Cancer-selective cytotoxic Ca2+ overload in acute myeloid leukemia cells and attenuation of disease progression in mice by synergistically acting polyphenols curcumin and carnosic acid

Oncotarget

Volumn 7, Issue 22, 2016, Pages 31847-31861

  Pesakhov, Stella ^a   Nachliely, Matan ^a   Barvish, Zeev ^a,c   Aqaqe, Nasma ^a,d   Schwartzman, Bar ^a   Voronov, Elena ^a   Sharoni, Yoav ^a   Studzinski, George P ^b   Fishman, Daniel ^a   Danilenko, Michael ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^c BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^d TEL AVIV UNIVERSITY   (Israel)

Author keywords

Acute myeloid leukemia; Apoptosis; Carnosic acid; Curcumin; Intracellular calcium

Indexed keywords

CALCIUM ION; CARNOSIC ACID; CASPASE 8; CASPASE 9; CURCUMIN; ABIETANE DERIVATIVE; ANTINEOPLASTIC AGENT; CALCIUM; CASPASE;

ACUTE MYELOBLASTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CANCER GROWTH; CELL COUNTING; CELL DAMAGE; CELL MEDIATED CYTOTOXICITY; CELL MEMBRANE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENTIATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; EXTRACELLULAR CALCIUM; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; TUNEL ASSAY; ACUTE MYELOID LEUKEMIA; ANIMAL; C57BL MOUSE; CALCIUM SIGNALING; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HL-60 CELL LINE; HOMEOSTASIS; METABOLISM; PATHOLOGY; SCID MOUSE; TIME FACTOR; U-937 CELL LINE;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CALCIUM; CALCIUM SIGNALING; CASPASES; CURCUMIN; DITERPENES, ABIETANE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; HL-60 CELLS; HOMEOSTASIS; HUMANS; LEUKEMIA, MYELOID, ACUTE; MICE, INBRED C57BL; MICE, SCID; TIME FACTORS; U937 CELLS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84965051406     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.7240     Document Type: Article

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