Anti-proliferative effects of cucurmosin on human hepatoma HepG2 cells

Molecular Medicine Reports

Volumn 5, Issue 1, 2012, Pages 196-201

  Xie, Jieming ^a   Que, Wenzhong ^a   Liu, Huili ^b   Liu, Mei ^c   Yang, Aiqin ^a   Chen, Minghuang ^d  

^a FUJIAN MEDICAL UNIVERSITY   (China)

^b Zhangzhou Health Vocational College   (China)

^c The Second Hospital of YuLin   (China)

^d FUJIAN INSTITUTE OF RESEARCH ON THE STRUCTURE OF MATTER   (China)

Author keywords

Apoptosis; Cucurmosin; HepG2 cells; Human hepatoma

Indexed keywords

ANTINEOPLASTIC AGENT; CUCURMOSIN; CYCLOPHOSPHAMIDE; PLANT EXTRACT; PROCASPASE 3; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CELL CYCLE ARREST; CELL PROLIFERATION; CELL STRAIN HEPG2; CELL STRUCTURE; CONTROLLED STUDY; CUCRUBITA MOSCHATA; DRUG ISOLATION; ENZYME ACTIVATION; FLOW CYTOMETRY; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; ORTHOTOPIC TRANSPLANTATION; PROTEIN EXPRESSION; SQUASH; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; CELL SURVIVAL; HEP G2 CELLS; HUMANS; MICE; MICE, INBRED NOD; NEOPLASM TRANSPLANTATION; PLANT PROTEINS; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-BCL-2;

MUS;

EID: 84855215420     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2011.605     Document Type: Article

References (14)

1. Chen MH, Ye X, Cai J, et al.: Crystallization and preliminary crystallographic study of cucurmosin, a ribosome-inactivating protein from the sarcocarp of Cucurbita moschata. Acta Cryst 56: 665-666, 2000. (Pubitemid 30324838)
2. Shi XL, Zhou EX, Ye XM, et a1: Molecular replacement studies of cucurmosin from Cucurbita moschata: structure homology with trichosanthin. Chin J Struct Chem 22: 165-168, 2003.
3. Hou X, Meehan EJ, Xie J, et al.: Atomic resolution structure of cucurmosin, a novel type 1 ribosome-inactivating protein from the sarcocarp of Cucurbita moschata. J Struct Biol 164: 81-87, 2008.
4. Sun JC, Xie JM, Zhang KZ, et al.: The effect of cucurmosin and STl571 on K562 cell growth in vitro. J Fujian Med Univ 42: 30-32, 2008.
5. Xu CS, Huang HG, Chen MH, et al.: Cytotoxic and chemosensitivity enhancement effect of cucurmosin on pancreatic cancer cell line PANC-1 in vitro. Chin J Gen Surg 18: 233-236, 2009.
6. Xie JM, Yu CX, Chen MH, et al.: Diferentiation-inducing efect of cucurmosin on B16 melanoma cells. Chin Pharmacol Bull 22: 329-332, 2006.
7. Wang XJ, Wei YQ, Yuan SL, et al.: Potential anticancer activity of tanshinone IIA against human breast cancer. Int J Cancer 116: 799-807, 2005.
8. Adams JM and Cory S: The Bcl-2 protein family: arbiters of cell survival. Science 281: 1322-1326, 1998. (Pubitemid 28406819)
9. Nomura M, Shimizu S, Ito T, et al.: Apoptotic cytosol facilitates Bax translocation to mitochondria that involves cytosolic factor regulated by Bcl-2. Cancer Res 59: 5542-5548, 1999. (Pubitemid 29526471)
10. Thees S, Hubbard GB, Winckler J, et al.: Specific alteration of the Bax/Bcl2 ratio and cytochrome c without execution of apoptosis in the hippocampus of aged baboons. Restor Neurol Neurosci 23: 1-9, 2005. (Pubitemid 40529557)
11. Krepela E: Cysteine proteinases in tumor cell growth and apoptosis. Neoplasma 48: 332-349, 2001.
12. Budihardjo I, Oliver H, Lutter M, et al.: Biochemical pathways of caspase activation during apoptosis. Ann Rev Cell Dev Biol 15: 269-290, 1999. (Pubitemid 32250377)
13. Oliver FJ, de la Rubia G, Rolli V, et al.: Importance of poly(ADPribose) polymerase and its cleavage in apoptosis. Lesson from an uncleavable mutant. J Biol Chem 273: 33533-33539, 1998. (Pubitemid 29005737)
14. Heindryckx F, Colle I and Van VH: Experimental mouse models for hepatocellular carcinoma research. Int J Exp Pathol 90: 367-386, 2009.