ, et al. Deficiency of CXCR2, but not other chemokine receptors, attenuates autoantibody-mediated arthritis in a murine model. Arthritis Rheum 2010;62:1921-32.
40. Haringman JJ, Tak PP. Chemokine blockade: a new era in the treatment of rheumatoid arthritis? Arthritis Res Ther 2004;6:93-7.
41. Barsante MM, Cunha TM, Allegretti M, et al. Blockade of the chemokine receptor CXCR2 ameliorates adjuvant-induced arthritis in rats. Br J Pharmacol 2008;153:992-1002.
42. Borzi RM, Mazzetti I, Macor S, et al. Flow cytometric analysis of intracellular chemokines in chondrocytes in vivo: constitutive expression and enhancement in osteoarthritis and rheumatoid arthritis. FEBS Lett 1999;455:238-42.
43. Endo H, Akahoshi T, Nishimura A, et al. Experimental arthritis induced by continuous infusion of IL-8 into rabbit knee joints. Clin Exp Immunol 1994;96:31-5.
44. Longobardi L, Li T, Myers TJ, et al. TGF-β type II receptor/MCP-5 axis: at the crossroad between joint and growth plate development. Dev Cell 2012;23: 71-81.
45. Kunwar PS, Siekhaus DE, Lehmann R. In vivo migration: a germ cell perspective. Annu Rev Cell Dev Biol 2006;22:237-65.
46. Heissig B, Hattori K, Dias S, et al. Recruitment of stem and progenitor cells from the bone marrow niche requires mmp-9 mediated release of kit-ligand. Cell 2002;109:625-37.
47. Sato T, Konomi K, Yamasaki S, et al. Comparative analysis of gene expression profiles in intact and damaged regions of human osteoarthritic cartilage. Arthritis Rheum 2006;54:808-17.
48. Cravero JD, Carlson CS, Im H-J, et al. Increased expression of the Akt/PKB inhibitor TRB3 in osteoarthritic chondrocytes inhibits insulin-like growth factor 1-mediated cell survival and proteoglycan synthesis. Arthritis Rheum 2009;60:492-500.