메뉴 건너뛰기




Volumn 29, Issue 4, 2015, Pages 760-769

Novel drugs for older patients with acute myeloid leukemia

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ANTINEOPLASTIC AGENT; AZACITIDINE; BARASERTIB; CELL CYCLE INHIBITOR; CLOFARABINE; CRENOLANIB; CYTOTOXIC AGENT; DNA METHYLTRANSFERASE INHIBITOR; FMS LIKE TYROSINE KINASE RECEPTOR 3 INHIBITOR; GEMTUZUMAB; HISTONE DEACETYLASE INHIBITOR; HYPOMETHYLATING AGENT; LINTUZUMAB; MIDOSTAURIN; MONOCLONAL ANTIBODY; OZOGAMICIN; PANOBINOSTAT; PRACINOSTAT; PROTEIN TYROSINE KINASE INHIBITOR; QUIZARTINIB; RIGOSERTIB; SAPACITABINE; SGI 110; SORAFENIB; TIPIFARNIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VOLASERTIB; VORINOSTAT; VOSAROXIN; ANTINEOPLASTIC ANTIMETABOLITE; CYTOTOXIN; NEW DRUG; PROTEIN KINASE INHIBITOR;

EID: 84927659328     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2014.244     Document Type: Review
Times cited : (65)

References (108)
  • 3
    • 84878372012 scopus 로고    scopus 로고
    • Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
    • Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult De novo acute myeloid leukemia. N Engl J Med 2013; 368: 2059-2074.
    • (2013) N Engl J Med , vol.368 , pp. 2059-2074
  • 4
    • 48749111872 scopus 로고    scopus 로고
    • Molecular pathways in myelodysplastic syndromes and acute myeloid leukemia: Relationships and distinctions-A review
    • Bernasconi P. Molecular pathways in myelodysplastic syndromes and acute myeloid leukemia: Relationships and distinctions-A review. Br J Haematol 2008; 142: 695-708.
    • (2008) Br J Haematol , vol.142 , pp. 695-708
    • Bernasconi, P.1
  • 5
    • 84879698783 scopus 로고    scopus 로고
    • Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia
    • Abdel-Wahab O, Levine RL. Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia. Blood 2013; 121: 3563-3572.
    • (2013) Blood , vol.121 , pp. 3563-3572
    • Abdel-Wahab, O.1    Levine, R.L.2
  • 6
    • 84896735528 scopus 로고    scopus 로고
    • Advances in understanding the leukaemia microenvironment
    • Tabe Y, Konopleva M. Advances in understanding the leukaemia microenvironment. Br J Haematol 2014; 164: 767-778.
    • (2014) Br J Haematol , vol.164 , pp. 767-778
    • Tabe, Y.1    Konopleva, M.2
  • 7
  • 8
    • 79952092487 scopus 로고    scopus 로고
    • Molecular genetics of adult acute myeloid leukemia: Prognostic and therapeutic implications
    • Marcucci G, Haferlach T, Dohner H. Molecular genetics of adult acute myeloid leukemia: Prognostic and therapeutic implications. J Clin Oncol 2011; 29: 475-486.
    • (2011) J Clin Oncol , vol.29 , pp. 475-486
    • Marcucci, G.1    Haferlach, T.2    Dohner, H.3
  • 9
    • 84867806184 scopus 로고    scopus 로고
    • A novel hierarchical prognostic model of AML solely based on molecular mutations
    • Grossmann V, Schnittger S, Kohlmann A, Eder C, Roller A, Dicker F et al. A novel hierarchical prognostic model of AML solely based on molecular mutations. Blood 2012; 120: 2963-2972.
    • (2012) Blood , vol.120 , pp. 2963-2972
    • Grossmann, V.1    Schnittger, S.2    Kohlmann, A.3    Eder, C.4    Roller, A.5    Dicker, F.6
  • 10
    • 79960256952 scopus 로고    scopus 로고
    • Long-term prognosis of acute myeloid leukemia according to the new genetic risk classification of the European LeukemiaNet recommendations: Evaluation of the proposed reporting system
    • Rollig C, Bornhauser M, Thiede C, Taube F, Kramer M, Mohr B et al. Long-term prognosis of acute myeloid leukemia according to the new genetic risk classification of the European LeukemiaNet recommendations: Evaluation of the proposed reporting system. J Clin Oncol 2011; 29: 2758-2765.
    • (2011) J Clin Oncol , vol.29 , pp. 2758-2765
    • Rollig, C.1    Bornhauser, M.2    Thiede, C.3    Taube, F.4    Kramer, M.5    Mohr, B.6
  • 11
    • 78249238527 scopus 로고    scopus 로고
    • Questions regarding frontline therapy of acute myeloid leukemia
    • Kantarjian H, O'Brien S. Questions regarding frontline therapy of acute myeloid leukemia. Cancer 2010; 116: 4896-4901.
    • (2010) Cancer , vol.116 , pp. 4896-4901
    • Kantarjian, H.1    O'Brien, S.2
  • 12
    • 33947205565 scopus 로고    scopus 로고
    • A comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment
    • Burnett AK, Milligan D, Prentice AG, Goldstone AH, McMullin MF, Hills RK et al. A comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment. Cancer 2007; 109: 1114-1124.
    • (2007) Cancer , vol.109 , pp. 1114-1124
    • Burnett, A.K.1    Milligan, D.2    Prentice, A.G.3    Goldstone, A.H.4    McMullin, M.F.5    Hills, R.K.6
  • 13
    • 84886859143 scopus 로고    scopus 로고
    • Clofarabine doubles the response rate in older patients with acute myeloid leukemia but does not improve survival
    • Burnett AK, Russell NH, Hunter AE, Milligan D, Knapper S, Wheatley K et al. Clofarabine doubles the response rate in older patients with acute myeloid leukemia but does not improve survival. Blood 2013; 122: 1384-1394.
    • (2013) Blood , vol.122 , pp. 1384-1394
    • Burnett, A.K.1    Russell, N.H.2    Hunter, A.E.3    Milligan, D.4    Knapper, S.5    Wheatley, K.6
  • 14
    • 69849092737 scopus 로고    scopus 로고
    • A randomized phase 3 study of tipifarnib compared with best supportive care, including hydroxyurea, in the treatment of newly diagnosed acute myeloid leukemia in patients 70 years or older
    • Harousseau JL, Martinelli G, Jedrzejczak WW, Brandwein JM, Bordessoule D, Masszi T et al. A randomized phase 3 study of tipifarnib compared with best supportive care, including hydroxyurea, in the treatment of newly diagnosed acute myeloid leukemia in patients 70 years or older. Blood 2009; 114: 1166-1173.
    • (2009) Blood , vol.114 , pp. 1166-1173
    • Harousseau, J.L.1    Martinelli, G.2    Jedrzejczak, W.W.3    Brandwein, J.M.4    Bordessoule, D.5    Masszi, T.6
  • 15
    • 34250213859 scopus 로고    scopus 로고
    • DNA methylation as a therapeutic target in cancer
    • Issa JP. DNA methylation as a therapeutic target in cancer. Clin Cancer Res 2007; 13: 1634-1637.
    • (2007) Clin Cancer Res , vol.13 , pp. 1634-1637
    • Issa, J.P.1
  • 16
    • 37249040925 scopus 로고    scopus 로고
    • Negative effect of DNA hypermethylation on the outcome of intensive chemotherapy in older patients with high-risk myelodysplastic syndromes and acute myeloid leukemia following myelodysplastic syndrome
    • Grövdal M, Khan R, Aggerholm A, Antunovic P, Astermark J, Bernell P et al. Negative effect of DNA hypermethylation on the outcome of intensive chemotherapy in older patients with high-risk myelodysplastic syndromes and acute myeloid leukemia following myelodysplastic syndrome. Clin Cancer Res 2007; 13: 7107-7112.
    • (2007) Clin Cancer Res , vol.13 , pp. 7107-7112
    • Grövdal, M.1    Khan, R.2    Aggerholm, A.3    Antunovic, P.4    Astermark, J.5    Bernell, P.6
  • 17
    • 77449149371 scopus 로고    scopus 로고
    • DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes
    • Shen L, Kantarjian H, Guo Y, Lin E, Shan J, Huang X et al. DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes. J Clin Oncol 2010; 28: 605-613.
    • (2010) J Clin Oncol , vol.28 , pp. 605-613
    • Shen, L.1    Kantarjian, H.2    Guo, Y.3    Lin, E.4    Shan, J.5    Huang, X.6
  • 18
    • 77749302093 scopus 로고    scopus 로고
    • A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines
    • Hollenbach PW, Nguyen AN, Brady H, Williams M, Ning Y, Richard N et al. A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines. PLoS One 2010; 5: E9001.
    • (2010) PLoS One , vol.5 , pp. e9001
    • Hollenbach, P.W.1    Nguyen, A.N.2    Brady, H.3    Williams, M.4    Ning, Y.5    Richard, N.6
  • 19
    • 14844313747 scopus 로고    scopus 로고
    • 5-Aza-2'-deoxycytidine induces p21WAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia
    • Schmelz K, Wagner M, Dorken B, Tamm I. 5-Aza-2'-deoxycytidine induces p21WAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia. Int J Cancer 2005; 114: 683-695.
    • (2005) Int J Cancer , vol.114 , pp. 683-695
    • Schmelz, K.1    Wagner, M.2    Dorken, B.3    Tamm, I.4
  • 20
    • 84927673527 scopus 로고    scopus 로고
    • Available at
    • National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology. Myelodysplastic SyndromeVersion 2. 2013. Available at http://www. nccn.org.
    • (2013) Myelodysplastic SyndromeVersion 2
  • 21
    • 84863411353 scopus 로고    scopus 로고
    • P53-Independent, normal stem cell sparing epigenetic differentiation therapy for myeloid and other malignancies
    • Saunthararajah Y, Triozzi P, Rini B, Singh A, Radivoyevitch T, Sekeres M et al. p53-Independent, normal stem cell sparing epigenetic differentiation therapy for myeloid and other malignancies. Semin Oncol 2012; 39: 97-108.
    • (2012) Semin Oncol , vol.39 , pp. 97-108
    • Saunthararajah, Y.1    Triozzi, P.2    Rini, B.3    Singh, A.4    Radivoyevitch, T.5    Sekeres, M.6
  • 22
    • 84855857727 scopus 로고    scopus 로고
    • Monosomal karyotype in adult acute myeloid leukemia: Prognostic impact and outcome after different treatment strategies
    • Kayser S, Zucknick M, Dohner K, Krauter J, Kohne CH, Horst HA et al. Monosomal karyotype in adult acute myeloid leukemia: Prognostic impact and outcome after different treatment strategies. Blood 2012; 119: 551-558.
    • (2012) Blood , vol.119 , pp. 551-558
    • Kayser, S.1    Zucknick, M.2    Dohner, K.3    Krauter, J.4    Kohne, C.H.5    Horst, H.A.6
  • 23
    • 84902086132 scopus 로고    scopus 로고
    • Prognostic value of TP53 gene mutations in myelodysplastic syndromes and acute myeloid leukemia treated with azacitidine
    • Bally C, Ades L, Renneville A, Sebert M, Eclache V, Preudhomme C et al. Prognostic value of TP53 gene mutations in myelodysplastic syndromes and acute myeloid leukemia treated with azacitidine. Leuk Res 2014; 38: 751-755.
    • (2014) Leuk Res , vol.38 , pp. 751-755
    • Bally, C.1    Ades, L.2    Renneville, A.3    Sebert, M.4    Eclache, V.5    Preudhomme, C.6
  • 24
    • 62849104641 scopus 로고    scopus 로고
    • Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: A randomised, open-label, phase III study
    • Fenaux P, Mufti GJ, Hellstrom-Lindberg E, Santini V, Finelli C, Giagounidis A et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: A randomised, open-label, phase III study. Lancet Oncol 2009; 10: 223-232.
    • (2009) Lancet Oncol , vol.10 , pp. 223-232
    • Fenaux, P.1    Mufti, G.J.2    Hellstrom-Lindberg, E.3    Santini, V.4    Finelli, C.5    Giagounidis, A.6
  • 25
    • 77449149373 scopus 로고    scopus 로고
    • Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia
    • Fenaux P, Mufti GJ, Hellstrom-Lindberg E, Santini V, Gattermann N, Germing U et al. Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia. J Clin Oncol 2010; 28: 562-569.
    • (2010) J Clin Oncol , vol.28 , pp. 562-569
    • Fenaux, P.1    Mufti, G.J.2    Hellstrom-Lindberg, E.3    Santini, V.4    Gattermann, N.5    Germing, U.6
  • 26
    • 84921436355 scopus 로고    scopus 로고
    • Results of a phase 3, multicenter, randomized, open-label study of azacitidine (AZA) vs conventional care regimens (CCR) in older patients with newly diagnosed acute myeloid leukemia (AML)
    • abstract LB2433
    • Dombret H, Seymour JF, Butrym A, Wierzbowska A, Selleslag D, Jang JH et al. Results of a phase 3, multicenter, randomized, open-label study of azacitidine (AZA) vs conventional care regimens (CCR) in older patients with newly diagnosed acute myeloid leukemia (AML). Haematologica 2014; 99(Suppl 1): 788-789, (abstract LB2433
    • (2014) Haematologica , vol.99 , pp. 788-789
    • Dombret, H.1    Seymour, J.F.2    Butrym, A.3    Wierzbowska, A.4    Selleslag, D.5    Jang, J.H.6
  • 27
    • 84864063679 scopus 로고    scopus 로고
    • Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia
    • Kantarjian HM, Thomas XG, Dmoszynska A, Wierzbowska A, Mazur G, Mayer J et al. Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia. J Clin Oncol 2012; 30: 2670-2677.
    • (2012) J Clin Oncol , vol.30 , pp. 2670-2677
    • Kantarjian, H.M.1    Thomas, X.G.2    Dmoszynska, A.3    Wierzbowska, A.4    Mazur, G.5    Mayer, J.6
  • 30
    • 0021254079 scopus 로고
    • Low dose cytosine arabinoside: Partial remission of acute myeloid leukaemia without evidence of differentiation induction
    • Leyden M, Manoharan A, Boyd A, Cheng ZM, Sullivan J. Low dose cytosine arabinoside: Partial remission of acute myeloid leukaemia without evidence of differentiation induction. Br J Haematol 1984; 57: 301-307.
    • (1984) Br J Haematol , vol.57 , pp. 301-307
    • Leyden, M.1    Manoharan, A.2    Boyd, A.3    Cheng, Z.M.4    Sullivan, J.5
  • 31
    • 0020034159 scopus 로고
    • Small doses of ARA-C in the treatment of acute myeloid leukaemia differentiation of myeloid leukaemia cells?
    • Housset M, Daniel MT, Degos L. Small doses of ARA-C in the treatment of acute myeloid leukaemia: Differentiation of myeloid leukaemia cells? Br J Haematol 1982; 51: 125-129.
    • (1982) Br J Haematol , vol.51 , pp. 125-129
    • Housset, M.1    Daniel, M.T.2    Degos, L.3
  • 33
    • 77449159668 scopus 로고    scopus 로고
    • Phase II study of clofarabine monotherapy in previously untreated older adults with acute myeloid leukemia and unfavorable prognostic factors
    • Kantarjian HM, Erba HP, Claxton D, Arellano M, Lyons RM, Kovascovics T et al. Phase II study of clofarabine monotherapy in previously untreated older adults with acute myeloid leukemia and unfavorable prognostic factors. J Clin Oncol 2010; 28: 549-555.
    • (2010) J Clin Oncol , vol.28 , pp. 549-555
    • Kantarjian, H.M.1    Erba, H.P.2    Claxton, D.3    Arellano, M.4    Lyons, R.M.5    Kovascovics, T.6
  • 34
    • 52649154001 scopus 로고    scopus 로고
    • A randomized study of clofarabine versus clofarabine plus low-dose cytarabine as front-line therapy for patients aged 60 years and older with acute myeloid leukemia and high-risk myelodysplastic syndrome
    • Faderl S, Ravandi F, Huang X, Garcia-Manero G, Ferrajoli A, Estrov Z et al. A randomized study of clofarabine versus clofarabine plus low-dose cytarabine as front-line therapy for patients aged 60 years and older with acute myeloid leukemia and high-risk myelodysplastic syndrome. Blood 2008; 112: 1638-1645.
    • (2008) Blood , vol.112 , pp. 1638-1645
    • Faderl, S.1    Ravandi, F.2    Huang, X.3    Garcia-Manero, G.4    Ferrajoli, A.5    Estrov, Z.6
  • 35
    • 0033052756 scopus 로고    scopus 로고
    • Antitumor activity and novel DNA-self-strand-breaking mechanism of CNDAC (1-(2-C-cyano-2-deoxy-beta-D-arabino-pentofuranosyl) cytosine) and its N4-palmitoyl derivative (CS-682)
    • Hanaoka K, Suzuki M, Kobayashi T, Tanzawa F, Tanaka K, Shibayama T et al. Antitumor activity and novel DNA-self-strand-breaking mechanism of CNDAC (1-(2-C-cyano-2-deoxy-beta-D-arabino-pentofuranosyl) cytosine) and its N4-palmitoyl derivative (CS-682). Int J Cancer 1999; 82: 226-236.
    • (1999) Int J Cancer , vol.82 , pp. 226-236
    • Hanaoka, K.1    Suzuki, M.2    Kobayashi, T.3    Tanzawa, F.4    Tanaka, K.5    Shibayama, T.6
  • 36
    • 23044441597 scopus 로고    scopus 로고
    • Molecular basis for G2 arrest induced by 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine and consequences of checkpoint abrogation
    • Liu X, Guo Y, Li Y, Jiang Y, Chubb S, Azuma A et al. Molecular basis for G2 arrest induced by 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine and consequences of checkpoint abrogation. Cancer Res 2005; 65: 6874-6881.
    • (2005) Cancer Res , vol.65 , pp. 6874-6881
    • Liu, X.1    Guo, Y.2    Li, Y.3    Jiang, Y.4    Chubb, S.5    Azuma, A.6
  • 37
    • 84865222487 scopus 로고    scopus 로고
    • Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks
    • Liu XJ, Nowak B, Wang YQ, Plunkett W. Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks. Chin J Cancer 2012; 31: 373-380.
    • (2012) Chin J Cancer , vol.31 , pp. 373-380
    • Liu, X.J.1    Nowak, B.2    Wang, Y.Q.3    Plunkett, W.4
  • 38
    • 84868093252 scopus 로고    scopus 로고
    • Oral sapacitabine for the treatment of acute myeloid leukaemia in elderly patients: A randomised phase 2 study
    • Kantarjian H, Faderl S, Garcia-Manero G, Luger S, Venugopal P, Maness L et al. Oral sapacitabine for the treatment of acute myeloid leukaemia in elderly patients: A randomised phase 2 study. Lancet Oncol 2012; 13: 1096-1104.
    • (2012) Lancet Oncol , vol.13 , pp. 1096-1104
    • Kantarjian, H.1    Faderl, S.2    Garcia-Manero, G.3    Luger, S.4    Venugopal, P.5    Maness, L.6
  • 39
    • 84921439086 scopus 로고    scopus 로고
    • Pooled analysis of elderly patients with newly diagnosed AML treated with sapacitabine and decitabine administered in alternating cycles
    • Ravandi F, Kadia TM, Borthakur G, Wierda WG, Goldberg SL, Wetzler M et al. Pooled analysis of elderly patients with newly diagnosed AML treated with sapacitabine and decitabine administered in alternating cycles. Blood 2012; 120: 2630.
    • (2012) Blood , vol.120 , pp. 2630
    • Ravandi, F.1    Kadia, T.M.2    Borthakur, G.3    Wierda, W.G.4    Goldberg, S.L.5    Wetzler, M.6
  • 40
    • 34247603906 scopus 로고    scopus 로고
    • Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase
    • Mortlock AA, Foote KM, Heron NM, Jung FH, Pasquet G, Lohmann JJ et al. Discovery, synthesis, and in vivo activity of a new class of pyrazoloquinazolines as selective inhibitors of aurora B kinase. J Med Chem 2007; 50: 2213-2224.
    • (2007) J Med Chem , vol.50 , pp. 2213-2224
    • Mortlock, A.A.1    Foote, K.M.2    Heron, N.M.3    Jung, F.H.4    Pasquet, G.5    Lohmann, J.J.6
  • 42
    • 34250771649 scopus 로고    scopus 로고
    • A novel treatment strategy targeting Aurora kinases in acute myelogenous leukemia
    • Ikezoe T, Yang J, Nishioka C, Tasaka T, Taniguchi A, Kuwayama Y et al. A novel treatment strategy targeting Aurora kinases in acute myelogenous leukemia. Mol Cancer Ther 2007; 6: 1851-1857.
    • (2007) Mol Cancer Ther , vol.6 , pp. 1851-1857
    • Ikezoe, T.1    Yang, J.2    Nishioka, C.3    Tasaka, T.4    Taniguchi, A.5    Kuwayama, Y.6
  • 43
    • 34548822673 scopus 로고    scopus 로고
    • AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo
    • Yang J, Ikezoe T, Nishioka C, Tasaka T, Taniguchi A, Kuwayama Y et al. AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo. Blood 2007; 110: 2034-2040.
    • (2007) Blood , vol.110 , pp. 2034-2040
    • Yang, J.1    Ikezoe, T.2    Nishioka, C.3    Tasaka, T.4    Taniguchi, A.5    Kuwayama, Y.6
  • 44
    • 82955217793 scopus 로고    scopus 로고
    • Phase 1/2 study to assess the safety, efficacy, and pharmacokinetics of barasertib (AZD1152) in patients with advanced acute myeloid leukemia
    • Lowenberg B, Muus P, Ossenkoppele G, Rousselot P, Cahn JY, Ifrah N et al. Phase 1/2 study to assess the safety, efficacy, and pharmacokinetics of barasertib (AZD1152) in patients with advanced acute myeloid leukemia. Blood 2011; 118: 6030-6036.
    • (2011) Blood , vol.118 , pp. 6030-6036
    • Lowenberg, B.1    Muus, P.2    Ossenkoppele, G.3    Rousselot, P.4    Cahn, J.Y.5    Ifrah, N.6
  • 45
    • 80052100694 scopus 로고    scopus 로고
    • A phase i study to assess the safety, pharmacokinetics and efficacy of barasertib (AZD1152), an Aurora B kinase inhibitor, in Japanese patients with advanced acute myeloid leukemia
    • Tsuboi K, Yokozawa T, Sakura T, Watanabe T, Fujisawa S, Yamauchi T et al. A phase I study to assess the safety, pharmacokinetics and efficacy of barasertib (AZD1152), an Aurora B kinase inhibitor, in Japanese patients with advanced acute myeloid leukemia. Leuk Res 2011; 35: 1384-1389.
    • (2011) Leuk Res , vol.35 , pp. 1384-1389
    • Tsuboi, K.1    Yokozawa, T.2    Sakura, T.3    Watanabe, T.4    Fujisawa, S.5    Yamauchi, T.6
  • 46
    • 84879644165 scopus 로고    scopus 로고
    • Stage i of a phase 2 study assessing the efficacy, safety, and tolerability of barasertib (AZD1152) versus low-dose cytosine arabinoside in elderly patients with acute myeloid leukemia
    • Kantarjian HM, Martinelli G, Jabbour EJ, Quintas-Cardama A, Ando K, Bay JO et al. Stage I of a phase 2 study assessing the efficacy, safety, and tolerability of barasertib (AZD1152) versus low-dose cytosine arabinoside in elderly patients with acute myeloid leukemia. Cancer 2013; 119: 2611-2619.
    • (2013) Cancer , vol.119 , pp. 2611-2619
    • Kantarjian, H.M.1    Martinelli, G.2    Jabbour, E.J.3    Quintas-Cardama, A.4    Ando, K.5    Bay, J.O.6
  • 47
    • 84884155615 scopus 로고    scopus 로고
    • Phase i study assessing the safety and tolerability of barasertib (AZD1152) with low-dose cytosine arabinoside in elderly patients with AML
    • Kantarjian HM, Sekeres MA, Ribrag V, Rousselot P, Garcia-Manero G, Jabbour EJ et al. Phase I study assessing the safety and tolerability of barasertib (AZD1152) with low-dose cytosine arabinoside in elderly patients with AML. Clin Lymphoma Myeloma Leuk 2013; 13: 559-567.
    • (2013) Clin Lymphoma Myeloma Leuk , vol.13 , pp. 559-567
    • Kantarjian, H.M.1    Sekeres, M.A.2    Ribrag, V.3    Rousselot, P.4    Garcia-Manero, G.5    Jabbour, E.J.6
  • 48
    • 65649105075 scopus 로고    scopus 로고
    • BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity
    • Rudolph D, Steegmaier M, Hoffmann M, Grauert M, Baum A, Quant J et al. BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity. Clin Cancer Res 2009; 15: 3094-3102.
    • (2009) Clin Cancer Res , vol.15 , pp. 3094-3102
    • Rudolph, D.1    Steegmaier, M.2    Hoffmann, M.3    Grauert, M.4    Baum, A.5    Quant, J.6
  • 49
    • 68049112546 scopus 로고    scopus 로고
    • Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology
    • Schoffski P. Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology. Oncologist 2009; 14: 559-570.
    • (2009) Oncologist , vol.14 , pp. 559-570
    • Schoffski, P.1
  • 50
    • 77955167321 scopus 로고    scopus 로고
    • Multifaceted polo-like kinases: Drug targets and antitargets for cancer therapy
    • Strebhardt K. Multifaceted polo-like kinases: Drug targets and antitargets for cancer therapy. Nat Rev Drug Discov 2010; 9: 643-660.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 643-660
    • Strebhardt, K.1
  • 51
    • 84907300532 scopus 로고    scopus 로고
    • Randomized, phase 2 trial comparing low-dose cytarabine with or without volasertib in AML patients not suitable for intensive induction therapy
    • Döhner H, Lübbert M, Fiedler W, Fouillard L, Haaland A, Brandwein JM et al. Randomized, phase 2 trial comparing low-dose cytarabine with or without volasertib in AML patients not suitable for intensive induction therapy. Blood 2014; 124: 1426-1433.
    • (2014) Blood , vol.124 , pp. 1426-1433
    • Döhner, H.1    Lübbert, M.2    Fiedler, W.3    Fouillard, L.4    Haaland, A.5    Brandwein, J.M.6
  • 52
    • 0035383789 scopus 로고    scopus 로고
    • Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: A phase 1 clinical-laboratory correlative trial
    • Karp JE, Lancet JE, Kaufmann SH, End DW, Wright JJ, Bol K et al. Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: A phase 1 clinical-laboratory correlative trial. Blood 2001; 97: 3361-3369.
    • (2001) Blood , vol.97 , pp. 3361-3369
    • Karp, J.E.1    Lancet, J.E.2    Kaufmann, S.H.3    End, D.W.4    Wright, J.J.5    Bol, K.6
  • 53
    • 33847001315 scopus 로고    scopus 로고
    • A phase 2 study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia
    • Lancet JE, Gojo I, Gotlib J, Feldman EJ, Greer J, Liesveld JL et al. A phase 2 study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia. Blood 2007; 109: 1387-1394.
    • (2007) Blood , vol.109 , pp. 1387-1394
    • Lancet, J.E.1    Gojo, I.2    Gotlib, J.3    Feldman, E.J.4    Greer, J.5    Liesveld, J.L.6
  • 54
    • 84864295735 scopus 로고    scopus 로고
    • The addition of the farnesyl transferase inhibitor, tipifarnib, to low dose cytarabine does not improve outcome for older patients with AML
    • Burnett AK, Russell NH, Culligan D, Cavanagh J, Kell J, Wheatley K et al. The addition of the farnesyl transferase inhibitor, tipifarnib, to low dose cytarabine does not improve outcome for older patients with AML. Br J Haematol 2012; 158: 519-522.
    • (2012) Br J Haematol , vol.158 , pp. 519-522
    • Burnett, A.K.1    Russell, N.H.2    Culligan, D.3    Cavanagh, J.4    Kell, J.5    Wheatley, K.6
  • 55
    • 79952757852 scopus 로고    scopus 로고
    • First-in-man study of CPX-351: A liposomal carrier containing cytarabine and daunorubicin in a fixed 5:1 molar ratio for the treatment of relapsed and refractory acute myeloid leukemia
    • Feldman EJ, Lancet JE, Kolitz JE, Ritchie EK, Roboz GJ, List AF et al. First-in-man study of CPX-351: A liposomal carrier containing cytarabine and daunorubicin in a fixed 5:1 molar ratio for the treatment of relapsed and refractory acute myeloid leukemia. J Clin Oncol 2011; 29: 979-985.
    • (2011) J Clin Oncol , vol.29 , pp. 979-985
    • Feldman, E.J.1    Lancet, J.E.2    Kolitz, J.E.3    Ritchie, E.K.4    Roboz, G.J.5    List, A.F.6
  • 56
    • 23644455476 scopus 로고    scopus 로고
    • Drug therapy for acute myeloid leukemia
    • Tallman MS, Gilliland DG, Rowe JM. Drug therapy for acute myeloid leukemia. Blood 2005; 106: 1154-1163.
    • (2005) Blood , vol.106 , pp. 1154-1163
    • Tallman, M.S.1    Gilliland, D.G.2    Rowe, J.M.3
  • 57
    • 55049108527 scopus 로고    scopus 로고
    • In vivo maintenance of synergistic cytarabine:daunorubicin ratios greatly enhances therapeutic efficacy
    • Tardi P, Johnstone S, Harasym N, Xie S, Harasym T, Zisman N et al. In vivo maintenance of synergistic cytarabine:daunorubicin ratios greatly enhances therapeutic efficacy. Leuk Res 2009; 33: 129-139.
    • (2009) Leuk Res , vol.33 , pp. 129-139
    • Tardi, P.1    Johnstone, S.2    Harasym, N.3    Xie, S.4    Harasym, T.5    Zisman, N.6
  • 58
    • 77955280642 scopus 로고    scopus 로고
    • Leukemia-selective uptake and cytotoxicity of CPX-351, a synergistic fixed-ratio cytarabine:daunorubicin formulation, in bone marrow xenografts
    • Lim WS, Tardi PG, Dos SN, Xie X, Fan M, Liboiron BD et al. Leukemia-selective uptake and cytotoxicity of CPX-351, a synergistic fixed-ratio cytarabine:daunorubicin formulation, in bone marrow xenografts. Leuk Res 2010; 34: 1214-1223.
    • (2010) Leuk Res , vol.34 , pp. 1214-1223
    • Lim, W.S.1    Tardi, P.G.2    Dos, S.N.3    Xie, X.4    Fan, M.5    Liboiron, B.D.6
  • 59
    • 81255127741 scopus 로고    scopus 로고
    • Phase 2B randomized study of CPX-351 vs cytarabine (CYT)+daunorubicin (DNR) (7+3 regimen) in newly diagnosed AML patients aged 60-75
    • Lancet JE, Cortes JE, Hogge DE, Tallman M, Kovacsovics T, Damon LE et al. Phase 2B randomized study of CPX-351 vs cytarabine (CYT)+daunorubicin (DNR) (7+3 regimen) in newly diagnosed AML patients aged 60-75. Blood 2010; 116: 655.
    • (2010) Blood , vol.116 , pp. 655
    • Lancet, J.E.1    Cortes, J.E.2    Hogge, D.E.3    Tallman, M.4    Kovacsovics, T.5    Damon, L.E.6
  • 60
    • 84901412022 scopus 로고    scopus 로고
    • Phase 2 trial of CPX-351, a fixed 5:1 molar ratio of cytarabine/daunorubicin, vs cytarabine/daunorubicin in older adults with untreated AML
    • Lancet JE, Cortes JE, Hogge DE, Tallman MS, Kovacsovics TJ, Damon LE et al. Phase 2 trial of CPX-351, a fixed 5:1 molar ratio of cytarabine/daunorubicin, vs cytarabine/daunorubicin in older adults with untreated AML. Blood 2014; 123: 3239-3246.
    • (2014) Blood , vol.123 , pp. 3239-3246
    • Lancet, J.E.1    Cortes, J.E.2    Hogge, D.E.3    Tallman, M.S.4    Kovacsovics, T.J.5    Damon, L.E.6
  • 61
    • 80054113954 scopus 로고    scopus 로고
    • Antibody-drug conjugates of calicheamicin derivative: Gemtuzumab ozogamicin and inotuzumab ozogamicin
    • Ricart AD. Antibody-drug conjugates of calicheamicin derivative: Gemtuzumab ozogamicin and inotuzumab ozogamicin. Clin Cancer Res 2011; 17: 6417-6427.
    • (2011) Clin Cancer Res , vol.17 , pp. 6417-6427
    • Ricart, A.D.1
  • 63
    • 0023712557 scopus 로고
    • Molecular cloning, expression, and chromosomal localization of a human gene encoding the CD33 myeloid differentiation antigen
    • Peiper SC, Ashmun RA, Look AT. Molecular cloning, expression, and chromosomal localization of a human gene encoding the CD33 myeloid differentiation antigen. Blood 1988; 72: 314-321.
    • (1988) Blood , vol.72 , pp. 314-321
    • Peiper, S.C.1    Ashmun, R.A.2    Look, A.T.3
  • 64
    • 0035874504 scopus 로고    scopus 로고
    • Targeting of the CD33-calicheamicin immunoconjugate Mylotarg (CMA-676) in acute myeloid leukemia: In vivo and in vitro saturation and internalization by leukemic and normal myeloid cells
    • Van Der Velden V, te Marvelde JG, Hoogeveen PG, Bernstein ID, Houtsmuller AB, Berger MS et al. Targeting of the CD33-calicheamicin immunoconjugate Mylotarg (CMA-676) in acute myeloid leukemia: In vivo and in vitro saturation and internalization by leukemic and normal myeloid cells. Blood 2001; 97: 3197-3204.
    • (2001) Blood , vol.97 , pp. 3197-3204
    • Van Der Velden, V.1    Te Marvelde, J.G.2    Hoogeveen, P.G.3    Bernstein, I.D.4    Houtsmuller, A.B.5    Berger, M.S.6
  • 65
    • 77957711298 scopus 로고    scopus 로고
    • Preliminary results of southwest oncology group study s0106: An international intergroup phase 3 randomized trial comparing the addition of gemtuzumab ozogamicin to standard induction therapy versus standard induction therapy followed by a second randomization to post-consolidation gemtuzumab ozogamicin versus no additional therapy for previously untreated acute myeloid leukemia
    • Petersdorf S, Kopecky K, Stuart RK, Larson RA, Nevill TJ, Stenke L et al. Preliminary results of Southwest Oncology Group Study S0106: An international intergroup phase 3 randomized trial comparing the addition of gemtuzumab ozogamicin to standard induction therapy versus standard induction therapy followed by a second randomization to post-consolidation gemtuzumab ozogamicin versus no additional therapy for previously untreated acute myeloid leukemia. Blood 2009; 114: 790.
    • (2009) Blood , vol.114 , pp. 790
    • Petersdorf, S.1    Kopecky, K.2    Stuart, R.K.3    Larson, R.A.4    Nevill, T.J.5    Stenke, L.6
  • 66
    • 77950796567 scopus 로고    scopus 로고
    • Randomized trial of two schedules of low-dose gemtuzumab ozogamicin as induction monotherapy for newly diagnosed acute myeloid leukaemia in older patients not considered candidates for intensive chemotherapy. A phase II study of the EORTC and GIMEMA leukaemia groups (AML-19
    • Amadori S, Suciu S, Selleslag D, Stasi R, Alimena G, Baila L et al. Randomized trial of two schedules of low-dose gemtuzumab ozogamicin as induction monotherapy for newly diagnosed acute myeloid leukaemia in older patients not considered candidates for intensive chemotherapy. A phase II study of the EORTC and GIMEMA leukaemia groups (AML-19). Br J Haematol 2010; 149: 376-382.
    • (2010) Br J Haematol , vol.149 , pp. 376-382
    • Amadori, S.1    Suciu, S.2    Selleslag, D.3    Stasi, R.4    Alimena, G.5    Baila, L.6
  • 67
    • 84873409057 scopus 로고    scopus 로고
    • The addition of gemtuzumab ozogamicin to low-dose Ara-C improves remission rate but does not significantly prolong survival in older patients with acute myeloid leukaemia: Results from the LRF AML14 and NCRI AML16 pick-a-winner comparison
    • Burnett AK, Hills RK, Hunter AE, Milligan D, Kell WJ, Wheatley K et al. The addition of gemtuzumab ozogamicin to low-dose Ara-C improves remission rate but does not significantly prolong survival in older patients with acute myeloid leukaemia: Results from the LRF AML14 and NCRI AML16 pick-a-winner comparison. Leukemia 2013; 27: 75-81.
    • (2013) Leukemia , vol.27 , pp. 75-81
    • Burnett, A.K.1    Hills, R.K.2    Hunter, A.E.3    Milligan, D.4    Kell, W.J.5    Wheatley, K.6
  • 68
    • 84888252567 scopus 로고    scopus 로고
    • A phase trial of azacitidine and gemtuzumab ozogamicin therapy in older patients with acute myeloid leukemia
    • Nand S, Othus M, Godwin JE, Willman CL, Norwood TH, Howard DS et al. A phase trial of azacitidine and gemtuzumab ozogamicin therapy in older patients with acute myeloid leukemia. Blood 2013; 122: 3432-3439.
    • (2013) Blood , vol.122 , pp. 3432-3439
    • Nand, S.1    Othus, M.2    Godwin, J.E.3    Willman, C.L.4    Norwood, T.H.5    Howard, D.S.6
  • 69
    • 0036720398 scopus 로고    scopus 로고
    • The roles of FLT3 in hematopoiesis and leukemia
    • Gilliland DG, Griffin JD. The roles of FLT3 in hematopoiesis and leukemia. Blood 2002; 100: 1532-1542.
    • (2002) Blood , vol.100 , pp. 1532-1542
    • Gilliland, D.G.1    Griffin, J.D.2
  • 70
    • 84867396974 scopus 로고    scopus 로고
    • Targeting the FMS-like tyrosine kinase 3 in acute myeloid leukemia
    • Swords R, Freeman C, Giles F. Targeting the FMS-like tyrosine kinase 3 in acute myeloid leukemia. Leukemia 2012; 26: 2176-2185.
    • (2012) Leukemia , vol.26 , pp. 2176-2185
    • Swords, R.1    Freeman, C.2    Giles, F.3
  • 71
    • 84863283404 scopus 로고    scopus 로고
    • Molecular targeted therapies for cancer: Sorafenib mono-therapy and its combination with other therapies (review
    • Ibrahim N, Yu Y, Walsh WR, Yang JL. Molecular targeted therapies for cancer: Sorafenib mono-therapy and its combination with other therapies (review). Oncol Rep 2012; 27: 1303-1311.
    • (2012) Oncol Rep , vol.27 , pp. 1303-1311
    • Ibrahim, N.1    Yu, Y.2    Walsh, W.R.3    Yang, J.L.4
  • 72
    • 77951645227 scopus 로고    scopus 로고
    • Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia
    • Ravandi F, Cortes JE, Jones D, Faderl S, Garcia-Manero G, Konopleva MY et al. Phase I/II study of combination therapy with sorafenib, idarubicin, and cytarabine in younger patients with acute myeloid leukemia. J Clin Oncol 2010; 28: 1856-1862.
    • (2010) J Clin Oncol , vol.28 , pp. 1856-1862
    • Ravandi, F.1    Cortes, J.E.2    Jones, D.3    Faderl, S.4    Garcia-Manero, G.5    Konopleva, M.Y.6
  • 73
    • 84886534519 scopus 로고    scopus 로고
    • Sorafenib in combination with intensive chemotherapy in elderly patients with acute myeloid leukemia: Results from a randomized, placebo-controlled trial
    • Serve H, Krug U, Wagner R, Sauerland MC, Heinecke A, Brunnberg U et al. Sorafenib in combination with intensive chemotherapy in elderly patients with acute myeloid leukemia: Results from a randomized, placebo-controlled trial. J Clin Oncol 2013; 31: 3110-3118.
    • (2013) J Clin Oncol , vol.31 , pp. 3110-3118
    • Serve, H.1    Krug, U.2    Wagner, R.3    Sauerland, M.C.4    Heinecke, A.5    Brunnberg, U.6
  • 74
    • 70449475105 scopus 로고    scopus 로고
    • AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML
    • Zarrinkar PP, Gunawardane RN, Cramer MD, Gardner MF, Brigham D, Belli B et al. AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML). Blood 2009; 114: 2984-2992.
    • (2009) Blood , vol.114 , pp. 2984-2992
    • Zarrinkar, P.P.1    Gunawardane, R.N.2    Cramer, M.D.3    Gardner, M.F.4    Brigham, D.5    Belli, B.6
  • 75
    • 84875635430 scopus 로고    scopus 로고
    • Final results of a phase 2 open-label, monotherapy efficacy and safety study of quizartinib (AC220) in patients with FLT3-ITD positive or negative relapsed/refractory acute myeloid leukemia after second-line chemotherapy or hematopoietic stem cell transplantation
    • (ASH Annual Meeting Abstracts
    • Levis MJ, Perl AE, Dombret H, Dohner H, Steffen B, Rousselot P et al. Final results of a phase 2 open-label, monotherapy efficacy and safety study of quizartinib (AC220) in patients with FLT3-ITD positive or negative relapsed/refractory acute myeloid leukemia after second-line chemotherapy or hematopoietic stem cell transplantation. Blood (ASH Annual Meeting Abstracts) 2012; 120: 673.
    • (2012) Blood , vol.120 , pp. 673
    • Levis, M.J.1    Perl, A.E.2    Dombret, H.3    Dohner, H.4    Steffen, B.5    Rousselot, P.6
  • 76
    • 84887805195 scopus 로고    scopus 로고
    • Efficacy and safety of quizartinib (AC220) in patients age 4= 70 years with FLT3-ITD positive or negative relapsed/refractory acute myeloid leukemia (AML)
    • Perl AE, Dohner H, Rousselot PH, Marie JP, Martinelli G, Shah NP et al. Efficacy and safety of quizartinib (AC220) in patients age 4= 70 years with FLT3-ITD positive or negative relapsed/refractory acute myeloid leukemia (AML). ASCO Meeting Abstracts 2013; 31: 7023.
    • (2013) ASCO Meeting Abstracts , vol.31 , pp. 7023
    • Perl, A.E.1    Dohner, H.2    Rousselot, P.H.3    Marie, J.P.4    Martinelli, G.5    Shah, N.P.6
  • 77
    • 0036595143 scopus 로고    scopus 로고
    • Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412
    • Weisberg E, Boulton C, Kelly LM, Manley P, Fabbro D, Meyer T et al. Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412. Cancer Cell 2002; 1: 433-443.
    • (2002) Cancer Cell , vol.1 , pp. 433-443
    • Weisberg, E.1    Boulton, C.2    Kelly, L.M.3    Manley, P.4    Fabbro, D.5    Meyer, T.6
  • 78
    • 19944427559 scopus 로고    scopus 로고
    • Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412
    • Stone RM, DeAngelo DJ, Klimek V, Galinsky I, Estey E, Nimer SD et al. Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412. Blood 2005; 105: 54-60.
    • (2005) Blood , vol.105 , pp. 54-60
    • Stone, R.M.1    Deangelo, D.J.2    Klimek, V.3    Galinsky, I.4    Estey, E.5    Nimer, S.D.6
  • 79
    • 78049426367 scopus 로고    scopus 로고
    • Phase iib trial of oral midostaurin (pkc412), the fms-like tyrosine kinase 3 receptor (flt3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3
    • Fischer T, Stone RM, DeAngelo DJ, Galinsky I, Estey E, Lanza C et al. Phase IIB trial of oral Midostaurin (PKC412), the FMS-like tyrosine kinase 3 receptor (FLT3) and multi-targeted kinase inhibitor, in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome with either wild-type or mutated FLT3. J Clin Oncol 2010; 28: 4339-4345.
    • (2010) J Clin Oncol , vol.28 , pp. 4339-4345
    • Fischer, T.1    Stone, R.M.2    Deangelo, D.J.3    Galinsky, I.4    Estey, E.5    Lanza, C.6
  • 80
    • 84891814607 scopus 로고    scopus 로고
    • Crenolanib is a potent inhibitor of FLT3 with activity against resistance-conferring point mutants
    • Galanis A, Ma H, Rajkhowa T, Ramachandran A, Small D, Cortes J et al. Crenolanib is a potent inhibitor of FLT3 with activity against resistance-conferring point mutants. Blood 2014; 123: 94-100.
    • (2014) Blood , vol.123 , pp. 94-100
    • Galanis, A.1    Ma, H.2    Rajkhowa, T.3    Ramachandran, A.4    Small, D.5    Cortes, J.6
  • 81
    • 84888263107 scopus 로고    scopus 로고
    • Crenolanib is active against models of drug-resistant FLT3-ITD-positive acute myeloid leukemia
    • Zimmerman EI, Turner DC, Buaboonnam J, Hu S, Orwick S, Roberts MS et al. Crenolanib is active against models of drug-resistant FLT3-ITD-positive acute myeloid leukemia. Blood 2013; 122: 3607-3615.
    • (2013) Blood , vol.122 , pp. 3607-3615
    • Zimmerman, E.I.1    Turner, D.C.2    Buaboonnam, J.3    Hu, S.4    Orwick, S.5    Roberts, M.S.6
  • 82
    • 80051718182 scopus 로고    scopus 로고
    • Mechanisms of resistance to decitabine in the myelodysplastic syndrome
    • Qin T, Castoro R, El AS, Jelinek J, Wang X, Si J et al. Mechanisms of resistance to decitabine in the myelodysplastic syndrome. PLoS One 2011; 6: E23372.
    • (2011) PLoS One , vol.6 , pp. e23372
    • Qin, T.1    Castoro, R.2    El, A.S.3    Jelinek, J.4    Wang, X.5    Si, J.6
  • 83
    • 77956862198 scopus 로고    scopus 로고
    • Outcome of patients with myelodysplastic syndrome after failure of decitabine therapy
    • Jabbour E, Garcia-Manero G, Batty N, Shan J, O'Brien S, Cortes J et al. Outcome of patients with myelodysplastic syndrome after failure of decitabine therapy. Cancer 2010; 116: 3830-3834.
    • (2010) Cancer , vol.116 , pp. 3830-3834
    • Jabbour, E.1    Garcia-Manero, G.2    Batty, N.3    Shan, J.4    O'Brien, S.5    Cortes, J.6
  • 84
    • 84906053256 scopus 로고    scopus 로고
    • First clinical results of a randomized phase 2 study of SGI-110 a novel subcutaneous (SQ) hypomethylating agent (HMA) in adult patients with acute myeloid leukemia (AML)
    • Kantarjian HM, Jabbour E, Yee K, Kropf P, O'Connell C, Stock W et al. First clinical results of a randomized phase 2 study of SGI-110, a novel subcutaneous (SQ) hypomethylating agent (HMA), in adult patients with acute myeloid leukemia (AML). Blood 2013; 122: 497.
    • (2013) Blood , vol.122 , pp. 497
    • Kantarjian, H.M.1    Jabbour, E.2    Yee, K.3    Kropf, P.4    O'Connell, C.5    Stock, W.6
  • 85
    • 84872172430 scopus 로고    scopus 로고
    • Vorinostat induces apoptosis and differentiation in myeloid malignancies: Genetic and molecular mechanisms
    • Silva G, Cardoso BA, Belo H, Almeida AM. Vorinostat induces apoptosis and differentiation in myeloid malignancies: Genetic and molecular mechanisms. PLoS One 2013; 8: E53766.
    • (2013) PLoS One , vol.8 , pp. e53766
    • Silva, G.1    Cardoso, B.A.2    Belo, H.3    Almeida, A.M.4
  • 87
    • 84860595206 scopus 로고    scopus 로고
    • Phase II trial of vorinostat and gemtuzumab ozogamicin as induction and post-remission therapy in older adults with previously untreated acute myeloid leukemia
    • Walter RB, Medeiros BC, Powell BL, Schiffer CA, Appelbaum FR, Estey EH. Phase II trial of vorinostat and gemtuzumab ozogamicin as induction and post-remission therapy in older adults with previously untreated acute myeloid leukemia. Haematologica 2012; 97: 739-742.
    • (2012) Haematologica , vol.97 , pp. 739-742
    • Walter, R.B.1    Medeiros, B.C.2    Powell, B.L.3    Schiffer, C.A.4    Appelbaum, F.R.5    Estey, E.H.6
  • 88
    • 84857232181 scopus 로고    scopus 로고
    • LBH-589 (panobinostat) potentiates fludarabine anti-leukemic activity through a JNK-and XIAP-dependent mechanism
    • Rosato R, Hock S, Dent P, Dai Y, Grant S. LBH-589 (panobinostat) potentiates fludarabine anti-leukemic activity through a JNK-and XIAP-dependent mechanism. Leuk Res 2012; 36: 491-498.
    • (2012) Leuk Res , vol.36 , pp. 491-498
    • Rosato, R.1    Hock, S.2    Dent, P.3    Dai, Y.4    Grant, S.5
  • 89
    • 84892972702 scopus 로고    scopus 로고
    • Panobinostat enhances cytarabine and daunorubicin sensitivities in AML cells through suppressing the expression of BRCA1, CHK1, and Rad51
    • Xie C, Drenberg C, Edwards H, Caldwell JT, Chen W, Inaba H et al. Panobinostat enhances cytarabine and daunorubicin sensitivities in AML cells through suppressing the expression of BRCA1, CHK1, and Rad51. PLoS One 2013; 8: E79106.
    • (2013) PLoS One , vol.8 , pp. e79106
    • Xie, C.1    Drenberg, C.2    Edwards, H.3    Caldwell, J.T.4    Chen, W.5    Inaba, H.6
  • 90
    • 84904571688 scopus 로고    scopus 로고
    • Very high rates of clinical and cytogenetic response with the combination of the histone deacetylase inhibitor pracinostat (SB939) and 5-azacitidine in high-risk myelodysplastic syndrome
    • ASH Annual Meeting Abstracts
    • Quintas-Cardama A, Kantarjian HM, Ravandi F, Foudray C, Pemmaraju N, Kadia TM et al. Very high rates of clinical and cytogenetic response with the combination of the histone deacetylase inhibitor pracinostat (SB939) and 5-azacitidine in high-risk myelodysplastic syndrome. Blood (ASH Annual Meeting Abstracts) 2012; 120: 3821.
    • (2012) Blood , vol.120 , pp. 3821
    • Quintas-Cardama, A.1    Kantarjian, H.M.2    Ravandi, F.3    Foudray, C.4    Pemmaraju, N.5    Kadia, T.M.6
  • 91
    • 84881453720 scopus 로고    scopus 로고
    • Understanding and targeting cancer stem cells: Therapeutic implications and challenges
    • Chen K, Huang YH, Chen JL. Understanding and targeting cancer stem cells: Therapeutic implications and challenges. Acta Pharmacol Sin 2013; 34: 732-740.
    • (2013) Acta Pharmacol Sin , vol.34 , pp. 732-740
    • Chen, K.1    Huang, Y.H.2    Chen, J.L.3
  • 92
    • 84891854229 scopus 로고    scopus 로고
    • EZH2 in normal and malignant hematopoiesis
    • Lund K, Adams PD, Copland M. EZH2 in normal and malignant hematopoiesis. Leukemia 2014; 28: 44-49.
    • (2014) Leukemia , vol.28 , pp. 44-49
    • Lund, K.1    Adams, P.D.2    Copland, M.3
  • 93
    • 84864315640 scopus 로고    scopus 로고
    • Ecotropic viral integration site 1, stem cell self-renewal and leukemogenesis
    • Kataoka K, Kurokawa M. Ecotropic viral integration site 1, stem cell self-renewal and leukemogenesis. Cancer Sci 2012; 103: 1371-1377.
    • (2012) Cancer Sci , vol.103 , pp. 1371-1377
    • Kataoka, K.1    Kurokawa, M.2
  • 95
    • 84879589256 scopus 로고    scopus 로고
    • Omacetaxine mepesuccinate for patients with accelerated phase chronic myeloid leukemia with resistance or intolerance to two or more tyrosine kinase inhibitors
    • Nicolini FE, Khoury HJ, Akard L, Rea D, Kantarjian H, Baccarani M et al. Omacetaxine mepesuccinate for patients with accelerated phase chronic myeloid leukemia with resistance or intolerance to two or more tyrosine kinase inhibitors. Haematologica 2013; 98: E78-e79.
    • (2013) Haematologica , vol.98 , pp. 78-79
    • Nicolini, F.E.1    Khoury, H.J.2    Akard, L.3    Rea, D.4    Kantarjian, H.5    Baccarani, M.6
  • 96
    • 84892565367 scopus 로고    scopus 로고
    • U.S. Food and drug administration approval summary: Omacetaxine mepesuccinate as treatment for chronic myeloid leukemia
    • Alvandi F, Kwitkowski VE, Ko CW, Rothmann MD, Ricci S, Saber H et al. U.S. Food and drug administration approval summary: Omacetaxine mepesuccinate as treatment for chronic myeloid leukemia. Oncologist 2014; 19: 94-99.
    • (2014) Oncologist , vol.19 , pp. 94-99
    • Alvandi, F.1    Kwitkowski, V.E.2    Ko, C.W.3    Rothmann, M.D.4    Ricci, S.5    Saber, H.6
  • 97
    • 84878369242 scopus 로고    scopus 로고
    • Homoharringtonine-based induction regimens for patients with de-novo acute myeloid leukaemia: A multicentre open-label randomised controlled phase 3 trial
    • Jin J, Wang JX, Chen FF, Wu DP, Hu J, Zhou JF et al. Homoharringtonine-based induction regimens for patients with de-novo acute myeloid leukaemia: A multicentre, open-label, randomised, controlled phase 3 trial. Lancet Oncol 2013; 14: 599-608.
    • (2013) Lancet Oncol , vol.14 , pp. 599-608
    • Jin, J.1    Wang, J.X.2    Chen, F.F.3    Wu, D.P.4    Hu, J.5    Zhou, J.F.6
  • 98
    • 84878859644 scopus 로고    scopus 로고
    • Vosaroxin: A new valuable tool with the potential to replace anthracyclines in the treatment of AML?
    • Freeman C, Keane N, Swords R, Giles F. Vosaroxin: A new valuable tool with the potential to replace anthracyclines in the treatment of AML? Expert Opin Pharmacother 2013; 14: 1417-1427.
    • (2013) Expert Opin Pharmacother , vol.14 , pp. 1417-1427
    • Freeman, C.1    Keane, N.2    Swords, R.3    Giles, F.4
  • 99
    • 83555165090 scopus 로고    scopus 로고
    • A phase Ib study of vosaroxin, an anticancer quinolone derivative, in patients with relapsed or refractory acute leukemia
    • Lancet JE, Ravandi F, Ricklis RM, Cripe LD, Kantarjian HM, Giles FJ et al. A phase Ib study of vosaroxin, an anticancer quinolone derivative, in patients with relapsed or refractory acute leukemia. Leukemia 2011; 25: 1808-1814.
    • (2011) Leukemia , vol.25 , pp. 1808-1814
    • Lancet, J.E.1    Ravandi, F.2    Ricklis, R.M.3    Cripe, L.D.4    Kantarjian, H.M.5    Giles, F.J.6
  • 100
    • 17644368237 scopus 로고    scopus 로고
    • ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent
    • Gumireddy K, Reddy MV, Cosenza SC, Boominathan R, Baker SJ, Papathi N et al. ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent. Cancer Cell 2005; 7: 275-286.
    • (2005) Cancer Cell , vol.7 , pp. 275-286
    • Gumireddy, K.1    Reddy, M.V.2    Cosenza, S.C.3    Boominathan, R.4    Baker, S.J.5    Papathi, N.6
  • 101
    • 79960390325 scopus 로고    scopus 로고
    • Effect of on 01910. Na, an anticancer mitotic inhibitor, on cell-cycle progression correlates with RanGAP1 hyperphosphorylation
    • Oussenko IA, Holland JF, Reddy EP, Ohnuma T. Effect of ON 01910.Na, an anticancer mitotic inhibitor, on cell-cycle progression correlates with RanGAP1 hyperphosphorylation. Cancer Res 2011; 71: 4968-4976.
    • (2011) Cancer Res , vol.71 , pp. 4968-4976
    • Oussenko, I.A.1    Holland, J.F.2    Reddy, E.P.3    Ohnuma, T.4
  • 102
    • 84862572347 scopus 로고    scopus 로고
    • Directed therapy for patients with myelodysplastic syndromes (MDS) by suppression of cyclin D1 with on 01910. Na
    • Olnes MJ, Shenoy A, Weinstein B, Pfannes L, Loeliger K, Tucker Z et al. Directed therapy for patients with myelodysplastic syndromes (MDS) by suppression of cyclin D1 with ON 01910.Na. Leuk Res 2012; 36: 982-989.
    • (2012) Leuk Res , vol.36 , pp. 982-989
    • Olnes, M.J.1    Shenoy, A.2    Weinstein, B.3    Pfannes, L.4    Loeliger, K.5    Tucker, Z.6
  • 103
    • 83555168311 scopus 로고    scopus 로고
    • Treatment of higher risk myelodysplastic syndrome patients unresponsive to hypomethylating agents with on 01910. Na
    • Seetharam M, Fan AC, Tran M, Xu L, Renschler JP, Felsher DW et al. Treatment of higher risk myelodysplastic syndrome patients unresponsive to hypomethylating agents with ON 01910.Na. Leuk Res 2012; 36: 98-103.
    • (2012) Leuk Res , vol.36 , pp. 98-103
    • Seetharam, M.1    Fan, A.C.2    Tran, M.3    Xu, L.4    Renschler, J.P.5    Felsher, D.W.6
  • 104
    • 77649282032 scopus 로고    scopus 로고
    • Complete remissions observed in acute myeloid leukemia following prolonged exposure to lintuzumab: A phase 1 trial
    • Raza A, Jurcic JG, Roboz GJ, Maris M, Stephenson JJ, Wood BL et al. Complete remissions observed in acute myeloid leukemia following prolonged exposure to lintuzumab: A phase 1 trial. Leuk Lymphoma 2009; 50: 1336-1344.
    • (2009) Leuk Lymphoma , vol.50 , pp. 1336-1344
    • Raza, A.1    Jurcic, J.G.2    Roboz, G.J.3    Maris, M.4    Stephenson, J.J.5    Wood, B.L.6
  • 105
    • 84872072793 scopus 로고    scopus 로고
    • Randomized phase IIb study of low-dose cytarabine and lintuzumab versus low-dose cytarabine and placebo in older adults with untreated acute myeloid leukemia
    • Sekeres MA, Lancet JE, Wood BL, Grove LE, Sandalic L, Sievers EL et al. Randomized phase IIb study of low-dose cytarabine and lintuzumab versus low-dose cytarabine and placebo in older adults with untreated acute myeloid leukemia. Haematologica 2013; 98: 119-128.
    • (2013) Haematologica , vol.98 , pp. 119-128
    • Sekeres, M.A.1    Lancet, J.E.2    Wood, B.L.3    Grove, L.E.4    Sandalic, L.5    Sievers, E.L.6
  • 106
    • 78049456138 scopus 로고    scopus 로고
    • Sequential cytarabine and alpha-particle immunotherapy with bismuth-213-lintuzumab (HuM195) for acute myeloid leukemia
    • Rosenblat TL, McDevitt MR, Mulford DA, Pandit-Taskar N, Divgi CR, Panageas KS et al. Sequential cytarabine and alpha-particle immunotherapy with bismuth-213-lintuzumab (HuM195) for acute myeloid leukemia. Clin Cancer Res 2010; 16: 5303-5311.
    • (2010) Clin Cancer Res , vol.16 , pp. 5303-5311
    • Rosenblat, T.L.1    McDevitt, M.R.2    Mulford, D.A.3    Pandit-Taskar, N.4    Divgi, C.R.5    Panageas, K.S.6
  • 107
    • 84903199472 scopus 로고    scopus 로고
    • Phase i trial of the targeted alpha-particle nano-generator Actinium-225 (225Ac)-lintuzumab (anti-CD33) in combination with low-dose cytarabine (LDAC) for older patients with untreated acute myeloid leukemia (AML)
    • Jurcic JG, Ravandi F, Pagel JM, Park JH, Douer D, Estey EH et al. Phase I trial of the targeted alpha-particle nano-generator Actinium-225 (225Ac)-lintuzumab (anti-CD33) in combination with low-dose cytarabine (LDAC) for older patients with untreated acute myeloid leukemia (AML). Blood 2013; 122: 1460.
    • (2013) Blood , vol.122 , pp. 1460
    • Jurcic, J.G.1    Ravandi, F.2    Pagel, J.M.3    Park, J.H.4    Douer, D.5    Estey, E.H.6
  • 108
    • 84886825064 scopus 로고    scopus 로고
    • SGN-CD33A: A novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML
    • Kung Sutherland MS, Walter RB, Jeffrey SC, Burke PJ, Yu C, Kostner H et al. SGN-CD33A: A novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML. Blood 2013; 122: 1455-1463.
    • (2013) Blood , vol.122 , pp. 1455-1463
    • Kung Sutherland, M.S.1    Walter, R.B.2    Jeffrey, S.C.3    Burke, P.J.4    Yu, C.5    Kostner, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.