Chimaphilin induces apoptosis in human breast cancer MCF-7 cells through a ROS-mediated mitochondrial pathway

Food and Chemical Toxicology

Volumn 70, Issue , 2014, Pages 1-8

  Ma, Wei Dong ^a   Zou, Yong Peng ^b   Wang, Peng ^a   Yao, Xiao Hui ^a   Sun, Yao ^a   Duan, Ming Hui ^a   Fu, Yu Jie ^a   Yu, Bo ^b  

^a NORTHEAST FORESTRY UNIVERSITY   (China)

^b HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Chimaphilin; MCF 7; Mitochondrial; Reactive oxygen species

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CELL NUCLEUS DNA; CHIMAPHILIN; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PLANT MEDICINAL PRODUCT; PROPIDIUM IODIDE; PROTEIN BAD; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; BAD PROTEIN, HUMAN; BAX PROTEIN, HUMAN; CASP3 PROTEIN, HUMAN; CASP9 PROTEIN, HUMAN; FITC-ANNEXIN A5; NAPHTHOQUINONE; PROTEIN BAX;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG MECHANISM; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; MCF 7 CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; GENETICS; IC50; METABOLISM; PASSIFLORA;

ACETYLCYSTEINE; ANNEXIN A5; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-ASSOCIATED DEATH PROTEIN; CASPASE 3; CASPASE 9; CELL PROLIFERATION; DNA FRAGMENTATION; FLUORESCEIN-5-ISOTHIOCYANATE; HUMANS; INHIBITORY CONCENTRATION 50; MCF-7 CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NAPHTHOQUINONES; PASSIFLORA; PROPIDIUM; REACTIVE OXYGEN SPECIES;

EID: 84901194118     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2014.04.014     Document Type: Article

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