Targeting sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2 by curcumin induces ER stress-associated apoptosis for treating human liposarcoma

Molecular Cancer Therapeutics

Volumn 10, Issue 3, 2011, Pages 461-471

  Wang, Lu ^a   Wang, Lingxian ^a   Song, Ran ^a   Shen, Yan ^a   Sun, Yang ^a   Gu, Yanhong ^a,b   Shu, Yongqian ^b   Xu, Qiang ^a  

^a NANJING UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CASPASE 3; CASPASE 8; CISPLATIN; CURCUMIN; DOXORUBICIN; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SORAFENIB; SUNITINIB;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL STRAIN SW872; CELL SURVIVAL; CONTROLLED STUDY; DOSE RESPONSE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; LIPOSARCOMA; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOMA CELL; SARCOPLASMIC RETICULUM;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 8; CELL LINE, TUMOR; CELL SURVIVAL; CURCUMIN; ENDOPLASMIC RETICULUM; HUMANS; LIPOSARCOMA; MICE; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RNA INTERFERENCE; RNA, SMALL INTERFERING; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; STRESS, PHYSIOLOGICAL; TRANSCRIPTION FACTOR CHOP;

EID: 79955763984     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-10-0812     Document Type: Article

References (33)

1. Mack TM. Sarcomas and other malignancies of soft-tissue, retro-peritoneum, peritoneum, pleura, heart, mediastinum, and spleen. Cancer 1995;75:211-44.
2. Amato G, Martella A, Ferraraccio F, Di Martino N, Maffettone V, Landolfi V, et al. Well differentiated "lipoma-like" liposarcoma of the sigmoid mesocolon and multiple lipomatosis of the rectosigmoid colon. Report of a case. Hepatogastroenterology 1998;45:2151-6.
3. Singer S, Socci ND, Ambrosini G, Sambol E, Decarolis P, Wu Y, et al. Gene expression profiling of liposarcoma identifies distinct biological types/subtypes and potential therapeutic targets in well-differentiated and dedifferentiated liposarcoma. Cancer Res 2007;67:6626-36. (Pubitemid 47105508)
4. Spira AI, Ettinger DS. The use of chemotherapy in soft-tissue sarcomas. Oncologist 2002;7:348-59. (Pubitemid 34919959)
5. Ambrosini G, Cheema HS, Seelman S, Teed A, Sambol EB, Singer S, et al. Sorafenib inhibits growth and mitogen-activated protein kinase signaling in malignant peripheral nerve sheath cells. Mol Cancer Ther 2008;7:890-6. (Pubitemid 351551042)
6. Sharma RA, Gescher AJ, Steward WP. Curcumin: the story so far. Eur J Cancer 2005;41:1955-68. (Pubitemid 41557681)
7. Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res 2003;23:363-98. (Pubitemid 36361976)
8. Chuang SE, Kuo ML, Hsu CH, Chen CR, Lin JK, Lai GM, et al. Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis. Carcinogenesis 2000;21:331-5. (Pubitemid 30098723)
9. Pollmann C, Huang XH, Mall J, Bech-Otschir D, Naumann M Dubiel W. The constitutive photomorphogenesis 9 signalosome directs vascular endothelial growth factor production in tumor cells. Cancer Res 2001;61:8416-21. (Pubitemid 33131118)
10. Dhillon N, Aggarwal BB, Newman RA, Wolff RA, Kunnumakkara AB, Abbruzzese JL, et al. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res 2008;14:4491-9.
11. Wang Lu, Shen Yan, Song Ran, Sun Y, Xu J, Xu Q, et al. An anticancer effect of curcumin mediated by down-regulating phosphatase of regenerating liver-3 expression on highly metastatic melanoma cells. Mol Pharmacol 2009;76:1238-45.
12. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of curcuma longa: a review of preclinical and clinical research. Altern Med Rev 2009;14:141-53.
13. Ravindran J, Prasad S, Aggarwal BB. Curcumin and cancer cells: how many ways can curry kill tumor cells selectively? AAPS J 2009;11:495-510.
14. Lao CD, Ruffin MT, Normolle D, Heath DD, Murray SI, Bailey JM, et al. Dose escalation of a curcuminoid formulation. BMC Complement Altern Med 2006;6:10.
15. Shahanas Chathoth, Faisal Thayyullathil, Galadari Sehamuddin. Curcumin cell signaling: a possible target for chemotherapy. Curr Trends Biotechnol Pharm. 2008;2:226-38.
16. Samaha HS, Kelloff GJ, Steele V, Rao CV, Reddy BS. Modulation of apoptosis by sulindac, curcumin, phenylethyl-3-methylcaffeate, and 6-phenylhexyl isothiocyanate: apoptotic index as a biomarker in colon cancer chemoprevention and promotion. Cancer Res 1997;57:1301-5. (Pubitemid 27152555)
17. Shukla PK, Khanna VK, Khan MY, Srimal RC. Protective effect of curcumin against lead neurotoxicity in rat. Hum Exp Toxicol 2003;22:653-8. (Pubitemid 38239785)
18. Ferri KF, Kroemer G. Organelle-specific initiation of cell death pathways. Nat Cell Biol 2001;3:E255-E63.
19. Lee AH, Iwakoshi NN, Anderson KC, Glimcher LH. Proteasome inhibitors disrupt the unfolded protein response in myeloma cells. Proc Natl Acad Sci U S A 2003;100:9946-51. (Pubitemid 37087048)
20. Menendez-Benito V, Verhoef L, Masucci MG, Dantuma NP. Endoplasmic reticulum stress compromises the ubiquitin-proteasome system. Hum Mol Genet 2005;14:2787-99. (Pubitemid 41418785)
21. Obeng EA, Carlson LM, Gutman DM, Harrington WJ Jr, Lee KP, Boise LH. Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Blood 2006;107:4907-16. (Pubitemid 43882644)
22. Copanaki E, Schurmann T, Eckert A, Leuner K, Müller WE, Prehn JH, et al. The amyloid precursor protein potentiates CHOP induction and cell death in response to ER Ca2+ depletion. Biochim Biophys Acta 2007;1773:157-65. (Pubitemid 46123616)
23. Kim R, Emi M, Tanabe K, Murakami S. Role of the unfolded protein response in cell death. Apoptosis 2006;11:5-13. (Pubitemid 43151639)
24. Denmeade SR, Isaacs JT. The SERCA pump as a therapeutic target - making a "smart bomb" for prostate cancer. Cancer Biol Ther 2005;4:14-22.
25. Wootton LL, Michelangeli F. The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors. J Biol Chem 2006;281:6970-6. (Pubitemid 43847459)
26. Bilmen JG, Khan SZ, Javed MUH, Michelangeli F. Inhibition of the SERCA Ca2+ pumps by curcumin - Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP. Eur J Biochem 2001;268:6318-27. (Pubitemid 33132054)
27. Kunwar A, Barik A, Mishra B, Rathinasamy K, Pandey R, Priyadarsini KI, et al. Quantitative cellular uptake, localization and cytotoxicity of curcumin in normal and tumor cells. Biochim Biophys Acta 2008;1780:673-9.
28. Monteith GR, McAndrew D, Faddy HM, Roberts-Thomson SJ. Calcium and cancer: targeting Ca2+ transport. Nat Rev Cancer 2007;7:519-30. (Pubitemid 46985398)
29. Dally S, Bredoux R, Corvazier E, Andersen JP, Clausen JD, Dode L, et al. Ca2+-ATPases in non-failing and failing heart: evidence for a novel cardiac sarco/endoplasmic reticulum Ca2+-ATPase 2 isoform (SERCA2c). Biochem J 2006;395:249-58.
30. Dally S, Corvazier E, Bredoux R, Bobe R, Enouf J. Multiple and diverse coexpression, location, and regulation of additional SERCA2 and SERCA3 isoforms in nonfailing and failing human heart. J Mol Cell Cardiol 2010;48:633-44.
31. Chung FY, Lin SR, Lu CY, Yeh CS, Chen FM, Hsieh JS, et al. Sarco/ endoplasmic reticulum calcium-ATPase 2 expression as a tumor marker in colorectal cancer. Am J Surg Pathol 2006;30:969-74.
32. Prasad V, Boivin GP, Miller ML, et al. Haploinsufficiency of Atp2a2, encoding the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 Ca-2 pump, predisposes mice to squamous cell tumors via a novel mode of cancer susceptibility. Cancer Res 2005;65:8655-61. (Pubitemid 41377352)
33. Ravindran J, Prasad S, Aggarwal BB. Curcumin and cancer cells: how many ways can curry kill tumor cells selectively? Aaps Journal 2009;11:495-510.