메뉴 건너뛰기




Volumn 56, Issue 3, 2016, Pages 233-246

Genetics and Genomics of the Genus Amycolatopsis

Author keywords

Amycolatopsis; Combinatorial biosynthesis; Genome sequence; Mutagenesis; Secondary metabolites

Indexed keywords


EID: 84965076205     PISSN: 00468991     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12088-016-0590-8     Document Type: Article
Times cited : (22)

References (53)
  • 2
    • 84969253557 scopus 로고    scopus 로고
    • Alternative pathway to a glycopeptide-resistant cell wall in the balhimycin producer Amycolatopsis balhimycina
    • COI: 1:CAS:528:DC%2BC2MXnslGhsLc%3D
    • Frasch HJ, Kalan L, Kilian R, Martin T, Wright GD, Stegmann E (2015) Alternative pathway to a glycopeptide-resistant cell wall in the balhimycin producer Amycolatopsis balhimycina. ACS Infect Dis 1:243–252. doi:10.1021/acsinfecdis.5b00011
    • (2015) ACS Infect Dis , vol.1 , pp. 243-252
    • Frasch, H.J.1    Kalan, L.2    Kilian, R.3    Martin, T.4    Wright, G.D.5    Stegmann, E.6
  • 6
    • 84943450847 scopus 로고    scopus 로고
    • Actinomycetes: source, identification, and their applications
    • Sharma M (2014) Actinomycetes: source, identification, and their applications. Int J Curr Microbiol Appl Sci 3:801–832. http://www.ijcmas.com/vol-3-2/Mukesh%20Sharma.pdf
    • (2014) Int J Curr Microbiol Appl Sci , vol.3 , pp. 801-832
    • Sharma, M.1
  • 7
    • 84975910890 scopus 로고    scopus 로고
    • Exploration of extracellular phytase production by Amycolatopsis vancoresmycina S-12 in submerged fermentation
    • Bandyopadhyay D, Das K, Sen SK (2016) Exploration of extracellular phytase production by Amycolatopsis vancoresmycina S-12 in submerged fermentation. Int J Curr Microbiol Appl Sci 5:478–487. doi:10.20546/ijcmas.2016.501.048
    • (2016) Int J Curr Microbiol Appl Sci , vol.5 , pp. 478-487
    • Bandyopadhyay, D.1    Das, K.2    Sen, S.K.3
  • 8
    • 84955170706 scopus 로고    scopus 로고
    • An isolated Amycolatopsis sp. GDS for cellulase and xylanase production using agricultural waste biomass
    • COI: 1:CAS:528:DC%2BC2MXitV2lu7%2FP, PID: 26507788
    • Kshirsagar SD, Saratale GD, Saratale RG, Govindwar SP, Oh MK (2016) An isolated Amycolatopsis sp. GDS for cellulase and xylanase production using agricultural waste biomass. J Appl Microbiol 120:112–125. doi:10.1111/jam.12988
    • (2016) J Appl Microbiol , vol.120 , pp. 112-125
    • Kshirsagar, S.D.1    Saratale, G.D.2    Saratale, R.G.3    Govindwar, S.P.4    Oh, M.K.5
  • 9
    • 0033650404 scopus 로고    scopus 로고
    • The natural functions of secondary metabolites
    • Fiechter A, (ed), Springer, Berlin
    • Demain AL, Fang A (2000) The natural functions of secondary metabolites. In: Fiechter A (ed) History of modern biotechnology I. Springer, Berlin, pp 1–39
    • (2000) History of modern biotechnology I , pp. 1-39
    • Demain, A.L.1    Fang, A.2
  • 11
    • 84868529483 scopus 로고    scopus 로고
    • Complete genome sequence of Amycolatopsis mediterranei S699 based on de novo assembly via a combinatorial sequencing strategy
    • COI: 1:CAS:528:DC%2BC38XhsV2itbbE, PID: 23012281
    • Tang B, Zhao W, Zheng H, Zhuo Y, Zhang L, Zhao GP (2012) Complete genome sequence of Amycolatopsis mediterranei S699 based on de novo assembly via a combinatorial sequencing strategy. J Bacteriol 194:5699–5700. doi:10.1128/JB.01295-12
    • (2012) J Bacteriol , vol.194 , pp. 5699-5700
    • Tang, B.1    Zhao, W.2    Zheng, H.3    Zhuo, Y.4    Zhang, L.5    Zhao, G.P.6
  • 14
    • 70350722394 scopus 로고    scopus 로고
    • Genomic basis for natural product biosynthetic diversity in the actinomycetes
    • COI: 1:CAS:528:DC%2BD1MXht12ht7vF, PID: 19844637
    • Nett M, Ikeda H, Moore BS (2009) Genomic basis for natural product biosynthetic diversity in the actinomycetes. Nat Prod Rep 26:1362–1384. doi:10.1039/B817069J
    • (2009) Nat Prod Rep , vol.26 , pp. 1362-1384
    • Nett, M.1    Ikeda, H.2    Moore, B.S.3
  • 15
    • 0022656043 scopus 로고
    • Two genera of nocardioform actinomycetes: Amycolata gen. nov. and Amycolatopsis gen. nov
    • Lechevalier MP, Prauser H, Labeda DP, Ruan JS (1986) Two genera of nocardioform actinomycetes: Amycolata gen. nov. and Amycolatopsis gen. nov. Int J Syst Bacteriol 36:29–37. doi:10.1099/00207713-36-1-29
    • (1986) Int J Syst Bacteriol , vol.36 , pp. 29-37
    • Lechevalier, M.P.1    Prauser, H.2    Labeda, D.P.3    Ruan, J.S.4
  • 16
    • 84883615133 scopus 로고    scopus 로고
    • Comparative genomics of actinomycetes with a focus on natural product biosynthetic genes
    • COI: 1:CAS:528:DC%2BC3sXhvVKnurfF
    • Doroghazi JR, Metcalf WM (2013) Comparative genomics of actinomycetes with a focus on natural product biosynthetic genes. BMC Genom 14:611. doi:10.1186/1471-2164-14-611
    • (2013) BMC Genom , vol.14 , pp. 611
    • Doroghazi, J.R.1    Metcalf, W.M.2
  • 17
    • 84955205313 scopus 로고    scopus 로고
    • Progress in understanding the genetic information and biosynthetic pathways behind Amycolatopsis antibiotics, with implications for the continued discovery of novel drugs
    • COI: 1:CAS:528:DC%2BC2MXhvFWlu7fP
    • Chen S, Wu Q, Shen Q, Wang H (2016) Progress in understanding the genetic information and biosynthetic pathways behind Amycolatopsis antibiotics, with implications for the continued discovery of novel drugs. Chem Biol Chem 17:119–128. doi:10.1002/cbic.201500542
    • (2016) Chem Biol Chem , vol.17 , pp. 119-128
    • Chen, S.1    Wu, Q.2    Shen, Q.3    Wang, H.4
  • 18
    • 84921500665 scopus 로고    scopus 로고
    • Characterization of plasmid pXL100 from Amycolatopsis orientalis HCCB10007 and construction of a shuttle vector
    • PID: 25384460
    • Xu L, Li Y, Zhu L, Zhao W, Chen D, Huang W, Yang S (2014) Characterization of plasmid pXL100 from Amycolatopsis orientalis HCCB10007 and construction of a shuttle vector. J Basic Microbiol 55:247–254. doi:10.1002/jobm.201400210
    • (2014) J Basic Microbiol , vol.55 , pp. 247-254
    • Xu, L.1    Li, Y.2    Zhu, L.3    Zhao, W.4    Chen, D.5    Huang, W.6    Yang, S.7
  • 19
    • 84908222389 scopus 로고    scopus 로고
    • Complete genome sequence of the actinobacterium Amycolatopsis japonica MG417-CF17T (=DSM 44213T) producing (S, S)-N, N′-ethylenediaminedisuccinic acid
    • COI: 1:CAS:528:DC%2BC2cXhsFWgsL3K, PID: 25193710
    • Stegmann E, Albersmeier A, Spohn M, Gert H, Weber T, Wohlleben W, Kalinowski J, Rückert C (2014) Complete genome sequence of the actinobacterium Amycolatopsis japonica MG417-CF17T (=DSM 44213T) producing (S, S)-N, N′-ethylenediaminedisuccinic acid. J Biotechnol 189:46–47. doi:10.1016/j.jbiotec.2014.08.034
    • (2014) J Biotechnol , vol.189 , pp. 46-47
    • Stegmann, E.1    Albersmeier, A.2    Spohn, M.3    Gert, H.4    Weber, T.5    Wohlleben, W.6    Kalinowski, J.7    Rückert, C.8
  • 20
    • 85003706943 scopus 로고    scopus 로고
    • Draft genome sequence of Rifamycin derivatives producing Amycolatopsis mediterranei strain DSM 46096/S955
    • PID: 25125653
    • Singh P, Kumari R, Mukherjee U, Saxena A, Sood U, Lal R (2014) Draft genome sequence of Rifamycin derivatives producing Amycolatopsis mediterranei strain DSM 46096/S955. Genome Announc 2:e00837-14. doi:10.1128/genomeA.00837-14
    • (2014) Genome Announc , vol.2 , pp. e00837-14
    • Singh, P.1    Kumari, R.2    Mukherjee, U.3    Saxena, A.4    Sood, U.5    Lal, R.6
  • 21
    • 85003429925 scopus 로고    scopus 로고
    • Draft genome sequence of Amycolatopsis mediterranei DSM 40773, a tangible antibiotic producer
    • PID: 25081263
    • Mukherjee U, Saxena A, Kumari R, Singh P, Lal R (2014) Draft genome sequence of Amycolatopsis mediterranei DSM 40773, a tangible antibiotic producer. Genome Announc 2:e00752-14. doi:10.1128/genomeA.00752-14
    • (2014) Genome Announc , vol.2 , pp. e00752-14
    • Mukherjee, U.1    Saxena, A.2    Kumari, R.3    Singh, P.4    Lal, R.5
  • 22
    • 85003678478 scopus 로고    scopus 로고
    • Draft genome sequence of the rifamycin producer Amycolatopsis rifamycinica DSM 46095
    • PID: 24994803
    • Saxena A, Kumari R, Mukherjee U, Singh P, Lal R (2014) Draft genome sequence of the rifamycin producer Amycolatopsis rifamycinica DSM 46095. Genome Announc 2:e00662-14. doi:10.1128/genomeA.00662-14
    • (2014) Genome Announc , vol.2 , pp. e00662-14
    • Saxena, A.1    Kumari, R.2    Mukherjee, U.3    Singh, P.4    Lal, R.5
  • 26
    • 85003794655 scopus 로고    scopus 로고
    • Draft genome sequence of Amycolatopsis lurida NRRL 2430, producer of the glycopeptide family antibiotic ristocetin
    • PID: 25323720
    • Kwun MJ, Hong H-J (2014) Draft genome sequence of Amycolatopsis lurida NRRL 2430, producer of the glycopeptide family antibiotic ristocetin. Genome Announc 2:e01050-14. doi:10.1128/genomeA.01050-14
    • (2014) Genome Announc , vol.2 , pp. e01050-14
    • Kwun, M.J.1    Hong, H.-J.2
  • 28
    • 84997822172 scopus 로고    scopus 로고
    • Genome sequences of Amycolatopsis orientalis subsp. orientalis strains DSM 43388 and DSM 46075
    • Jeong H, Sim YM, Kim HJ, Lee YJ, Lee DW, Lim SK, Lee SJ (2013) Genome sequences of Amycolatopsis orientalis subsp. orientalis strains DSM 43388 and DSM 46075. Genome Announc 1:e00543-13. doi:10.1128/genomeA.00545-13
    • (2013) Genome Announc , vol.1 , pp. e00543-13
    • Jeong, H.1    Sim, Y.M.2    Kim, H.J.3    Lee, Y.J.4    Lee, D.W.5    Lim, S.K.6    Lee, S.J.7
  • 30
    • 85004000380 scopus 로고    scopus 로고
    • Draft genome sequence of ristocetin-producing strain Amycolatopsis sp. strain MJM2582 isolated in South Korea
    • PID: 25359910
    • Kwun MJ, Cheng J, Yang SH, Lee D-R, Suh J-W, Hong H-J (2014) Draft genome sequence of ristocetin-producing strain Amycolatopsis sp. strain MJM2582 isolated in South Korea. Genome Announc 2:e01091-14. doi:10.1128/genomeA.01091-14
    • (2014) Genome Announc , vol.2 , pp. e01091-14
    • Kwun, M.J.1    Cheng, J.2    Yang, S.H.3    Lee, D.-R.4    Suh, J.-W.5    Hong, H.-J.6
  • 31
    • 13144258781 scopus 로고    scopus 로고
    • Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699
    • COI: 1:CAS:528:DyaK1cXhsl2ntr0%3D, PID: 9512878
    • August PR, Tang L, Yoon YJ, Ning S, Müller R, Yu TW, Taylor M, Hoffmann D, Kim CG, Zhang X, Hutchinson CR, Floss HG (1998) Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699. Chem Biol 5:69–79. doi:10.1016/S1074-5521(98)90141-7
    • (1998) Chem Biol , vol.5 , pp. 69-79
    • August, P.R.1    Tang, L.2    Yoon, Y.J.3    Ning, S.4    Müller, R.5    Yu, T.W.6    Taylor, M.7    Hoffmann, D.8    Kim, C.G.9    Zhang, X.10    Hutchinson, C.R.11    Floss, H.G.12
  • 32
    • 84930662789 scopus 로고    scopus 로고
    • A preliminary study of the mechanism of nitrate-stimulated remarkable increase of rifamycin production in Amycolatopsis mediterranei U32 by RNA-seq
    • PID: 26041361
    • Shao ZH, Ren SX, Liu XQ, Xu J, Zhao GP, Wang J (2015) A preliminary study of the mechanism of nitrate-stimulated remarkable increase of rifamycin production in Amycolatopsis mediterranei U32 by RNA-seq. Microb Cell Fact 14:75. doi:10.1186/s12934-015-0264-y
    • (2015) Microb Cell Fact , vol.14 , pp. 75
    • Shao, Z.H.1    Ren, S.X.2    Liu, X.Q.3    Xu, J.4    Zhao, G.P.5    Wang, J.6
  • 33
    • 79959619515 scopus 로고    scopus 로고
    • Identification and functional analysis of a nitrate assimilation operon nasACKBDEF from Amycolatopsis mediterranei U32
    • COI: 1:CAS:528:DC%2BC3MXnsFWmur4%3D, PID: 21424691
    • Shao Z, Gao J, Ding X, Wang J, Chiao J, Zhao G (2011) Identification and functional analysis of a nitrate assimilation operon nasACKBDEF from Amycolatopsis mediterranei U32. Arch Microbiol 193:463–477. doi:10.1007/s00203-011-0690-0
    • (2011) Arch Microbiol , vol.193 , pp. 463-477
    • Shao, Z.1    Gao, J.2    Ding, X.3    Wang, J.4    Chiao, J.5    Zhao, G.6
  • 34
    • 0035918586 scopus 로고    scopus 로고
    • The loading module of rifamycin synthetase is an adenylation–thiolation didomain with substrate tolerance for substituted benzoates
    • COI: 1:CAS:528:DC%2BD3MXisl2kt7Y%3D, PID: 11352749
    • Admiraal SJ, Walsh CT, Khosla C (2001) The loading module of rifamycin synthetase is an adenylation–thiolation didomain with substrate tolerance for substituted benzoates. Biochemistry 40:6116–6123. doi:10.1021/bi010080z
    • (2001) Biochemistry , vol.40 , pp. 6116-6123
    • Admiraal, S.J.1    Walsh, C.T.2    Khosla, C.3
  • 35
    • 23844557104 scopus 로고    scopus 로고
    • Identification of tailoring genes involved in the modification of the polyketide backbone of rifamycin B by Amycolatopsis mediterranei S699
    • COI: 1:CAS:528:DC%2BD2MXpsFGgu7c%3D, PID: 16079331
    • Xu J, Wan E, Kim CJ, Floss HG, Mahmud T (2005) Identification of tailoring genes involved in the modification of the polyketide backbone of rifamycin B by Amycolatopsis mediterranei S699. Microbiology 151:2515–2528. doi:10.1099/mic.0.28138-0
    • (2005) Microbiology , vol.151 , pp. 2515-2528
    • Xu, J.1    Wan, E.2    Kim, C.J.3    Floss, H.G.4    Mahmud, T.5
  • 36
    • 0242574852 scopus 로고    scopus 로고
    • A Switch for the transfer of substrate between nonribosomal peptide and polyketide modules of the rifamycin synthetase assembly line
    • COI: 1:CAS:528:DC%2BD3sXot1Ojsbc%3D, PID: 14599196
    • Admiraal SJ, Khosla C, Walsh CT (2003) A Switch for the transfer of substrate between nonribosomal peptide and polyketide modules of the rifamycin synthetase assembly line. J Am Chem Soc 125:13664–13665. doi:10.1021/ja0379060
    • (2003) J Am Chem Soc , vol.125 , pp. 13664-13665
    • Admiraal, S.J.1    Khosla, C.2    Walsh, C.T.3
  • 37
    • 14844356959 scopus 로고    scopus 로고
    • Rifamycin-mode of action, resistance, and biosynthesis
    • COI: 1:CAS:528:DC%2BD2MXjtFGjsw%3D%3D, PID: 15700959
    • Floss HG, Yu TW (2005) Rifamycin-mode of action, resistance, and biosynthesis. Chem Rev 105:621–632. doi:10.1021/cr030112j
    • (2005) Chem Rev , vol.105 , pp. 621-632
    • Floss, H.G.1    Yu, T.W.2
  • 39
    • 84858765120 scopus 로고    scopus 로고
    • MDR, XDR, TDR tuberculosis: ominous progression
    • PID: 22427352
    • Udwadia ZF (2012) MDR, XDR, TDR tuberculosis: ominous progression. Thorax 67:286–288. doi:10.1136/thoraxjnl-2012-201663
    • (2012) Thorax , vol.67 , pp. 286-288
    • Udwadia, Z.F.1
  • 40
    • 0037443814 scopus 로고    scopus 로고
    • Isolation and characterization of 27-O-demethylrifamycin SV methyltransferase provides new insights into the post-PKS modification steps during the biosynthesis of the antitubercular drug rifamycin B by Amycolatopsis mediterranei S699
    • COI: 1:CAS:528:DC%2BD3sXhs1Khtbc%3D, PID: 12623077
    • Xu J, Mahmud T, Floss HG (2003) Isolation and characterization of 27-O-demethylrifamycin SV methyltransferase provides new insights into the post-PKS modification steps during the biosynthesis of the antitubercular drug rifamycin B by Amycolatopsis mediterranei S699. Arch Biochem Biophys 411:277–288. doi:10.1016/S0003-9861(03)00004-3
    • (2003) Arch Biochem Biophys , vol.411 , pp. 277-288
    • Xu, J.1    Mahmud, T.2    Floss, H.G.3
  • 42
    • 0031042785 scopus 로고    scopus 로고
    • Amycolatopsis japonicum sp. nov, an actinomycete producing (S, S)-N, N′-ethylenediaminedisuccinic acid
    • COI: 1:CAS:528:DyaK2sXhtlCgtbc%3D
    • Goodfellow M, Brown AB, Cai JP, Chun JS, Collins MD (1997) Amycolatopsis japonicum sp. nov, an actinomycete producing (S, S)-N, N′-ethylenediaminedisuccinic acid. Syst Appl Microbiol 20:78–84. doi:10.1016/S0723-2020(97)80051-3
    • (1997) Syst Appl Microbiol , vol.20 , pp. 78-84
    • Goodfellow, M.1    Brown, A.B.2    Cai, J.P.3    Chun, J.S.4    Collins, M.D.5
  • 44
    • 79960564561 scopus 로고    scopus 로고
    • Evaluation of the antibiotic biosynthetic potential of the genus Amycolatopsis and description of Amycolatopsis circi sp. nov., Amycolatopsis equina sp. nov. and Amycolatopsis hippodromi sp. nov
    • COI: 1:STN:280:DC%2BC3MnovFymtg%3D%3D, PID: 21615633
    • Everest GJ, Meyers PR (2011) Evaluation of the antibiotic biosynthetic potential of the genus Amycolatopsis and description of Amycolatopsis circi sp. nov., Amycolatopsis equina sp. nov. and Amycolatopsis hippodromi sp. nov. J Appl Microbiol 111:300–311. doi:10.1111/j.1365-2672.2011.05058.x
    • (2011) J Appl Microbiol , vol.111 , pp. 300-311
    • Everest, G.J.1    Meyers, P.R.2
  • 47
    • 0005092259 scopus 로고    scopus 로고
    • Metabolic regulation in the actinomycete Amycolatopsis methanolica, a facultative methylotroph employing the rump cycle for formaldehyde assimilation. In: Microbial growth on C1 compounds. Springer, pp 9–15
    • Dijkhuizen L (1996) Metabolic regulation in the actinomycete Amycolatopsis methanolica, a facultative methylotroph employing the rump cycle for formaldehyde assimilation. In: Microbial growth on C1 compounds. Springer, pp 9–15. doi: 10.1007/978-94-009-0213-8_3
    • (1996) doi: 10.1007/978-94-009-0213-8_3
    • Dijkhuizen, L.1
  • 48
    • 79960880056 scopus 로고    scopus 로고
    • Structure and biosynthesis of amychelin, an unusual mixed-ligand siderophore from Amycolatopsis sp. AA4
    • COI: 1:CAS:528:DC%2BC3MXosFykt78%3D, PID: 21699219
    • Seyedsayamdost MR, Traxler MF, Zheng SL, Kolter R, Clardy J (2011) Structure and biosynthesis of amychelin, an unusual mixed-ligand siderophore from Amycolatopsis sp. AA4. J Am Chem Soc 133:11434–11437. doi:10.1021/ja203577e
    • (2011) J Am Chem Soc , vol.133 , pp. 11434-11437
    • Seyedsayamdost, M.R.1    Traxler, M.F.2    Zheng, S.L.3    Kolter, R.4    Clardy, J.5
  • 50
    • 33749033361 scopus 로고    scopus 로고
    • The structure of MbtI from Mycobacterium tuberculosis, the first enzyme in the biosynthesis of the siderophore mycobactin, reveals it to be a salicylate synthase
    • COI: 1:CAS:528:DC%2BD28Xpt1aksL4%3D, PID: 16923875
    • Harrison AJ, Yu M, Gårdenborg T, Middleditch M, Ramsay RJ, Baker EN, Lott JS (2006) The structure of MbtI from Mycobacterium tuberculosis, the first enzyme in the biosynthesis of the siderophore mycobactin, reveals it to be a salicylate synthase. J Bacteriol 188:6081–6091. doi:10.1128/JB.00338-06
    • (2006) J Bacteriol , vol.188 , pp. 6081-6091
    • Harrison, A.J.1    Yu, M.2    Gårdenborg, T.3    Middleditch, M.4    Ramsay, R.J.5    Baker, E.N.6    Lott, J.S.7
  • 51
    • 22544431921 scopus 로고    scopus 로고
    • Salicylate biosynthesis: overexpression, purification, and characterization of Irp9, a bifunctional salicylate synthase from Yersinia enterocolitica
    • COI: 1:CAS:528:DC%2BD2MXmslCrsrw%3D, PID: 16030197
    • Kerbarh O, Ciulli A, Howard NI, Abell C (2005) Salicylate biosynthesis: overexpression, purification, and characterization of Irp9, a bifunctional salicylate synthase from Yersinia enterocolitica. J Bacteriol 187:5061–5066. doi:10.1128/JB.187.15.5061-5066.2005
    • (2005) J Bacteriol , vol.187 , pp. 5061-5066
    • Kerbarh, O.1    Ciulli, A.2    Howard, N.I.3    Abell, C.4
  • 53
    • 0023900986 scopus 로고
    • New glycopeptide antibiotics. I. The structures of orienticins
    • COI: 1:CAS:528:DyaL1cXlt1Gmsrc%3D
    • Tsuji K, Kobayashi M, Kamigauchi T, Yoshimura Y, Terui Y (1988) New glycopeptide antibiotics. I. The structures of orienticins. J Antibiot (Tokyo) 41:819–822. doi:10.7164/antibiotics.41.819
    • (1988) J Antibiot (Tokyo) , vol.41 , pp. 819-822
    • Tsuji, K.1    Kobayashi, M.2    Kamigauchi, T.3    Yoshimura, Y.4    Terui, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.