Gliotoxin suppresses macrophage immune function by subverting phosphatidylinositol 3,4,5-trisphosphate homeostasis

mBio

Volumn 7, Issue 2, 2016, Pages

  Schlam, Daniel ^a,b   Canton, Johnathan ^a   Carreño, Marvin ^a   Kopinski, Hannah ^a,e   Freeman, Spencer A ^a   Grinstein, Sergio ^a,b,c   Fairn, Gregory D ^b,c,d  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c ST MICHAEL'S HOSPITAL   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTEGRIN; CYCLIC AMP; DIACYLGLYCEROL; FC RECEPTOR; GLIOTOXIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PROTEIN CDC42; RAC PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5-TRIPHOSPHATE; POLYPHOSPHOINOSITIDE;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; ASPERGILLUS FUMIGATUS; CELL ADHESION; CELL SPREADING; CELL SURFACE; CELL VIABILITY; CONTROLLED STUDY; MACROPHAGE; MOUSE; NONHUMAN; PHAGOCYTE; PHAGOCYTOSIS; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TIME LAPSE IMAGING; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; HOMEOSTASIS; HUMAN; IMMUNE EVASION; IMMUNOLOGY; METABOLISM; MICROSCOPY; PATHOGENICITY;

ANIMALS; ASPERGILLUS FUMIGATUS; CELLS, CULTURED; GLIOTOXIN; HOMEOSTASIS; HUMANS; IMMUNE EVASION; MACROPHAGES; MICE; MICROSCOPY; PHAGOCYTOSIS; PHOSPHATIDYLINOSITOL PHOSPHATES; TIME-LAPSE IMAGING;

EID: 84965041835     PISSN: 21612129     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.02242-15     Document Type: Article

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