Isoorientin from Gypsophila elegans induces apoptosis in liver cancer cells via mitochondrial-mediated pathway

Journal of Ethnopharmacology

Volumn 187, Issue , 2016, Pages 187-194

  Lin, Xing ^a   Wei, Jinbin ^a   Chen, Yongxin ^a,b   He, Ping ^a   Lin, Jun ^a   Tan, Shimei ^a   Nie, Jinlan ^a   Lu, Shengjuan ^a   He, Min ^a   Lu, Zhongpeng ^b,c   Huang, Quanfang ^b  

^a GUANGXI MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF GUANGXI UNIVERSITY OF CHINESE MEDICINE   (China)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Cytotoxicity; Gypsophila elegans; Isoorientin; Mitochondrial mediated pathway; Reactive oxygen species

Indexed keywords

CYCLIN D; CYCLIN DEPENDENT KINASE 2; CYCLIN E; CYTOCHROME C; ISOORIENTIN; LACTATE DEHYDROGENASE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; ANTINEOPLASTIC AGENT; BAX PROTEIN, HUMAN; CASPASE; CDK2 PROTEIN, HUMAN; LUTEOLIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; G1 PHASE CELL CYCLE CHECKPOINT; GYPSOPHILA ELEGANS; HUMAN; HUMAN CELL; LIVER CANCER CELL LINE; MEDICINAL PLANT; MITOCHONDRIAL MEMBRANE POTENTIAL; UPREGULATION; CARYOPHYLLACEAE; CELL CYCLE; CELL MOTION; CELL SURVIVAL; DRUG EFFECTS; GENETICS; HEP-G2 CELL LINE; METABOLISM; MITOCHONDRION; PHYSIOLOGY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARYOPHYLLACEAE; CASPASES; CELL CYCLE; CELL MOVEMENT; CELL SURVIVAL; CYCLIN D; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; HEP G2 CELLS; HUMANS; L-LACTATE DEHYDROGENASE; LUTEOLIN; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES;

EID: 84965053752     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2016.04.050     Document Type: Article

References (31)

1. M. Brentnall, L. Rodriguez-Menocal, R.L. De Guevara, E. Cepero, and L.H. Boise Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis BMC Cell Biol. 14 2013 32
2. J.K. Brunelle, and A. Letai Control of mitochondrial apoptosis by the Bcl-2 family J. Cell Sci. 122 2009 437 441
3. G. Cao The clinical application of Dong-Yao (Chinese Minorities medicine herb) Gypsophila elegans J. Med. Pharm. Chin. Minor. 15 2007 24 25
4. +-ATPase alpha3 subunit-involved mitochondrial stress and amplification of caspase cascades Biochem. Pharmacol. 86 2013 1564 1575
5. M.L. Circu, and T.Y. Aw Reactive oxygen species, cellular redox systems, and apoptosis Free Radic. Biol. Med. 48 2010 749 762
6. A.V.C. França, J. Elias Júnior, B.L.G. Lima, A.L.C. Martinelli, and F.J. Carrilho Diagnosis, staging and treatment of hepatocellular carcinoma Braz. J. Med. Biol. Res. 37 2004 1689 1705
7. N.A. Franken, H.M. Rodermond, J. Stap, J. Haveman, and C. Van Bree Clonogenic assay of cells in vitro Nat. Protoc. 1 2006 2315 2319
8. S. Fulda, and K.M. Debatin Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy Oncogene 25 2006 4798 4811
9. Y. Gao, Y. Su, L. Qu, S. Xu, L. Meng, S.Q. Cai, and C. Shou Mitochondrial apoptosis contributes to the anti-cancer effect of Smilax glabra Roxb Toxicol. Lett. 207 2011 112 120
10. S.L. Hempel, G.R. Buettner, Y.Q. O'Malley, D.A. Wessels, and D.M. Flaherty Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2′,7′-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2′,7′-dichlorodihydrofluorescein diacetate, and dihydrorhodamine 123 Free Radic. Biol. Med. 27 1999 146 159
11. S.H. Henry, F.X. Bosch, and J. Bowers Aflatoxin, Hepatitis and Worldwide Liver Cancer Risks, Mycotoxins and Food Safety 2002 Springer 229 233
12. M. Huang, J. Lu, M. Huang, J. Bao, X. Chen, and Y. Wang Terpenoids: natural products for cancer therapy Expert Opin. Investig. Drugs 21 2012 1801 1818
13. Q. Huang, S. Zhang, L. Zheng, M. Liao, M. He, R. Huang, L. Zhuo, and X. Lin Protective effect of isoorientin-2″-O-α-l-arabinopyranosyl isolated from Gypsophila elegans on alcohol induced hepatic fibrosis in rats Food Chem. Toxicol. 50 2012 1992 2001
14. D. Kong, T. Zheng, M. Zhang, D. Wang, S. Du, X. Li, J. Fang, and X. Cao Static mechanical stress induces apoptosis in rat endplate chondrocytes through MAPK and mitochondria-dependent caspase activation signaling pathways PLoS One 8 2013 e69403
15. D.V. Krysko, T. Vanden Berghe, K. D'Herde, and P. Vandenabeele Apoptosis and necrosis: detection, discrimination and phagocytosis Methods 44 2008 205 221
16. P. Li, D. Nijhawan, I. Budihardjo, S.M. Srinivasula, M. Ahmad, E.S. Alnemri, and X. Wang Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade Cell 91 1997 479 489
17. S.E. Logue, and S.J. Martin Caspase activation cascades in apoptosis Biochem. Soc. Trans. 36 2008 1 9
18. J. Lu, J. Bao, X. Chen, M. Huang, and Y. Wang Alkaloids isolated from natural herbs as the anticancer agents Evid. Based Complement. Altern. Med. 2012 2012 1 12
19. J. Lu, J. Bao, G. Wu, W. Xu, M. Huang, X. Chen, and Y. Wang Quinones derived from plant secondary metabolites as anti-cancer agents Anticancer Agents Med. Chem. 13 2013 456 463
20. S. Luna-More, B. Weil, D. Bautista, E. Garrido, P. Florez, and C. Martinez Bcl-2 protein in normal, hyperplastic and neoplastic breast tissues. A metabolite of the putative stem-cell subpopulation of the mammary gland Histol. Histopathol. 19 2004 457 463
21. W. Ma, Y. Zou, P. Wang, X. Yao, Y. Sun, M. Duan, Y. Fu, and B. Yu Chimaphilin induces apoptosis in human breast cancer MCF-7 cells through a ROS-mediated mitochondrial pathway Food Chem. Toxicol. 70 2014 1 8
22. S. Nagata Apoptosis by death factor Cell 88 1997 355 365
23. P. Rougier, E. Mitry, J.-C. Barbare, and J. Taieb Hepatocellular carcinoma (HCC): an update Semin. Oncol. 2007 S12 S20
24. X.M. Sun, M. MacFarlane, J. Zhuang, B.B. Wolf, D.R. Green, and G.M. Cohen Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis J. Biol. Chem. 274 1999 5053 5060
25. X. Tan, H. Xia, J. Xu, and J. Cao Induction of apoptosis in human liver carcinoma HepG2 cell line by 5-allyl-7-gen-difluoromethylenechrysin World J. Gastroenterol. 15 2009 2234 2239
26. J. Wang, Z. Yang, J. Wen, F. Ma, F. Wang, K. Yu, M. Tang, W. Wu, Y. Dong, and X. Cheng SKLB-M8 induces apoptosis through the AKT/mTOR signaling pathway in melanoma models and inhibits angiogenesis with decrease of ERK1/2 phosphorylation J. Pharmacol. Sci. 126 2014 198 207
27. J. Wang, L. Yuan, H. Xiao, C. Xiao, Y. Wang, and X. Liu Momordin Ic induces HepG2 cell apoptosis through MAPK and PI3K/Akt-mediated mitochondrial pathways Apoptosis 18 2013 751 765
28. Y. Wang, X. Li, X. Wang, W. Lau, Y. Wang, Y. Xing, X. Zhang, X. Ma, and F. Gao Ginsenoside Rd attenuates myocardial ischemia/reperfusion injury via Akt/GSK-3beta signaling and inhibition of the mitochondria-dependent apoptotic pathway PLoS One 8 2013 e70956
29. W. Wu, X. Zhou, P. Liu, W. Fei, L. Li, and H. Yun Isoflurane reduces hypoxia/reoxygenation-induced apoptosis and mitochondrial permeability transition in rat primary cultured cardiocytes BMC Anesthesiol. 2014 14 17
30. J. Xie, W. Que, H. Liu, M. Liu, A. Yang, and M. Chen Anti-proliferative effects of cucurmosin on human hepatoma HepG2 cells Mol. Med. Rep. 5 2012 196 201
31. M. Youn, J. Kim, S. Park, Y. Kim, S. Kim, J. Lee, K. Chai, H. Kim, M. Cui, and H. So Chaga mushroom (Inonotus obliquus) induces G0/G1 arrest and apoptosis in human hepatoma HepG2 cells World J. Gastroenterol. 14 2008 511 517