On the vasoprotective mechanisms underlying novel β-phosphorylated nitrones: Focus on free radical characterization, scavenging and NO-donation in a biological model of oxidative stress

European Journal of Medicinal Chemistry

Volumn 119, Issue , 2016, Pages 197-217

  Cassien, Mathieu ^a   Petrocchi, Consuelo ^a   Thétiot Laurent, Sophie ^a   Robin, Maxime ^a   Ricquebourg, Emilie ^a   Kandouli, Chouaib ^a   Asteian, Alice ^a   Rockenbauer, Antal ^a,b   Mercier, Anne ^a   Culcasi, Marcel ^a   Pietri, Sylvia ^a  

^a AIX MARSEILLE UNIV   (France)

^b BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

Author keywords

Antioxidant; Aortic rings relaxation; EPR spin trapping; NO donors; Phenolic acids; Diethoxyphosphoryl nitrones

Indexed keywords

2 (DIETHOXYPHOSPHORYL) N (2 HYDROXYBENZYLIDENE)PROPAN 2 AMINE OXIDE; 2 (DIETHOXYPHOSPHORYL) N (2 NITROBENZYLIDENE)PROPAN 2 AMINE OXIDE; 2 (DIETHOXYPHOSPHORYL) N (2 TRIFLUOROMETHYLBENZYLIDENE)PROPAN 2 AMINE OXIDE; 2 (DIETHOXYPHOSPHORYL) N (2,4 DIHYDROXYBENZYLIDENE)PROPAN 2 AMINE OXIDE; 2 (DIETHOXYPHOSPHORYL) N (2,6 DIMETHYLBENZYLIDENE)PROPAN 2 AMINE OXIDE; 2 (DIETHOXYPHOSPHORYL) N (3 HYDROXYBENZYLIDENE)PROPAN 2 AMINE OXIDE; 2 (DIETHOXYPHOSPHORYL) N (3 NITROBENZYLIDENE)PROPAN 2 AMINE OXIDE; 2 (DIETHOXYPHOSPHORYL) N (3,4 DIHYDROXYBENZYLIDENE)PROPAN 2 AMINE OXIDE; 2 (DIETHOXYPHOSPHORYL) N (3,4,5 TRIHYDROXYBENZYLIDENE)PROPAN 2 AMINE OXIDE; 2 (DIETHOXYPHOSPHORYL) N (3,5 DIHYDROXYBENZYLIDENE)PROPAN 2 AMINE OXIDE; 2 (DIETHOXYPHOSPHORYL) N (4 ACETAMIDOBENZYLIDENE)PROPAN 2 AMINE OXIDE; 2 (DIETHOXYPHOSPHORYL) N (4 CARBOXYBENZYLIDENE)PROPAN 2 AMINE OXIDE; 2 (DIETHOXYPHOSPHORYL) N (4 CHLOROBENZYLIDENE)PROPAN 2 AMINE OXIDE; 2 (DIETHOXYPHOSPHORYL) N (4 ETHOXYCARBONYLBENZYLIDENE)PROPAN 2 AMINE OXIDE; 2 (DIETHOXYPHOSPHORYL) N (4 HYDROXY 3 METHOXYBENZYLIDENE)PROPAN 2 AMINE OXIDE; 2 (DIETHOXYPHOSPHORYL) N (4 HYDROXY 3,5 DIMETHOXYBENZYLIDENE)PROPAN 2 AMINE OXIDE; 2 (DIETHOXYPHOSPHORYL) N (4 HYDROXYBENZYLIDENE)PROPAN 2 AMINE OXIDE; 2 (DIETHOXYPHOSPHORYL) N (4 NITROBENZYLIDENE)PROPAN 2 AMINE OXIDE; 2 (DIETHOXYPHOSPHORYL) N (BENZYLIDENE)PROPAN 2 AMINE OXIDE; ANTIOXIDANT; FREE RADICAL; NITRIC OXIDE; NITRONE DERIVATIVE; UNCLASSIFIED DRUG; 1,1-DIPHENYL-2-PICRYLHYDRAZYL; BIPHENYL DERIVATIVE; NITROGEN OXIDE; NITRONES; PICRIC ACID; SCAVENGER; SUPEROXIDE;

ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; BIOLOGICAL MODEL; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ELECTRON SPIN RESONANCE; ENZYME ACTIVITY; IC50; IN VITRO STUDY; LIPOPHILICITY; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; SPIN TRAPPING; STEREOSPECIFICITY; X RAY DIFFRACTION; ANIMAL; AORTA; BOVINE; CHEMICAL PHENOMENA; CHEMISTRY; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN CARBONYLATION; TUMOR CELL LINE; VASODILATATION;

ANIMALS; AORTA; BIPHENYL COMPOUNDS; CATTLE; CELL LINE, TUMOR; FREE RADICAL SCAVENGERS; FREE RADICALS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; NITRIC OXIDE; NITROGEN OXIDES; OXIDATIVE STRESS; PHOSPHORYLATION; PICRATES; PROTEIN CARBONYLATION; RATS; SPIN TRAPPING; SUPEROXIDES; VASODILATION;

EID: 84965109984     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2016.04.067     Document Type: Article

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