Correlation between gliotoxin production and virulence of Aspergillus fumigatus in Galleria mellonella

Mycopathologia

Volumn 158, Issue 1, 2004, Pages 73-79

  Reeves, Emer P ^a   Messina, C G M ^b   Doyle, S ^a   Kavanagh, K ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^b Instituto Superiore di Sanita   (Italy)

Author keywords

Aspergillus fumigatus; fungal infection; Galleria mellonella; gliotoxin; immunosuppression

Indexed keywords

CATALASE; GLIOTOXIN; PANCREATIC ELASTASE;

ANIMAL; ARTICLE; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; ASPERGILLUS NIGER; BIOSYNTHESIS; ENZYMOLOGY; HUMAN; METABOLISM; MICROBIOLOGY; MOTH; PATHOGENICITY; VIRULENCE;

ANIMALS; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; ASPERGILLUS NIGER; CATALASE; GLIOTOXIN; HUMANS; MOTHS; PANCREATIC ELASTASE; VIRULENCE;

ANIMALIA; ASPERGILLUS; ASPERGILLUS FUMIGATUS; ASPERGILLUS NIGER; FUNGI; GALLERIA MELLONELLA; INSECTA; INVERTEBRATA; LEPIDOPTERA;

EID: 4444297435     PISSN: 0301486X     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:MYCO.0000038434.55764.16     Document Type: Article

References (36)

1. Daly P, Kavanagh K. Pulmonary aspergillosis: clinical presentation, diagnosis and therapy. B Biomed Sci 2001; 58: 197-205.
2. Saha DT, Larsen B. Clinical isolates of yeast produce a gliotoxin like substance. Mycopathologia 1991; 116: 203-208.
3. Richard J, DeBey M, Chermette R, Pier A, Hasegawa A, Lund A, Bratberg A, Padhye A, Connole M. Advances in veterinary mycology. J Med Vet Mycol 1994; 32: 169-187.
4. Waring P, Beaver J. Gliotoxin and Related Epipolythiodioxopiperazine. Gen Pharmac 1996; 27: 1311-1316.
5. Braithwaite AW, Eichner RD, Waring P, Müllbacher A. The immunomodulating agent gliotoxin causes genomic DNA fragmentation. Mol Immunol 1987; 24: 47-55.
6. Müllbacher A, Eichner RD. Immunosuppression in vitro by a metabolite of a human pathogenic fungi. Proc Natl Acad Sci USA 1984; 81: 3835-3837.
7. Waring P, Eichner RD, Müllbacher A, Sjaarda A. Gliotoxin induces apoptosis in macrophages unrelated to its antiphagocytic properties. J Biol Chem 1988; 263: 18493-18499.
8. Boutibonnes P, Auffray Y, Malherbe C, Kogbo W, Marais C. Proprietes antibacteriennes et genotoxiques de 33 mycotoxines. Mycopathologia 1984; 87: 43-49.
9. Larin NM, Copping MP, Herbst-Laier RH, Roberts B, Wenham RMM. Antiviral activity of gliotoxin. Chemotheraphy 1965; 10: 14-25.
10. Richard JL, Dvorak TJ, Ross PF. Natural occurrence of gliotoxin in turkeys infected with Aspergillus fumigatus, Fresenius. Mycopathologia 1996; 134: 167-170.
11. Mondon P, De Champs C, Donadille A, Ambroise-Thomas P, Grillot R. Variation in virulence of Aspergillus fumigatus strains in a murine model of invasive pulmonary aspergillosis. J Med Microbiol 1995; 45: 186-191.
12. Kang D, Liu G, Lundstrom A, Gelius E, Steiner H. A peptigoglycan recognition protein in innate immunity conserved from insects to humans. Proc Natl Acad Sci USA 1998; 95: 10078-10082.
13. Yoshimura A, Lien E, Ingalls RR, Tuomanen E, Dziarski R, Golenbock D. Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Tol-like receptor 2. J Immunol 1999; 163: 1-5.
14. Vilmos P, Kurucz E. Insect Immunity: evolutionary roots of the mammalian innate immune system. Immunol Letts 1998; 62: 59-66.
15. Slepneva IA, Glupov VV, Sergeeva SV, Khramtsov VV. EPR detection of reactive oxygen species in hemolymph of Galleria mellonella and Dendrolimus superans Sibiriens (Lepidoptera) larvae. Biochem Biophys Res Commun 1999; 264: 212-215.
16. Irving P, Troxler L, Heuer TS, Belvin M, Kopczynski C, Reichhart JM, Hoffmann JA, Hetru C. A genome-wide analysis of immune responses in Drosophila. Proc Natl Acad Sci USA 2001; 98: 15119-15124.
17. Cotter G, Doyle S, Kavanagh K. Development of an insect model for the in vivo pathogenicity testing of yeast. FEMS Immunol Med Microbiol 2000; 27: 163-169.
18. Jander G, Rahme LG, Ausubel FM. Positive correlation between virulence of Pseudomonas aeruginosa mutants in mice and insects. J Bacteriol 2000; 182: 3843-3845.
19. Dunphy G, Morton D, Kropinski A, Chadwick J. Patogenicity of lipopolysaccharide mutants of Pseudomonas aeruginosa for larvae of Galleria mellonella: bacterial properties associated with virulence. J Invert Pathol 1986; 47: 48-55.
20. Brennan M, Thomas DY, Whiteway M, Kavanagh K. Correlation between virulence of Candida albicans mutants in mice and Galleria mellonella larvae. FEMS Immunol Med Microbiol 2002; 341: 153-157.
21. Kettle AJ, Winterbourn CC. A kinetic analysis of the catalase activity of myeloperoxidase. Biochemistry 2001; 40: 10204-10212.
22. Borger P, Koeter GH, Timmerman JAB, Vellenga E, Tomee JFC, Kauffman HF. Proteases from Aspergillus fumigatus. J Infect Dis 1999; 180: 1267-1274.
23. Nieminen SM, Maki-Paakkanen J, Hirvonen M-R, Roponen M, von Wright A. Genotoxicity of gliotoxin, a secondary metabolite of Aspergillus fumigatus, in a battery of short-term systems. Mut Res 2002; 520: 161-170.
24. Sutton P, Waring P, Müllbacher A. Exacerbation of invasive aspergillosis by the immunosuppressive fungal metabolite, gliotoxin. Immunol Cell Biol 1996; 74: 318-322.
25. Richard JL, Lyon RI, Fichtner RE, Ross PF. Use of thin layer chromatography for dection and high performance liquid chromatography for quantitating gliotoxin from rice cultures of Aspergillus fumigatus. Mycopathologia 1989; 107: 145-151.
26. + flux. Nature 2002; 416: 291-297.
27. Washburn RG, Gallin JI, Bennett JE. Oxidative killing of Aspergillus fumigatus proceeds by parallel myeloperoxidase-dependent and -independent pathways. Infect Immun 1987; 55: 2088-2092.
28. Odeberg H, Olsson I. Mechanisms for the microbicidal activity of cationic proteins of human granulocytes. Infect Immun 1976; 14: 1269-1275.
29. Eichner RD, Al Salami M, Wood PR, Müllbacher A. The effect of gliotoxin upon macrophage function. Int J Immunopharmacol 1986; 8: 789-797.
30. Leitz SM, Diamond RD. Mechanisms of resistance of Aspergillus fumigatus conidia to killing by neutrophils in vitro. J Infect Dis 1985; 152: 33-42.
31. Shimizu K, Kondoh Y, Tanaka K. Proteinase production and pathogenicity of Candida albicans. Microbiol Immunol 1987; 31: 1045-1060.
32. Kolattukudy PE, Lee JD, Rogers LM, Zimmerman P, Ceselski S, Fox B, Stein B, Copelan EA. Evidence for possible involvement of an elastolytic serine protease in aspergillosis. Infect Immun 1993; 61: 2357-2368.
33. Taylor A. The toxicology of sporodesim and other epipolydioxopiperasine. In: Kadis S, Ciegler A, Ajl SJ, eds. Microbiol.Toxins. Vol. 7. New York: Academic Press, 1971: 370-376.
34. Bertout S, Badoc C, Mallie M, Giaimis J, Bastide J-M. Spore diffusate isolated from some strains of Aspergillus fumigatus inhibits phagocytosis by murine alveolar macrophages. FEMS Immunol Med Microbiol 2002; 33: 101-106.
35. Sutton P, Newcombe NR, Waring P, Müllbacher A. In vivo immunosuppressive activity of gliotoxin, a metabolite produced by human pathogenic Fungi. Infect Immun 1994; 62: 1192-1198.
36. Aratani Y, Koyama H, Nyui S-I, Suzuki K, Kura F, Maeda N. Severe impairment in early host defence against Candida albicans in mice deficient in myeloperoxidase. Infect Immun 1999; 67: 1828-1836.